DE69925032D1 - Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening - Google Patents
Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screeningInfo
- Publication number
- DE69925032D1 DE69925032D1 DE69925032T DE69925032T DE69925032D1 DE 69925032 D1 DE69925032 D1 DE 69925032D1 DE 69925032 T DE69925032 T DE 69925032T DE 69925032 T DE69925032 T DE 69925032T DE 69925032 D1 DE69925032 D1 DE 69925032D1
- Authority
- DE
- Germany
- Prior art keywords
- screening
- fluorescent colors
- solid phase
- liquid phase
- phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007790 solid phase Substances 0.000 title abstract 2
- 239000003086 colorant Substances 0.000 title 1
- 239000007791 liquid phase Substances 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 238000013537 high throughput screening Methods 0.000 abstract 1
- 239000012456 homogeneous solution Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Luminescent Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US217795 | 1998-12-21 | ||
US09/217,795 US6207831B1 (en) | 1998-12-21 | 1998-12-21 | Fluorescent dyes (AIDA) for solid phase and solution phase screening |
PCT/EP1999/010126 WO2000037448A1 (en) | 1998-12-21 | 1999-12-20 | Fluorescent dyes for solid phase and solution phase screening |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69925032D1 true DE69925032D1 (de) | 2005-06-02 |
DE69925032T2 DE69925032T2 (de) | 2006-03-09 |
Family
ID=22812559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69925032T Expired - Fee Related DE69925032T2 (de) | 1998-12-21 | 1999-12-20 | Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening |
Country Status (8)
Country | Link |
---|---|
US (3) | US6207831B1 (de) |
EP (1) | EP1140856B1 (de) |
JP (1) | JP2002533329A (de) |
AT (1) | ATE294164T1 (de) |
AU (1) | AU3040300A (de) |
CA (1) | CA2356344A1 (de) |
DE (1) | DE69925032T2 (de) |
WO (1) | WO2000037448A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207831B1 (en) * | 1998-12-21 | 2001-03-27 | Novartis Ag | Fluorescent dyes (AIDA) for solid phase and solution phase screening |
EP3034627B1 (de) * | 2000-10-06 | 2019-01-30 | The Trustees of Columbia University in the City of New York | Massives paralleles verfahren zum entschlüsseln von dna und rna |
US9708358B2 (en) | 2000-10-06 | 2017-07-18 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
GB0026560D0 (en) * | 2000-10-30 | 2000-12-13 | Novartis Ag | Organic compounds |
US6972326B2 (en) * | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
GB0208989D0 (en) * | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
GB0228429D0 (en) * | 2002-12-05 | 2003-01-08 | Novartis Ag | Organic compounds |
DE102004016247A1 (de) * | 2004-04-02 | 2005-10-20 | Chromeon Gmbh | Feste Trägersysteme zum homogenen Nachweis von Wechselwirkungen von Biomolekülen ohne Waschschritte |
US7982029B2 (en) | 2005-10-31 | 2011-07-19 | The Trustees Of Columbia University In The City Of New York | Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods |
WO2007053719A2 (en) | 2005-10-31 | 2007-05-10 | The Trustees Of Columbia University In The City Of New York | Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods |
DE112007002932B4 (de) | 2006-12-01 | 2015-08-06 | The Trustees Of Columbia University In The City Of New York | Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren |
WO2009000775A1 (en) * | 2007-06-22 | 2008-12-31 | Novartis Ag | Post-screening labeling of on-bead compounds |
EP3431615A3 (de) | 2007-10-19 | 2019-02-20 | The Trustees of Columbia University in the City of New York | Dna-sequenzierung mit nichtfluoreszierenden, reversiblen nukleotidterminatoren und spaltbaren, etikettmodifizierten nukleotidterminatoren |
EP2207900B1 (de) | 2007-10-19 | 2015-04-29 | The Trustees of Columbia University in the City of New York | Konstruktion und synthese spaltbarer fluoreszenznukleotide als reversible terminatoren für die dna-sequenzierung mittels synthese |
US20110039289A1 (en) * | 2008-03-14 | 2011-02-17 | Pierre Graves | Fluorogenic peptides and their method of production |
CN102439444B (zh) | 2009-01-29 | 2014-10-22 | 联邦科学技术研究组织 | 测量g蛋白偶联受体激活 |
DE102009013147A1 (de) * | 2009-03-05 | 2010-09-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Spektroskopie heterogener Proben |
CA2812208C (en) * | 2010-09-24 | 2019-10-22 | The Governing Council Of The University Of Toronto | Synthesis of fluorescent noble metal nanoparticles |
WO2012162429A2 (en) | 2011-05-23 | 2012-11-29 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using raman and infrared spectroscopy detection |
KR101320097B1 (ko) * | 2011-06-23 | 2013-10-18 | 한국생명공학연구원 | 고유 형광 공명 에너지 전이용 탐침을 이용한 단백질 검출 또는 이미지화 현미경 장치 및 이를 이용한 단백질 검출 또는 이미징방법 |
US20140242606A1 (en) * | 2011-06-23 | 2014-08-28 | Korea Research Institute Of Bioscience And Biotechnology | PROBE FOR iFRET AND USE THEREOF |
WO2014144883A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
DE102013012685A1 (de) * | 2013-07-31 | 2015-02-05 | Johann-Wolfgang-Goethe Universität Frankfurt am Main | Arylierte Pyrazolderivate und deren Verwendung als Fluoreszenzfarbstoffe |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US20210255104A1 (en) * | 2020-02-18 | 2021-08-19 | Reflectronics, Inc. | Light extinction of fluorescence for composition measurements |
CN113702342B (zh) * | 2021-04-21 | 2022-12-06 | 苏州科技大学 | 一种利用荧光转换检测溶液中汞离子的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989003385A1 (en) | 1987-10-13 | 1989-04-20 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused pyrazole compounds, process for their preparation, and their medicinal use |
EP0641564A4 (de) | 1992-05-21 | 1995-05-03 | Yoshitomi Pharmaceutical | Optisch aktive kondensierte pyrazolverbindungen zur verwendung in der behandlung von thrombozytopenie und erythropenie. |
WO1998041866A1 (en) | 1997-03-14 | 1998-09-24 | Merck & Co., Inc. | A high throughput assay using fusion proteins |
US6207831B1 (en) * | 1998-12-21 | 2001-03-27 | Novartis Ag | Fluorescent dyes (AIDA) for solid phase and solution phase screening |
US7135288B2 (en) * | 2002-09-27 | 2006-11-14 | Ut-Battelle, Llc | Combinatorial synthesis of ceramic materials |
-
1998
- 1998-12-21 US US09/217,795 patent/US6207831B1/en not_active Expired - Fee Related
-
1999
- 1999-12-20 EP EP99964612A patent/EP1140856B1/de not_active Expired - Lifetime
- 1999-12-20 WO PCT/EP1999/010126 patent/WO2000037448A1/en active IP Right Grant
- 1999-12-20 AT AT99964612T patent/ATE294164T1/de not_active IP Right Cessation
- 1999-12-20 JP JP2000589520A patent/JP2002533329A/ja active Pending
- 1999-12-20 DE DE69925032T patent/DE69925032T2/de not_active Expired - Fee Related
- 1999-12-20 AU AU30403/00A patent/AU3040300A/en not_active Abandoned
- 1999-12-20 CA CA002356344A patent/CA2356344A1/en not_active Abandoned
-
2001
- 2001-01-05 US US09/754,958 patent/US20010005752A1/en not_active Abandoned
-
2005
- 2005-05-27 US US11/139,753 patent/US20050227299A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1140856A1 (de) | 2001-10-10 |
CA2356344A1 (en) | 2000-06-29 |
DE69925032T2 (de) | 2006-03-09 |
ATE294164T1 (de) | 2005-05-15 |
US6207831B1 (en) | 2001-03-27 |
US20050227299A1 (en) | 2005-10-13 |
EP1140856B1 (de) | 2005-04-27 |
WO2000037448A1 (en) | 2000-06-29 |
AU3040300A (en) | 2000-07-12 |
US20010005752A1 (en) | 2001-06-28 |
JP2002533329A (ja) | 2002-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |