DK0802909T3 - Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorer - Google Patents
Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorerInfo
- Publication number
- DK0802909T3 DK0802909T3 DK95943478T DK95943478T DK0802909T3 DK 0802909 T3 DK0802909 T3 DK 0802909T3 DK 95943478 T DK95943478 T DK 95943478T DK 95943478 T DK95943478 T DK 95943478T DK 0802909 T3 DK0802909 T3 DK 0802909T3
- Authority
- DK
- Denmark
- Prior art keywords
- calpain
- cathepsin
- inhibitors
- substituted oxazolidines
- oxazolidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37119295A | 1995-01-11 | 1995-01-11 | |
PCT/US1995/016565 WO1996021655A2 (fr) | 1995-01-11 | 1995-12-15 | Inhibiteurs de la calpaine et/ou de la cathepsine b derives d'oxazolidine substituee |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0802909T3 true DK0802909T3 (da) | 2002-01-28 |
Family
ID=23462894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95943478T DK0802909T3 (da) | 1995-01-11 | 1995-12-15 | Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorer |
Country Status (23)
Country | Link |
---|---|
US (1) | US5691368A (fr) |
EP (1) | EP0802909B1 (fr) |
JP (1) | JP4157601B2 (fr) |
KR (1) | KR100393701B1 (fr) |
CN (1) | CN1088456C (fr) |
AR (1) | AR001787A1 (fr) |
AT (1) | ATE206413T1 (fr) |
AU (1) | AU692044B2 (fr) |
CA (1) | CA2210258C (fr) |
DE (1) | DE69523072T2 (fr) |
DK (1) | DK0802909T3 (fr) |
ES (1) | ES2165441T3 (fr) |
FI (1) | FI972935A0 (fr) |
HU (1) | HUT77649A (fr) |
IL (1) | IL116724A (fr) |
MX (1) | MX9705235A (fr) |
NO (1) | NO309267B1 (fr) |
NZ (1) | NZ298999A (fr) |
PT (1) | PT802909E (fr) |
SI (1) | SI0802909T1 (fr) |
TW (1) | TW454001B (fr) |
WO (1) | WO1996021655A2 (fr) |
ZA (1) | ZA96100B (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1270882B (it) * | 1993-10-05 | 1997-05-13 | Isagro Srl | Oligopeptidi ad attivita' fungicida |
US5925633A (en) * | 1996-03-06 | 1999-07-20 | Synphar Laboraties, Inc. | 3-Substituted-4-oxa-1-azabicyclo 3,2,0!heptan-7-one as cysteine protease inhibitors |
WO1998038990A1 (fr) * | 1997-03-07 | 1998-09-11 | Hoechst Marion Roussel, Inc. | Methode de traitement d'un trauma associe a des lesions du cerveau, de la moelle epiniere ou de nerfs peripheriques au moyen de carbobenzyloxy phenylalaninals di- et tri-pepetidiques n-proteges |
WO2000021550A2 (fr) * | 1998-10-13 | 2000-04-20 | President And Fellows Of Harvard College | Methodes et compositions de traitement des maladies neurodegeneratives |
WO2000027418A2 (fr) * | 1998-11-12 | 2000-05-18 | Research Corporation Technologies, Inc. | Traitement de tissus ischemiquement degrades |
WO2000051998A1 (fr) * | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Composes utiles en tant qu'inhibiteurs reversibles de la cathepsine s |
EP1516877A1 (fr) * | 1999-03-15 | 2005-03-23 | Axys Pharmaceuticals, Inc. | Derivés d'amine comme inhibiteurs de protease |
EP1159260A1 (fr) | 1999-03-15 | 2001-12-05 | Axys Pharmaceuticals, Inc. | Composes et compositions utilises comme inhibiteurs de protease |
TW200404789A (en) | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
FR2800737B1 (fr) * | 1999-11-05 | 2006-06-30 | Sod Conseils Rech Applic | Nouveaux composes heterocycliques et leur application a titre de medicaments |
JP2003513092A (ja) * | 1999-11-05 | 2003-04-08 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) | 新規複素環化合物及びその医薬としての使用 |
WO2002010768A2 (fr) * | 2000-07-31 | 2002-02-07 | The Regents Of The University Of California | Modele pour la maladie d'alzheimer et autres maladies neurodegenerative |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
IL156577A0 (en) | 2000-12-22 | 2004-01-04 | Axys Pharm Inc | Selective cathepsin s inhibitors and pharmaceutical compositions containing the same |
BR0212535A (pt) | 2001-09-14 | 2004-10-19 | Aventis Pharma Inc | Compostos e composições como inibidores de catepsina |
CN1324018C (zh) | 2001-11-14 | 2007-07-04 | 安万特药物公司 | 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物 |
WO2004084830A2 (fr) * | 2003-03-21 | 2004-10-07 | Buck Institute | Méthode de traitement de la maladie d'alzheimer |
US7109243B2 (en) * | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
US7384970B2 (en) * | 2003-03-24 | 2008-06-10 | Irm Llc | Inhibitors of cathepsin S |
WO2004089395A2 (fr) * | 2003-04-01 | 2004-10-21 | Aventis Pharmaceuticals Inc. | Utilisation d'un inhibiteur de la cathepsine-s ou -b afin de traiter ou de prevenir les maladies pulmonaires obstructives chroniques |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US7173051B2 (en) * | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
US7256207B2 (en) * | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
FR2863268B1 (fr) * | 2003-12-09 | 2006-02-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments |
EP2089383B1 (fr) | 2006-11-09 | 2015-09-16 | Probiodrug AG | Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
MX2009009234A (es) | 2007-03-01 | 2009-12-01 | Probiodrug Ag | Uso nuevo de inhibidores de ciclasa de glutaminilo. |
WO2008128985A1 (fr) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
WO2010003092A1 (fr) * | 2008-07-03 | 2010-01-07 | University Of Massachusetts | Procédés et compositions pour réduire une inflammation et traiter des troubles inflammatoires |
KR101755737B1 (ko) | 2009-09-11 | 2017-07-07 | 프로비오드룩 아게 | 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 |
US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CA2789440C (fr) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Inhibiteurs heterocycliques de la glutaminyl cyclase (qc, ec 2.3.2.5) |
JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
WO2024018245A1 (fr) | 2022-07-22 | 2024-01-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Utilisation d'inhibiteurs de calpaïne pour le traitement de la maladie rénale diabétique |
Family Cites Families (36)
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---|---|---|---|---|
US3867364A (en) * | 1968-11-21 | 1975-02-18 | Microbial Chem Res Found | Process for the synthesis of leupeptins and their analogues |
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US4277395A (en) * | 1980-06-16 | 1981-07-07 | Richardson-Merrell Inc. | Novel enzyme inhibitors |
JPS5754157A (en) * | 1980-09-19 | 1982-03-31 | Nippon Kayaku Co Ltd | L-argininal derivative and its preparation |
US4535167A (en) * | 1981-12-14 | 1985-08-13 | Merck & Co. Inc. | Chiral, N-protected, N-substituted α-amino acids |
GB2124233B (en) * | 1982-07-19 | 1985-09-18 | Nat Res Dev | Synthetic peptides and their preparation |
US5091575A (en) * | 1985-01-23 | 1992-02-25 | Abbott Laboratories | Peptidylaminodiols |
US4845079A (en) * | 1985-01-23 | 1989-07-04 | Luly Jay R | Peptidylaminodiols |
US5214129A (en) * | 1985-01-23 | 1993-05-25 | Abbott Laboratories | Peptidylaminodiols |
US5496927A (en) * | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
JPH079705B2 (ja) * | 1986-05-28 | 1995-02-01 | オリンパス光学工業株式会社 | 光カ−ド用デ−タ記録再生装置 |
US4851387A (en) * | 1986-10-14 | 1989-07-25 | Banyu Pharmaceutical Co., Ltd. | 5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use |
US5032577A (en) * | 1986-12-31 | 1991-07-16 | Abbott Laboratories | Peptidylaminodiols |
NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
US4820691A (en) * | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
EP0313847A3 (fr) * | 1987-10-01 | 1989-11-29 | G.D. Searle & Co. | Alpha-succinamidoacyl aminodiols non peptidiques comme agents anti-hypertensifs |
EP0397779A1 (fr) * | 1988-02-01 | 1990-11-22 | The Upjohn Company | Peptides inhibiteur de renine avec groupes terminaux polaires |
WO1990000399A1 (fr) * | 1988-07-08 | 1990-01-25 | Smithkline Beckman Corporation | Peptides de liaison de protease retrovirale |
ZA897514B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
US4990525A (en) * | 1988-12-22 | 1991-02-05 | Rohm And Haas Company | Synergistic microbicidal combinations containing 3-isothiazolone and commerical biocides |
US5510531A (en) * | 1989-04-10 | 1996-04-23 | Suntory Limited | Proteinase inhibitor |
JP2701932B2 (ja) * | 1989-04-10 | 1998-01-21 | サントリー株式会社 | タンパク質分解酵素阻害剤 |
CA2032259A1 (fr) * | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Inhibiteurs de la protease du vih utiles dans le traitement du sida |
HUT64738A (en) * | 1990-06-01 | 1994-02-28 | Du Pont Merck Pharma | Process for preparing 1,4-diamino-2,3-dihydroxi-butane compounds and pharmaceutical compositions contianing them |
DE4037437A1 (de) * | 1990-11-24 | 1992-05-27 | Hoechst Ag | Aminodiol-derivate |
AU667463B2 (en) * | 1990-12-28 | 1996-03-28 | Cortex Pharmaceuticals, Inc. | Use of calpain inhibitors in the inhibition and treatment of neurodegeneration |
US5444042A (en) * | 1990-12-28 | 1995-08-22 | Cortex Pharmaceuticals | Method of treatment of neurodegeneration with calpain inhibitors |
JPH06504547A (ja) * | 1990-12-28 | 1994-05-26 | ジョージア・テック・リサーチ・コーポレーション | ペプチドケトアミド、ケト酸およびケトエステル |
CA2071621C (fr) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Derives d'aldehyde |
JP3190431B2 (ja) * | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | ケトン誘導体 |
ZA926185B (en) * | 1991-08-22 | 1993-03-01 | Merrell Dow Pharma | Novel orally-active elastase inhibitors. |
EP0580161A1 (fr) * | 1992-07-22 | 1994-01-26 | THE McLEAN HOSPITAL CORPORATION | Traitement prophylactique et thérapeutique de la maladie d'Alzheimer |
DE69321087T2 (de) * | 1992-12-25 | 1999-05-20 | Mitsubishi Chem Corp | Alpha-aminoketon Derivate |
JP2848232B2 (ja) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
US5541290A (en) * | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
KR100316865B1 (ko) * | 1993-10-01 | 2002-11-29 | 메렐 파마슈티칼스 인크. | 베타-아밀로이드단백질생성억제제 |
-
1995
- 1995-12-11 US US08/552,139 patent/US5691368A/en not_active Expired - Lifetime
- 1995-12-15 NZ NZ298999A patent/NZ298999A/xx unknown
- 1995-12-15 SI SI9530539T patent/SI0802909T1/xx unknown
- 1995-12-15 CN CN95197320A patent/CN1088456C/zh not_active Expired - Fee Related
- 1995-12-15 HU HU9800041A patent/HUT77649A/hu unknown
- 1995-12-15 AT AT95943478T patent/ATE206413T1/de not_active IP Right Cessation
- 1995-12-15 WO PCT/US1995/016565 patent/WO1996021655A2/fr active IP Right Grant
- 1995-12-15 PT PT95943478T patent/PT802909E/pt unknown
- 1995-12-15 EP EP95943478A patent/EP0802909B1/fr not_active Expired - Lifetime
- 1995-12-15 KR KR1019970704709A patent/KR100393701B1/ko not_active IP Right Cessation
- 1995-12-15 CA CA002210258A patent/CA2210258C/fr not_active Expired - Lifetime
- 1995-12-15 ES ES95943478T patent/ES2165441T3/es not_active Expired - Lifetime
- 1995-12-15 DK DK95943478T patent/DK0802909T3/da active
- 1995-12-15 DE DE69523072T patent/DE69523072T2/de not_active Expired - Lifetime
- 1995-12-15 AU AU44731/96A patent/AU692044B2/en not_active Ceased
- 1995-12-15 JP JP52166996A patent/JP4157601B2/ja not_active Expired - Lifetime
- 1995-12-15 MX MX9705235A patent/MX9705235A/es unknown
-
1996
- 1996-01-08 ZA ZA96100A patent/ZA96100B/xx unknown
- 1996-01-09 AR AR33495896A patent/AR001787A1/es unknown
- 1996-01-09 IL IL11672496A patent/IL116724A/xx not_active IP Right Cessation
- 1996-01-10 TW TW085100250A patent/TW454001B/zh not_active IP Right Cessation
-
1997
- 1997-07-10 FI FI972935A patent/FI972935A0/fi not_active IP Right Cessation
- 1997-07-10 NO NO973216A patent/NO309267B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUT77649A (hu) | 1998-07-28 |
NO973216L (no) | 1997-09-09 |
DE69523072T2 (de) | 2002-06-20 |
NO309267B1 (no) | 2001-01-08 |
US5691368A (en) | 1997-11-25 |
NO973216D0 (no) | 1997-07-10 |
EP0802909A2 (fr) | 1997-10-29 |
AU4473196A (en) | 1996-07-31 |
TW454001B (en) | 2001-09-11 |
JPH10512257A (ja) | 1998-11-24 |
IL116724A (en) | 2000-08-31 |
WO1996021655A2 (fr) | 1996-07-18 |
AU692044B2 (en) | 1998-05-28 |
WO1996021655A3 (fr) | 1996-09-06 |
CN1173174A (zh) | 1998-02-11 |
SI0802909T1 (en) | 2002-02-28 |
ES2165441T3 (es) | 2002-03-16 |
CA2210258A1 (fr) | 1996-07-18 |
KR100393701B1 (ko) | 2003-11-28 |
AR001787A1 (es) | 1997-12-10 |
JP4157601B2 (ja) | 2008-10-01 |
CA2210258C (fr) | 2002-10-01 |
DE69523072D1 (en) | 2001-11-08 |
FI972935A (fi) | 1997-07-10 |
ZA96100B (en) | 1996-07-24 |
EP0802909B1 (fr) | 2001-10-04 |
IL116724A0 (en) | 1996-05-14 |
FI972935A0 (fi) | 1997-07-10 |
CN1088456C (zh) | 2002-07-31 |
MX9705235A (es) | 1997-10-31 |
ATE206413T1 (de) | 2001-10-15 |
PT802909E (pt) | 2002-03-28 |
NZ298999A (en) | 1999-01-28 |
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