ES2196150T3 - Induccion de tolerancia inmunologica por el uso de anticuerpos anti-cd4 que no inducen deplecion. - Google Patents

Induccion de tolerancia inmunologica por el uso de anticuerpos anti-cd4 que no inducen deplecion.

Info

Publication number
ES2196150T3
ES2196150T3 ES96915808T ES96915808T ES2196150T3 ES 2196150 T3 ES2196150 T3 ES 2196150T3 ES 96915808 T ES96915808 T ES 96915808T ES 96915808 T ES96915808 T ES 96915808T ES 2196150 T3 ES2196150 T3 ES 2196150T3
Authority
ES
Spain
Prior art keywords
deployment
antibodies
induce
immunological tolerance
tolerance induction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96915808T
Other languages
English (en)
Inventor
Robert W Knowles
Druie E Cavender
Judith M Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Application granted granted Critical
Publication of ES2196150T3 publication Critical patent/ES2196150T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)

Abstract

LA INVENCION PROPORCIONA UN METODO DE INDUCCION DE TOLERANCIA INMUNOLOGICA Y UN METODO DE PREVENCION DEL RECHAZO DE HETEROINJERTOS. EN AMBOS METODOS, SE ADMINISTRAN COMPOSICIONES DE ANTICUERPO ANTICD4 NO DEPLECIONANTE A UN PRIMATE. TAMBIEN SE PRESENTAN COMPOSICIONES DE ANTICUERPO NO DEPLECIONANTE Y MEDULA OSEA DE DONANTE.
ES96915808T 1995-05-18 1996-05-16 Induccion de tolerancia inmunologica por el uso de anticuerpos anti-cd4 que no inducen deplecion. Expired - Lifetime ES2196150T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44373995A 1995-05-18 1995-05-18

Publications (1)

Publication Number Publication Date
ES2196150T3 true ES2196150T3 (es) 2003-12-16

Family

ID=23762005

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96915808T Expired - Lifetime ES2196150T3 (es) 1995-05-18 1996-05-16 Induccion de tolerancia inmunologica por el uso de anticuerpos anti-cd4 que no inducen deplecion.

Country Status (10)

Country Link
EP (2) EP1161955A3 (es)
JP (1) JPH11505251A (es)
AT (1) ATE238066T1 (es)
AU (1) AU715052B2 (es)
CA (1) CA2221350A1 (es)
DE (1) DE69627665T2 (es)
DK (1) DK0840618T3 (es)
ES (1) ES2196150T3 (es)
PT (1) PT840618E (es)
WO (1) WO1996036359A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037454A (en) * 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
WO1998023746A1 (en) * 1996-11-27 1998-06-04 Genentech, Inc. Antibody mutants
US7541443B2 (en) 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
EP1985306A3 (en) * 2001-06-14 2009-04-01 TolerRx, Inc CD4-specific antibody TRX1 and uses therefor
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
TW200817438A (en) 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
CL2008000707A1 (es) 2007-03-13 2008-09-22 Hoffmann La Roche Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion.
US20090022720A1 (en) 2007-07-20 2009-01-22 Stephan Fischer Conjugate of an antibody against CD4 and antifusogenic peptides
EP2262838B1 (en) 2008-03-13 2016-04-13 Biotest AG Agent for treating disease
CN102027018A (zh) 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
CA2718184A1 (en) 2008-03-13 2009-10-08 Biotest Ag Agent for treating disease
US8637466B2 (en) 2008-08-11 2014-01-28 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
EP2471543A1 (en) * 2010-12-02 2012-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904481A (en) * 1985-04-17 1990-02-27 The Board Of Trustess Of Leland Stanford University Method of conferring immuno-tolerance to a specific antigen
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies
GB8912497D0 (en) * 1989-05-31 1989-07-19 Cobbold Stephen P Monoclonal antibodies
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9020282D0 (en) * 1990-09-17 1990-10-31 Gorman Scott D Altered antibodies and their preparation

Also Published As

Publication number Publication date
ATE238066T1 (de) 2003-05-15
AU715052B2 (en) 2000-01-13
DE69627665D1 (de) 2003-05-28
AU5747996A (en) 1996-11-29
WO1996036359A1 (en) 1996-11-21
DK0840618T3 (da) 2003-08-11
JPH11505251A (ja) 1999-05-18
PT840618E (pt) 2003-08-29
CA2221350A1 (en) 1996-11-21
EP0840618B1 (en) 2003-04-23
EP1161955A3 (en) 2001-12-19
EP0840618A1 (en) 1998-05-13
EP1161955A2 (en) 2001-12-12
DE69627665T2 (de) 2004-02-19

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