DK0483237T3 - Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMC - Google Patents
Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMCInfo
- Publication number
- DK0483237T3 DK0483237T3 DK90911369.8T DK90911369T DK0483237T3 DK 0483237 T3 DK0483237 T3 DK 0483237T3 DK 90911369 T DK90911369 T DK 90911369T DK 0483237 T3 DK0483237 T3 DK 0483237T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- pbmc
- protection
- cytolytic activity
- amino acid
- Prior art date
Links
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 title abstract 2
- 230000001461 cytolytic effect Effects 0.000 title 1
- 210000000822 natural killer cell Anatomy 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000031942 natural killer cell mediated cytotoxicity Effects 0.000 abstract 2
- VPSSPAXIFBTOHY-LURJTMIESA-N (2s)-2-amino-4-methylpentan-1-ol Chemical compound CC(C)C[C@H](N)CO VPSSPAXIFBTOHY-LURJTMIESA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- STVVMTBJNDTZBF-VIFPVBQESA-N L-phenylalaninol Chemical compound OC[C@@H](N)CC1=CC=CC=C1 STVVMTBJNDTZBF-VIFPVBQESA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/383,222 US5198334A (en) | 1989-07-21 | 1989-07-21 | Protection of natural killer cell cytolytic activity in peripheral blood mononuclear cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0483237T3 true DK0483237T3 (da) | 1995-04-10 |
Family
ID=23512227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90911369.8T DK0483237T3 (da) | 1989-07-21 | 1990-07-17 | Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMC |
Country Status (10)
Country | Link |
---|---|
US (1) | US5198334A (de) |
EP (1) | EP0483237B1 (de) |
JP (1) | JPH05504884A (de) |
AT (1) | ATE112309T1 (de) |
AU (1) | AU6049390A (de) |
CA (1) | CA2063788A1 (de) |
DE (1) | DE69012999T2 (de) |
DK (1) | DK0483237T3 (de) |
ES (1) | ES2061057T3 (de) |
WO (1) | WO1991001370A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4308350B2 (ja) * | 1998-11-27 | 2009-08-05 | 小林製薬株式会社 | シイタケ菌糸体抽出物を含有するlak活性スクリーニング物質およびそれを用いたlak活性スクリーニング法 |
US6153113A (en) * | 1999-02-22 | 2000-11-28 | Cobe Laboratories, Inc. | Method for using ligands in particle separation |
US6354986B1 (en) | 2000-02-16 | 2002-03-12 | Gambro, Inc. | Reverse-flow chamber purging during centrifugal separation |
AU2001262697A1 (en) * | 2000-06-06 | 2001-12-17 | Kirin Beer Kabushiki Kaisha | Method of amplifying natural killer t cells |
BR112012013581A8 (pt) * | 2009-12-05 | 2017-12-26 | Univ Heidelberg Ruprecht Karls | vacinas de malária baseadas em ferlinas apicomplexas, proteínas semelhantes a ferlinas e outras proteínas que contêm o domínio c2 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4752602A (en) * | 1985-09-09 | 1988-06-21 | Board Of Regents, The University Of Texas System | Dipeptide alkyl esters and their uses |
US4849329A (en) * | 1986-05-30 | 1989-07-18 | E. I. Du Pont De Nemours And Company | Process for preparing lymphokine activated killer cells |
-
1989
- 1989-07-21 US US07/383,222 patent/US5198334A/en not_active Expired - Lifetime
-
1990
- 1990-07-17 DE DE69012999T patent/DE69012999T2/de not_active Expired - Fee Related
- 1990-07-17 CA CA002063788A patent/CA2063788A1/en not_active Abandoned
- 1990-07-17 AT AT90911369T patent/ATE112309T1/de not_active IP Right Cessation
- 1990-07-17 ES ES90911369T patent/ES2061057T3/es not_active Expired - Lifetime
- 1990-07-17 AU AU60493/90A patent/AU6049390A/en not_active Abandoned
- 1990-07-17 WO PCT/US1990/003902 patent/WO1991001370A1/en active IP Right Grant
- 1990-07-17 EP EP90911369A patent/EP0483237B1/de not_active Expired - Lifetime
- 1990-07-17 JP JP2510589A patent/JPH05504884A/ja active Pending
- 1990-07-17 DK DK90911369.8T patent/DK0483237T3/da active
Also Published As
Publication number | Publication date |
---|---|
ATE112309T1 (de) | 1994-10-15 |
EP0483237B1 (de) | 1994-09-28 |
JPH05504884A (ja) | 1993-07-29 |
ES2061057T3 (es) | 1994-12-01 |
WO1991001370A1 (en) | 1991-02-07 |
DE69012999D1 (de) | 1994-11-03 |
EP0483237A1 (de) | 1992-05-06 |
CA2063788A1 (en) | 1991-01-22 |
DE69012999T2 (de) | 1995-01-26 |
AU6049390A (en) | 1991-02-22 |
US5198334A (en) | 1993-03-30 |
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