DE69925032D1 - Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening - Google Patents

Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening

Info

Publication number
DE69925032D1
DE69925032D1 DE69925032T DE69925032T DE69925032D1 DE 69925032 D1 DE69925032 D1 DE 69925032D1 DE 69925032 T DE69925032 T DE 69925032T DE 69925032 T DE69925032 T DE 69925032T DE 69925032 D1 DE69925032 D1 DE 69925032D1
Authority
DE
Germany
Prior art keywords
screening
fluorescent colors
solid phase
liquid phase
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69925032T
Other languages
English (en)
Other versions
DE69925032T2 (de
Inventor
Manfred Auer
Hubert Gstach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE69925032D1 publication Critical patent/DE69925032D1/de
Publication of DE69925032T2 publication Critical patent/DE69925032T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
DE69925032T 1998-12-21 1999-12-20 Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening Expired - Fee Related DE69925032T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US217795 1998-12-21
US09/217,795 US6207831B1 (en) 1998-12-21 1998-12-21 Fluorescent dyes (AIDA) for solid phase and solution phase screening
PCT/EP1999/010126 WO2000037448A1 (en) 1998-12-21 1999-12-20 Fluorescent dyes for solid phase and solution phase screening

Publications (2)

Publication Number Publication Date
DE69925032D1 true DE69925032D1 (de) 2005-06-02
DE69925032T2 DE69925032T2 (de) 2006-03-09

Family

ID=22812559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69925032T Expired - Fee Related DE69925032T2 (de) 1998-12-21 1999-12-20 Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening

Country Status (8)

Country Link
US (3) US6207831B1 (de)
EP (1) EP1140856B1 (de)
JP (1) JP2002533329A (de)
AT (1) ATE294164T1 (de)
AU (1) AU3040300A (de)
CA (1) CA2356344A1 (de)
DE (1) DE69925032T2 (de)
WO (1) WO2000037448A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207831B1 (en) * 1998-12-21 2001-03-27 Novartis Ag Fluorescent dyes (AIDA) for solid phase and solution phase screening
EP3034627B1 (de) * 2000-10-06 2019-01-30 The Trustees of Columbia University in the City of New York Massives paralleles verfahren zum entschlüsseln von dna und rna
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
GB0026560D0 (en) * 2000-10-30 2000-12-13 Novartis Ag Organic compounds
US6972326B2 (en) * 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
GB0228429D0 (en) * 2002-12-05 2003-01-08 Novartis Ag Organic compounds
DE102004016247A1 (de) * 2004-04-02 2005-10-20 Chromeon Gmbh Feste Trägersysteme zum homogenen Nachweis von Wechselwirkungen von Biomolekülen ohne Waschschritte
US7982029B2 (en) 2005-10-31 2011-07-19 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
WO2007053719A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
DE112007002932B4 (de) 2006-12-01 2015-08-06 The Trustees Of Columbia University In The City Of New York Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren
WO2009000775A1 (en) * 2007-06-22 2008-12-31 Novartis Ag Post-screening labeling of on-bead compounds
EP3431615A3 (de) 2007-10-19 2019-02-20 The Trustees of Columbia University in the City of New York Dna-sequenzierung mit nichtfluoreszierenden, reversiblen nukleotidterminatoren und spaltbaren, etikettmodifizierten nukleotidterminatoren
EP2207900B1 (de) 2007-10-19 2015-04-29 The Trustees of Columbia University in the City of New York Konstruktion und synthese spaltbarer fluoreszenznukleotide als reversible terminatoren für die dna-sequenzierung mittels synthese
US20110039289A1 (en) * 2008-03-14 2011-02-17 Pierre Graves Fluorogenic peptides and their method of production
CN102439444B (zh) 2009-01-29 2014-10-22 联邦科学技术研究组织 测量g蛋白偶联受体激活
DE102009013147A1 (de) * 2009-03-05 2010-09-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Spektroskopie heterogener Proben
CA2812208C (en) * 2010-09-24 2019-10-22 The Governing Council Of The University Of Toronto Synthesis of fluorescent noble metal nanoparticles
WO2012162429A2 (en) 2011-05-23 2012-11-29 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using raman and infrared spectroscopy detection
KR101320097B1 (ko) * 2011-06-23 2013-10-18 한국생명공학연구원 고유 형광 공명 에너지 전이용 탐침을 이용한 단백질 검출 또는 이미지화 현미경 장치 및 이를 이용한 단백질 검출 또는 이미징방법
US20140242606A1 (en) * 2011-06-23 2014-08-28 Korea Research Institute Of Bioscience And Biotechnology PROBE FOR iFRET AND USE THEREOF
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
DE102013012685A1 (de) * 2013-07-31 2015-02-05 Johann-Wolfgang-Goethe Universität Frankfurt am Main Arylierte Pyrazolderivate und deren Verwendung als Fluoreszenzfarbstoffe
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US20210255104A1 (en) * 2020-02-18 2021-08-19 Reflectronics, Inc. Light extinction of fluorescence for composition measurements
CN113702342B (zh) * 2021-04-21 2022-12-06 苏州科技大学 一种利用荧光转换检测溶液中汞离子的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003385A1 (en) 1987-10-13 1989-04-20 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
EP0641564A4 (de) 1992-05-21 1995-05-03 Yoshitomi Pharmaceutical Optisch aktive kondensierte pyrazolverbindungen zur verwendung in der behandlung von thrombozytopenie und erythropenie.
WO1998041866A1 (en) 1997-03-14 1998-09-24 Merck & Co., Inc. A high throughput assay using fusion proteins
US6207831B1 (en) * 1998-12-21 2001-03-27 Novartis Ag Fluorescent dyes (AIDA) for solid phase and solution phase screening
US7135288B2 (en) * 2002-09-27 2006-11-14 Ut-Battelle, Llc Combinatorial synthesis of ceramic materials

Also Published As

Publication number Publication date
EP1140856A1 (de) 2001-10-10
CA2356344A1 (en) 2000-06-29
DE69925032T2 (de) 2006-03-09
ATE294164T1 (de) 2005-05-15
US6207831B1 (en) 2001-03-27
US20050227299A1 (en) 2005-10-13
EP1140856B1 (de) 2005-04-27
WO2000037448A1 (en) 2000-06-29
AU3040300A (en) 2000-07-12
US20010005752A1 (en) 2001-06-28
JP2002533329A (ja) 2002-10-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee