DK0601486T3 - Cis-epoxidderivater, der er egnede som irreversible HIV-proteaseinhibitorer, og fremgangsmåde og mellemprodukter til deres - Google Patents
Cis-epoxidderivater, der er egnede som irreversible HIV-proteaseinhibitorer, og fremgangsmåde og mellemprodukter til deresInfo
- Publication number
- DK0601486T3 DK0601486T3 DK93119458T DK93119458T DK0601486T3 DK 0601486 T3 DK0601486 T3 DK 0601486T3 DK 93119458 T DK93119458 T DK 93119458T DK 93119458 T DK93119458 T DK 93119458T DK 0601486 T3 DK0601486 T3 DK 0601486T3
- Authority
- DK
- Denmark
- Prior art keywords
- intermediates
- methods
- protease inhibitors
- hiv protease
- derivatives useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Crystallography & Structural Chemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920023089A KR960000078B1 (ko) | 1992-12-02 | 1992-12-02 | 인간 면역 결핍 바이러스 프로테아제의 억제 화합물 및 그의 제조방법 |
KR1019920023088A KR960000077B1 (ko) | 1992-12-02 | 1992-12-02 | 인간 면역 결핍 바이러스 프로테아제의 억제 화합물 및 그의 제조방법 |
KR1019930010811A KR970011577B1 (ko) | 1993-06-14 | 1993-06-14 | 항 에이즈(aids) 효과를 갖는 신규한 인간 면역 결핍 바이러스 프로테아제의 억제 화합물 및 그의 제조방법 |
KR1019930021300A KR0134497B1 (ko) | 1993-10-14 | 1993-10-14 | 비가역적 에이치아이브이 프로테아제 억제제 |
KR1019930021298A KR0125104B1 (ko) | 1993-10-14 | 1993-10-14 | 신규 인간 면역 결핍 바이러스(hiv) 프로테아제 억제 화합물 및 그의 제조방법 |
KR1019930021299A KR960011580B1 (ko) | 1993-10-14 | 1993-10-14 | 비가역적 에이치아이브이(hiv) 프로테아제 억제제의 중간체 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0601486T3 true DK0601486T3 (da) | 1998-07-20 |
Family
ID=27555058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93119458T DK0601486T3 (da) | 1992-12-02 | 1993-12-02 | Cis-epoxidderivater, der er egnede som irreversible HIV-proteaseinhibitorer, og fremgangsmåde og mellemprodukter til deres |
Country Status (8)
Country | Link |
---|---|
US (3) | US5587388A (da) |
EP (1) | EP0601486B1 (da) |
JP (2) | JP2916359B2 (da) |
AT (1) | ATE159728T1 (da) |
DE (1) | DE69314911T2 (da) |
DK (1) | DK0601486T3 (da) |
ES (1) | ES2111700T3 (da) |
GR (1) | GR3025968T3 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2565745B2 (ja) * | 1988-08-03 | 1996-12-18 | 新明和工業株式会社 | 垂直循環式駐車装置 |
US5587388A (en) * | 1992-12-02 | 1996-12-24 | Lucky Limited | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof |
US5696134A (en) * | 1993-11-30 | 1997-12-09 | Lg Chemical Limited | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof |
EP0812857A1 (en) * | 1994-12-08 | 1997-12-17 | LG Chemical Limited | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof |
KR0159652B1 (ko) * | 1995-10-26 | 1998-12-01 | 성재갑 | 항 에이즈 효과를 갖는 비가역적 인간 면역 결핍 바이러스 프로테아제 저해제 및 그의 제조방법 |
KR0125117B1 (ko) * | 1994-06-15 | 1997-12-05 | 성재갑 | 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법 |
EP0812839A1 (en) * | 1994-12-08 | 1997-12-17 | LG Chemical Limited | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof |
US5670517A (en) * | 1993-11-30 | 1997-09-23 | Lg Chemical Limited | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof |
US5679687A (en) * | 1993-11-30 | 1997-10-21 | Lg Chemical Limited | Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof |
DE19641691A1 (de) | 1996-10-10 | 1998-04-16 | Bayer Ag | Substituierte 2-Amino-4-alkylamino-1,3,5-triazine |
PT2328875E (pt) | 2008-07-17 | 2015-02-04 | Univ Pittsburgh | Agentes de nitróxido dirigidos |
GB201814067D0 (en) * | 2018-08-29 | 2018-10-10 | Univ Edinburgh | Compounds for the inhibition of cyclophilins |
US11548847B2 (en) | 2019-02-26 | 2023-01-10 | Mitsubishi Gas Chemical Company, Inc. | Amine composition, amine compound, production method, and application thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
KR900012945A (ko) * | 1989-02-16 | 1990-09-03 | 가와무라 요시부미 | 렌닌 억제활성을 갖는 펩타이트, 그 제조방법 및 용도 |
US5114937A (en) * | 1989-11-28 | 1992-05-19 | Warner-Lambert Company | Renin inhibiting nonpeptides |
EP0492136A3 (en) * | 1990-12-20 | 1993-05-26 | American Cyanamid Company | Retroviral protease inhibitors derived from 3-chloro-2-chloromethyl-1-propene |
US5268361A (en) * | 1991-06-07 | 1993-12-07 | Sri International | Hydroxyazido derivatives and related compounds as renin inhibitors |
US5587385A (en) * | 1991-12-24 | 1996-12-24 | Farmitalia Carlo Erba S.R.L. | Arylidene-heterocyclic derivatives and process for their preparation |
US5587388A (en) * | 1992-12-02 | 1996-12-24 | Lucky Limited | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof |
-
1993
- 1993-11-30 US US08/159,382 patent/US5587388A/en not_active Expired - Fee Related
- 1993-12-02 DE DE69314911T patent/DE69314911T2/de not_active Expired - Fee Related
- 1993-12-02 ES ES93119458T patent/ES2111700T3/es not_active Expired - Lifetime
- 1993-12-02 DK DK93119458T patent/DK0601486T3/da active
- 1993-12-02 EP EP93119458A patent/EP0601486B1/en not_active Expired - Lifetime
- 1993-12-02 AT AT93119458T patent/ATE159728T1/de not_active IP Right Cessation
- 1993-12-02 JP JP5303063A patent/JP2916359B2/ja not_active Expired - Lifetime
-
1996
- 1996-06-20 US US08/667,133 patent/US5763631A/en not_active Expired - Fee Related
- 1996-06-20 US US08/667,888 patent/US5744621A/en not_active Expired - Lifetime
-
1997
- 1997-08-08 JP JP9214411A patent/JP2978848B2/ja not_active Expired - Fee Related
-
1998
- 1998-01-21 GR GR980400138T patent/GR3025968T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE159728T1 (de) | 1997-11-15 |
JPH072820A (ja) | 1995-01-06 |
US5763631A (en) | 1998-06-09 |
US5744621A (en) | 1998-04-28 |
JPH1081653A (ja) | 1998-03-31 |
DE69314911D1 (de) | 1997-12-04 |
JP2916359B2 (ja) | 1999-07-05 |
DE69314911T2 (de) | 1998-04-09 |
EP0601486B1 (en) | 1997-10-29 |
JP2978848B2 (ja) | 1999-11-15 |
GR3025968T3 (en) | 1998-04-30 |
ES2111700T3 (es) | 1998-03-16 |
EP0601486A1 (en) | 1994-06-15 |
US5587388A (en) | 1996-12-24 |
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