DE69903930D1 - N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen - Google Patents

N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen

Info

Publication number
DE69903930D1
DE69903930D1 DE69903930T DE69903930T DE69903930D1 DE 69903930 D1 DE69903930 D1 DE 69903930D1 DE 69903930 T DE69903930 T DE 69903930T DE 69903930 T DE69903930 T DE 69903930T DE 69903930 D1 DE69903930 D1 DE 69903930D1
Authority
DE
Germany
Prior art keywords
hydrogen
aryloxyethyl
alkylamine
indolyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69903930T
Other languages
English (en)
Other versions
DE69903930T2 (de
Inventor
Eric Mewshaw
Albert Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE69903930D1 publication Critical patent/DE69903930D1/de
Publication of DE69903930T2 publication Critical patent/DE69903930T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of El Displays (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69903930T 1998-04-08 1999-04-07 N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen Expired - Fee Related DE69903930T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5715998A 1998-04-08 1998-04-08
PCT/US1999/007658 WO1999051591A2 (en) 1998-04-08 1999-04-07 N-aryloxyethyl-indoly-alkylamines for the treatment of depression

Publications (2)

Publication Number Publication Date
DE69903930D1 true DE69903930D1 (de) 2002-12-19
DE69903930T2 DE69903930T2 (de) 2003-07-17

Family

ID=22008868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903930T Expired - Fee Related DE69903930T2 (de) 1998-04-08 1999-04-07 N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen

Country Status (11)

Country Link
EP (1) EP1068199B1 (de)
JP (1) JP2002510681A (de)
CN (1) CN1135228C (de)
AT (1) ATE227718T1 (de)
AU (1) AU3479299A (de)
CA (1) CA2327513A1 (de)
DE (1) DE69903930T2 (de)
DK (1) DK1068199T3 (de)
ES (1) ES2188155T3 (de)
PT (1) PT1068199E (de)
WO (1) WO1999051591A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108993496B (zh) * 2018-10-30 2021-01-15 山东第一医科大学(山东省医学科学院) 一种治疗运动障碍用药物罗匹尼罗中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
DK37790A (da) * 1990-02-13 1991-08-14 Novo Nordisk As Indolderivater, deres fremstilling og anvendelse
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
JPH05255302A (ja) * 1992-03-09 1993-10-05 Yamanouchi Pharmaceut Co Ltd 新規なクロマニルオキシアルキルアミン誘導体
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
JPH0940648A (ja) * 1995-08-02 1997-02-10 Yamanouchi Pharmaceut Co Ltd 新規な８−（２−アミノアルコキシ）キノリン誘導体
DE19615232A1 (de) * 1996-04-18 1997-10-23 Merck Patent Gmbh Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
PT923551E (pt) * 1996-08-27 2002-09-30 American Home Prod Derivados de 4-aminoetoxi indolona
EP0923548B1 (de) * 1996-08-27 2003-03-12 Wyeth 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives

Also Published As

Publication number Publication date
JP2002510681A (ja) 2002-04-09
AU3479299A (en) 1999-10-25
CA2327513A1 (en) 1999-10-14
CN1304407A (zh) 2001-07-18
WO1999051591A3 (en) 1999-12-09
EP1068199A2 (de) 2001-01-17
DE69903930T2 (de) 2003-07-17
DK1068199T3 (da) 2003-03-03
PT1068199E (pt) 2003-02-28
EP1068199B1 (de) 2002-11-13
WO1999051591A2 (en) 1999-10-14
ATE227718T1 (de) 2002-11-15
ES2188155T3 (es) 2003-06-16
CN1135228C (zh) 2004-01-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee