ATE150022T1 - 10-(1-hydroxyethyl)-11-oxo-1- azatricyclo(7.2.0.0.3,8>undec-2-en-2-carbonsäur - derivate - Google Patents

10-(1-hydroxyethyl)-11-oxo-1- azatricyclo(7.2.0.0.3,8>undec-2-en-2-carbonsäur - derivate

Info

Publication number: ATE150022T1
Authority: AT; Austria
Prior art keywords: group; atom; zero; represent; hydrogen atom
Prior art date: 1989-09-08

Application number

AT90309848T

Other languages

English (en)

Inventor

Bruno Tamburini

Alcide Perboni

Tino Rossi

Daniele Donati

Daniele Andreotti

Giovanni Gaviraghi

Roberto Carlesso

Claudio Bismara

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-08

Filing date

1990-09-07

Publication date

1997-03-15

1989-09-08 Priority claimed from GB898920337A external-priority patent/GB8920337D0/en

1990-07-13 Priority claimed from GB909015484A external-priority patent/GB9015484D0/en

1990-09-07 Application filed by Glaxo Spa filed Critical Glaxo Spa

1997-03-15 Application granted granted Critical

1997-03-15 Publication of ATE150022T1 publication Critical patent/ATE150022T1/de

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
-1 azidoethoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
101100276977 Caenorhabditis elegans dapk-1 gene Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Pyrrole Compounds (AREA)

AT90309848T 1989-09-08 1990-09-07 10-(1-hydroxyethyl)-11-oxo-1- azatricyclo(7.2.0.0.3,8>undec-2-en-2-carbonsäur - derivate ATE150022T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898920337A GB8920337D0 (en)	1989-09-08	1989-09-08	Heterocyclic compounds
GB909015484A GB9015484D0 (en)	1990-07-13	1990-07-13	Heterocyclic compounds

Publications (1)

Publication Number	Publication Date
ATE150022T1 true ATE150022T1 (de)	1997-03-15

Family

ID=26295887

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT90309847T ATE147394T1 (de)	1989-09-08	1990-09-07	4-(1'-oxocyclohex-2'-yl)azetidin-2-on-derivate
AT90309848T ATE150022T1 (de)	1989-09-08	1990-09-07	10-(1-hydroxyethyl)-11-oxo-1- azatricyclo(7.2.0.0.3,8>undec-2-en-2-carbonsäur - derivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT90309847T ATE147394T1 (de)	1989-09-08	1990-09-07	4-(1'-oxocyclohex-2'-yl)azetidin-2-on-derivate

Country Status (28)

Country	Link
US (2)	US5407931A (de)
EP (2)	EP0416953B1 (de)
JP (2)	JP3035325B2 (de)
KR (1)	KR100188175B1 (de)
AT (2)	ATE147394T1 (de)
AU (1)	AU632163B2 (de)
CA (1)	CA2024880C (de)
CZ (1)	CZ285778B6 (de)
DD (1)	DD298102A5 (de)
DE (2)	DE69029627T2 (de)
DK (1)	DK0416953T3 (de)
ES (2)	ES2100872T3 (de)
FI (1)	FI93450C (de)
GR (1)	GR3023647T3 (de)
HR (1)	HRP940559B1 (de)
HU (1)	HU218222B (de)
IE (1)	IE903257A1 (de)
IL (1)	IL95609A (de)
MY (1)	MY106980A (de)
NO (1)	NO175479C (de)
NZ (1)	NZ235223A (de)
PL (1)	PL166197B1 (de)
PT (1)	PT95247B (de)
RU (1)	RU2054006C1 (de)
SG (1)	SG73399A1 (de)
SI (1)	SI9011699A (de)
SK (1)	SK435990A3 (de)
YU (1)	YU48073B (de)

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* Cited by examiner, † Cited by third party
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AU636913B2 (en) *	1989-10-11	1993-05-13	Takeda Chemical Industries Ltd.	Tricyclic carbapenem compounds
GB9015485D0 (en) *	1990-07-13	1990-08-29	Glaxo Spa	Heterocyclic derivatives
SI9111427B (sl) *	1990-08-21	2000-10-31	Glaxo S.P.A.	Heterociklične spojine
GB9104769D0 (en) *	1991-03-07	1991-04-17	Glaxo Spa	Heterocyclic compounds
GB9104838D0 (en) *	1991-03-07	1991-04-17	Glaxo Spa	Heterocyclic compounds
AP198A (en) *	1991-03-07	1992-06-30	Glaxo Spa	Heterocyclic compounds.
GB9104832D0 (en) *	1991-03-07	1991-04-17	Glaxo Spa	Heterocyclic compounds
GB9104833D0 (en) *	1991-03-07	1991-04-17	Glaxo Spa	Heterocyclic compounds
KR920019791A (ko) *	1991-04-05	1992-11-20	우메모또 요시마사	다환성 카르바페넴 화합물, 그의 제조방법 및 용도
TW198035B (de) *	1991-05-29	1993-01-11	Hoechst Ag
GB9218240D0 (en) *	1992-08-27	1992-10-14	Glaxo Spa	Heterocyclic compounds
GB9218781D0 (en) *	1992-09-04	1992-10-21	Glaxo Spa	Heterocyclic derivatives
US5849907A (en) *	1993-03-20	1998-12-15	Glaxo Wellcome Spa	Chemical process
GB9305853D0 (en) *	1993-03-20	1993-05-05	Glaxo Spa	Chemical compounds
GB9305813D0 (en) *	1993-03-20	1993-05-05	Glaxo Spa	Chemical process
GB9305806D0 (en) *	1993-03-20	1993-05-05	Glaxo Spa	Chemical compounds
GB9305805D0 (en) *	1993-03-20	1993-05-05	Glaxo Spa	Chemical process
US5372993A (en) *	1993-06-10	1994-12-13	Merck & Co., Inc.	Bridged carbapenem compounds, compositions containing such compounds and methods of use
US5374630A (en) *	1993-06-10	1994-12-20	Merck & Co., Inc.	Bridged carbapenem antibacterial compounds
US5401735A (en) *	1993-08-02	1995-03-28	Merck & Co., Inc.	Bridged biphenyl carbapenem antibacterial compounds
US5384317A (en) *	1993-08-02	1995-01-24	Merck & Co., Inc.	Bridged biphenyl carbapenem compounds, compositions containing such compounds and methods of use
GB9323137D0 (en) *	1993-11-10	1994-01-05	Glaxo Spa	Chemical compounds
GB9403729D0 (en) *	1994-02-26	1994-04-13	Glaxo Spa	Amine derivatives
GB2287709A (en) *	1994-03-26	1995-09-27	Glaxo Spa	Silylated azetidinone intermediates
GB9406074D0 (en) *	1994-03-26	1994-05-18	Glaxo Spa	Chemical process
US5688786A (en) *	1994-04-01	1997-11-18	Microcide Pharmaceuticals, Inc.	β-lactam antibiotics
US5698547A (en) *	1994-04-01	1997-12-16	Microcide Pharmaceuticals, Inc.	Cephalosporin antibiotics
GB9516118D0 (en) *	1995-08-05	1995-10-04	Glaxo Spa	Chemical process
GB9623684D0 (en) *	1996-11-14	1997-01-08	Glaxo Wellcome Spa	Chemical compounds
US6531466B2 (en)	1996-11-14	2003-03-11	Glaxosmithkline Spa	Tricyclic carbapenem compounds
JPH10168057A (ja) *	1996-12-12	1998-06-23	Takasago Internatl Corp	シクロヘキシルアゼチジノン誘導体の製造法
WO1998034937A1 (fr) *	1997-02-10	1998-08-13	Sankyo Company, Limited	Composes heterocycliques tricycliques
US5994343A (en) *	1997-10-02	1999-11-30	Merck & Co., Inc.	Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6207823B1 (en) *	1997-10-23	2001-03-27	Merck & Co., Inc.	Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JP2001520192A (ja) *	1997-10-23	2001-10-30	メルクエンドカムパニーインコーポレーテッド	カルバペネム抗菌性化合物、組成物及び治療方法
US6271222B1 (en)	1998-05-28	2001-08-07	Merck & Co., Inc.	Penem antibacterial compounds, compositions and methods of treatment
CN101367817B (zh) *	2007-06-26	2011-01-12	山东轩竹医药科技有限公司	含有环己烯酮甲酰氨基的碳青霉烯化合物
EP2085084A1 (de) *	2008-01-29	2009-08-05	LEK Pharmaceuticals D.D.	Verwendung eines Hemmers von Beta-Lactamasen und dessen Kombination mit Beta-Lactam-Antibiotika
EP2135871A1 (de) *	2008-06-18	2009-12-23	LEK Pharmaceuticals D.D.	Neuartige Trinemantibiotika und Hemmer von Beta-Lactamasen
HRP20221212T1 (hr)	2017-05-08	2022-12-09	Glaxosmithkline Intellectual Property Development Limited	Sanfetrinem ili njegova sol ili esteri za uporabu u liječenju mikobakterijskih infekcija
KR102471353B1 (ko) *	2020-07-03	2022-11-28	한국공학대학교산학협력단	바이메탈을 이용한 복원 기능을 포함하는 퓨즈

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US4260627A (en) *	1978-10-24	1981-04-07	Merck & Co., Inc.	1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4600713A (en) *	1979-12-03	1986-07-15	Merck & Co., Inc.	1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4374848A (en) *	1981-09-14	1983-02-22	Merck & Co., Inc.	6-(1-Hydroxyethyl)cyclonocardicin
US4374849A (en) *	1981-09-14	1983-02-22	Merck & Co., Inc.	6-Amidocyclonocardicins
JPS61236785A (ja) *	1985-04-15	1986-10-22	Sankyo Co Ltd	アゼチジノン誘導体
GB8607921D0 (en)	1986-04-01	1986-05-08	Fujisawa Pharmaceutical Co	3,4-disubstituted-2-azetidinone derivatives
AU636913B2 (en) *	1989-10-11	1993-05-13	Takeda Chemical Industries Ltd.	Tricyclic carbapenem compounds

1990
- 1990-09-04 CZ CS904359A patent/CZ285778B6/cs not_active IP Right Cessation
- 1990-09-06 YU YU169990A patent/YU48073B/sh unknown
- 1990-09-06 DD DD90343863A patent/DD298102A5/de not_active IP Right Cessation
- 1990-09-06 SI SI9011699A patent/SI9011699A/sl unknown
- 1990-09-07 HU HU826/90A patent/HU218222B/hu not_active IP Right Cessation
- 1990-09-07 AU AU62265/90A patent/AU632163B2/en not_active Ceased
- 1990-09-07 JP JP2235975A patent/JP3035325B2/ja not_active Expired - Fee Related
- 1990-09-07 IE IE325790A patent/IE903257A1/en not_active IP Right Cessation
- 1990-09-07 CA CA002024880A patent/CA2024880C/en not_active Expired - Fee Related
- 1990-09-07 JP JP2235976A patent/JP3018442B2/ja not_active Expired - Lifetime
- 1990-09-07 ES ES90309848T patent/ES2100872T3/es not_active Expired - Lifetime
- 1990-09-07 KR KR1019900014226A patent/KR100188175B1/ko not_active IP Right Cessation
- 1990-09-07 MY MYPI90001540A patent/MY106980A/en unknown
- 1990-09-07 PL PL90286796A patent/PL166197B1/pl unknown
- 1990-09-07 IL IL9560990A patent/IL95609A/en not_active IP Right Cessation
- 1990-09-07 NZ NZ235223A patent/NZ235223A/xx unknown
- 1990-09-07 SK SK4359-90A patent/SK435990A3/sk unknown
- 1990-09-07 US US07/578,948 patent/US5407931A/en not_active Expired - Fee Related
- 1990-09-07 AT AT90309847T patent/ATE147394T1/de active
- 1990-09-07 PT PT95247A patent/PT95247B/pt not_active IP Right Cessation
- 1990-09-07 NO NO903914A patent/NO175479C/no unknown
- 1990-09-07 EP EP90309848A patent/EP0416953B1/de not_active Expired - Lifetime
- 1990-09-07 AT AT90309848T patent/ATE150022T1/de not_active IP Right Cessation
- 1990-09-07 ES ES90309847T patent/ES2095860T3/es not_active Expired - Lifetime
- 1990-09-07 FI FI904423A patent/FI93450C/fi not_active IP Right Cessation
- 1990-09-07 DE DE69029627T patent/DE69029627T2/de not_active Expired - Fee Related
- 1990-09-07 US US07/578,949 patent/US5138048A/en not_active Expired - Fee Related
- 1990-09-07 DE DE69030147T patent/DE69030147T2/de not_active Expired - Fee Related
- 1990-09-07 EP EP90309847A patent/EP0416952B1/de not_active Expired - Lifetime
- 1990-09-07 SG SG1996006269A patent/SG73399A1/en unknown
- 1990-09-07 DK DK90309848.1T patent/DK0416953T3/da active
1992
- 1992-06-04 RU SU5011726/04A patent/RU2054006C1/ru not_active IP Right Cessation
1994
- 1994-09-16 HR HRP-1699/90A patent/HRP940559B1/xx not_active IP Right Cessation
1997
- 1997-05-09 GR GR970401017T patent/GR3023647T3/el unknown

Also Published As

Publication number	Publication date
MY106980A (en)	1995-08-30
AU632163B2 (en)	1992-12-17
US5138048A (en)	1992-08-11
FI93450C (fi)	1995-04-10
EP0416952A3 (en)	1992-03-11
DE69030147T2 (de)	1997-07-10
ES2095860T3 (es)	1997-03-01
CA2024880C (en)	2000-05-30
HRP940559B1 (en)	1999-08-31
DK0416953T3 (da)	1997-09-01
JPH03169854A (ja)	1991-07-23
US5407931A (en)	1995-04-18
EP0416953A3 (en)	1992-03-25
DE69029627D1 (de)	1997-02-20
FI904423A0 (fi)	1990-09-07
SG73399A1 (en)	2000-06-20
HRP940559A2 (en)	1997-02-28
YU48073B (sh)	1997-01-08
SI9011699A (en)	1997-10-31
HU905826D0 (en)	1991-03-28
CZ435990A3 (cs)	1999-11-17
PL166197B1 (pl)	1995-04-28
NZ235223A (en)	1992-11-25
EP0416953A2 (de)	1991-03-13
SK278688B6 (sk)	1998-01-14
SK435990A3 (en)	1998-01-14
JP3018442B2 (ja)	2000-03-13
NO903914L (no)	1991-03-11
NO175479C (no)	1994-10-19
FI93450B (fi)	1994-12-30
YU169990A (sh)	1993-05-28
JP3035325B2 (ja)	2000-04-24
EP0416953B1 (de)	1997-03-12
IL95609A (en)	1995-03-30
PT95247A (pt)	1991-06-25
GR3023647T3 (en)	1997-09-30
ES2100872T3 (es)	1997-07-01
DD298102A5 (de)	1992-02-06
NO175479B (no)	1994-07-11
PL286796A1 (en)	1991-08-26
DE69029627T2 (de)	1997-04-24
KR100188175B1 (ko)	1999-06-01
HUT56105A (en)	1991-07-29
PT95247B (pt)	1997-06-30
DE69030147D1 (de)	1997-04-17
RU2054006C1 (ru)	1996-02-10
CZ285778B6 (cs)	1999-11-17
ATE147394T1 (de)	1997-01-15
KR910006291A (ko)	1991-04-29
JPH03167187A (ja)	1991-07-19
NO903914D0 (no)	1990-09-07
EP0416952B1 (de)	1997-01-08
EP0416952A2 (de)	1991-03-13
CA2024880A1 (en)	1991-03-09
IE903257A1 (en)	1991-03-13
HU218222B (hu)	2000-06-28
AU6226590A (en)	1991-03-14

Legal Events

Date	Code	Title	Description
1997-09-15	UEP	Publication of translation of european patent specification
2004-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0416953T3 (da)	1997-09-01	10-(1-hydroxyethyl)-11-oxo-1-azatri-cyclo 7.2.0.03,8 -undec-2-en-2-carboxylsyrederivater.
DE69201451T2 (de)	1995-10-12	Thiazolidinone und Oxazolidenonederivate, ihre Herstellung und ihre Anwendung als Vasodilatatoren.
FI931688A0 (fi)	1993-04-14	Benzoxazinon- och benzotiazinonderivat med effekt pao hjaertblodkaerlen