DK0535192T3 - Hidtil ukendte DNA-gyraseinhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende dem - Google Patents

Hidtil ukendte DNA-gyraseinhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende dem

Info

Publication number
DK0535192T3
DK0535192T3 DK92908147.9T DK92908147T DK0535192T3 DK 0535192 T3 DK0535192 T3 DK 0535192T3 DK 92908147 T DK92908147 T DK 92908147T DK 0535192 T3 DK0535192 T3 DK 0535192T3
Authority
DK
Denmark
Prior art keywords
preparation
methods
dna gyrase
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK92908147.9T
Other languages
English (en)
Inventor
Mikio Arisawa
Erwin Goetschi
Tsutomu Kamiyama
Raffaello Masciadri
Hisao Shimada
Junko Watanabe
Paul Hebeisen
Helmut Link
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0535192T3 publication Critical patent/DK0535192T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D419/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D291/00Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/08Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/886Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
DK92908147.9T 1991-04-17 1992-04-09 Hidtil ukendte DNA-gyraseinhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende dem DK0535192T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91106105 1991-04-17
PCT/EP1992/000809 WO1992018490A1 (en) 1991-04-17 1992-04-09 Novel dna gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same

Publications (1)

Publication Number Publication Date
DK0535192T3 true DK0535192T3 (da) 1996-08-05

Family

ID=8206629

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92908147.9T DK0535192T3 (da) 1991-04-17 1992-04-09 Hidtil ukendte DNA-gyraseinhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende dem

Country Status (7)

Country Link
US (3) US5294609A (da)
EP (1) EP0535192B1 (da)
JP (1) JPH05508167A (da)
AT (1) ATE139532T1 (da)
DE (1) DE69211637T2 (da)
DK (1) DK0535192T3 (da)
WO (1) WO1992018490A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018490A1 (en) * 1991-04-17 1992-10-29 F. Hoffmann-La Roche Ag Novel dna gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same
TW343965B (en) * 1994-03-30 1998-11-01 Hoffmann La Roche Novel mono- and bicyclic DNA gyrase inhibitors
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
EP1532132B1 (en) * 2002-07-29 2008-03-19 F.Hoffmann-La Roche Ag Novel benzodioxoles
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds
GB0500683D0 (en) 2005-01-13 2005-02-23 Novartis Ag Organic compounds
CN104211655B (zh) * 2005-12-14 2016-08-17 云南维和药业股份有限公司 具有抗菌和抗肿瘤活性的大环内酯化合物
US9416290B2 (en) 2012-12-28 2016-08-16 Nthdegree Technologies Worldwide Inc. Nickel inks and oxidation resistant and conductive coatings

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239350A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
US3678159A (en) * 1966-03-28 1972-07-18 Meiji Seika Kaisha Antibiotics obtained from streptomyces miharaensis
US4175007A (en) * 1976-10-29 1979-11-20 Merck & Co., Inc. Process for producing antibiotic A21A
JPS594120B2 (ja) * 1979-06-15 1984-01-27 大塚製薬株式会社 抗生物質セフアマイシンcの製造法
US4534970A (en) * 1983-06-23 1985-08-13 American Cyanamid Company Antibacterial antibiotics LL-CO8078α1, α2, α3 and β
WO1992018490A1 (en) * 1991-04-17 1992-10-29 F. Hoffmann-La Roche Ag Novel dna gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same
US5266484A (en) * 1991-10-16 1993-11-30 Shin-Etsu Bio, Inc. Streptomyces spectabilis strains employed for producing streptovaricin C

Also Published As

Publication number Publication date
US5399741A (en) 1995-03-21
DE69211637D1 (de) 1996-07-25
DE69211637T2 (de) 1997-01-30
US5294609A (en) 1994-03-15
WO1992018490A1 (en) 1992-10-29
ATE139532T1 (de) 1996-07-15
EP0535192B1 (en) 1996-06-19
EP0535192A1 (en) 1993-04-07
JPH05508167A (ja) 1993-11-18
US5486466A (en) 1996-01-23

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