DE69808266D1 - Herstellung und verwendung von alpha-ketoamid derivate und anordnunge - Google Patents
Herstellung und verwendung von alpha-ketoamid derivate und anordnungeInfo
- Publication number
- DE69808266D1 DE69808266D1 DE69808266T DE69808266T DE69808266D1 DE 69808266 D1 DE69808266 D1 DE 69808266D1 DE 69808266 T DE69808266 T DE 69808266T DE 69808266 T DE69808266 T DE 69808266T DE 69808266 D1 DE69808266 D1 DE 69808266D1
- Authority
- DE
- Germany
- Prior art keywords
- arrangements
- production
- ketoamide derivatives
- alpha ketoamide
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84358497A | 1997-04-16 | 1997-04-16 | |
| PCT/US1998/007747 WO1998046559A1 (en) | 1997-04-16 | 1998-04-16 | SYNTHESIS AND USE OF α-KETOAMIDE DERIVATIVES AND ARRAYS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69808266D1 true DE69808266D1 (de) | 2002-10-31 |
Family
ID=25290444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69808266T Expired - Lifetime DE69808266D1 (de) | 1997-04-16 | 1998-04-16 | Herstellung und verwendung von alpha-ketoamid derivate und anordnunge |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0975584B1 (de) |
| AU (1) | AU7129098A (de) |
| CA (1) | CA2286660A1 (de) |
| DE (1) | DE69808266D1 (de) |
| WO (1) | WO1998046559A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6117870A (en) * | 1998-11-12 | 2000-09-12 | Fujirebio Kabushiki Kaisha | Cyclic amide derivatives |
| US6355641B1 (en) | 1999-03-17 | 2002-03-12 | Syntex (U.S.A.) Llc | Oxazolone derivatives and uses thereof |
| US7932213B2 (en) | 1999-05-11 | 2011-04-26 | President And Fellows Of Harvard College | Small molecule printing |
| JP2005515254A (ja) | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンｋ阻害剤として有用なシクロアルキルケトアミド誘導体 |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| BRPI0414313A (pt) | 2003-09-11 | 2006-11-07 | Kemia Inc | inibidores de citocinas |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
| ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| KR101790806B1 (ko) | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제 |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| CN103403553B (zh) | 2010-12-22 | 2016-03-09 | 康奈尔大学 | Sirt6的调节物及其筛选分析 |
| ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (de) * | 1959-09-25 | 1900-01-01 | ||
| US3056784A (en) * | 1960-10-03 | 1962-10-02 | Richardson Merrell Inc | Substituted 5, 6-dihydro-2(1h)-pyrazinones |
| IL31692A (en) * | 1968-03-13 | 1973-06-29 | Roussel Uclaf | Thienyl acetamides and process of preparation |
| US4118298A (en) * | 1977-04-15 | 1978-10-03 | Stauffer Chemical Company | Photopolymerizable aryl and heterocyclic glyoxylamide compositions |
| US5116851A (en) * | 1990-01-26 | 1992-05-26 | E. R. Squibb & Sons, Inc. | Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides |
| DE69209357D1 (de) * | 1991-05-09 | 1996-05-02 | Hoffmann La Roche | Substituierte Carbonsäurederivate |
| US5514694A (en) * | 1992-09-21 | 1996-05-07 | Georgia Tech Research Corp | Peptidyl ketoamides |
| TR199700334T1 (tr) * | 1995-09-01 | 1997-08-21 | Lilly Co Eli | Indolil nöropeptid y reseptör antagonistleri. |
| JP2002514192A (ja) * | 1996-11-13 | 2002-05-14 | セフアロン・インコーポレーテツド | ベンゾチアゾおよび関連の複素環基を含有するシステインおよびセリンプロテアーゼ阻害剤 |
| TR199901305T2 (xx) * | 1996-12-11 | 1999-08-23 | Basf Aktiengesellschaft | Calpain-�nleyicileri olarak ketonbenzamidler |
-
1998
- 1998-04-16 EP EP98918344A patent/EP0975584B1/de not_active Expired - Lifetime
- 1998-04-16 AU AU71290/98A patent/AU7129098A/en not_active Abandoned
- 1998-04-16 WO PCT/US1998/007747 patent/WO1998046559A1/en active IP Right Grant
- 1998-04-16 DE DE69808266T patent/DE69808266D1/de not_active Expired - Lifetime
- 1998-04-16 CA CA002286660A patent/CA2286660A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998046559A1 (en) | 1998-10-22 |
| EP0975584A1 (de) | 2000-02-02 |
| AU7129098A (en) | 1998-11-11 |
| EP0975584B1 (de) | 2002-09-25 |
| CA2286660A1 (en) | 1998-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |