DK0804479T3 - Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF - Google Patents

Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF

Info

Publication number
DK0804479T3
DK0804479T3 DK95934808T DK95934808T DK0804479T3 DK 0804479 T3 DK0804479 T3 DK 0804479T3 DK 95934808 T DK95934808 T DK 95934808T DK 95934808 T DK95934808 T DK 95934808T DK 0804479 T3 DK0804479 T3 DK 0804479T3
Authority
DK
Denmark
Prior art keywords
kgf
diabetes mellitus
treating diabetes
mammals
pharmaceutical compositions
Prior art date
Application number
DK95934808T
Other languages
Danish (da)
English (en)
Inventor
Sharon Lea Aukerman
Glenn Francis Pierce
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0804479T3 publication Critical patent/DK0804479T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK95934808T 1994-10-13 1995-10-12 Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF DK0804479T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32334094A 1994-10-13 1994-10-13
US32347594A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000992 WO1996011950A1 (en) 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf

Publications (1)

Publication Number Publication Date
DK0804479T3 true DK0804479T3 (da) 2007-01-29

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95934808T DK0804479T3 (da) 1994-10-13 1995-10-12 Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF
DK95934793T DK0785948T3 (da) 1994-10-13 1995-10-12 Analoger af keratinocyt vækstfaktor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK95934793T DK0785948T3 (da) 1994-10-13 1995-10-12 Analoger af keratinocyt vækstfaktor

Country Status (23)

Country Link
EP (2) EP0804479B1 (pt)
JP (2) JP4216329B2 (pt)
KR (1) KR100278597B1 (pt)
CN (1) CN1168678A (pt)
AT (2) ATE342278T1 (pt)
AU (1) AU3707795A (pt)
BG (2) BG101392A (pt)
BR (2) BR9509269A (pt)
CA (2) CA2201940C (pt)
CZ (3) CZ98197A3 (pt)
DE (2) DE69535264T2 (pt)
DK (2) DK0804479T3 (pt)
EE (2) EE9700225A (pt)
ES (2) ES2196082T3 (pt)
FI (2) FI971420A0 (pt)
HU (2) HU226168B1 (pt)
NO (2) NO971566L (pt)
NZ (2) NZ505502A (pt)
PL (2) PL182888B1 (pt)
PT (2) PT804479E (pt)
SI (2) SI0804479T1 (pt)
SK (2) SK284534B6 (pt)
WO (2) WO1996011949A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033668T2 (de) 1989-01-31 2001-04-12 Jeffrey S Rubin Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
DE69434053T2 (de) 1993-06-29 2006-02-23 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Verkürzter keratinocytenwachstumsfaktor(kgf)mit erhöhter biologischer aktivität
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
CN1161380C (zh) * 1994-10-13 2004-08-11 安姆根有限公司 角化细胞生长因子的纯化方法
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
EP0822943B9 (en) * 1995-04-27 2007-02-28 Coöperatie Cosun U.A. Inulin derivatives
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
EP0935652B1 (en) * 1996-10-15 2004-03-31 Amgen Inc. Keratinocyte growth factor-2 products
SI0935652T1 (en) * 1996-10-15 2004-06-30 Amgen Inc. Keratinocyte growth factor-2 products
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
DE69838552T2 (de) 1997-07-14 2008-05-21 Bolder Biotechnology, Inc., Louisville Derivate des wachstumshormons und verwandte proteine
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
CA2316015A1 (en) 1997-12-22 1999-07-01 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
ATE526401T1 (de) * 1999-01-14 2011-10-15 Bolder Biotechnology Inc Verfahren zur herstellung von proteinen mit freien cysteinresten
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
WO2002062842A1 (en) * 2001-02-06 2002-08-15 Merck Patent Gmbh Modified keratinocyte growth factor (kgf) with reduced immunogenicity
MXPA04001526A (es) 2001-08-21 2004-05-31 Chiron Corp Composiciones de polipetidos kgf.
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
SI1827483T1 (sl) 2004-12-15 2014-11-28 Swedish Orphan Biovitrum Ab (Publ) Terapevtske formulacije keratinocitnega rastnega faktorja
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd reg蛋白質
WO1990000877A1 (en) * 1988-07-27 1990-02-08 Marjan International Pty Ltd Carpet stretcher
DE69033668T2 (de) * 1989-01-31 2001-04-12 Jeffrey S Rubin Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 bFGFムテインおよびその製造法
CN1064710C (zh) * 1993-03-26 2001-04-18 安姆根有限公司 角质细胞生长因子的治疗应用
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
DE69434053T2 (de) * 1993-06-29 2006-02-23 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Verkürzter keratinocytenwachstumsfaktor(kgf)mit erhöhter biologischer aktivität
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
WO1995003831A1 (en) * 1993-08-02 1995-02-09 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates

Also Published As

Publication number Publication date
PL182888B1 (pl) 2002-03-29
ATE342278T1 (de) 2006-11-15
ES2273338T3 (es) 2007-05-01
NO971566L (no) 1997-04-14
HU226168B1 (en) 2008-05-28
DE69535264T2 (de) 2007-02-01
SI0785948T1 (en) 2003-08-31
PT804479E (pt) 2007-02-28
BG101408A (en) 1997-12-30
CZ297328B6 (cs) 2006-11-15
EP0785948A1 (en) 1997-07-30
NO971568L (no) 1997-06-12
AU3707795A (en) 1996-05-06
CA2202075C (en) 2003-12-09
EP0785948B1 (en) 2003-04-16
FI971536A (fi) 1997-06-09
NZ335109A (en) 2000-08-25
JPH10507193A (ja) 1998-07-14
FI971420A (fi) 1997-04-04
WO1996011949A3 (en) 1996-12-12
EP0804479A1 (en) 1997-11-05
SK43197A3 (en) 1999-03-12
CA2201940C (en) 2009-05-12
ATE237633T1 (de) 2003-05-15
CZ297329B6 (cs) 2006-11-15
JPH10507080A (ja) 1998-07-14
ES2196082T3 (es) 2003-12-16
PT785948E (pt) 2003-09-30
BR9509329A (pt) 1997-10-14
CA2201940A1 (en) 1996-04-25
DE69530403T2 (de) 2003-10-30
PL319784A1 (en) 1997-08-18
SK284534B6 (sk) 2005-06-02
CA2202075A1 (en) 1996-04-25
WO1996011950A1 (en) 1996-04-25
NO971566D0 (no) 1997-04-04
SK45597A3 (en) 1999-02-11
DE69530403D1 (de) 2003-05-22
FI971536A0 (fi) 1997-04-11
WO1996011949A2 (en) 1996-04-25
AU3708395A (en) 1996-05-06
KR100278597B1 (ko) 2001-01-15
FI971420A0 (fi) 1997-04-04
SI0804479T1 (sl) 2006-12-31
HUT78050A (hu) 1999-07-28
NZ505502A (en) 2005-01-28
DK0785948T3 (da) 2003-08-04
CN1168678A (zh) 1997-12-24
PL320484A1 (en) 1997-09-29
BR9509269A (pt) 1997-12-23
NO318761B1 (no) 2005-05-02
JP4216329B2 (ja) 2009-01-28
BG63167B1 (bg) 2001-05-31
EE9700225A (et) 1998-02-16
BG101392A (en) 1997-10-31
NO971568D0 (no) 1997-04-04
DE69535264D1 (de) 2006-11-23
EP0804479B1 (en) 2006-10-11
EE03975B1 (et) 2003-02-17
HUT78058A (hu) 1999-07-28
JP4426646B2 (ja) 2010-03-03
EE9700081A (et) 1997-10-15
FI120040B (fi) 2009-06-15
CZ105097A3 (cs) 1998-10-14
CZ98197A3 (cs) 1998-11-11
AU681546B2 (en) 1997-08-28

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