PT891331E - Derivados do acido n-(2-oxoacetil ou sulfonil)-pirrolidino/piperidina-2-carboxilico com actividade melhorada de resistencia a multifarmacos - Google Patents
Derivados do acido n-(2-oxoacetil ou sulfonil)-pirrolidino/piperidina-2-carboxilico com actividade melhorada de resistencia a multifarmacosInfo
- Publication number
- PT891331E PT891331E PT97916231T PT97916231T PT891331E PT 891331 E PT891331 E PT 891331E PT 97916231 T PT97916231 T PT 97916231T PT 97916231 T PT97916231 T PT 97916231T PT 891331 E PT891331 E PT 891331E
- Authority
- PT
- Portugal
- Prior art keywords
- resistance
- multifarms
- pyrolidine
- oxoacetic
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/626,259 US5717092A (en) | 1996-03-29 | 1996-03-29 | Compounds with improved multi-drug resistance activity |
Publications (1)
Publication Number | Publication Date |
---|---|
PT891331E true PT891331E (pt) | 2004-02-27 |
Family
ID=24509627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97916231T PT891331E (pt) | 1996-03-29 | 1997-03-24 | Derivados do acido n-(2-oxoacetil ou sulfonil)-pirrolidino/piperidina-2-carboxilico com actividade melhorada de resistencia a multifarmacos |
Country Status (11)
Country | Link |
---|---|
US (2) | US5717092A (pt) |
EP (1) | EP0891331B1 (pt) |
JP (1) | JP4759762B2 (pt) |
AT (1) | ATE251140T1 (pt) |
AU (1) | AU2346597A (pt) |
CA (1) | CA2249369A1 (pt) |
DE (1) | DE69725293T2 (pt) |
DK (1) | DK0891331T3 (pt) |
ES (1) | ES2208890T3 (pt) |
PT (1) | PT891331E (pt) |
WO (1) | WO1997036869A1 (pt) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150527A (en) * | 1994-08-18 | 2000-11-21 | Ariad Pharmaceuticals, Inc. | Synthetic multimerizing agents |
US6133456A (en) * | 1994-08-18 | 2000-10-17 | Ariad Gene Therapeutics, Inc. | Synthetic multimerizing agents |
US20030036654A1 (en) | 1994-08-18 | 2003-02-20 | Holt Dennis A. | Synthetic multimerizing agents |
US5795877A (en) * | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US6218424B1 (en) | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US5874449A (en) * | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
NZ335480A (en) | 1996-12-31 | 2001-04-27 | Guilford Pharm Inc | Neurotrophic low molecular weight N-linked sulfonamides of heterocyclic thioesters and their use as inhibitors of immunophilin proteins |
SK57899A3 (en) * | 1996-12-31 | 2000-05-16 | Guilford Pharm Inc | N-linked ureas and carbamates of heterocyclic thioesters |
US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6852496B1 (en) * | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
HUP0101736A3 (en) * | 1998-04-08 | 2002-04-29 | Lilly Co Eli | Isoxazolo[3,4-c]quinoline derivatives, their use and pharmaceutical compositions containing them |
WO1999051228A1 (en) | 1998-04-08 | 1999-10-14 | Eli Lilly And Company | Methods for inhibiting mrp1 |
US6410041B1 (en) * | 1998-04-28 | 2002-06-25 | Trustees Of Tufts College | Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine |
US20020131972A1 (en) * | 1998-05-21 | 2002-09-19 | Daniel Sem | Multi-partite ligands and methods of identifying and using same |
WO1999062511A1 (en) | 1998-06-02 | 1999-12-09 | Bristol-Myers Squibb Company | Neurotrophic difluoroamide agents |
HUP0102935A3 (en) | 1998-06-03 | 2002-01-28 | Gpi Nil Holdings Inc Wilmingto | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres and pharmaceutical compositions containing them |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
AU6060099A (en) * | 1998-09-30 | 2000-04-17 | Procter & Gamble Company, The | 2-substituted ketoamides |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
US6358531B1 (en) * | 1999-02-01 | 2002-03-19 | The Curators Of The University Of Missouri | Method for preparing porous shells or gels from glass particles |
AU6387500A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent exocyclic diketo compounds |
ATE316531T1 (de) * | 1999-10-07 | 2006-02-15 | Lilly Co Eli | Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1 |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
ATE319712T1 (de) | 1999-12-21 | 2006-03-15 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
MXPA03011095A (es) * | 2001-05-29 | 2005-04-28 | Guilford Pharm Inc | Metodo para tratar una lesion nerviosa causada por cirugia. |
US7653490B2 (en) * | 2001-09-10 | 2010-01-26 | Triad Liquidating Company LLC | Nuclear magnetic resonance assembly of chemical entities |
JP2005508990A (ja) * | 2001-11-07 | 2005-04-07 | ファルマシア・コーポレーション | 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法 |
US6635892B2 (en) * | 2002-01-24 | 2003-10-21 | Pei Electronics, Inc. | Compact integrated infrared scene projector |
US20030180797A1 (en) * | 2002-03-20 | 2003-09-25 | Lin Yu | Identification of ligands for a receptor family and related methods |
US20060051354A1 (en) * | 2002-03-25 | 2006-03-09 | Eric Simard | Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof |
WO2005007162A1 (en) * | 2003-07-10 | 2005-01-27 | Vertex Pharmaceuticals Incorporated | Compounds augmenting the activity of antibacterial agents |
CN1281210C (zh) * | 2003-11-29 | 2006-10-25 | 胡汛 | 五味子乙素在制备***药物中的应用 |
US20060189551A1 (en) * | 2004-10-04 | 2006-08-24 | Duke University | Combination therapies for fungal pathogens |
WO2006068905A2 (en) * | 2004-12-20 | 2006-06-29 | Wyeth | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders |
WO2006068932A2 (en) * | 2004-12-20 | 2006-06-29 | Wyeth | Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders |
JP5767900B2 (ja) | 2011-08-24 | 2015-08-26 | 株式会社東芝 | 水中溶接装置及び方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4920218A (en) * | 1988-10-12 | 1990-04-24 | Merck & Co., Inc. | Novel hydroxide mediated FK-506 rearrangement process |
DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
GB2247456A (en) * | 1990-09-03 | 1992-03-04 | Fujisawa Pharmaceutical Co | Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same |
AU1995792A (en) * | 1991-05-09 | 1992-12-21 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
US5620971A (en) * | 1991-05-09 | 1997-04-15 | Vertex Pharmaceuticals Incorporated | Biologically active acylated amino acid derivatives |
US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
WO1993000427A2 (en) * | 1991-06-24 | 1993-01-07 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
CA2143952A1 (en) * | 1992-09-07 | 1994-03-17 | Peter Samuel Atherton | Diffraction surface data detector |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
WO1996006097A1 (en) * | 1994-08-18 | 1996-02-29 | Ariad Gene Therapeutics, Inc. | New multimerizing agents |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
-
1996
- 1996-03-29 US US08/626,259 patent/US5717092A/en not_active Expired - Lifetime
-
1997
- 1997-03-24 AU AU23465/97A patent/AU2346597A/en not_active Abandoned
- 1997-03-24 DK DK97916231T patent/DK0891331T3/da active
- 1997-03-24 AT AT97916231T patent/ATE251140T1/de not_active IP Right Cessation
- 1997-03-24 CA CA002249369A patent/CA2249369A1/en not_active Abandoned
- 1997-03-24 WO PCT/US1997/004916 patent/WO1997036869A1/en active IP Right Grant
- 1997-03-24 DE DE69725293T patent/DE69725293T2/de not_active Expired - Lifetime
- 1997-03-24 ES ES97916231T patent/ES2208890T3/es not_active Expired - Lifetime
- 1997-03-24 PT PT97916231T patent/PT891331E/pt unknown
- 1997-03-24 EP EP97916231A patent/EP0891331B1/en not_active Expired - Lifetime
- 1997-03-24 JP JP53539597A patent/JP4759762B2/ja not_active Expired - Fee Related
- 1997-10-30 US US08/961,551 patent/US5935954A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0891331T3 (da) | 2004-02-09 |
DE69725293D1 (de) | 2003-11-06 |
CA2249369A1 (en) | 1997-10-09 |
US5935954A (en) | 1999-08-10 |
EP0891331A1 (en) | 1999-01-20 |
JP2000507578A (ja) | 2000-06-20 |
JP4759762B2 (ja) | 2011-08-31 |
AU2346597A (en) | 1997-10-22 |
EP0891331B1 (en) | 2003-10-01 |
ATE251140T1 (de) | 2003-10-15 |
WO1997036869A1 (en) | 1997-10-09 |
DE69725293T2 (de) | 2004-07-15 |
US5717092A (en) | 1998-02-10 |
ES2208890T3 (es) | 2004-06-16 |
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