DK0640599T3 - 4-Aminopyrimidin-derivater - Google Patents
4-Aminopyrimidin-derivaterInfo
- Publication number
- DK0640599T3 DK0640599T3 DK94305973T DK94305973T DK0640599T3 DK 0640599 T3 DK0640599 T3 DK 0640599T3 DK 94305973 T DK94305973 T DK 94305973T DK 94305973 T DK94305973 T DK 94305973T DK 0640599 T3 DK0640599 T3 DK 0640599T3
- Authority
- DK
- Denmark
- Prior art keywords
- nitrogen
- alkylene
- bond
- membered heterocyclic
- heterocyclic ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11190693A | 1993-08-26 | 1993-08-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0640599T3 true DK0640599T3 (da) | 1998-09-28 |
Family
ID=22341063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94305973T DK0640599T3 (da) | 1993-08-26 | 1994-08-12 | 4-Aminopyrimidin-derivater |
Country Status (11)
Country | Link |
---|---|
US (1) | US5525604A (da) |
EP (1) | EP0640599B1 (da) |
JP (1) | JPH0789958A (da) |
KR (1) | KR100204433B1 (da) |
CN (1) | CN1109055A (da) |
AT (1) | ATE163647T1 (da) |
CA (1) | CA2130878C (da) |
DE (1) | DE69408750T2 (da) |
DK (1) | DK0640599T3 (da) |
ES (1) | ES2114662T3 (da) |
TW (1) | TW273548B (da) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9325217D0 (en) * | 1993-12-09 | 1994-02-09 | Zeneca Ltd | Pyrimidine derivatives |
EP1005343A4 (en) | 1996-03-08 | 2000-06-07 | Smithkline Beecham Corp | USE OF CSAIDS AS ANGIOGENESIS INHIBITORS |
DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
KR100239800B1 (ko) * | 1996-11-28 | 2000-03-02 | 손경식 | 4,5-디아미노 피리미딘 유도체 및 이의 제조방법 |
US6432947B1 (en) | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
DE69836422T2 (de) * | 1997-02-19 | 2007-06-14 | Berlex, Inc., Richmond | N-heterocyclische derivate als nos inhibitoren |
IN188411B (da) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
CA2321153A1 (en) | 1998-02-17 | 1999-08-19 | Timothy D. Cushing | Anti-viral pyrimidine derivatives |
DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
KR100272471B1 (ko) | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
AU3078000A (en) * | 1999-01-25 | 2000-08-07 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compounds and antitumor agents containing the same as the active ingredient |
US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
KR100546992B1 (ko) * | 1999-04-09 | 2006-02-01 | 씨제이 주식회사 | 4,5-다이아미노 피리미딘 유도체 및 이의 제조방법 |
US7037916B2 (en) | 1999-07-15 | 2006-05-02 | Pharmacopeia Drug Discovery, Inc. | Pyrimidine derivatives as IL-8 receptor antagonists |
PT1219609E (pt) * | 1999-09-16 | 2007-06-19 | Tanabe Seiyaku Co | ''compostos cíclicos aromático azotados de seis membros'' |
AU7683500A (en) | 1999-10-12 | 2001-04-23 | Takeda Chemical Industries Ltd. | Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof |
US6777416B2 (en) | 1999-12-24 | 2004-08-17 | Bayer Aktiengesellschaft | Isoxazolo pyrimidinones and the use thereof |
US6943161B2 (en) * | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
US6525051B2 (en) | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
CA2416442C (en) | 2000-07-24 | 2010-06-08 | Krenitsky Pharmaceuticals, Inc. | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
US6716851B2 (en) | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
WO2002047690A1 (en) * | 2000-12-12 | 2002-06-20 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US7081470B2 (en) | 2001-01-31 | 2006-07-25 | H. Lundbeck A/S | Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods |
US20040127502A1 (en) | 2001-01-31 | 2004-07-01 | Synaptic Pharmaceutical Corporation | Use of GAL3 antagonist for treatment of depression |
WO2002068419A1 (fr) * | 2001-02-26 | 2002-09-06 | Tanabe Seiyaku Co., Ltd. | Derive de pyridopyrimidine ou naphthyridine |
EP1389617B1 (en) | 2001-04-27 | 2007-01-03 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compound and antitumor agent containing the same as active ingredient |
US6982259B2 (en) | 2002-04-30 | 2006-01-03 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
PL375263A1 (en) | 2002-07-02 | 2005-11-28 | F.Hoffmann-La Roche Ag | 2,5-substituted pyrimidine derivatives as ccr-3 receptor antagonists |
TW200608976A (en) * | 2004-05-08 | 2006-03-16 | Neurogen Corp | 4,5-disubstituted-2-aryl pyrimidines |
EP1812424A4 (en) | 2004-11-17 | 2009-07-08 | Miikana Therapeutics Inc | Kinase Inhibitors |
PT1864665E (pt) | 2005-03-11 | 2012-06-27 | Zenyaku Kogyo Kk | Agente imunossupressor compreendendo um composto heterocíclico como ingrediente activo |
US20060293343A1 (en) * | 2005-05-18 | 2006-12-28 | Asahi Kasei Pharma Corporation | Pyrimidine derivatives |
WO2006123639A1 (ja) * | 2005-05-18 | 2006-11-23 | Asahi Kasei Pharma Corporation | ピリミジン誘導体 |
WO2007041358A2 (en) * | 2005-09-30 | 2007-04-12 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
US20090029992A1 (en) * | 2007-06-11 | 2009-01-29 | Agoston Gregory E | Substituted pyrazole compounds |
WO2009064388A2 (en) * | 2007-11-09 | 2009-05-22 | Liu Jun O | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders |
TW201014841A (en) * | 2008-09-04 | 2010-04-16 | Mitsubishi Tanabe Pharma Corp | Tri-substituted pyrimidine compounds and their use as PDE10 inhibitors |
JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
WO2013004332A1 (en) * | 2011-07-07 | 2013-01-10 | Merck Patent Gmbh | Substituted azaheterocycles for the treatment of cancer |
EP2751093A1 (en) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9868722B2 (en) | 2013-12-10 | 2018-01-16 | Cleave Biosciences, Inc. | Monocyclic pyrimidine/pyridine compounds as inhibitors of P97 complex |
PL3089971T3 (pl) | 2014-01-01 | 2021-01-25 | Medivation Technologies Llc | Związki i sposoby ich zastosowania |
BR112016016421B1 (pt) | 2014-01-20 | 2022-10-18 | Cleave Biosciences, Inc | Composto de pirimidina fundida, composição farmacêutica e respectivos uso |
CN105294661B (zh) * | 2015-07-27 | 2017-10-24 | 西南大学 | 5‑氟尿嘧啶苯并咪唑类化合物及其制备方法和应用 |
GB201705263D0 (en) * | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3992320A (en) * | 1974-08-24 | 1976-11-16 | Basf Aktiengesellschaft | Manufacture of a modified titanium component for catalysts of the Ziegler-Natta type |
US4018770A (en) * | 1975-03-03 | 1977-04-19 | Sterling Drug Inc. | N-(2-(pyridinyl)-4-pyrimidinyl)-aminomethylenemalonates and analogs |
US4032523A (en) * | 1975-03-03 | 1977-06-28 | Sterling Drug Inc. | 4-amino (or halo or hydroxy or hydrazino)-2-(pyridinyl)pyrimidines |
US3992380A (en) * | 1975-03-03 | 1976-11-16 | Sterling Drug Inc. | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters |
DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
WO1994007867A1 (en) * | 1992-09-28 | 1994-04-14 | Pfizer Inc. | Substituted pyrimidines for control of diabetic complications |
US5318975A (en) * | 1993-02-16 | 1994-06-07 | Berlex Laboratories, Inc. | 5-pyrimdineamine derivatives |
-
1994
- 1994-08-12 DE DE69408750T patent/DE69408750T2/de not_active Expired - Fee Related
- 1994-08-12 AT AT94305973T patent/ATE163647T1/de not_active IP Right Cessation
- 1994-08-12 ES ES94305973T patent/ES2114662T3/es not_active Expired - Lifetime
- 1994-08-12 DK DK94305973T patent/DK0640599T3/da active
- 1994-08-12 EP EP94305973A patent/EP0640599B1/en not_active Expired - Lifetime
- 1994-08-24 US US08/295,377 patent/US5525604A/en not_active Expired - Fee Related
- 1994-08-24 JP JP6222654A patent/JPH0789958A/ja active Pending
- 1994-08-25 CN CN94109363A patent/CN1109055A/zh active Pending
- 1994-08-25 CA CA002130878A patent/CA2130878C/en not_active Expired - Fee Related
- 1994-08-25 KR KR1019940021017A patent/KR100204433B1/ko not_active IP Right Cessation
- 1994-08-29 TW TW083107897A patent/TW273548B/zh active
Also Published As
Publication number | Publication date |
---|---|
CN1109055A (zh) | 1995-09-27 |
ATE163647T1 (de) | 1998-03-15 |
CA2130878C (en) | 1999-03-23 |
DE69408750T2 (de) | 1998-07-23 |
ES2114662T3 (es) | 1998-06-01 |
EP0640599A1 (en) | 1995-03-01 |
KR100204433B1 (ko) | 1999-06-15 |
EP0640599B1 (en) | 1998-03-04 |
KR950005825A (ko) | 1995-03-20 |
CA2130878A1 (en) | 1995-02-27 |
JPH0789958A (ja) | 1995-04-04 |
TW273548B (da) | 1996-04-01 |
US5525604A (en) | 1996-06-11 |
DE69408750D1 (de) | 1998-04-09 |
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