DK0423322T3 - GRF-VIIA-analoger - Google Patents

GRF-VIIA-analoger

Info

Publication number: DK0423322T3
Authority: DK; Denmark
Prior art keywords: arg; ala; leu; phe; ser
Prior art date: 1989-04-25

Application number

DK90907830.5T

Other languages

English (en)

Inventor

Jean Edouard Frederic Rivier

Wylie Walker Vale Jr

Catherine Laure Rivier

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-25

Filing date

1990-04-24

Publication date

1996-06-24

1990-04-24 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1996-06-24 Application granted granted Critical

1996-06-24 Publication of DK0423322T3 publication Critical patent/DK0423322T3/da

Links

-1 Phe Chemical compound 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
XKCWNEVAXQCMGP-RXMQYKEDSA-N (2R)-2-amino-5-[carbamimidoyl(methyl)amino]pentanoic acid Chemical compound CN(CCC[C@@H](N)C(O)=O)C(N)=N XKCWNEVAXQCMGP-RXMQYKEDSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Chemical group OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical group OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 1
HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000007515 enzymatic degradation Effects 0.000 abstract 1
230000001817 pituitary effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Oscillators With Electromechanical Resonators (AREA)
Amplifiers (AREA)
Electrophonic Musical Instruments (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK90907830.5T 1989-04-25 1990-04-24 GRF-VIIA-analoger DK0423322T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/342,751 US5098995A (en)	1987-05-22	1989-04-25	GRF Analogs VIIA

Publications (1)

Publication Number	Publication Date
DK0423322T3 true DK0423322T3 (da)	1996-06-24

Family

ID=23343123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90907830.5T DK0423322T3 (da)	1989-04-25	1990-04-24	GRF-VIIA-analoger

Country Status (14)

Country	Link
US (1)	US5098995A (da)
EP (1)	EP0423322B1 (da)
JP (1)	JP2974254B2 (da)
KR (1)	KR0163033B1 (da)
AT (1)	ATE133687T1 (da)
AU (1)	AU628558B2 (da)
CA (1)	CA2030810C (da)
DE (1)	DE69025123T2 (da)
DK (1)	DK0423322T3 (da)
ES (1)	ES2085350T3 (da)
FI (1)	FI94356C (da)
IL (1)	IL94171A (da)
NO (1)	NO178031C (da)
WO (1)	WO1990012810A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5756458A (en) *	1989-06-16	1998-05-26	Pharmacia & Upjohn Company	Stabilized potent GRF analogs
JPH06507402A (ja) *	1991-03-20	1994-08-25	ワーナー−ランバート・コンパニー	治療活性を有するα−置換ポリペプチド
JPH06506941A (ja) *	1991-04-24	1994-08-04	ワーナー−ランバート・コンパニー	α−置換アミノ酸含有ＣＣＫ類似体
US5262519A (en) *	1991-05-15	1993-11-16	The Salk Institute For Biological Studies	GRF analogs XI
CA2158782C (en) *	1994-09-23	2010-01-12	Pierrette Gaudreau	Marker for growth hormone-releasing factor receptors
PT1499888E (pt) *	2002-04-29	2010-10-14	Euro Celtique Sa	Péptidos conformacionalmente constrangidos que se ligam ao receptor orl-1
US9079974B2 (en) *	2011-12-21	2015-07-14	The University Of Miami	GH-RH analogs with potent agonistic effects
WO2014100816A2 (en)	2012-12-21	2014-06-26	University Of Miami	Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
US9855312B2 (en)	2012-12-21	2018-01-02	University Of Miami	GHRH agonists for the treatment of ischemic disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4728726A (en) *	1982-10-04	1988-03-01	The Salk Institute For Biological Studies	GRF analogs IIIb
US4594329A (en) *	1984-05-14	1986-06-10	The Salk Institute For Biological Studies	CRF analogs
US4689318A (en) *	1985-08-29	1987-08-25	The Salk Institute For Biological Studies	GRF analogs
US5002931A (en) *	1987-05-22	1991-03-26	The Salk Institute For Biological Studies	GRF analogs VII

1989
- 1989-04-25 US US07/342,751 patent/US5098995A/en not_active Expired - Lifetime
1990
- 1990-04-23 IL IL9417190A patent/IL94171A/en not_active IP Right Cessation
- 1990-04-24 AT AT90907830T patent/ATE133687T1/de not_active IP Right Cessation
- 1990-04-24 CA CA002030810A patent/CA2030810C/en not_active Expired - Fee Related
- 1990-04-24 DK DK90907830.5T patent/DK0423322T3/da active
- 1990-04-24 KR KR1019900702671A patent/KR0163033B1/ko not_active IP Right Cessation
- 1990-04-24 EP EP90907830A patent/EP0423322B1/en not_active Expired - Lifetime
- 1990-04-24 ES ES90907830T patent/ES2085350T3/es not_active Expired - Lifetime
- 1990-04-24 WO PCT/US1990/002224 patent/WO1990012810A1/en active IP Right Grant
- 1990-04-24 AU AU55569/90A patent/AU628558B2/en not_active Ceased
- 1990-04-24 DE DE69025123T patent/DE69025123T2/de not_active Expired - Fee Related
- 1990-04-24 JP JP2507102A patent/JP2974254B2/ja not_active Expired - Fee Related
- 1990-12-18 FI FI906240A patent/FI94356C/fi not_active IP Right Cessation
- 1990-12-20 NO NO905505A patent/NO178031C/no unknown

Also Published As

Publication number	Publication date
ATE133687T1 (de)	1996-02-15
US5098995A (en)	1992-03-24
KR0163033B1 (ko)	1998-11-16
ES2085350T3 (es)	1996-06-01
NO905505L (no)	1991-02-20
DE69025123D1 (de)	1996-03-14
IL94171A0 (en)	1991-01-31
WO1990012810A1 (en)	1990-11-01
FI94356C (fi)	1995-08-25
JPH04500526A (ja)	1992-01-30
FI906240A0 (fi)	1990-12-18
NO178031B (no)	1995-10-02
DE69025123T2 (de)	1996-09-19
CA2030810A1 (en)	1990-10-26
NO178031C (no)	1996-01-10
IL94171A (en)	1994-11-11
EP0423322B1 (en)	1996-01-31
AU5556990A (en)	1990-11-16
FI94356B (fi)	1995-05-15
CA2030810C (en)	1999-12-14
JP2974254B2 (ja)	1999-11-10
KR920700225A (ko)	1992-02-19
EP0423322A1 (en)	1991-04-24
NO905505D0 (no)	1990-12-20
AU628558B2 (en)	1992-09-17

Publication	Publication Date	Title
ES8600217A1 (es)	1985-10-01	Un procedimiento para producir peptidos que influyen en la funcion de la glandula pituitaria
EG17394A (en)	1992-12-30	G r f analogs iv
ES2001274A6 (es)	1988-05-01	Un metodo para preparar peptidos que tienen influencia sobre la funcion de la glandula pituitaria en seres humanos y otros animales
ATE103609T1 (de)	1994-04-15	Zyklische grf-analoge.
DE69025123D1 (de)	1996-03-14	Grf-viia-analoge