DE69808631T2 - Neue spiroazabizyklische heterozyklische verbindungen - Google Patents

Neue spiroazabizyklische heterozyklische verbindungen

Info

Publication number
DE69808631T2
DE69808631T2 DE69808631T DE69808631T DE69808631T2 DE 69808631 T2 DE69808631 T2 DE 69808631T2 DE 69808631 T DE69808631 T DE 69808631T DE 69808631 T DE69808631 T DE 69808631T DE 69808631 T2 DE69808631 T2 DE 69808631T2
Authority
DE
Germany
Prior art keywords
new
heterocyclic compounds
spiroazabicyclic
spiroazabicyclic heterocyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69808631T
Other languages
English (en)
Other versions
DE69808631D1 (de
Inventor
Eifion Phillips
Robert Mack
John Macor
Simon Semus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9702746A external-priority patent/SE9702746D0/xx
Priority claimed from SE9800977A external-priority patent/SE9800977D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE69808631D1 publication Critical patent/DE69808631D1/de
Application granted granted Critical
Publication of DE69808631T2 publication Critical patent/DE69808631T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69808631T 1997-07-18 1998-07-10 Neue spiroazabizyklische heterozyklische verbindungen Expired - Fee Related DE69808631T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702746A SE9702746D0 (sv) 1997-07-18 1997-07-18 New compounds
SE9800977A SE9800977D0 (sv) 1998-03-24 1998-03-24 New compounds
PCT/SE1998/001364 WO1999003859A1 (en) 1997-07-18 1998-07-10 Novel spiroazabicyclic heterocyclic compounds

Publications (2)

Publication Number Publication Date
DE69808631D1 DE69808631D1 (de) 2002-11-14
DE69808631T2 true DE69808631T2 (de) 2003-06-12

Family

ID=26663041

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69827977T Expired - Fee Related DE69827977T2 (de) 1997-07-18 1998-07-10 Spiro [1-azabicyclo[2.2.2]octan-3,2'(3'H)-furo[2,3-b]pyridin zur Verwendung in der Behandlung von psychotischen und intellektuellen Störungen
DE69808631T Expired - Fee Related DE69808631T2 (de) 1997-07-18 1998-07-10 Neue spiroazabizyklische heterozyklische verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69827977T Expired - Fee Related DE69827977T2 (de) 1997-07-18 1998-07-10 Spiro [1-azabicyclo[2.2.2]octan-3,2'(3'H)-furo[2,3-b]pyridin zur Verwendung in der Behandlung von psychotischen und intellektuellen Störungen

Country Status (31)

Country Link
US (6) US6110914A (de)
EP (2) EP1213291B1 (de)
JP (1) JP2001510194A (de)
KR (1) KR100560036B1 (de)
CN (1) CN1117755C (de)
AR (2) AR013184A1 (de)
AT (2) ATE225792T1 (de)
AU (1) AU739022B2 (de)
BR (1) BR9810924A (de)
CA (1) CA2296031C (de)
DE (2) DE69827977T2 (de)
DK (1) DK0996622T3 (de)
EE (1) EE04399B1 (de)
ES (2) ES2185185T3 (de)
HK (3) HK1025322A1 (de)
HU (1) HUP0003844A3 (de)
ID (1) ID25548A (de)
IL (2) IL134086A0 (de)
IS (2) IS2027B (de)
MY (1) MY116761A (de)
NO (1) NO325324B1 (de)
NZ (1) NZ502298A (de)
PL (1) PL193065B1 (de)
PT (1) PT996622E (de)
RU (1) RU2202553C2 (de)
SA (1) SA98190668B1 (de)
SI (1) SI0996622T1 (de)
SK (1) SK283484B6 (de)
TR (1) TR200000129T2 (de)
TW (1) TW515799B (de)
WO (1) WO1999003859A1 (de)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0984970B1 (de) 1997-05-30 2003-11-19 Neurosearch A/S Spiro chinuclidin-derivate, ihre herstellung und verwendung
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
AR013184A1 (es) * 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
US6277870B1 (en) 1998-05-04 2001-08-21 Astra Ab Use
SE9900100D0 (sv) * 1999-01-15 1999-01-15 Astra Ab New compounds
FR2790474B1 (fr) * 1999-03-05 2001-04-06 Synthelabo Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
TWI298068B (en) * 2000-06-21 2008-06-21 Dainippon Sumitomo Pharma Co Pharmaceutical composition for schizophrenia
MXPA03010996A (es) * 2001-06-01 2004-02-27 Aztrazeneca Ab Nuevo ligando para receptores nicotinicos de acetilcolina utiles en terapia.
US6569865B2 (en) 2001-06-01 2003-05-27 Astrazeneca Ab Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine
US20040259909A1 (en) * 2001-10-16 2004-12-23 Mccarthy Dennis Treatment of fibromyalgia syndrome
NZ533259A (en) 2001-12-14 2007-10-26 Targacept Inc Methods and compositions for treatment of central nervous system disorders
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
DE60328010D1 (de) * 2002-04-18 2009-07-30 Astrazeneca Ab Heterocyclische verbindungen
JP4511196B2 (ja) 2002-04-18 2010-07-28 アストラゼネカ・アクチエボラーグ チエニル化合物
JP4511195B2 (ja) * 2002-04-18 2010-07-28 アストラゼネカ・アクチエボラーグ フリル化合物
ES2294330T3 (es) 2002-08-02 2008-04-01 MERCK & CO., INC. Derivados de furo(2,3-b)piridina sustituidos.
SE0202598D0 (sv) * 2002-09-02 2002-09-02 Astrazeneca Ab Alpha-7 Nicotinic receptor agonists and statins in combination
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
CN1735414A (zh) * 2002-12-06 2006-02-15 北岸长岛犹太人研究学院 用α7受体结合类胆碱激动剂抑制炎症
JP4598674B2 (ja) * 2003-01-08 2010-12-15 田辺三菱製薬株式会社 統合失調症治療剤
WO2005000250A2 (en) * 2003-06-24 2005-01-06 Johns Hopkins University Imaging agents and methods of imaging alpha 7-nicotinic cholinergic receptor
EP1668016A1 (de) * 2003-09-25 2006-06-14 AstraZeneca AB Liganden
JP2007533641A (ja) 2003-10-15 2007-11-22 ターガセプト,インコーポレイテッド 疼痛緩和および中枢神経系障害治療のためのアザビシクロ化合物
JP4855264B2 (ja) * 2003-10-21 2012-01-18 アストラゼネカ・アクチエボラーグ スピロフロピリジンアリール誘導体
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
AU2005225458B2 (en) 2004-03-25 2008-12-04 The Feinstein Institutes For Medical Research Neural tourniquet
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性(biosynchronous)経皮的薬物送達
EP2298410B1 (de) 2004-12-27 2013-10-09 The Feinstein Institute for Medical Research Behandlung von entzündlichen Erkrankungen durch elektrische Stimulation des Vagusnervs
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
ATE482959T1 (de) 2005-08-22 2010-10-15 Targacept Inc Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
TW200813067A (en) * 2006-05-17 2008-03-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
US20080242688A1 (en) * 2007-03-19 2008-10-02 Astrazeneca Ab Method 741
ES2521494T3 (es) 2007-04-02 2014-11-12 Parkinson's Institute Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos
WO2009017454A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab New therapeutic combination of a gsk3 inhibitor and an a7-nicotinic agonist 960
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
WO2009029614A1 (en) 2007-08-27 2009-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
CN101883771A (zh) 2007-10-01 2010-11-10 科门蒂斯公司 作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
MX2010008875A (es) 2008-02-13 2010-08-31 Targacept Inc Agonistas nicotinicos alfa 7 y antipsicoticos.
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
AU2009260905B2 (en) 2008-06-20 2012-08-23 Astrazeneca Ab Dibenzothiazepine derivatives and use thereof
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
WO2010144578A2 (en) 2009-06-09 2010-12-16 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
GB0922434D0 (en) 2009-12-22 2010-02-03 Ucb Pharma Sa antibodies and fragments thereof
GB0922435D0 (en) 2009-12-22 2010-02-03 Ucb Pharma Sa Method
US9234037B2 (en) 2009-10-27 2016-01-12 Ucb Biopharma Sprl Method to generate antibodies to ion channels
EP2493926B1 (de) 2009-10-27 2020-03-11 UCB Biopharma SRL Funktionelle modifizierung von nav1.7-antikörpern
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
EP3636314B1 (de) 2009-12-23 2021-09-08 Setpoint Medical Corporation Nervenstimulatoren und systeme zur behandlung von chronischer entzündung
US9018227B2 (en) 2010-03-19 2015-04-28 Indiana State University Nicotinic acetylcholine receptor agonists
PT3029039T (pt) 2010-05-17 2017-11-28 Forum Pharmaceuticals Inc Formulações farmacêuticas que compreendem formas cristalinas de cloridrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida mono-hidratado
EP2707094B1 (de) 2011-05-09 2016-02-03 Setpoint Medical Corporation Einzelimpulsaktivierung des cholinergen entzündungshemmenden pfades zur behandlung chronischer entzündungen
RU2455306C1 (ru) * 2011-05-19 2012-07-10 Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 3',4',5,6-ТЕТРАГИДРО-1Н-СПИРО[ПИРИДИН-4,5'-ТИЕНО[2,3-d]ПИРИМИДИНОВ]
KR20140027939A (ko) 2011-06-30 2014-03-07 도레이 카부시키가이샤 지양제
GB201111704D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Novel compounds
GB201111705D0 (en) 2011-07-07 2011-08-24 Takeda Pharmaceutical Compounds and their use
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
GB201209587D0 (en) 2012-05-30 2012-07-11 Takeda Pharmaceutical Therapeutic compounds
EP2953940B1 (de) 2013-02-07 2018-08-22 Heptares Therapeutics Limited Piperidin-1-yl- und azepin-1-yl-carboxylate als muskarin-m4-rezeptoragonisten
US8893339B2 (en) 2013-03-14 2014-11-25 Select Comfort Corporation System and method for adjusting settings of a bed with a remote control
CN105324372B (zh) 2013-06-21 2018-03-06 武田药品工业株式会社 作为前动力蛋白受体调节剂的1‑磺酰基哌啶衍生物
GB201314286D0 (en) 2013-08-08 2013-09-25 Takeda Pharmaceutical Therapeutic Compounds
GB201318222D0 (en) 2013-10-15 2013-11-27 Takeda Pharmaceutical Novel compounds
GB201320905D0 (en) 2013-11-27 2014-01-08 Takeda Pharmaceutical Therapeutic compounds
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
JP2017524736A (ja) 2014-07-11 2017-08-31 アルファーマゲン,エルエルシー アルファ7−ニコチン性アセチルコリン受容体活性を調節するためのキヌクリジン化合物
US9139648B1 (en) 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
CA2974324A1 (en) 2015-01-28 2016-08-04 Zita S. Netzel Drug delivery methods and systems
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
WO2017127758A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
CN108882885A (zh) 2016-01-20 2018-11-23 赛博恩特医疗器械公司 迷走神经刺激的控制
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
GB201616839D0 (en) 2016-10-04 2016-11-16 Takeda Pharmaceutical Company Limited Therapeutic compounds
EP3534947A1 (de) 2016-11-03 2019-09-11 Kymab Limited Antikörper, kombinationen mit antikörpern, biomarker, verwendungen und verfahren
GB201619514D0 (en) 2016-11-18 2017-01-04 Takeda Pharmaceuticals Co Novel compounds
EP3565617A1 (de) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Vorrichtungen und verfahren zur transdermalen wirkstofffreisetzung
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US11660443B2 (en) 2018-04-20 2023-05-30 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation
WO2019232077A1 (en) 2018-05-29 2019-12-05 Chrono Therapeutics Inc. Drug delivery methods and systems
US20220040158A1 (en) * 2018-09-24 2022-02-10 Astrazeneca Ab Azd0328 dosage regime for treating cognitive impairment
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
JP2021138648A (ja) 2020-03-04 2021-09-16 武田薬品工業株式会社 経口固形製剤
US11938324B2 (en) 2020-05-21 2024-03-26 The Feinstein Institutes For Medical Research Systems and methods for vagus nerve stimulation
CN115340736B (zh) * 2022-05-20 2023-09-29 扬州实嘉电缆材料有限公司 一种氮磷阻燃剂改性聚氯乙烯防火电缆料

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681363A (en) * 1970-08-20 1972-08-01 Univ Temple Spiro(imidazolidine-4,3{40 -quinuclidine)-2,5-diones
US5902814A (en) * 1994-08-24 1999-05-11 Astra Ab Spiro-Azabicyclic Compounds useful in therapy
US5468875A (en) * 1994-12-22 1995-11-21 American Home Products Corporation 1-azabicycloheptane derivatives
PT842178E (pt) * 1995-07-28 2001-08-30 Abbott Lab Furopiridina tienopiridina pirrolopiridina e compostos relacionados de pirimidina piridazina e triazina uteis no controlo da transmissao sinaptica quimica
AR013184A1 (es) 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis

Also Published As

Publication number Publication date
ATE283859T1 (de) 2004-12-15
HK1025322A1 (en) 2000-11-10
HUP0003844A2 (hu) 2001-07-30
AR013184A1 (es) 2000-12-13
IS2434B (is) 2008-10-15
SA98190668B1 (ar) 2006-09-25
TR200000129T2 (tr) 2000-07-21
PL338259A1 (en) 2000-10-09
US20020187994A1 (en) 2002-12-12
ATE225792T1 (de) 2002-10-15
HK1031382A1 (en) 2001-06-15
PL193065B1 (pl) 2007-01-31
HK1046274A1 (en) 2003-01-03
US6110914A (en) 2000-08-29
CA2296031A1 (en) 1999-01-28
NO20000226D0 (no) 2000-01-17
DK0996622T3 (da) 2002-12-30
EP1213291A1 (de) 2002-06-12
US6369224B1 (en) 2002-04-09
TW515799B (en) 2003-01-01
CN1270592A (zh) 2000-10-18
EP1213291B1 (de) 2004-12-01
EE200000031A (et) 2000-10-16
NO325324B1 (no) 2008-03-31
IS7747A (is) 2005-03-16
ES2185185T3 (es) 2003-04-16
SK283484B6 (sk) 2003-08-05
MY116761A (en) 2004-03-31
IL134086A (en) 2007-08-19
PT996622E (pt) 2003-01-31
SI0996622T1 (en) 2003-04-30
RU2202553C2 (ru) 2003-04-20
DE69808631D1 (de) 2002-11-14
AU739022B2 (en) 2001-10-04
EP0996622A1 (de) 2000-05-03
IS2027B (is) 2005-08-15
US20080153864A1 (en) 2008-06-26
BR9810924A (pt) 2000-08-15
IL134086A0 (en) 2001-04-30
ES2231599T3 (es) 2005-05-16
IS5338A (is) 2000-01-13
DE69827977D1 (de) 2005-01-05
NO20000226L (no) 2000-03-14
AU8367998A (en) 1999-02-10
US20030166935A1 (en) 2003-09-04
CN1117755C (zh) 2003-08-13
US6706878B2 (en) 2004-03-16
US6703502B2 (en) 2004-03-09
HUP0003844A3 (en) 2002-11-28
ID25548A (id) 2000-10-12
EP0996622B1 (de) 2002-10-09
NZ502298A (en) 2002-02-01
US7507744B2 (en) 2009-03-24
WO1999003859A1 (en) 1999-01-28
EE04399B1 (et) 2004-12-15
SK183599A3 (en) 2000-08-14
KR100560036B1 (ko) 2006-03-13
HK1046274B (zh) 2005-05-20
JP2001510194A (ja) 2001-07-31
US20050004099A1 (en) 2005-01-06
KR20010021961A (de) 2001-03-15
DE69827977T2 (de) 2005-12-08
CA2296031C (en) 2008-01-08
AR068013A2 (es) 2009-10-28

Similar Documents

Publication Publication Date Title
ATE225792T1 (de) Neue spiroazabizyklische heterozyklische verbindungen
DE69838791D1 (de) Neue exendinagonist verbindungen
DE69822513D1 (de) Neue antiarrhytmische bispidin-verbindungen
DE69804498D1 (de) Neue wasserlösliche photochromische verbindungen
BR9612465A (pt) Compostos heterocíclicos
ATE290001T1 (de) Neue substituierte imidazolverbindungen
IS5479A (is) Efnasambönd
IS5478A (is) Efnasambönd
IS5477A (is) Efnasambönd
ID22850A (id) Senyawa-senyawa pirazina
DE69625806D1 (de) Neue heterocyclische verbindungen
NO994877D0 (no) Kalsilytiske forbindelser
DE69807397D1 (de) Triazinylaminostilben Verbindungen
DE69808403T2 (de) Tetradecachlorcyclohexasilandianon enthaltende Verbindungen
EE9900448A (et) Ühendid
DE69836023D1 (de) Neue verbindungen
DE69531522D1 (de) Heterozyklische Verbindungen
DE59811182D1 (de) Heterocyclische Verbindungen
IS5237A (is) Efnasambönd
ID22983A (id) Senyawa-senyawa fluorometoksimino
IS5323A (is) Efnasambönd
EE9900466A (et) Ühendid
DE59804807D1 (de) Pi-komplex-verbindungen
DE69737634D1 (de) Insektizide oxadiazinverbindungen
TR199802196A3 (tr) Heterosiklik bilesimler.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee