DE69725611D1 - Nicht-Nukleotid verknüpfende Reagentien - Google Patents

Nicht-Nukleotid verknüpfende Reagentien

Info

Publication number
DE69725611D1
DE69725611D1 DE69725611T DE69725611T DE69725611D1 DE 69725611 D1 DE69725611 D1 DE 69725611D1 DE 69725611 T DE69725611 T DE 69725611T DE 69725611 T DE69725611 T DE 69725611T DE 69725611 D1 DE69725611 D1 DE 69725611D1
Authority
DE
Germany
Prior art keywords
pct
reagents
nucleotide
linking reagents
nucleotide linking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69725611T
Other languages
English (en)
Other versions
DE69725611T2 (de
Inventor
Su George Sheng-Hui
Siva Iyer
K Aggarwal
L Kalra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIOGENEX LAB SAN RAMON
Biogenex Laboratories Inc
Original Assignee
BIOGENEX LAB SAN RAMON
Biogenex Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOGENEX LAB SAN RAMON, Biogenex Laboratories Inc filed Critical BIOGENEX LAB SAN RAMON
Application granted granted Critical
Publication of DE69725611D1 publication Critical patent/DE69725611D1/de
Publication of DE69725611T2 publication Critical patent/DE69725611T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2416—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69725611T 1996-05-15 1997-05-15 Nicht-Nukleotid verknüpfende Reagentien Expired - Fee Related DE69725611T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64782096A 1996-05-15 1996-05-15
US647820 1996-05-15
PCT/US1997/009094 WO1997043451A1 (en) 1996-05-15 1997-05-15 Non-nucleotide linking reagents

Publications (2)

Publication Number Publication Date
DE69725611D1 true DE69725611D1 (de) 2003-11-20
DE69725611T2 DE69725611T2 (de) 2004-07-29

Family

ID=24598396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69725611T Expired - Fee Related DE69725611T2 (de) 1996-05-15 1997-05-15 Nicht-Nukleotid verknüpfende Reagentien

Country Status (8)

Country Link
US (1) US6130323A (de)
EP (1) EP0954606B1 (de)
JP (1) JP2001509784A (de)
AT (1) ATE252158T1 (de)
AU (1) AU733647B2 (de)
CA (1) CA2253969A1 (de)
DE (1) DE69725611T2 (de)
WO (1) WO1997043451A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000028326A1 (fr) * 1998-11-06 2000-05-18 Iatron Laboratories, Inc. Nouveaux complexes contenant de l'avidine reticulee, procede analytique dans lequel on utilise de l'avidine reticulee, reactifs et kits d'analyse
WO2002014555A2 (en) 2000-08-11 2002-02-21 University Of Utah Research Foundation Single-labeled oligonucleotide probes
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
WO2004089295A2 (en) * 2003-04-01 2004-10-21 Chromagen, Inc. Homogeneous and heterogeneous assay methods using nucleation centers and novel covalent chemistries for the rapid measurement of phosphorylation and de-phosphorylation
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
EP1502958A1 (de) * 2003-08-01 2005-02-02 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
EP1700922B1 (de) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituierte 5-Nitroindolderivate und diese enthaltende markierte Oligonukleotidsonden
DE502005008153D1 (de) 2005-11-23 2009-10-29 Roche Diagnostics Gmbh Polynukleotid mit Phosphatmimetikum
JP4713514B2 (ja) 2006-02-20 2011-06-29 エフ．ホフマン−ラ ロシュ アーゲー 改善された標識試薬
US8335360B2 (en) 2007-05-14 2012-12-18 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
WO2008156669A1 (en) 2007-06-15 2008-12-24 Historx, Inc. Method and system for standardizing microscope instruments
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
WO2009029810A1 (en) 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
ES2573945T3 (es) 2008-09-16 2016-06-13 Novartis Ag Cuantificación reproducible de expresión de biomarcadores
RU2573915C2 (ru) 2009-09-16 2016-01-27 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применение
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
WO2012085064A1 (en) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a posttranslationally modified polypeptide by a bi-valent binding agent
EP2812357B1 (de) 2012-02-10 2020-11-04 F.Hoffmann-La Roche Ag Einzelketten-antikörper und andere heteromultimere
JP6203838B2 (ja) 2012-06-27 2017-09-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
ES2764111T3 (es) 2014-12-03 2020-06-02 Hoffmann La Roche Anticuerpos multiespecíficos
US10781175B2 (en) 2016-07-15 2020-09-22 Am Chemicals Llc Solid supports and phosphoramidite building blocks for oligonucleotide conjugates
CN108219513B (zh) * 2018-03-14 2019-11-08 青岛科技大学 一种羧基荧光素的制备方法

Also Published As

Publication number Publication date
DE69725611T2 (de) 2004-07-29
JP2001509784A (ja) 2001-07-24
EP0954606A1 (de) 1999-11-10
AU3146597A (en) 1997-12-05
CA2253969A1 (en) 1997-11-20
EP0954606B1 (de) 2003-10-15
ATE252158T1 (de) 2003-11-15
AU733647B2 (en) 2001-05-17
EP0954606A4 (de) 1999-12-22
WO1997043451A1 (en) 1997-11-20
US6130323A (en) 2000-10-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee