DE69840426D1 - Penetrationsfördernde und irritationsvermindernde Systeme mit Testosteron - Google Patents
Penetrationsfördernde und irritationsvermindernde Systeme mit TestosteronInfo
- Publication number
- DE69840426D1 DE69840426D1 DE69840426T DE69840426T DE69840426D1 DE 69840426 D1 DE69840426 D1 DE 69840426D1 DE 69840426 T DE69840426 T DE 69840426T DE 69840426 T DE69840426 T DE 69840426T DE 69840426 D1 DE69840426 D1 DE 69840426D1
- Authority
- DE
- Germany
- Prior art keywords
- penetration
- testosterone
- irritation
- promoting
- reducing systems
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title abstract 4
- 229960003604 testosterone Drugs 0.000 title abstract 2
- 238000012377 drug delivery Methods 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- 206010040880 Skin irritation Diseases 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 230000036556 skin irritation Effects 0.000 abstract 1
- 231100000475 skin irritation Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6498097P | 1997-11-10 | 1997-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69840426D1 true DE69840426D1 (de) | 2009-02-12 |
Family
ID=22059554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69840426T Expired - Lifetime DE69840426D1 (de) | 1997-11-10 | 1998-11-09 | Penetrationsfördernde und irritationsvermindernde Systeme mit Testosteron |
Country Status (17)
Country | Link |
---|---|
US (3) | US6319913B1 (de) |
EP (2) | EP1030668A4 (de) |
JP (2) | JP4139860B2 (de) |
KR (1) | KR100648536B1 (de) |
CN (1) | CN1172674C (de) |
AT (1) | ATE418988T1 (de) |
AU (1) | AU747041B2 (de) |
BR (1) | BR9814014B1 (de) |
CA (1) | CA2309688C (de) |
DE (1) | DE69840426D1 (de) |
DK (1) | DK1510213T3 (de) |
ES (1) | ES2318233T3 (de) |
IL (1) | IL136042A (de) |
NO (1) | NO20002422L (de) |
NZ (1) | NZ504423A (de) |
PT (1) | PT1510213E (de) |
WO (1) | WO1999024041A1 (de) |
Families Citing this family (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL136042A (en) * | 1997-11-10 | 2005-12-18 | Cellegy Pharma Inc | Alcohol-containing composition for topical application |
CN101305994A (zh) * | 2000-04-26 | 2008-11-19 | 沃特森药物公司 | 最小化与奥昔布宁疗法有关的副作用 |
US7179483B2 (en) | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US7029694B2 (en) * | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US7897559B2 (en) * | 2000-06-29 | 2011-03-01 | Parks L Dean | Dermatological composition and kit containing avermectin compound for treating dermatological conditions |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
DE60143360D1 (de) * | 2000-08-03 | 2010-12-09 | Antares Pharma Ipl Ag | Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert |
US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
US8980290B2 (en) * | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
PL360992A1 (en) * | 2000-08-30 | 2004-09-20 | Unimed Pharmaceuticals,Inc. | Method of increasing testosterone and related steroid concentrations in women |
US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
PL205279B1 (pl) * | 2000-08-30 | 2010-03-31 | Besins International Lab | Zastosowanie żelu hydroalkoholowego zawierającego testosteron i zestaw do leczenia zaburzenia erekcji |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
JP5039252B2 (ja) * | 2000-08-31 | 2012-10-03 | ユニメッド ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 性機能低下を治療するための医薬組成物及び方法 |
EP1347764B1 (de) * | 2000-12-22 | 2007-03-14 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Gelzusammensetzung auf alkoholischer basis zur behandlung von hypogonadismus durch transskrotale applikation |
TWI331522B (en) * | 2001-06-22 | 2010-10-11 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
WO2003015789A2 (en) * | 2001-08-15 | 2003-02-27 | Leo Pharma A/S | A pharmaceutical composition for dermal application |
US20030175329A1 (en) * | 2001-10-04 | 2003-09-18 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
MXPA04006017A (es) | 2001-12-20 | 2005-06-08 | Femmepharma Inc | Suministro de farmacos por via vaginal. |
WO2004091631A1 (en) * | 2002-03-15 | 2004-10-28 | Unimed Pharmaceuticals, Inc. | Androgen pharmaceutical composition and method for treating depression |
AR036970A1 (es) * | 2002-03-15 | 2004-10-20 | Unimed Pharmaceuticals Inc | Composicion farmaceutica androgenica y metodo para el tratamiento de la depresion |
MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
US6959640B2 (en) * | 2002-06-06 | 2005-11-01 | Omega Patents, L.L.C. | Device for magnetically treating materials and associated methods |
EA009024B1 (ru) | 2002-06-25 | 2007-10-26 | АКРУКС ДиДиЭс ПиТиУай ЭлТиДи | Фармацевтическая композиция для чрескожной доставки активного агента (варианты) |
US7099713B2 (en) | 2002-06-28 | 2006-08-29 | Battelle Memorial Institute | Skin conduction and transport systems |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
ES2532906T5 (es) | 2002-10-25 | 2022-03-23 | Foamix Pharmaceuticals Ltd | Espuma cosmética y farmacéutica |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
EP1578421A4 (de) | 2003-01-02 | 2009-04-22 | Femmepharma Holding Co Inc | Pharmazeutische präparate für diebehandlung von erkrankungen und pathologischen zuständen der brust |
US9173836B2 (en) | 2003-01-02 | 2015-11-03 | FemmeParma Holding Company, Inc. | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
FR2851470B1 (fr) * | 2003-02-20 | 2007-11-16 | Besins Int Belgique | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
WO2004075822A2 (fr) * | 2003-02-20 | 2004-09-10 | Besins International Belgique | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US8883769B2 (en) * | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
US20050042182A1 (en) * | 2003-08-13 | 2005-02-24 | Moshe Arkin | Topical compositions of urea |
US20050036953A1 (en) * | 2003-08-13 | 2005-02-17 | Moshe Arkin | Topical compositions of ammonium lactate |
US20050037040A1 (en) * | 2003-08-13 | 2005-02-17 | Moshe Arkin | Topical compositions of urea and ammonium lactate |
FR2856926B1 (fr) * | 2003-07-02 | 2005-09-30 | Centre Nat Rech Scient | Utilisation des n-alkanols comme activateurs du canal cftr |
US20050025833A1 (en) * | 2003-07-16 | 2005-02-03 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
US20050020552A1 (en) * | 2003-07-16 | 2005-01-27 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
US20050042268A1 (en) * | 2003-07-16 | 2005-02-24 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
MXPA06003316A (es) | 2003-10-10 | 2006-06-08 | Antares Pharma Ipl Ag | Formulacion farmaceutica transdermica para minimizar los residuos en la piel. |
US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
US20050244502A1 (en) * | 2004-04-28 | 2005-11-03 | Mathias Neil R | Composition for enhancing absorption of a drug and method |
US7425340B2 (en) | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
EP1634583A1 (de) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterongele enthaltend Propylenglykol als Resorptionsverstärker |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
US20070042026A1 (en) * | 2005-03-17 | 2007-02-22 | Wille John J | Prophylactic and therapeutic treatment of topical and transdermal drug-induced skin reactions |
US8372040B2 (en) | 2005-05-24 | 2013-02-12 | Chrono Therapeutics, Inc. | Portable drug delivery device including a detachable and replaceable administration or dosing element |
US8067399B2 (en) | 2005-05-27 | 2011-11-29 | Antares Pharma Ipl Ag | Method and apparatus for transdermal or transmucosal application of testosterone |
CN102091079B (zh) | 2005-06-03 | 2014-03-12 | 艾克若克斯Dds有限公司 | 用于透皮给药的方法和组合物 |
GB0518558D0 (en) * | 2005-09-12 | 2005-10-19 | Givaudan Sa | Improvements in or related to organic compounds |
ZA200803087B (en) | 2005-10-12 | 2009-11-25 | Unimed Pharmaceuticals Llc | Improved testosterone gel and method of use |
CN101426475A (zh) | 2006-04-21 | 2009-05-06 | 安塔雷斯制药Ipl股份公司 | 使用用于经皮或经粘膜应用的制剂治疗热潮红的方法 |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
EP2104489A2 (de) * | 2006-12-26 | 2009-09-30 | FemmePharma Holding Company, Inc. | Topische verabreichung von danazol |
KR101301116B1 (ko) | 2007-01-11 | 2013-09-03 | 애크럭스 디디에스 피티와이 리미티드 | 분산 기구 |
WO2008089242A1 (en) * | 2007-01-16 | 2008-07-24 | Dermworx, Incorporated | Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic |
US9283177B2 (en) * | 2007-01-16 | 2016-03-15 | Juventio, Llc | Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
EP2242476A2 (de) | 2008-01-14 | 2010-10-27 | Foamix Ltd. | Aufschäumbare pharmazeutische poloxamer-zusammensetzungen mit wirkstoffen und/oder therapeutischen zellen und verwendungen |
MX2010007665A (es) * | 2008-05-21 | 2010-08-18 | Teikoku Pharma Usa Inc | Tratamiento de dismenorrea via administracion transdermal de farmacos anti-inflamatorios no esteroideos. |
CA2730787A1 (en) * | 2008-07-16 | 2010-01-21 | David M. Cohen | Topical drug delivery system |
RU2011111206A (ru) * | 2008-10-31 | 2012-12-10 | Моберг Дерма Аб | Композиции для местного применения, содержащие комбинацию по меньшей мере двух агентов, усиливающих проникновение |
PT2373305T (pt) * | 2008-12-11 | 2017-06-14 | Besins Healthcare Lu Sarl | Resumo |
CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2771308C (en) | 2009-08-21 | 2020-01-21 | Novan, Inc. | Topical gels comprising nitric oxide releasing polysiloxane macromolecules |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US8871184B2 (en) | 2009-10-02 | 2014-10-28 | Foamix Ltd. | Topical tetracycline compositions |
US10080760B2 (en) | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
US8174881B2 (en) | 2009-11-24 | 2012-05-08 | Micron Technology, Inc. | Techniques for reducing disturbance in a semiconductor device |
CN102309669B (zh) * | 2010-07-08 | 2013-07-03 | 高健生 | 一种治疗***反应性结膜炎的中药制剂 |
US9642862B2 (en) | 2010-11-18 | 2017-05-09 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
KR102088038B1 (ko) * | 2011-05-15 | 2020-03-13 | 에이세러스 바이오파마 인크. | 비내용 테스토스테론 겔의 조절된 방출, 경비성 투여를 위한 방법 및 미리-충전된 다회 용량 도포기 시스템 |
JP6277124B2 (ja) | 2011-07-05 | 2018-02-07 | ノヴァン,インコーポレイテッド | 局所用組成物 |
WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
CN102335390B (zh) * | 2011-09-30 | 2013-01-02 | 王巍 | 一种治疗面部湿疹的洗剂 |
CN104302175B (zh) | 2012-03-14 | 2017-04-12 | 诺万公司 | 释放一氧化氮的药物组合物 |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
BR112016002387B1 (pt) | 2013-08-08 | 2019-05-21 | Novan, Inc. | Composições farmacêuticas tópicas, e método para seu armazenamento |
USD750788S1 (en) | 2013-11-26 | 2016-03-01 | Acrux Dds Pty Ltd | Topical spreading applicator |
USD749225S1 (en) | 2013-11-26 | 2016-02-09 | Acrux Dds Pty Ltd | Topical spreading applicator |
US8785426B1 (en) | 2013-12-13 | 2014-07-22 | Upsher-Smith Laboratories, Inc. | Testosterone gel compositions and related methods |
WO2016007834A1 (en) | 2014-07-11 | 2016-01-14 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
CN105813617B (zh) | 2014-08-08 | 2021-05-28 | 诺万公司 | 局部用组合物和使用所述组合物的方法 |
AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
US20170014417A1 (en) | 2015-07-14 | 2017-01-19 | Lipp Life Sciences Llc | Pharmaceutical administration system for the transdermal application of vardenafil |
WO2017057743A1 (ja) * | 2015-09-30 | 2017-04-06 | 富士フイルム株式会社 | 経皮吸収用組成物 |
US10912743B2 (en) | 2016-03-02 | 2021-02-09 | Novan, Inc. | Compositions for treating inflammation and methods of treating the same |
EP3442502A4 (de) | 2016-04-13 | 2019-11-06 | Novan, Inc. | Zusammensetzungen, systeme, kits und verfahren zur behandlung von infektionen |
CA2978573A1 (en) | 2016-09-08 | 2018-03-08 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
JP2020503950A (ja) | 2017-01-06 | 2020-02-06 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 経皮薬剤送達の装置及び方法 |
US10821075B1 (en) | 2017-07-12 | 2020-11-03 | James Blanchard | Compositions for topical application of a medicaments onto a mammalian body surface |
US12036257B2 (en) | 2017-10-31 | 2024-07-16 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
US11285171B2 (en) | 2018-03-01 | 2022-03-29 | Novan, Inc. | Nitric oxide releasing suppositories and methods of use thereof |
JP7420797B2 (ja) | 2018-05-29 | 2024-01-23 | モーニングサイド ベンチャー インベストメンツ リミテッド | 薬剤送達の方法及びシステム |
EP3870150A1 (de) | 2018-10-26 | 2021-09-01 | Viramal Limited | Mukoadhäsive gelzusammensetzung |
ES2948955T3 (es) | 2018-11-30 | 2023-09-22 | Viramal Ltd | Un método de preparación de un agente gelificante, el agente gelificante obtenido de este modo y el uso de dicho agente gelificante |
BR112023022681A2 (pt) | 2021-04-30 | 2024-01-23 | Kalivir Immunotherapeutics Inc | Vírus oncolíticos para expressão modificada de mhc |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US175329A (en) * | 1876-03-28 | Improvement in processes of preserving burial-cases | ||
CA1165240A (en) | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
JPS59134710A (ja) | 1983-01-21 | 1984-08-02 | Suntory Ltd | 発酵養毛化粧料 |
US4537776A (en) * | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
US4557934A (en) * | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
US4552872A (en) | 1983-06-21 | 1985-11-12 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing corticosteroids |
JPS6067409A (ja) | 1983-09-22 | 1985-04-17 | Suntory Ltd | 頭髪用化粧料 |
US4743588A (en) * | 1984-06-13 | 1988-05-10 | Allergan Pharmaceuticals, Inc. | Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents |
US5196410A (en) * | 1986-10-31 | 1993-03-23 | Pfizer Inc. | Transdermal flux enhancing compositions |
US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
EP0267617B1 (de) * | 1986-11-14 | 1992-06-24 | Theratech, Inc. | Erhöhung des Penetrationsvermögens mittels eines aus die Zellhülle verändernden Substanzen und kurzkettigen Alkoholen bestehenden binären Systems |
ES2051998T3 (es) * | 1988-02-29 | 1994-07-01 | Pfizer | Composiciones aumentadoras del flujo transdermal. |
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US4855294A (en) * | 1988-09-06 | 1989-08-08 | Theratech, Inc. | Method for reducing skin irritation associated with drug/penetration enhancer compositions |
AU4745390A (en) * | 1988-12-01 | 1990-06-26 | Schering Corporation | Compositions for transdermal delivery of estradiol |
DE68927675T2 (de) * | 1989-08-23 | 1997-07-10 | Hitachi Ltd | Verfahren zur Richtigstellung von Netzwerkwichtungsfaktoren in einer mehrschichtigen Perceptronvorrichtung und eine solche Vorrichtung mit Mitteln zur Ausführung dieses Verfahrens |
US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
WO1993003751A1 (en) * | 1991-08-26 | 1993-03-04 | Abbott Laboratories | Compositions and methods for the sublingual or buccal administration of therapeutic agents |
ATE184473T1 (de) * | 1992-06-11 | 1999-10-15 | Theratech Inc | Verwendung von glyzerin zur dämpfung der transdermalen arzneimittelverabreichung |
US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
WO1995029678A1 (en) * | 1994-04-28 | 1995-11-09 | F.Hoffmann-La Roche Ag | Pharmaceutical composition for transdermal delivery |
US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
US5780050A (en) * | 1995-07-20 | 1998-07-14 | Theratech, Inc. | Drug delivery compositions for improved stability of steroids |
AU1429697A (en) * | 1995-12-29 | 1997-07-28 | Cygnus, Inc. | Systems and methods for the transdermal administration of androgenic agents |
IT1283102B1 (it) * | 1996-06-06 | 1998-04-07 | Permatec Nv | Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele |
US5760096A (en) * | 1996-10-18 | 1998-06-02 | Thornfeldt; Carl R. | Potent penetration enhancers |
EP0942697A1 (de) * | 1996-10-30 | 1999-09-22 | THERATECH, INC. (a Delaware Corporation) | Fettsäureester von milchsäuresalzen als penetrationsförderer |
IL136042A (en) * | 1997-11-10 | 2005-12-18 | Cellegy Pharma Inc | Alcohol-containing composition for topical application |
US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
US20030175329A1 (en) | 2001-10-04 | 2003-09-18 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
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1998
- 1998-11-09 IL IL13604298A patent/IL136042A/xx not_active IP Right Cessation
- 1998-11-09 CN CNB988130491A patent/CN1172674C/zh not_active Expired - Fee Related
- 1998-11-09 NZ NZ504423A patent/NZ504423A/xx not_active IP Right Cessation
- 1998-11-09 AU AU13132/99A patent/AU747041B2/en not_active Ceased
- 1998-11-09 DK DK04028426T patent/DK1510213T3/da active
- 1998-11-09 WO PCT/US1998/023750 patent/WO1999024041A1/en active IP Right Grant
- 1998-11-09 CA CA002309688A patent/CA2309688C/en not_active Expired - Fee Related
- 1998-11-09 US US09/189,090 patent/US6319913B1/en not_active Expired - Lifetime
- 1998-11-09 EP EP98956663A patent/EP1030668A4/de not_active Withdrawn
- 1998-11-09 DE DE69840426T patent/DE69840426D1/de not_active Expired - Lifetime
- 1998-11-09 ES ES04028426T patent/ES2318233T3/es not_active Expired - Lifetime
- 1998-11-09 EP EP04028426A patent/EP1510213B1/de not_active Revoked
- 1998-11-09 KR KR1020007005094A patent/KR100648536B1/ko active IP Right Grant
- 1998-11-09 BR BRPI9814014-0A patent/BR9814014B1/pt not_active IP Right Cessation
- 1998-11-09 AT AT04028426T patent/ATE418988T1/de active
- 1998-11-09 JP JP2000520133A patent/JP4139860B2/ja not_active Expired - Fee Related
- 1998-11-09 PT PT04028426T patent/PT1510213E/pt unknown
-
2000
- 2000-05-10 NO NO20002422A patent/NO20002422L/no not_active Application Discontinuation
-
2001
- 2001-09-24 US US09/963,287 patent/US6579865B2/en not_active Expired - Lifetime
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2003
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Publication number | Publication date |
---|---|
US20020058650A1 (en) | 2002-05-16 |
WO1999024041A1 (en) | 1999-05-20 |
US6319913B1 (en) | 2001-11-20 |
PT1510213E (pt) | 2009-02-12 |
JP2001522804A (ja) | 2001-11-20 |
IL136042A (en) | 2005-12-18 |
JP4139860B2 (ja) | 2008-08-27 |
EP1510213A3 (de) | 2005-03-23 |
NZ504423A (en) | 2003-04-29 |
ES2318233T3 (es) | 2009-05-01 |
EP1510213B1 (de) | 2008-12-31 |
IL136042A0 (en) | 2001-05-20 |
EP1030668A4 (de) | 2002-09-25 |
US7157097B2 (en) | 2007-01-02 |
ATE418988T1 (de) | 2009-01-15 |
CA2309688C (en) | 2007-04-24 |
AU747041C (en) | 1999-05-31 |
NO20002422D0 (no) | 2000-05-10 |
KR20010031984A (ko) | 2001-04-16 |
CN1172674C (zh) | 2004-10-27 |
DK1510213T3 (da) | 2009-03-23 |
BR9814014B1 (pt) | 2014-10-07 |
EP1030668A1 (de) | 2000-08-30 |
US20030166625A1 (en) | 2003-09-04 |
AU1313299A (en) | 1999-05-31 |
US6579865B2 (en) | 2003-06-17 |
BR9814014A (pt) | 2000-09-26 |
AU747041B2 (en) | 2002-05-09 |
CA2309688A1 (en) | 1999-05-20 |
CN1285749A (zh) | 2001-02-28 |
JP2005047932A (ja) | 2005-02-24 |
EP1510213A2 (de) | 2005-03-02 |
NO20002422L (no) | 2000-06-21 |
KR100648536B1 (ko) | 2006-11-24 |
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