DK0483237T3 - Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMC - Google Patents

Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMC

Info

Publication number: DK0483237T3
Authority: DK; Denmark
Prior art keywords: cells; pbmc; protection; cytolytic activity; amino acid
Prior art date: 1989-07-21

Application number

DK90911369.8T

Other languages

English (en)

Inventor

Kam Hung Leung

Original Assignee

Terumo Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-21

Filing date

1990-07-17

Publication date

1995-04-10

1990-07-17 Application filed by Terumo Corp filed Critical Terumo Corp

1995-04-10 Application granted granted Critical

1995-04-10 Publication of DK0483237T3 publication Critical patent/DK0483237T3/da

Links

210000003819 peripheral blood mononuclear cell Anatomy 0.000 title abstract 2
230000001461 cytolytic effect Effects 0.000 title 1
210000000822 natural killer cell Anatomy 0.000 title 1
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
230000031942 natural killer cell mediated cytotoxicity Effects 0.000 abstract 2
VPSSPAXIFBTOHY-LURJTMIESA-N (2s)-2-amino-4-methylpentan-1-ol Chemical compound CC(C)C[C@H](N)CO VPSSPAXIFBTOHY-LURJTMIESA-N 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
108010002350 Interleukin-2 Proteins 0.000 abstract 1
STVVMTBJNDTZBF-VIFPVBQESA-N L-phenylalaninol Chemical compound OC[C@@H](N)CC1=CC=CC=C1 STVVMTBJNDTZBF-VIFPVBQESA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000011534 incubation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

DK90911369.8T 1989-07-21 1990-07-17 Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMC DK0483237T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/383,222 US5198334A (en)	1989-07-21	1989-07-21	Protection of natural killer cell cytolytic activity in peripheral blood mononuclear cells

Publications (1)

Publication Number	Publication Date
DK0483237T3 true DK0483237T3 (da)	1995-04-10

Family

ID=23512227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90911369.8T DK0483237T3 (da)	1989-07-21	1990-07-17	Beskyttelse af cytolytisk aktivitet hos NK-celler i PBMC

Country Status (10)

Country	Link
US (1)	US5198334A (da)
EP (1)	EP0483237B1 (da)
JP (1)	JPH05504884A (da)
AT (1)	ATE112309T1 (da)
AU (1)	AU6049390A (da)
CA (1)	CA2063788A1 (da)
DE (1)	DE69012999T2 (da)
DK (1)	DK0483237T3 (da)
ES (1)	ES2061057T3 (da)
WO (1)	WO1991001370A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4308350B2 (ja) *	1998-11-27	2009-08-05	小林製薬株式会社	シイタケ菌糸体抽出物を含有するｌａｋ活性スクリーニング物質およびそれを用いたｌａｋ活性スクリーニング法
US6153113A (en) *	1999-02-22	2000-11-28	Cobe Laboratories, Inc.	Method for using ligands in particle separation
US6354986B1 (en)	2000-02-16	2002-03-12	Gambro, Inc.	Reverse-flow chamber purging during centrifugal separation
AU2001262697A1 (en) *	2000-06-06	2001-12-17	Kirin Beer Kabushiki Kaisha	Method of amplifying natural killer t cells
BR112012013581A8 (pt) *	2009-12-05	2017-12-26	Univ Heidelberg Ruprecht Karls	vacinas de malária baseadas em ferlinas apicomplexas, proteínas semelhantes a ferlinas e outras proteínas que contêm o domínio c2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4752602A (en) *	1985-09-09	1988-06-21	Board Of Regents, The University Of Texas System	Dipeptide alkyl esters and their uses
US4849329A (en) *	1986-05-30	1989-07-18	E. I. Du Pont De Nemours And Company	Process for preparing lymphokine activated killer cells

1989
- 1989-07-21 US US07/383,222 patent/US5198334A/en not_active Expired - Lifetime
1990
- 1990-07-17 DE DE69012999T patent/DE69012999T2/de not_active Expired - Fee Related
- 1990-07-17 CA CA002063788A patent/CA2063788A1/en not_active Abandoned
- 1990-07-17 AT AT90911369T patent/ATE112309T1/de not_active IP Right Cessation
- 1990-07-17 ES ES90911369T patent/ES2061057T3/es not_active Expired - Lifetime
- 1990-07-17 AU AU60493/90A patent/AU6049390A/en not_active Abandoned
- 1990-07-17 WO PCT/US1990/003902 patent/WO1991001370A1/en active IP Right Grant
- 1990-07-17 EP EP90911369A patent/EP0483237B1/en not_active Expired - Lifetime
- 1990-07-17 JP JP2510589A patent/JPH05504884A/ja active Pending
- 1990-07-17 DK DK90911369.8T patent/DK0483237T3/da active

Also Published As

Publication number	Publication date
ATE112309T1 (de)	1994-10-15
EP0483237B1 (en)	1994-09-28
JPH05504884A (ja)	1993-07-29
ES2061057T3 (es)	1994-12-01
WO1991001370A1 (en)	1991-02-07
DE69012999D1 (de)	1994-11-03
EP0483237A1 (en)	1992-05-06
CA2063788A1 (en)	1991-01-22
DE69012999T2 (de)	1995-01-26
AU6049390A (en)	1991-02-22
US5198334A (en)	1993-03-30

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