DK0806479T3 - Produktion af biotin ved fermentering - Google Patents

Produktion af biotin ved fermentering

Info

Publication number
DK0806479T3
DK0806479T3 DK97106762T DK97106762T DK0806479T3 DK 0806479 T3 DK0806479 T3 DK 0806479T3 DK 97106762 T DK97106762 T DK 97106762T DK 97106762 T DK97106762 T DK 97106762T DK 0806479 T3 DK0806479 T3 DK 0806479T3
Authority
DK
Denmark
Prior art keywords
biotin
desthiobiotin
production
nifu
nifs
Prior art date
Application number
DK97106762T
Other languages
English (en)
Inventor
Tatsuo Hoshino
Akira Asakura
Tatsuya Kiyasu
Yoshie Nagahashi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0806479T3 publication Critical patent/DK0806479T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK97106762T 1996-05-06 1997-04-24 Produktion af biotin ved fermentering DK0806479T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96107064 1996-05-06

Publications (1)

Publication Number Publication Date
DK0806479T3 true DK0806479T3 (da) 2003-10-06

Family

ID=8222753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97106762T DK0806479T3 (da) 1996-05-06 1997-04-24 Produktion af biotin ved fermentering

Country Status (9)

Country Link
US (1) US6361978B1 (da)
EP (1) EP0806479B1 (da)
JP (1) JP4084440B2 (da)
CN (1) CN1161476C (da)
AT (1) ATE243256T1 (da)
BR (1) BR9703055A (da)
DE (1) DE69722852T2 (da)
DK (1) DK0806479T3 (da)
ES (1) ES2201219T3 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2231835T3 (es) 1996-09-27 2005-05-16 Dsm Ip Assets B.V. Genes biosinteticos ii de biotina.
DE19731274A1 (de) * 1997-07-22 1999-01-28 Basf Ag Verfahren zur Herstellung von Biotin
DE19806872A1 (de) * 1998-02-19 1999-08-26 Basf Ag Verfahren zur Herstellung von Biotin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61149091A (ja) 1984-12-24 1986-07-07 Nippon Soda Co Ltd ビオチン合成酵素をコ−ドする二重鎖ｄｎａ、それを含む微生物及びビオチンの製造法
CA1317245C (en) * 1985-08-26 1993-05-04 Eric F. Fisher System for biotin synthesis
JPS62155081A (ja) 1985-12-27 1987-07-10 Shiseido Co Ltd 新規微生物およびそれを用いる醗酵法によるビオチンの製造法
JP2722504B2 (ja) 1988-07-14 1998-03-04 田辺製薬株式会社 新規微生物及びそれを用いるｄ−ビオチンの製法
FR2642768B1 (fr) 1989-01-19 1991-05-17 Transgene Sa Procede perfectionne pour l'expression de la biotine dans bacillus sphaericus
JPH03240489A (ja) 1990-02-19 1991-10-25 Mitsubishi Petrochem Co Ltd 新規なプラスミド、それを保有するコリネ型細菌及びビオチンの製造法
JPH06339371A (ja) * 1991-04-15 1994-12-13 Nippon Zeon Co Ltd クレビシエラ属に属する形質転換微生物及びそれを用いたビオチンの製造方法
AU4820293A (en) 1992-10-02 1994-04-26 Lonza A.G. Biotechnological method of producing biotin
JP3240489B2 (ja) 1993-01-21 2001-12-17 株式会社日立製作所 Ｉｇｂｔの過電流保護装置及びｉｇｂｔの保護装置
JPH07236493A (ja) 1994-03-03 1995-09-12 Shiseido Co Ltd デスチオビオチンからビオチンへの変換方法
JP3180174B2 (ja) 1994-06-23 2001-06-25 新日本製鐵株式会社 窒素酸化物含有排ガスの生物学的脱硝方法
EP0747483B1 (en) 1995-06-09 2004-03-24 DSM IP Assets B.V. Fermentative carotenoid production

Also Published As

Publication number Publication date
JPH1033189A (ja) 1998-02-10
US6361978B1 (en) 2002-03-26
EP0806479A1 (en) 1997-11-12
EP0806479B1 (en) 2003-06-18
DE69722852T2 (de) 2004-05-06
ES2201219T3 (es) 2004-03-16
CN1161476C (zh) 2004-08-11
ATE243256T1 (de) 2003-07-15
JP4084440B2 (ja) 2008-04-30
CN1170762A (zh) 1998-01-21
DE69722852D1 (de) 2003-07-24
BR9703055A (pt) 1998-09-29

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