DE69804671D1 - Verwendung von mikropartikeln mit submikron öl/wasser emulsionen - Google Patents
Verwendung von mikropartikeln mit submikron öl/wasser emulsionenInfo
- Publication number
- DE69804671D1 DE69804671D1 DE69804671T DE69804671T DE69804671D1 DE 69804671 D1 DE69804671 D1 DE 69804671D1 DE 69804671 T DE69804671 T DE 69804671T DE 69804671 T DE69804671 T DE 69804671T DE 69804671 D1 DE69804671 D1 DE 69804671D1
- Authority
- DE
- Germany
- Prior art keywords
- submicron oil
- water emulsions
- microparticles
- entrapped
- submicron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/918—Immunological
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6972497P | 1997-12-16 | 1997-12-16 | |
PCT/US1998/001656 WO1999030737A1 (en) | 1997-12-16 | 1998-01-29 | Use of microparticles combined with submicron oil-in-water emulsions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69804671D1 true DE69804671D1 (de) | 2002-05-16 |
DE69804671T2 DE69804671T2 (de) | 2002-11-21 |
Family
ID=22090819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69804671T Expired - Lifetime DE69804671T2 (de) | 1997-12-16 | 1998-01-29 | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
Country Status (11)
Country | Link |
---|---|
US (4) | US6086901A (de) |
EP (1) | EP1042001B1 (de) |
JP (3) | JP4918188B2 (de) |
AT (1) | ATE215385T1 (de) |
AU (1) | AU6253898A (de) |
CA (1) | CA2314934C (de) |
DE (1) | DE69804671T2 (de) |
DK (1) | DK1042001T3 (de) |
ES (1) | ES2175668T3 (de) |
PT (1) | PT1042001E (de) |
WO (1) | WO1999030737A1 (de) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0832638B2 (ja) * | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
CA2156718A1 (en) | 1993-12-23 | 1995-06-29 | Bruno Gander | Immunological response potentiation process |
CA2266656A1 (en) * | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
US20040202680A1 (en) * | 1997-01-30 | 2004-10-14 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
DK0991403T3 (da) * | 1997-01-30 | 2003-07-28 | Chiron Corp | Anvendelse af mikropartikler med adsorberet antigen til stimulering af immunresponser |
US7393630B2 (en) * | 1997-12-16 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Use of microparticles combined with submicron oil-in-water emulsions |
EP1042001B1 (de) * | 1997-12-16 | 2002-04-03 | Chiron Corporation | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
JP4812942B2 (ja) * | 1999-02-26 | 2011-11-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | CGモチーフを含むオリゴヌクレオチドを用いるNeisseria抗原殺菌活性の増強 |
EP2286792A1 (de) | 1999-02-26 | 2011-02-23 | Novartis Vaccines and Diagnostics, Inc. | Mikroemulsionen mit einer adsorbierenden Oberfläche, enthaltend eine Mikrotropfenemulsion |
EP1221968B1 (de) * | 1999-10-13 | 2010-01-13 | Novartis Vaccines and Diagnostics, Inc. | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
ATE319810T1 (de) * | 1999-11-19 | 2006-03-15 | Zycos Inc | Durchflussverfahren zur herstellung von mikropartikeln |
PT1233782E (pt) * | 1999-12-01 | 2009-02-13 | Novartis Vaccines & Diagnostic | Estimulação da produção de anticorpos específicos para o hcv |
US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
US20040022814A1 (en) * | 2000-06-15 | 2004-02-05 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
US20030138769A1 (en) * | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
DE60118228T2 (de) * | 2000-09-28 | 2006-12-14 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Mikropartikel zur verabreichung von heterologen nukleinsäure |
WO2002026212A2 (en) | 2000-09-28 | 2002-04-04 | Chiron Corporation | Microparticle compositions and methods for the manufacture thereof |
JP2004527524A (ja) * | 2001-04-05 | 2004-09-09 | カイロン コーポレイション | 非経口初回抗原刺激後の粘膜追加免疫 |
US8481043B2 (en) * | 2001-06-22 | 2013-07-09 | Cpex Pharmaceuticals, Inc. | Nasal immunization |
US20030138458A1 (en) * | 2001-06-29 | 2003-07-24 | Michael Houghton | HCV E1E2 vaccine compositions |
US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
US20030175863A1 (en) * | 2001-08-15 | 2003-09-18 | Birkett Ashley J. | Influenza immunogen and vaccine |
US20030185858A1 (en) * | 2001-08-15 | 2003-10-02 | Birkett Ashley J. | Immunogenic HBc chimer particles stabilized with an N-terminal cysteine |
AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
CN1620253A (zh) * | 2001-12-27 | 2005-05-25 | 创世纪集团公司 | 海豹油基脂质乳液及其用途 |
ES2339762T3 (es) * | 2002-01-14 | 2010-05-25 | Novartis Vaccines And Diagnostics, Inc. | Vacuna contra el vih y procedimiento de uso. |
US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
US6861410B1 (en) * | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
EP1490083A1 (de) * | 2002-03-29 | 2004-12-29 | The Regents of the University of California | Mikrogelteilchen zur abgabe von biologisch wirksamen materialien |
WO2004004654A2 (en) * | 2002-07-03 | 2004-01-15 | Cambridge Scientific, Inc. | Vaccines to induce mucosal immunity |
AU2003254792A1 (en) * | 2002-08-02 | 2004-02-23 | Sumitomo Pharmaceuticals Company, Limited | Bacterial cell wall skeleton component preparaion |
KR20050052467A (ko) * | 2002-08-12 | 2005-06-02 | 다이나박스 테크놀로지 코퍼레이션 | 면역조절 조성물, 이의 제조방법 및 이의 이용방법 |
US20060110736A1 (en) * | 2002-10-07 | 2006-05-25 | John Donnelly | Hiv vaccine formulations |
EP1558122A4 (de) * | 2002-10-18 | 2011-04-13 | Charles N Ellis | Verfahren zur bewertung der schwere von psoriasis |
EP1585542B1 (de) * | 2002-12-27 | 2012-06-13 | Novartis Vaccines and Diagnostics, Inc. | Immunogene zusammensetzungen enthaltend phospholipid |
CA2513418C (en) * | 2003-01-14 | 2016-04-19 | Chiron Corporation | Microparticles with adsorbed polynucleotide-containing species |
DK1613346T3 (da) * | 2003-04-04 | 2013-01-07 | Pah Usa 15 Llc | Mikrofluidiske olie-i-vand-emulsioner og vaccinesammensætninger |
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US9107813B2 (en) * | 2004-11-15 | 2015-08-18 | Derek T. O'Hagan | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
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US8637053B2 (en) | 2007-12-03 | 2014-01-28 | President And Fellows Of Harvard College | Chlamydia antigens |
US8815253B2 (en) * | 2007-12-07 | 2014-08-26 | Novartis Ag | Compositions for inducing immune responses |
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EP2296696B1 (de) | 2008-06-05 | 2014-08-27 | ImmunoVaccine Technologies Inc. | Zusammensetzungen mit liposomen, einem antigen, einem polynucleotid und einem träger mit einer kontinuierlichen phase einer hydrophoben substanz |
US20110236489A1 (en) * | 2008-09-18 | 2011-09-29 | Novartis Ag | Vaccine adjuvant combinations |
JP2012510289A (ja) | 2008-12-03 | 2012-05-10 | プロティア ワクチン テクノロジーズ リミテッド | グルタミルtRNA合成酵素(GtS)フラグメント |
WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
EP2550362B1 (de) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv-glycoproteine und rekombinante vektoren |
US20110293690A1 (en) * | 2010-05-27 | 2011-12-01 | Tyco Healthcare Group Lp | Biodegradable Polymer Encapsulated Microsphere Particulate Film and Method of Making Thereof |
BR112013000391B8 (pt) | 2010-07-06 | 2022-10-04 | Novartis Ag | Composição de emulsão catiônica de óleo em água e seu uso |
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-
1998
- 1998-01-29 EP EP98904739A patent/EP1042001B1/de not_active Expired - Lifetime
- 1998-01-29 JP JP2000538716A patent/JP4918188B2/ja not_active Expired - Fee Related
- 1998-01-29 ES ES98904739T patent/ES2175668T3/es not_active Expired - Lifetime
- 1998-01-29 AT AT98904739T patent/ATE215385T1/de active
- 1998-01-29 DE DE69804671T patent/DE69804671T2/de not_active Expired - Lifetime
- 1998-01-29 DK DK98904739T patent/DK1042001T3/da active
- 1998-01-29 CA CA002314934A patent/CA2314934C/en not_active Expired - Fee Related
- 1998-01-29 WO PCT/US1998/001656 patent/WO1999030737A1/en active IP Right Grant
- 1998-01-29 US US09/015,736 patent/US6086901A/en not_active Expired - Lifetime
- 1998-01-29 PT PT98904739T patent/PT1042001E/pt unknown
- 1998-01-29 AU AU62538/98A patent/AU6253898A/en not_active Abandoned
-
2000
- 2000-05-02 US US09/564,416 patent/US6306405B1/en not_active Expired - Lifetime
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2001
- 2001-08-20 US US09/935,466 patent/US6458370B1/en not_active Expired - Lifetime
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2002
- 2002-08-02 US US10/211,025 patent/US6855492B2/en not_active Expired - Lifetime
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2007
- 2007-11-09 JP JP2007292637A patent/JP2008050374A/ja not_active Withdrawn
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US6086901A (en) | 2000-07-11 |
JP4918188B2 (ja) | 2012-04-18 |
CA2314934A1 (en) | 1999-06-24 |
US6855492B2 (en) | 2005-02-15 |
PT1042001E (pt) | 2002-09-30 |
EP1042001B1 (de) | 2002-04-03 |
DE69804671T2 (de) | 2002-11-21 |
EP1042001A1 (de) | 2000-10-11 |
DK1042001T3 (da) | 2002-07-08 |
US20020025329A1 (en) | 2002-02-28 |
US20030082213A1 (en) | 2003-05-01 |
JP2008050374A (ja) | 2008-03-06 |
US6306405B1 (en) | 2001-10-23 |
ATE215385T1 (de) | 2002-04-15 |
CA2314934C (en) | 2006-08-29 |
US6458370B1 (en) | 2002-10-01 |
AU6253898A (en) | 1999-07-05 |
JP2002508334A (ja) | 2002-03-19 |
ES2175668T3 (es) | 2002-11-16 |
JP2012036223A (ja) | 2012-02-23 |
WO1999030737A1 (en) | 1999-06-24 |
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