DK0445862T3 - N-(4-piperidinyl)-(dihydrobenzofuran eller dihydro-2H-benzopyran)-carboxamidderivater - Google Patents

N-(4-piperidinyl)-(dihydrobenzofuran eller dihydro-2H-benzopyran)-carboxamidderivater

Info

Publication number
DK0445862T3
DK0445862T3 DK91200382T DK91200382T DK0445862T3 DK 0445862 T3 DK0445862 T3 DK 0445862T3 DK 91200382 T DK91200382 T DK 91200382T DK 91200382 T DK91200382 T DK 91200382T DK 0445862 T3 DK0445862 T3 DK 0445862T3
Authority
DK
Denmark
Prior art keywords
aryl
alkyl
alk
cycloalkyl
piperidinyl
Prior art date
Application number
DK91200382T
Other languages
Danish (da)
English (en)
Inventor
Daele Georges Henri Paul Van
Jean-Paul Rene Marie A Bosmans
Cleyn Michel Anna Jozef De
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0445862T3 publication Critical patent/DK0445862T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
DK91200382T 1990-03-06 1991-02-22 N-(4-piperidinyl)-(dihydrobenzofuran eller dihydro-2H-benzopyran)-carboxamidderivater DK0445862T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909005014A GB9005014D0 (en) 1990-03-06 1990-03-06 N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (1)

Publication Number Publication Date
DK0445862T3 true DK0445862T3 (da) 2000-09-04

Family

ID=10672103

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91200382T DK0445862T3 (da) 1990-03-06 1991-02-22 N-(4-piperidinyl)-(dihydrobenzofuran eller dihydro-2H-benzopyran)-carboxamidderivater

Country Status (39)

Country Link
US (2) US5185335A (fr)
EP (1) EP0445862B1 (fr)
JP (1) JP2601566B2 (fr)
KR (1) KR0177521B1 (fr)
CN (1) CN1038936C (fr)
AT (1) ATE191912T1 (fr)
AU (1) AU636012B2 (fr)
BG (1) BG60381B1 (fr)
CA (1) CA2037575C (fr)
CY (1) CY2235B1 (fr)
CZ (1) CZ286617B6 (fr)
DE (1) DE69132119T2 (fr)
DK (1) DK0445862T3 (fr)
ES (1) ES2147175T3 (fr)
FI (1) FI101622B1 (fr)
GB (1) GB9005014D0 (fr)
GR (1) GR3033461T3 (fr)
HK (1) HK1010727A1 (fr)
HR (1) HRP930483B1 (fr)
HU (2) HU221627B1 (fr)
IE (1) IE910710A1 (fr)
IL (1) IL97018A (fr)
LT (1) LT3708B (fr)
LV (1) LV10085B (fr)
MA (1) MA22076A1 (fr)
MY (1) MY108831A (fr)
NO (1) NO177424C (fr)
NZ (1) NZ237189A (fr)
PL (6) PL168693B1 (fr)
PT (1) PT96937B (fr)
RU (1) RU2070884C1 (fr)
SG (1) SG47482A1 (fr)
SI (1) SI9110396B (fr)
SK (2) SK282407B6 (fr)
TN (1) TNSN91010A1 (fr)
UA (1) UA25969A1 (fr)
YU (1) YU48854B (fr)
ZA (1) ZA911611B (fr)
ZW (1) ZW2391A1 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
CZ283619B6 (cs) * 1991-09-12 1998-05-13 Smithkline Beecham P.L.C Použití derivátů kyseliny benzoové pro výrobu farmaceutických prostředků, deriváty kyseliny benzoo vé, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
WO1993016072A1 (fr) * 1992-02-06 1993-08-19 Smithkline Beecham Plc Derives de benzopyrane, de benzothiopyrane et de coumarone utilises comme antagonistes du recepteur 5-ht4
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
AU5150393A (en) * 1992-10-13 1994-05-09 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
TW294595B (fr) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
JPH0820586A (ja) * 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
GB9418326D0 (en) * 1994-09-12 1994-11-02 Lilly Industries Ltd Pharmaceutical compounds
JPH0873463A (ja) 1994-07-05 1996-03-19 Sanwa Kagaku Kenkyusho Co Ltd ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
JP3953097B2 (ja) * 1994-09-27 2007-08-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｎ−置換ピペリジニル二環式ベンゾエート誘導体
DK0784619T3 (da) * 1994-09-27 1999-10-11 Janssen Pharmaceutica Nv Phenyloxoalkyl-(4-piperidinyl)benzoatderivater
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
EP1076055B1 (fr) 1998-04-28 2004-11-24 Dainippon Pharmaceutical Co., Ltd. Derives de 1- (1-substituee-4-piperidinyle)methyle]-4-piperidine, procede de production de ceux-ci, compositions medicinales contenant ces composes et intermediaires de ces composes
KR20010043618A (ko) * 1998-05-14 2001-05-25 사바 키스 ; 아틸라 만디 야노스 템페 ; 기울라 시미그 벤조푸란 유도체, 이를 포함하는 약제 조성물과 활성성분으로서 벤조푸란 유도체의 제조방법
CA2340952C (fr) * 1998-09-10 2009-12-08 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide et derives de cetone utilises comme antagonistes du recepteur 5-ht4
JP2002530334A (ja) * 1998-11-23 2002-09-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 消化不良の処置用医薬の製造のためのプルカロプリドの使用
TW592709B (en) * 1999-04-29 2004-06-21 Janssen Pharmaceutica Nv Prucalopride oral solution
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN1288730A (zh) * 1999-09-07 2001-03-28 麦克内尔-Ppc股份有限公司 轻泻组合物
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
US20050085510A1 (en) * 2002-01-16 2005-04-21 Telefonaktiebolaget Lm Ericsson (Publ) Prucalopride-n-oxide
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
EP2007756B1 (fr) * 2006-04-07 2015-08-26 Vertex Pharmaceuticals Incorporated Modulateurs des transporteurs de cassettes de liaison de l'atp
CN102477002B (zh) * 2010-11-26 2015-04-15 苏州凯达生物医药技术有限公司 3-氨基-2,2-双甲基丙酰胺的制备方法
JP5890436B2 (ja) 2011-02-25 2016-03-22 ユーハン・コーポレイションＹＵＨＡＮ Ｃｏｒｐｏｒａｔｉｏｎ ジアミノピリミジン誘導体及びその製造方法
GB201103397D0 (fr) 2011-02-28 2011-04-13 Shire Movetis N V
KR101256908B1 (ko) 2011-04-28 2013-04-23 (주)에이치비메디컬스 주름제거용 충전체
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
EP2744493A1 (fr) 2011-08-18 2014-06-25 Shire AG Combinaisons d'un agoniste de récepteur 5-ht4 et d'un inhibiteur de pde4 pour utilisation en thérapie
KR101657616B1 (ko) 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
EP3413891B1 (fr) * 2016-02-11 2024-01-03 Symed Labs Limited Procédés pour la préparation de succinate de prucalopride très pur
CN110963999B (zh) * 2019-11-27 2021-05-11 广东东阳光药业有限公司 2,3-二氢苯并呋喃酰胺衍生物及其用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186135A (en) * 1976-08-04 1980-01-29 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
FR2396757A2 (fr) * 1977-07-08 1979-02-02 Ile De France Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
EP0069481A1 (fr) * 1981-06-17 1983-01-12 Beecham Group Plc Azabicycloalkylbenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0068700A1 (fr) * 1981-06-29 1983-01-05 Beecham Group Plc Azabicycloalkylbenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CA1183847A (fr) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide; derives
AU563225B2 (en) * 1982-04-14 1987-07-02 Alizyme Therapeutics Limited I-aza bicyclic compounds
EP0108986A1 (fr) * 1982-11-02 1984-05-23 Hokuriku Pharmaceutical Co.,Ltd Flavones-8-carboxamides N-substituées
WO1984003281A1 (fr) * 1983-02-19 1984-08-30 Beecham Group Plc Derives anylides et benzamides d'azabicycloalkyle
JPS59186969A (ja) * 1983-04-08 1984-10-23 Yoshitomi Pharmaceut Ind Ltd ベンゾフラン−およびベンゾピランカルボキサミド誘導体
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
CA1297877C (fr) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides utilises comme agents antiemetiques ou antipsychotiques
US4808624A (en) * 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
GB8519707D0 (en) * 1985-08-06 1985-09-11 Fordonal Sa Chemical compounds
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
FR2593504B1 (fr) * 1986-01-30 1988-12-09 Ile De France Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US5130312A (en) * 1987-07-17 1992-07-14 Janssen Pharmaceutica N.V. Substituted N-(3-hydroxy-4-piperidinyl)benzamides
NZ225152A (en) 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US4906643A (en) * 1987-07-17 1990-03-06 Janssen Pharmaceutica N.V. Substituted N-(3-hydroxy-4-piperidinyl)benzamides as gastrointestinal agents
GB8718346D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa Substituted benzamides
ZA886585B (en) * 1987-09-08 1990-05-30 Lilly Co Eli Specific 5-ht,antagonists
US5041454A (en) * 1987-09-25 1991-08-20 Janssen Pharmaceutica N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US4975439A (en) * 1987-09-25 1990-12-04 Janssen Pharmaceutical N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
CA1317940C (fr) 1987-09-25 1993-05-18 Georges H. P. Van Daele N-(1-alkyl-3-hydroxy-4-piperidinyl) benzamides a substituant
US4863921A (en) * 1988-04-27 1989-09-05 Rorer Pharmaceutical Corporation Dibenzofurancarboxamides and their pharmaceutical compositions and methods
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives

Also Published As

Publication number Publication date
CS46091A3 (en) 1991-10-15
CY2235B1 (en) 2003-07-04
HU910706D0 (en) 1991-09-30
LTIP846A (en) 1995-02-27
LT3708B (en) 1996-02-26
EP0445862A3 (en) 1992-05-20
SI9110396A (en) 1997-12-31
DE69132119T2 (de) 2000-12-21
NO910863L (no) 1991-09-09
CZ286617B6 (cs) 2000-05-17
MY108831A (en) 1996-11-30
SI9110396B (sl) 2000-06-30
FI101622B (fi) 1998-07-31
UA25969A1 (uk) 1999-02-26
HUT60733A (en) 1992-10-28
ZW2391A1 (en) 1992-09-07
NZ237189A (en) 1992-11-25
SK282406B6 (sk) 2002-01-07
RU2070884C1 (ru) 1996-12-27
US5185335A (en) 1993-02-09
EP0445862B1 (fr) 2000-04-19
IL97018A (en) 1995-11-27
PL168384B1 (en) 1996-02-29
HRP930483B1 (en) 2001-04-30
CA2037575C (fr) 2003-09-16
PL168686B1 (pl) 1996-03-29
NO910863D0 (no) 1991-03-05
GR3033461T3 (en) 2000-09-29
YU39691A (sh) 1994-06-10
SK282407B6 (sk) 2002-01-07
PT96937A (pt) 1991-10-31
FI101622B1 (fi) 1998-07-31
BG60381B1 (bg) 1995-01-31
EP0445862A2 (fr) 1991-09-11
DE69132119D1 (de) 2000-05-25
PL289323A1 (en) 1992-03-09
GB9005014D0 (en) 1990-05-02
PL168356B1 (pl) 1996-02-29
LV10085A (lv) 1994-05-10
ES2147175T3 (es) 2000-09-01
JPH04211685A (ja) 1992-08-03
MA22076A1 (fr) 1991-10-01
AU636012B2 (en) 1993-04-08
CN1038936C (zh) 1998-07-01
YU48854B (sh) 2002-06-19
SG47482A1 (en) 1998-04-17
PL168811B1 (pl) 1996-04-30
CN1054598A (zh) 1991-09-18
NO177424B (no) 1995-06-06
PT96937B (pt) 1998-07-31
KR0177521B1 (ko) 1999-03-20
TNSN91010A1 (fr) 1992-10-25
AU7207991A (en) 1991-09-12
HU221627B1 (hu) 2002-12-28
FI911096A (fi) 1991-09-07
HK1010727A1 (en) 1999-06-25
IE910710A1 (en) 1991-09-11
NO177424C (no) 1995-09-13
JP2601566B2 (ja) 1997-04-16
HRP930483A2 (en) 1995-12-31
KR910016744A (ko) 1991-11-05
PL168693B1 (pl) 1996-03-29
IL97018A0 (en) 1992-03-29
ZA911611B (en) 1992-11-25
FI911096A0 (fi) 1991-03-05
CA2037575A1 (fr) 1991-09-07
ATE191912T1 (de) 2000-05-15
HU211350A9 (en) 1995-11-28
LV10085B (en) 1995-02-20
US5262418A (en) 1993-11-16
PL169238B1 (pl) 1996-06-28

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