DK0751782T3 - Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet - Google Patents

Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet

Info

Publication number
DK0751782T3
DK0751782T3 DK95911043T DK95911043T DK0751782T3 DK 0751782 T3 DK0751782 T3 DK 0751782T3 DK 95911043 T DK95911043 T DK 95911043T DK 95911043 T DK95911043 T DK 95911043T DK 0751782 T3 DK0751782 T3 DK 0751782T3
Authority
DK
Denmark
Prior art keywords
present
stimulating
luteinizing hormone
fertility
activity
Prior art date
Application number
DK95911043T
Other languages
Danish (da)
English (en)
Inventor
William R Moyle
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of DK0751782T3 publication Critical patent/DK0751782T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control Of Eletrric Generators (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK95911043T 1994-02-18 1995-02-17 Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet DK0751782T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19938294A 1994-02-18 1994-02-18
PCT/US1995/002067 WO1995022340A1 (fr) 1994-02-18 1995-02-17 Procedes de modification de la fecondite

Publications (1)

Publication Number Publication Date
DK0751782T3 true DK0751782T3 (da) 2007-01-29

Family

ID=22737277

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95911043T DK0751782T3 (da) 1994-02-18 1995-02-17 Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet

Country Status (11)

Country Link
US (2) US7001597B1 (fr)
EP (3) EP0751782B1 (fr)
JP (3) JPH09509418A (fr)
AT (2) ATE314392T1 (fr)
AU (1) AU695111B2 (fr)
CA (1) CA2183564C (fr)
DE (2) DE69534723T2 (fr)
DK (1) DK0751782T3 (fr)
ES (2) ES2273335T3 (fr)
PT (1) PT751782E (fr)
WO (1) WO1995022340A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0910648A1 (fr) * 1996-04-15 1999-04-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions solubles de recepteurs couples a des proteine g du domaine transmembranaire 7 et leurs procedes de fabrication
WO1998021238A1 (fr) * 1996-11-12 1998-05-22 Teikoku Hormone Mfg. Co., Ltd. Gonadotrophine chorionique equine, monocatenaire et recombinee
ZA987497B (en) * 1997-09-08 1999-02-23 Akzo Nobel Nv Expression of gonadotropins in dictyostelium
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
US6635256B1 (en) * 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US5981249A (en) * 1998-02-05 1999-11-09 Spectral Diagnostics, Inc. Single-chain polypeptides comprising creatine kinase M and creatine kinase B
EP1115866A1 (fr) * 1998-09-22 2001-07-18 University of Maryland at Baltimore Mutants du facteur de croissance a noeud de cystine
DE19910394A1 (de) * 1999-03-03 2000-09-07 Schering Ag Substanzen für die Fertilitätskontrolle
US6342411B1 (en) * 1999-09-03 2002-01-29 Motorola Inc. Electronic component and method for manufacture
KR20010077538A (ko) * 2000-02-03 2001-08-20 김강권 단일체인 융모성성선자극호르몬 및 그 제조방법
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
WO2001081406A2 (fr) * 2000-04-25 2001-11-01 Washington University Hormones de fertilite a une seule chaine avec activite lh variable
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
ES2371465T3 (es) * 2003-09-26 2012-01-03 Institut National De La Recherche Agronomique (Inra) Anticuerpos que modulan la actividad de gonadotropina coriónica equina.
EP3765841A4 (fr) * 2018-03-16 2022-06-08 Quest Diagnostics Investments LLC Détermination par spectrométrie de masse de la testostérone dans des échantillons de patients multiplexés
BR102019004147A2 (pt) 2019-02-28 2020-10-06 Ouro Fino Saude Animal Participacoes S.A. Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514505A (en) * 1982-05-21 1985-04-30 The Trustees Of Columbia University In The City Of New York Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
US5284778A (en) * 1985-08-12 1994-02-08 The Trustees Of Columbia University In The City Of New York Sensitive bioassay using monoclonal antibodies which bind to hormone-receptor complexes
US4973577A (en) * 1986-04-04 1990-11-27 The Salk Institute For Biological Studies FSH-releasing peptides
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1988009344A1 (fr) * 1987-05-21 1988-12-01 Creative Biomolecules, Inc. Proteines mutifonctionnelles a cible predeterminee
CA2082424C (fr) * 1990-05-08 2003-09-23 Robert K. Campbell Analogues d'hormones glycoproteiniques presentant des caracteristiques immunologiques, une efficacite et/ou une specificite pour un recepteur alterees
ATE193540T1 (de) * 1991-06-18 2000-06-15 Univ New Jersey Med Analoga von glykoproteinhormonen mit geänderter rezeptorbindungsspezifität und aktivität und verfahren zur darstellung und verwendung derselben
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
EP0725795B1 (fr) * 1994-08-12 2004-01-14 Washington University Formes monocatenaires du quadruplet d'hormones de glycoproteine

Also Published As

Publication number Publication date
JPH09509418A (ja) 1997-09-22
ATE342061T1 (de) 2006-11-15
JPH11263799A (ja) 1999-09-28
US20070253955A1 (en) 2007-11-01
WO1995022340A1 (fr) 1995-08-24
EP0839831A3 (fr) 1999-09-29
CA2183564C (fr) 2010-07-13
PT751782E (pt) 2007-01-31
ATE314392T1 (de) 2006-01-15
DE69535260D1 (de) 2006-11-23
EP0751782B1 (fr) 2006-10-11
AU1878795A (en) 1995-09-04
JP2002060347A (ja) 2002-02-26
EP0751782A4 (fr) 2000-09-27
EP0839831A2 (fr) 1998-05-06
AU695111B2 (en) 1998-08-06
EP0751782A1 (fr) 1997-01-08
DE69534723T2 (de) 2006-08-31
DE69535260T2 (de) 2007-08-09
ES2273335T3 (es) 2007-05-01
EP0839831B1 (fr) 2005-12-28
EP1849802A2 (fr) 2007-10-31
DE69534723D1 (de) 2006-02-02
US7001597B1 (en) 2006-02-21
CA2183564A1 (fr) 1995-08-24
ES2251731T3 (es) 2006-05-01

Similar Documents

Publication Publication Date Title
DK0751782T3 (da) Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet
Flack et al. Increased biological activity due to basic isoforms in recombinant human follicle-stimulating hormone produced in a human cell line
EP0276166A3 (fr) Composition et méthode pour provoquer une superovulation chez le bétail
DE3884776T2 (de) Durch "site-directed" Mutagenese modifzierte Glukoprotein-Hormone und Verfahren zu deren Verwendung.
US6414123B1 (en) Method for purifying FSH
ATE115409T1 (de) Glykoprotein-hormonrezeptor-moleküle.
Bernardo et al. Adrenal luteinizing hormone releasing hormone receptors.
Jablonka-Shariff et al. Expression and bioactivity of a single chain recombinant equine luteinizing hormone (reLH)
ATE193540T1 (de) Analoga von glykoproteinhormonen mit geänderter rezeptorbindungsspezifität und aktivität und verfahren zur darstellung und verwendung derselben
Geris et al. Influence of corticotropin-releasing factor on the in vitro thyroxine and thyrotropin secretion in newly hatched fowl
Xing et al. Efficient preparation of glycoprotein hormones lacking an α-subunit oligosaccharide
KR900702048A (ko) 고나도트로핀 및 그에 의한 과할성 작용제의 제조 방법
Matteri et al. Biochemical and biological properties of urinary follicle‐stimulating hormone (FSH) from the rhesus monkey (Macaca mulatta)
PL1518863T3 (pl) Przeciwciała modulujące aktywność końskiej gonadotropiny kosmówkowej
Chaudhary et al. Caprine (Capra hircus) luteinizing hormone: purification and chromatographic investigation of its different isoforms
Quesnel et al. Solubilization and purification of the gonadotropin (GTH II) receptor from rainbow trout (Oncorhynchus mykiss) ovaries
Chand et al. A reference preparation of buffalo pituitary follicle stimulating hormone using lectin affinity chromatography
Petrusz Biological and immunological characterization of gonadotrophic profiles
Peebles et al. Single treatment superovulation in the cashmere goat using porcine follicle stimulating hormone
Muralidhar Indigenous Production of Bovine/Bubaline Reproductive Hormones
Schally In vitro studies on the control of the release of ACTH.
Lamond Alteration of ovarian function of immature mice treated with androgen after birth
Chan et al. Binding inhibition by monoclonal antibodies of ovine placental lactogen to growth hormone receptors in human liver
CA2219948A1 (fr) Chaine unique de gonadotrophines, adn les codant et methode de production
Bettendorf Donini, Pietro