ES2069892T3 - Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico. - Google Patents
Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico.Info
- Publication number
- ES2069892T3 ES2069892T3 ES91910279T ES91910279T ES2069892T3 ES 2069892 T3 ES2069892 T3 ES 2069892T3 ES 91910279 T ES91910279 T ES 91910279T ES 91910279 T ES91910279 T ES 91910279T ES 2069892 T3 ES2069892 T3 ES 2069892T3
- Authority
- ES
- Spain
- Prior art keywords
- complexes
- pct
- diagnosis
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HPYIUKIBUJFXII-UHFFFAOYSA-N Cyclopentadienyl radical Chemical class [CH]1C=CC=C1 HPYIUKIBUJFXII-UHFFFAOYSA-N 0.000 title 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
LA INVENCION CONCIERNE A COMPLEJOS 99MTC DE CICLOPENTADIENILCARBONILO DE LA FORMULA GENERAL (I), EN DONDE XR PUEDE TENER DIVERSOS SIGNIFICADOS. ESTOS NUEVOS COMPLEJOS DEL TECNECIO 99M SE PUEDEN APLICAR EN EL SECTOR DEL DIAGNOSTICO MEDICO. ADEMAS, LA INVENCION CONCIERNE A UN PROCEDIMIENTO PARA LA OBTENCION DE LOS COMPLEJOS DE LA INVENCION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4018172 | 1990-06-01 | ||
DE4028867 | 1990-09-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2069892T3 true ES2069892T3 (es) | 1995-05-16 |
Family
ID=25893909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91910279T Expired - Lifetime ES2069892T3 (es) | 1990-06-01 | 1991-05-31 | Complejos de ciclopentadienilcarbonilo-99mtc, procedimiento para su preparacion asi como su utilizacion en el diagnostico. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5538712A (es) |
EP (1) | EP0532566B1 (es) |
JP (1) | JPH06501450A (es) |
AT (1) | ATE119539T1 (es) |
CA (1) | CA2084315A1 (es) |
DE (1) | DE59104905D1 (es) |
DK (1) | DK0532566T3 (es) |
ES (1) | ES2069892T3 (es) |
GR (1) | GR3015362T3 (es) |
WO (1) | WO1991018908A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6359120B1 (en) | 1991-10-29 | 2002-03-19 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia-localizing moiety |
US5808091A (en) | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
DE4313670A1 (de) * | 1993-04-22 | 1994-10-27 | Diagnostikforschung Inst | Radioaktive Metallocen-carbonsäuren und deren Homologe zur Proteinmarkierung |
US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
US5700446A (en) * | 1996-06-13 | 1997-12-23 | Neuro Imaging Technologies, Llc | Synthesis of ferrocenyl phenyltropane analogs and their radio-transformation to technetium neuroprobes for mapping monoamine reuptake sites |
EP1233968A2 (en) * | 1999-12-03 | 2002-08-28 | Yale University | Transition metal-cyclopentadienyl-tropane conjugates |
AU2003226169C1 (en) * | 2002-04-01 | 2010-01-07 | Molecular Insight Pharmaceuticals, Inc. | Pendant fatty acid imaging agents |
JP2008512360A (ja) * | 2004-09-07 | 2008-04-24 | トライアンフ,オペレーティング アズ ア ジョイント ヴェンチャー バイ ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ,ザ ユニバーシティ オブ ブリティッシュ コロンビア,カールトン | 放射性同位体でラベル化された糖−金属錯体の合成方法 |
EP1846042A2 (en) * | 2005-01-05 | 2007-10-24 | Board of Regents, The University of Texas System | Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications |
CN101654465B (zh) * | 2009-09-11 | 2012-10-03 | 兰州大学 | 一种羰基锝标记的2-硝基咪唑配合物及其制备方法与用途 |
CN102311459B (zh) * | 2011-06-03 | 2014-06-25 | 北京师范大学 | 新型锝-99m标记的高级脂肪酸衍生物 |
CN103435655B (zh) * | 2013-08-06 | 2016-04-06 | 北京师范大学 | 结合σ1受体的三羰基环戊二烯类配体化合物、其制备方法及应用 |
CN103772440B (zh) * | 2014-01-10 | 2017-02-15 | 北京师范大学 | 一种锝‑99m标记的高级脂肪酸衍生物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3028404A (en) * | 1958-11-03 | 1962-04-03 | Ethyl Corp | Manufacture of cyclopentadienyl metal carbonyl compounds |
DE2246460A1 (de) * | 1972-09-21 | 1974-04-04 | Schering Ag | Metallocene und metallocen-derivate mit radioaktivem zentralatom |
DE3218859A1 (de) * | 1982-05-15 | 1983-11-17 | Wenzel, Martin, Prof. Dr., 1000 Berlin | Amin-derivate des ruthenocens und ferrocens als radiopharmaka |
DE3244886A1 (de) * | 1982-12-01 | 1984-06-07 | Byk-Mallinckrodt Cil B.V., Petten | Metallocen-derivate der aminosaeuren glycin und alanin mit radioaktivem zentralatom als radiopharmaka. |
DE3445782A1 (de) * | 1984-12-12 | 1986-06-12 | Martin Prof. Dr. 1000 Berlin Wenzel | Metallocen-derivate zur gehirn- und lungendiagnostik |
DE3523262A1 (de) * | 1984-12-12 | 1987-01-08 | Martin Prof Dr Wenzel | Metallocen-derivate fuer die diagnostik des gehirns und anderer organe |
US4765971A (en) * | 1985-05-31 | 1988-08-23 | Mallinckrodt, Inc. | Technetium (Tc-99m)-arene complexes useful in myocardial imaging |
US5167948A (en) * | 1987-08-07 | 1992-12-01 | Mallinckrodt Medical, Inc. | Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound |
-
1991
- 1991-05-31 DK DK91910279.8T patent/DK0532566T3/da active
- 1991-05-31 AT AT91910279T patent/ATE119539T1/de not_active IP Right Cessation
- 1991-05-31 US US07/966,183 patent/US5538712A/en not_active Expired - Fee Related
- 1991-05-31 DE DE59104905T patent/DE59104905D1/de not_active Expired - Fee Related
- 1991-05-31 CA CA002084315A patent/CA2084315A1/en not_active Abandoned
- 1991-05-31 WO PCT/DE1991/000470 patent/WO1991018908A1/de active IP Right Grant
- 1991-05-31 JP JP3509505A patent/JPH06501450A/ja active Pending
- 1991-05-31 EP EP91910279A patent/EP0532566B1/de not_active Expired - Lifetime
- 1991-05-31 ES ES91910279T patent/ES2069892T3/es not_active Expired - Lifetime
-
1995
- 1995-03-10 GR GR950400520T patent/GR3015362T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0532566B1 (de) | 1995-03-08 |
ATE119539T1 (de) | 1995-03-15 |
WO1991018908A1 (de) | 1991-12-12 |
US5538712A (en) | 1996-07-23 |
CA2084315A1 (en) | 1991-12-02 |
DE59104905D1 (de) | 1995-04-13 |
GR3015362T3 (en) | 1995-06-30 |
DK0532566T3 (da) | 1995-07-31 |
EP0532566A1 (de) | 1993-03-24 |
JPH06501450A (ja) | 1994-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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