DK0662958T3 - 1-(2-Oxoacetyl)piperidin-2-carboxylsyrederivater som multilægemiddelresistente cancercellesensibiliserende midler - Google Patents

1-(2-Oxoacetyl)piperidin-2-carboxylsyrederivater som multilægemiddelresistente cancercellesensibiliserende midler

Info

Publication number
DK0662958T3
DK0662958T3 DK93922748T DK93922748T DK0662958T3 DK 0662958 T3 DK0662958 T3 DK 0662958T3 DK 93922748 T DK93922748 T DK 93922748T DK 93922748 T DK93922748 T DK 93922748T DK 0662958 T3 DK0662958 T3 DK 0662958T3
Authority
DK
Denmark
Prior art keywords
drug resistant
oxoacetyl
piperidine
carboxylic acid
resistant cancer
Prior art date
Application number
DK93922748T
Other languages
English (en)
Inventor
Joshua S Boger
Jeffrey O Saunders
David M Armistead
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK0662958T3 publication Critical patent/DK0662958T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
DK93922748T 1992-09-28 1993-09-27 1-(2-Oxoacetyl)piperidin-2-carboxylsyrederivater som multilægemiddelresistente cancercellesensibiliserende midler DK0662958T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95229992A 1992-09-28 1992-09-28
PCT/US1993/009145 WO1994007858A1 (en) 1992-09-28 1993-09-27 1-(2-oxo-acetyl)-piperidine-2-carboxylic acid derivatives as multi-drug-resistent cancer cell sensitizers

Publications (1)

Publication Number Publication Date
DK0662958T3 true DK0662958T3 (da) 2003-03-31

Family

ID=25492759

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93922748T DK0662958T3 (da) 1992-09-28 1993-09-27 1-(2-Oxoacetyl)piperidin-2-carboxylsyrederivater som multilægemiddelresistente cancercellesensibiliserende midler

Country Status (30)

Country Link
EP (1) EP0662958B1 (da)
JP (1) JP3635493B2 (da)
KR (1) KR100300112B1 (da)
CN (2) CN1086386C (da)
AT (1) ATE229506T1 (da)
AU (1) AU690082B2 (da)
BG (1) BG62729B1 (da)
CA (1) CA2144962C (da)
CZ (1) CZ287396B6 (da)
DE (1) DE69332563T2 (da)
DK (1) DK0662958T3 (da)
ES (1) ES2188595T3 (da)
FI (1) FI951454A (da)
HK (1) HK1013992A1 (da)
HU (1) HUT72046A (da)
IL (1) IL107109A (da)
IS (1) IS4073A (da)
MX (1) MX9305934A (da)
MY (1) MY119483A (da)
NO (1) NO305596B1 (da)
NZ (2) NZ314207A (da)
PL (1) PL308217A1 (da)
PT (1) PT662958E (da)
RO (1) RO117791B1 (da)
RU (1) RU2158258C2 (da)
SG (1) SG47517A1 (da)
SK (1) SK284129B6 (da)
TW (1) TW304943B (da)
UA (1) UA63874C2 (da)
WO (1) WO1994007858A1 (da)

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US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
US5726184A (en) * 1995-05-19 1998-03-10 Vertex Pharmaceuticals Incorporated Tetralin compounds with improved MDR activity
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
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BR9811923A (pt) * 1997-08-29 2000-08-15 Vertex Pharma Compostos possuindo atividade neuronal
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US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
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Also Published As

Publication number Publication date
FI951454A0 (fi) 1995-03-27
IL107109A0 (en) 1993-12-28
NZ314207A (en) 2000-12-22
SK284129B6 (sk) 2004-09-08
NZ256772A (en) 1997-03-24
CN1086386C (zh) 2002-06-19
RO117791B1 (ro) 2002-07-30
IL107109A (en) 1999-03-12
HK1013992A1 (en) 1999-09-17
IS4073A (is) 1994-03-29
KR100300112B1 (ko) 2001-10-22
CN1088577A (zh) 1994-06-29
WO1994007858A1 (en) 1994-04-14
UA63874C2 (en) 2004-02-16
CN1494906A (zh) 2004-05-12
JPH08502256A (ja) 1996-03-12
AU690082B2 (en) 1998-04-23
CZ76995A3 (en) 1995-12-13
MX9305934A (es) 1994-03-31
FI951454A (fi) 1995-03-27
NO951162D0 (no) 1995-03-27
SK38995A3 (en) 1995-08-09
BG62729B1 (bg) 2000-06-30
AU5164893A (en) 1994-04-26
DE69332563D1 (de) 2003-01-23
TW304943B (da) 1997-05-11
SG47517A1 (en) 1998-04-17
MY119483A (en) 2005-06-30
BG99585A (bg) 1995-12-29
RU95110938A (ru) 1997-01-10
NO951162L (no) 1995-05-29
JP3635493B2 (ja) 2005-04-06
PT662958E (pt) 2003-04-30
CA2144962A1 (en) 1994-04-14
ES2188595T3 (es) 2003-07-01
EP0662958A1 (en) 1995-07-19
ATE229506T1 (de) 2002-12-15
HUT72046A (en) 1996-03-28
PL308217A1 (en) 1995-07-24
NO305596B1 (no) 1999-06-28
DE69332563T2 (de) 2003-11-27
CA2144962C (en) 2003-05-20
EP0662958B1 (en) 2002-12-11
RU2158258C2 (ru) 2000-10-27
CZ287396B6 (en) 2000-11-15

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