DK0674631T3 - Substituerede pyrazoler som CRF-antogonister - Google Patents

Substituerede pyrazoler som CRF-antogonister

Info

Publication number
DK0674631T3
DK0674631T3 DK93922407T DK93922407T DK0674631T3 DK 0674631 T3 DK0674631 T3 DK 0674631T3 DK 93922407 T DK93922407 T DK 93922407T DK 93922407 T DK93922407 T DK 93922407T DK 0674631 T3 DK0674631 T3 DK 0674631T3
Authority
DK
Denmark
Prior art keywords
crf
antogonists
substituted pyrazoles
pyrazoles
substituted
Prior art date
Application number
DK93922407T
Other languages
Danish (da)
English (en)
Inventor
Gene M Bright
Willard M Welch Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0674631T3 publication Critical patent/DK0674631T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, ***e
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK93922407T 1992-12-17 1993-09-30 Substituerede pyrazoler som CRF-antogonister DK0674631T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99222892A 1992-12-17 1992-12-17
PCT/US1993/009170 WO1994013661A1 (en) 1992-12-17 1993-09-30 Substituted pyrazoles as crf antagonists

Publications (1)

Publication Number Publication Date
DK0674631T3 true DK0674631T3 (da) 2000-04-10

Family

ID=25538068

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93922407T DK0674631T3 (da) 1992-12-17 1993-09-30 Substituerede pyrazoler som CRF-antogonister

Country Status (26)

Country Link
EP (2) EP0674631B1 (ru)
JP (1) JP2781661B2 (ru)
KR (1) KR100190730B1 (ru)
CN (1) CN1045293C (ru)
AT (1) ATE187451T1 (ru)
AU (1) AU690079B2 (ru)
BR (1) BR9307664A (ru)
CA (1) CA2150703C (ru)
CZ (1) CZ287925B6 (ru)
DE (1) DE69327254T2 (ru)
DK (1) DK0674631T3 (ru)
EG (1) EG20440A (ru)
ES (1) ES2139676T3 (ru)
FI (1) FI111254B (ru)
GR (1) GR3032461T3 (ru)
HU (1) HUT65822A (ru)
IL (1) IL107947A (ru)
MY (1) MY109522A (ru)
NO (1) NO307884B1 (ru)
NZ (1) NZ256620A (ru)
PL (1) PL175982B1 (ru)
PT (1) PT674631E (ru)
RU (1) RU2130453C1 (ru)
TW (1) TW237455B (ru)
WO (1) WO1994013661A1 (ru)
ZA (1) ZA939406B (ru)

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GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
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Also Published As

Publication number Publication date
NO307884B1 (no) 2000-06-13
CN1045293C (zh) 1999-09-29
KR950704299A (ko) 1995-11-17
IL107947A0 (en) 1994-04-12
HUT65822A (en) 1994-07-28
ZA939406B (en) 1995-06-15
AU5141393A (en) 1994-07-04
PT674631E (pt) 2000-04-28
JP2781661B2 (ja) 1998-07-30
AU690079B2 (en) 1998-04-23
EG20440A (en) 1999-04-29
EP0959074A2 (en) 1999-11-24
WO1994013661A1 (en) 1994-06-23
CZ158295A3 (en) 1995-12-13
PL175982B1 (pl) 1999-03-31
ES2139676T3 (es) 2000-02-16
CA2150703A1 (en) 1994-06-23
FI935672A (fi) 1994-06-18
FI935672A0 (fi) 1993-12-16
FI111254B (fi) 2003-06-30
DE69327254T2 (de) 2000-03-30
CN1093363A (zh) 1994-10-12
TW237455B (ru) 1995-01-01
EP0959074A3 (en) 2000-06-07
ATE187451T1 (de) 1999-12-15
RU2130453C1 (ru) 1999-05-20
NO952397L (no) 1995-08-14
BR9307664A (pt) 1999-06-29
EP0674631A1 (en) 1995-10-04
PL309355A1 (en) 1995-10-02
IL107947A (en) 1998-08-16
CZ287925B6 (cs) 2001-03-14
MY109522A (en) 1997-02-28
CA2150703C (en) 2002-01-08
NO952397D0 (no) 1995-06-16
NZ256620A (en) 1996-05-28
DE69327254D1 (de) 2000-01-13
JPH08500121A (ja) 1996-01-09
EP0674631B1 (en) 1999-12-08
GR3032461T3 (en) 2000-05-31
KR100190730B1 (ko) 1999-06-01

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