ES2070076A1 - Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento. - Google Patents

Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.

Info

Publication number
ES2070076A1
ES2070076A1 ES09300827A ES9300827A ES2070076A1 ES 2070076 A1 ES2070076 A1 ES 2070076A1 ES 09300827 A ES09300827 A ES 09300827A ES 9300827 A ES9300827 A ES 9300827A ES 2070076 A1 ES2070076 A1 ES 2070076A1
Authority
ES
Spain
Prior art keywords
nanocapsules
stability
increase
during storage
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300827A
Other languages
English (en)
Other versions
ES2070076B1 (es
Inventor
Perdiguer Nuria Carreras
Dachs Anna Coll
Valdivia Francisco J Galan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09300827A priority Critical patent/ES2070076B1/es
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to DE69406178T priority patent/DE69406178T2/de
Priority to EP94200884A priority patent/EP0621073B1/en
Priority to DK94200884.8T priority patent/DK0621073T3/da
Priority to AT94200884T priority patent/ATE159186T1/de
Priority to JP6080194A priority patent/JPH0815550B2/ja
Publication of ES2070076A1 publication Critical patent/ES2070076A1/es
Application granted granted Critical
Publication of ES2070076B1 publication Critical patent/ES2070076B1/es
Priority to US08/900,036 priority patent/US5885491A/en
Priority to GR980400061T priority patent/GR3025888T3/el
Priority to HK98113203A priority patent/HK1011943A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/203—Exchange of core-forming material by diffusion through the capsule wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/715—On an organic substrate
    • Y10S977/717—Lipid substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

METODO PARA AUMENTAR LA ESTABILIDAD DE LAS NANOCAPSULAS DURANTE SU ALMACENAMIENTO. COMPRENDE: INCORPORAR UN AGENTE CRIOPROTECTOR EN UNA DISPERSION ACUOSA DE LAS CITADAS NANOCAPSULAS MANTENIENDO UNA SUAVE AGITACION HASTA SU TOTAL DISOLUCION, SEGUIDAMENTE, SOMETER A CONGELACION LA DISPERSION ASI OBTENIDA A UNA TEMPERATURA NO INFERIOR A LOS -40 C DURANTE 2 A 4 HORAS APROXIMADAMENTE Y, FINALMENTE, ELIMINAR EL AGUA CALENTANDO PROGRESIVAMENTE HASTA UNA TEMPERATURA DE 35 C APROXIMADAMENTE Y A PRESION REDUCIDA, CON LO QUE SE OBTIENE UN PRODUCTO LIOFILIZADO ESTABLE, QUE PUEDE RECONSTITUIRSE CONVENIENTEMENTE AÑADIENDOLE AGUA O UNA SOLUCION ACUOSA MAS COMPLEJA. LAS NANOCAPSULAS TIENEN APLICACION EN MEDICINA, FARMACIA, COSMETICA, INDUSTRIA QUIMICA, AGRICULTURA, VETERINARIA, ETC.
ES09300827A 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento. Expired - Fee Related ES2070076B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (es) 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
EP94200884A EP0621073B1 (en) 1993-04-20 1994-03-30 Method to increase the stability of nanocapsules during storage thereof
DK94200884.8T DK0621073T3 (da) 1993-04-20 1994-03-30 Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf
AT94200884T ATE159186T1 (de) 1993-04-20 1994-03-30 Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung
DE69406178T DE69406178T2 (de) 1993-04-20 1994-03-30 Verfahren zur Erhöhung der Stabilität von Nanokapseln während deren Lagerung
JP6080194A JPH0815550B2 (ja) 1993-04-20 1994-04-19 ナノカプセルの貯蔵安定度改良法
US08/900,036 US5885491A (en) 1993-04-20 1997-07-24 Method to increase the stability of nanocapsules during storage thereof
GR980400061T GR3025888T3 (en) 1993-04-20 1998-01-14 Method to increase the stability of nanocapsules during storage thereof.
HK98113203A HK1011943A1 (en) 1993-04-20 1998-12-11 Method to increase the stability of nanocapsules during storage thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (es) 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.

Publications (2)

Publication Number Publication Date
ES2070076A1 true ES2070076A1 (es) 1995-05-16
ES2070076B1 ES2070076B1 (es) 1996-04-16

Family

ID=8281529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300827A Expired - Fee Related ES2070076B1 (es) 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.

Country Status (9)

Country Link
US (1) US5885491A (es)
EP (1) EP0621073B1 (es)
JP (1) JPH0815550B2 (es)
AT (1) ATE159186T1 (es)
DE (1) DE69406178T2 (es)
DK (1) DK0621073T3 (es)
ES (1) ES2070076B1 (es)
GR (1) GR3025888T3 (es)
HK (1) HK1011943A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10008305A1 (de) * 2000-02-23 2001-09-06 Henkel Kgaa Mittel zur Reinigung und Pflege von Haut und/oder Haaren
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
US20060286064A1 (en) * 2000-08-30 2006-12-21 Medivas, Llc Therapeutic polymers and methods
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
JP2005504090A (ja) * 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
EP1643972A4 (en) * 2003-06-27 2010-01-20 Smithkline Beecham Corp STABILIZED LIPOSOMAL TOPOTECAN COMPOSITION AND METHOD
US8652504B2 (en) * 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
WO2007067744A2 (en) * 2005-12-07 2007-06-14 Medivas, Llc Method for assembling a polymer-biologic delivery composition
EP2019645A4 (en) * 2006-05-02 2013-03-06 Medivas Llc RELEASE OF OPHTHALMOLOGICAL ACTIVITIES OUTSIDE OR WITHIN THE EYE
EP2021141A4 (en) * 2006-05-09 2013-07-03 Medivas Llc BIODEGRADABLE WATER SOLUBLE POLYMERS
EP2068937A2 (en) * 2006-09-05 2009-06-17 Medivas, LLC Polymer-stabilized liposomal compositions and methods of use
CA2709412A1 (en) * 2007-07-24 2009-01-29 Medivas, Llc Biodegradable cationic polymer gene transfer compositions and methods of use
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
JP2011241147A (ja) * 2008-08-29 2011-12-01 Nano Egg:Kk インドメタシン含有ナノカプセルおよびその製造方法
US8660810B2 (en) 2011-04-19 2014-02-25 Schneider Electric It Corporation System and method to calculate RMS current and true power in a multidrop sensor network
US8666685B2 (en) 2011-04-19 2014-03-04 Schneider Electronic IT Corporation System of intelligent sensors in an electrical panelboard
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2839841C (en) 2011-06-23 2019-11-05 Dsm Ip Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
EP3233067B1 (en) 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
TWI745358B (zh) * 2016-03-10 2021-11-11 日商大日本住友製藥股份有限公司 含有細微粒子之組合物及其製法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501060A1 (fr) * 1981-03-06 1982-09-10 Kureha Chemical Ind Co Ltd Procede pour produire une microcapsule
FR2608942A1 (fr) * 1986-12-31 1988-07-01 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
WO1993025195A1 (fr) * 1992-06-16 1993-12-23 Centre National De La Recherche Scientifique (Cnrs) Preparation et utilisation de nouveaux systemes colloidaux dispersibles a base de cyclodextrine, sous forme de nanospheres

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FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
FR2515960A1 (fr) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
EP0190833B1 (en) * 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Method for producing microcapsule
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
JP3226300B2 (ja) * 1990-07-18 2001-11-05 エーザイ株式会社 プロナノスフィア及びその製造方法
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501060A1 (fr) * 1981-03-06 1982-09-10 Kureha Chemical Ind Co Ltd Procede pour produire une microcapsule
US4460722A (en) * 1981-03-06 1984-07-17 Kureha Kagaku Kogyo Kabushiki Kaisha Process for producing a microcapsule
FR2608942A1 (fr) * 1986-12-31 1988-07-01 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
WO1993025195A1 (fr) * 1992-06-16 1993-12-23 Centre National De La Recherche Scientifique (Cnrs) Preparation et utilisation de nouveaux systemes colloidaux dispersibles a base de cyclodextrine, sous forme de nanospheres

Also Published As

Publication number Publication date
EP0621073B1 (en) 1997-10-15
HK1011943A1 (en) 1999-07-23
DE69406178T2 (de) 1998-06-04
JPH0815550B2 (ja) 1996-02-21
US5885491A (en) 1999-03-23
EP0621073A1 (en) 1994-10-26
ATE159186T1 (de) 1997-11-15
ES2070076B1 (es) 1996-04-16
DK0621073T3 (da) 1998-06-02
DE69406178D1 (de) 1997-11-20
JPH06343854A (ja) 1994-12-20
GR3025888T3 (en) 1998-04-30

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Date Code Title Description
FD1A Patent lapsed

Effective date: 20101018