DE69905621T2 - 3-(thio-substituierte amido)-lactame, verwendbar als inhibitoren der matrix-metalloproteinase - Google Patents
3-(thio-substituierte amido)-lactame, verwendbar als inhibitoren der matrix-metalloproteinaseInfo
- Publication number
- DE69905621T2 DE69905621T2 DE69905621T DE69905621T DE69905621T2 DE 69905621 T2 DE69905621 T2 DE 69905621T2 DE 69905621 T DE69905621 T DE 69905621T DE 69905621 T DE69905621 T DE 69905621T DE 69905621 T2 DE69905621 T2 DE 69905621T2
- Authority
- DE
- Germany
- Prior art keywords
- lactame
- thio
- inhibitors
- matrix metalloproteinase
- substituted amido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22394198A | 1998-12-31 | 1998-12-31 | |
PCT/US1999/028236 WO2000040578A1 (en) | 1998-12-31 | 1999-11-30 | 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69905621D1 DE69905621D1 (de) | 2003-04-03 |
DE69905621T2 true DE69905621T2 (de) | 2003-11-27 |
Family
ID=22838632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69905621T Expired - Fee Related DE69905621T2 (de) | 1998-12-31 | 1999-11-30 | 3-(thio-substituierte amido)-lactame, verwendbar als inhibitoren der matrix-metalloproteinase |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1150976B1 (de) |
JP (1) | JP2002534425A (de) |
AR (1) | AR033642A1 (de) |
AT (1) | ATE233259T1 (de) |
AU (1) | AU1926700A (de) |
CA (1) | CA2358939A1 (de) |
DE (1) | DE69905621T2 (de) |
DK (1) | DK1150976T3 (de) |
ES (1) | ES2190672T3 (de) |
PT (1) | PT1150976E (de) |
WO (1) | WO2000040578A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
GB0114005D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527795A (en) * | 1990-10-18 | 1996-06-18 | Merrell Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
DE69317764T2 (de) * | 1992-02-14 | 1998-07-30 | Merrell Pharma Inc | Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung |
US5821231A (en) * | 1993-12-06 | 1998-10-13 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using same |
KR100357354B1 (ko) * | 1994-02-14 | 2003-01-30 | 메렐 파마슈티칼스 인크. | 엔케팔리나제및안지오텐신전환효소(ace)의억제제로서유용한신규의머캅토아세틸아미드디설파이드유도체 |
EP0750631B1 (de) * | 1994-02-14 | 2000-04-05 | Merrell Pharmaceuticals Inc. | Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren |
DK0784629T3 (da) * | 1994-10-05 | 1999-10-25 | Darwin Discovery Ltd | Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser |
US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
GB9702377D0 (en) * | 1996-02-23 | 1997-03-26 | Zeneca Ltd | Peptide derivatives |
GB9624562D0 (en) * | 1996-11-27 | 1997-01-15 | Zeneca Ltd | Peptide derivatives |
GB9625865D0 (en) * | 1996-12-12 | 1997-01-29 | Zeneca Ltd | Peptides |
-
1999
- 1999-11-30 AU AU19267/00A patent/AU1926700A/en not_active Abandoned
- 1999-11-30 WO PCT/US1999/028236 patent/WO2000040578A1/en active IP Right Grant
- 1999-11-30 PT PT99962921T patent/PT1150976E/pt unknown
- 1999-11-30 EP EP99962921A patent/EP1150976B1/de not_active Expired - Lifetime
- 1999-11-30 DK DK99962921T patent/DK1150976T3/da active
- 1999-11-30 AT AT99962921T patent/ATE233259T1/de not_active IP Right Cessation
- 1999-11-30 ES ES99962921T patent/ES2190672T3/es not_active Expired - Lifetime
- 1999-11-30 DE DE69905621T patent/DE69905621T2/de not_active Expired - Fee Related
- 1999-11-30 CA CA002358939A patent/CA2358939A1/en not_active Abandoned
- 1999-11-30 JP JP2000592286A patent/JP2002534425A/ja active Pending
- 1999-12-30 AR ARP990106859A patent/AR033642A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002534425A (ja) | 2002-10-15 |
DK1150976T3 (da) | 2003-06-02 |
ES2190672T3 (es) | 2003-08-01 |
EP1150976B1 (de) | 2003-02-26 |
AR033642A1 (es) | 2004-01-07 |
AU1926700A (en) | 2000-07-24 |
CA2358939A1 (en) | 2000-07-13 |
DE69905621D1 (de) | 2003-04-03 |
PT1150976E (pt) | 2003-07-31 |
WO2000040578A1 (en) | 2000-07-13 |
EP1150976A1 (de) | 2001-11-07 |
ATE233259T1 (de) | 2003-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |