DK0442724T3 - Modificeret hIL-6. - Google Patents

Modificeret hIL-6.

Info

Publication number
DK0442724T3
DK0442724T3 DK91301166T DK91301166T DK0442724T3 DK 0442724 T3 DK0442724 T3 DK 0442724T3 DK 91301166 T DK91301166 T DK 91301166T DK 91301166 T DK91301166 T DK 91301166T DK 0442724 T3 DK0442724 T3 DK 0442724T3
Authority
DK
Denmark
Prior art keywords
well
modified hil
modified
difficiencies
unglycosylated
Prior art date
Application number
DK91301166T
Other languages
English (en)
Inventor
Toshifumi Mikayama
Toshihiko Kadoya
Makoto Kakitani
Hideo Inoue
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Application granted granted Critical
Publication of DK0442724T3 publication Critical patent/DK0442724T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK91301166T 1990-02-13 1991-02-13 Modificeret hIL-6. DK0442724T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3227390 1990-02-13
JP22235390 1990-08-22
JP2250460A JPH04218000A (ja) 1990-02-13 1990-09-21 修飾ポリペプチド

Publications (1)

Publication Number Publication Date
DK0442724T3 true DK0442724T3 (da) 2000-04-10

Family

ID=27287645

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91301166T DK0442724T3 (da) 1990-02-13 1991-02-13 Modificeret hIL-6.

Country Status (9)

Country Link
US (1) US5264209A (da)
EP (1) EP0442724B1 (da)
JP (1) JPH04218000A (da)
AT (1) ATE185602T1 (da)
AU (1) AU634343B2 (da)
CA (1) CA2036197C (da)
DE (1) DE69131699T2 (da)
DK (1) DK0442724T3 (da)
ES (1) ES2136596T3 (da)

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MXPA05006994A (es) 2002-12-27 2005-10-18 Diobex Inc Composiciones y metodos para la prevencion y el control de hipoglucemia inducida por insulina.
US7655618B2 (en) 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US20060014248A1 (en) * 2003-01-06 2006-01-19 Xencor, Inc. TNF super family members with altered immunogenicity
US20050221443A1 (en) * 2003-01-06 2005-10-06 Xencor, Inc. Tumor necrosis factor super family agonists
US20050130892A1 (en) * 2003-03-07 2005-06-16 Xencor, Inc. BAFF variants and methods thereof
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US7381410B2 (en) * 2003-03-12 2008-06-03 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
EP1491554A1 (en) * 2003-06-23 2004-12-29 CONARIS research institute AG PEGylated soluble gp130-dimers useful as a medicament
IL159558A0 (en) * 2003-12-24 2004-06-01 Applied Research Systems Use of il-6 in liver injury
WO2005085283A1 (ja) * 2004-03-03 2005-09-15 Yamanouchi Pharmaceutical Co., Ltd. 修飾インターロイキン−１１及びそれを含有する医薬組成物
DE602005025459D1 (de) 2004-03-12 2011-02-03 Vasgene Therapeutics Inc Ephb4-bindende antikörper zur inhibierung von angiogenese und tumorwachstum
EP2275445A3 (en) 2004-03-12 2012-02-29 Vasgene Therapeutics, Inc. Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
US20050215710A1 (en) * 2004-03-23 2005-09-29 Gegg Colin V Jr Chemically modified protein compositions and methods
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CN101124243A (zh) 2004-12-23 2008-02-13 莫尔梅德股份有限公司 缀合产物
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CN101163716B (zh) * 2005-04-30 2011-09-07 成都生物制品研究所 白细胞介素-6聚乙二醇结合物及其制备方法和应用
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JP5735650B2 (ja) 2010-09-14 2015-06-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｐｅｇ化エリスロポエチンを精製するための方法
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TW202330584A (zh) * 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途

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Also Published As

Publication number Publication date
DE69131699T2 (de) 2000-02-24
EP0442724B1 (en) 1999-10-13
DE69131699D1 (de) 1999-11-18
CA2036197C (en) 2001-09-18
US5264209A (en) 1993-11-23
CA2036197A1 (en) 1991-08-14
ES2136596T3 (es) 1999-12-01
AU634343B2 (en) 1993-02-18
ATE185602T1 (de) 1999-10-15
AU7087891A (en) 1991-08-15
JPH04218000A (ja) 1992-08-07
EP0442724A2 (en) 1991-08-21
EP0442724A3 (en) 1992-02-26

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