DK0621073T3 - Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf - Google Patents

Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf

Info

Publication number
DK0621073T3
DK0621073T3 DK94200884.8T DK94200884T DK0621073T3 DK 0621073 T3 DK0621073 T3 DK 0621073T3 DK 94200884 T DK94200884 T DK 94200884T DK 0621073 T3 DK0621073 T3 DK 0621073T3
Authority
DK
Denmark
Prior art keywords
nanocapsules
stability
increasing
during storage
temperature
Prior art date
Application number
DK94200884.8T
Other languages
English (en)
Inventor
Valdivia Francisco Javie Galan
Dachs Anna Coll
Perdiguer Nuria Carreras
Original Assignee
Alcon Cusi S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Cusi S A filed Critical Alcon Cusi S A
Application granted granted Critical
Publication of DK0621073T3 publication Critical patent/DK0621073T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/20After-treatment of capsule walls, e.g. hardening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/20After-treatment of capsule walls, e.g. hardening
    • B01J13/203Exchange of core-forming material by diffusion through the capsule wall
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/701Integrated with dissimilar structures on a common substrate
    • Y10S977/715On an organic substrate
    • Y10S977/717Lipid substrate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
DK94200884.8T 1993-04-20 1994-03-30 Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf DK0621073T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (es) 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.

Publications (1)

Publication Number Publication Date
DK0621073T3 true DK0621073T3 (da) 1998-06-02

Family

ID=8281529

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94200884.8T DK0621073T3 (da) 1993-04-20 1994-03-30 Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf

Country Status (9)

Country Link
US (1) US5885491A (da)
EP (1) EP0621073B1 (da)
JP (1) JPH0815550B2 (da)
AT (1) ATE159186T1 (da)
DE (1) DE69406178T2 (da)
DK (1) DK0621073T3 (da)
ES (1) ES2070076B1 (da)
GR (1) GR3025888T3 (da)
HK (1) HK1011943A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10008305A1 (de) * 2000-02-23 2001-09-06 Henkel Kgaa Mittel zur Reinigung und Pflege von Haut und/oder Haaren
FR2805761B1 (fr) 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
US20060286064A1 (en) * 2000-08-30 2006-12-21 Medivas, Llc Therapeutic polymers and methods
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
EP1429749A2 (en) * 2001-09-26 2004-06-23 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US20060222694A1 (en) * 2003-06-27 2006-10-05 Oh Choon K Stabilized topotecan liposomal composition and methods
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
CA2623239C (en) * 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
WO2007067744A2 (en) * 2005-12-07 2007-06-14 Medivas, Llc Method for assembling a polymer-biologic delivery composition
CA2649672C (en) * 2006-05-02 2015-07-07 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
EP2021141A4 (en) * 2006-05-09 2013-07-03 Medivas Llc BIODEGRADABLE WATER SOLUBLE POLYMERS
EP2068937A2 (en) * 2006-09-05 2009-06-17 Medivas, LLC Polymer-stabilized liposomal compositions and methods of use
EP2178944A1 (en) * 2007-07-24 2010-04-28 Medivas, LLC Biodegradable cationic polymer gene transfer compositions and methods of use
JP2012500207A (ja) * 2008-08-13 2012-01-05 メディバス エルエルシー Aabb−ポリ(デプシペプチド)生分解性ポリマー及び使用方法
JP2011241147A (ja) * 2008-08-29 2011-12-01 Nano Egg:Kk インドメタシン含有ナノカプセルおよびその製造方法
US8666685B2 (en) 2011-04-19 2014-03-04 Schneider Electronic IT Corporation System of intelligent sensors in an electrical panelboard
US8660810B2 (en) 2011-04-19 2014-02-25 Schneider Electric It Corporation System and method to calculate RMS current and true power in a multidrop sensor network
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US9963549B2 (en) 2011-06-23 2018-05-08 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP3233067B1 (en) 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
EP3427724A4 (en) * 2016-03-10 2019-11-13 Sumitomo Dainippon Pharma Co., Ltd. COMPOSITION CONTAINING FINE PARTICLES, AND PRODUCTION METHOD THEREOF

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
JPS57147430A (en) * 1981-03-06 1982-09-11 Kureha Chem Ind Co Ltd Preparation of microcapsule
FR2515960A1 (fr) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
JP3226300B2 (ja) * 1990-07-18 2001-11-05 エーザイ株式会社 プロナノスフィア及びその製造方法
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles

Also Published As

Publication number Publication date
US5885491A (en) 1999-03-23
ATE159186T1 (de) 1997-11-15
HK1011943A1 (en) 1999-07-23
EP0621073B1 (en) 1997-10-15
ES2070076B1 (es) 1996-04-16
DE69406178D1 (de) 1997-11-20
JPH0815550B2 (ja) 1996-02-21
EP0621073A1 (en) 1994-10-26
DE69406178T2 (de) 1998-06-04
ES2070076A1 (es) 1995-05-16
GR3025888T3 (en) 1998-04-30
JPH06343854A (ja) 1994-12-20

Similar Documents

Publication Publication Date Title
DK0621073T3 (da) Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf
ATE84681T1 (de) Karrageenan enthaltendes waessriges gel.
ATE201333T1 (de) Verfahren zur herstellung von wasseradsorptionsmaterial und dessen verwendung in hygieneartikeln und zur bodenverbesserung
ATE106774T1 (de) Verfahren zur herstellung von wasserabsorptionsmaterial auf polymerbasis und dessen verwendung.
HU902472D0 (en) Process for the production of freeze-dryed pharmaceutical products containing active agents
ES2153395T3 (es) Polimerasa termoestable del acido nucleico.
ATE84710T1 (de) Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln.
AU2673688A (en) Method of producing free flowing beads of biological materials and method for their application to the leaf surface of plants
DE3584610D1 (de) Lebende mikroorganismen enthaltendes fluessiges praeparat, verfahren zu dessen herstellung, lebende mikroorganismen enthaltendes pelletiertes produkt und verfahren zu dessen herstellung.
ES8404160A1 (es) Un procedimiento para producir productos de plantas aromaticas.
DE59206398D1 (de) Verfahren zur Herstellung von 1-Carbamoyl-pyrazolen
AU526532B2 (en) Aqueous dispersions of polymers
RU92016570A (ru) Способ и устройство для стабилизации изделий из теста
ATE16393T1 (de) Verfahren zur herstellung von chlor-phenylphosphanen.
ATE163541T1 (de) Herstellungsverfahren von mit biologischen strukturen, biopolymeren und/oder oligomeren beladenen vesikeln
Vol'kenshteĭn et al. Electronic-conformational interactions of molecular-biological systems. I. Quantum-chemical aspect of the theory of electronic-conformational interaction
TH17769A (th) วิธีการผลิตโปรทีนไฮโดรไลเซท
TH17769EX (th) วิธีการผลิตโปรทีนไฮโดรไลเซท
JPS55123635A (en) Production of nonsoluble molding of high polymer
DE59404408D1 (de) Verfahren zur Herstellung von Isocyansäure aus Cyanursäure
DE59807906D1 (de) Verfahren zur Herstellung von bissfesten Früchten
DK0990393T3 (da) Limvandshydrolysat samt fremgangsmåde til dets fremstilling
RU93048540A (ru) Водная дисперсия зеина, способ получения, твердый препарат с регулируемой проницаемостью по основному продукту
SU1840413A1 (ru) Полимерный гемоглобин, обладающий способностью сохранять газотранспортную функцию гемоглобина, и способ его получения
EP0222704A3 (fr) Procédé de préparation d'un complexe de polygalactane macromoléculaire et de composé azoté et utilisation de ce complexe