DE69719781D1 - Zwischenprodukte zur Herstellung von Duocarmycin SA und dessen Derivaten sowie ein Verfahren zur Herstellung der Zwischenprodukte - Google Patents
Zwischenprodukte zur Herstellung von Duocarmycin SA und dessen Derivaten sowie ein Verfahren zur Herstellung der ZwischenprodukteInfo
- Publication number
- DE69719781D1 DE69719781D1 DE69719781T DE69719781T DE69719781D1 DE 69719781 D1 DE69719781 D1 DE 69719781D1 DE 69719781 T DE69719781 T DE 69719781T DE 69719781 T DE69719781 T DE 69719781T DE 69719781 D1 DE69719781 D1 DE 69719781D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- intermediates
- derivatives
- duocarmycin
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000543 intermediate Substances 0.000 title abstract 3
- VQNATVDKACXKTF-UHFFFAOYSA-N Duocarmycin SA Natural products COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C(C64CC6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-UHFFFAOYSA-N 0.000 title abstract 2
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title abstract 2
- 229960005510 duocarmycin SA Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 150000005592 pyrroloindoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8246097A JPH1087666A (ja) | 1996-09-18 | 1996-09-18 | デュオカルマイシンsa及びその誘導体の製造中間体と製造方法 |
PCT/JP1997/002207 WO1998012197A1 (fr) | 1996-09-18 | 1997-06-26 | Produits intermediaires destines a la preparation de duocarmycine sa et de derives de ce dernier, et procede de production de ces produits intermediaires |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69719781D1 true DE69719781D1 (de) | 2003-04-17 |
Family
ID=17143451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69719781T Expired - Lifetime DE69719781D1 (de) | 1996-09-18 | 1997-06-26 | Zwischenprodukte zur Herstellung von Duocarmycin SA und dessen Derivaten sowie ein Verfahren zur Herstellung der Zwischenprodukte |
Country Status (10)
Country | Link |
---|---|
US (1) | US6066742A (de) |
EP (1) | EP0937726B1 (de) |
JP (1) | JPH1087666A (de) |
KR (1) | KR20000036211A (de) |
CN (1) | CN1090632C (de) |
AT (1) | ATE234304T1 (de) |
AU (1) | AU3274997A (de) |
CA (1) | CA2266505A1 (de) |
DE (1) | DE69719781D1 (de) |
WO (1) | WO1998012197A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
EP1193270B1 (de) | 1998-08-27 | 2003-05-14 | Spirogen Limited | Pyrrolobenzodiazepine |
US6909006B1 (en) * | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
KR20030033007A (ko) * | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제 |
GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
CA2564076C (en) * | 2004-05-19 | 2014-02-18 | Medarex, Inc. | Chemical linkers and conjugates thereof |
CN101124249B (zh) * | 2005-02-18 | 2011-06-29 | 米德列斯公司 | 抗***特异性膜抗原(psma)的人单克隆抗体 |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
BRPI0617546A2 (pt) * | 2005-09-26 | 2011-07-26 | Medarex Inc | conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto |
CA2627046C (en) | 2005-10-26 | 2015-09-15 | Medarex, Inc. | Methods and compounds for preparing cc-1065 analogs |
CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
TW200900059A (en) | 2007-02-21 | 2009-01-01 | Medarex Inc | Chemical linkers with single amino acids and conjugates thereof |
AU2011215900A1 (en) | 2010-02-10 | 2012-07-26 | Immunogen, Inc. | CD20 antibodies and uses thereof |
JP6133431B2 (ja) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用 |
US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
AU2015242213A1 (en) | 2015-07-12 | 2018-03-08 | Hangzhou Dac Biotech Co., Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
KR20220147720A (ko) | 2016-11-14 | 2022-11-03 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0527189A1 (de) * | 1990-04-25 | 1993-02-17 | PHARMACIA & UPJOHN COMPANY | Cc-1065-anlaloge |
JP3037965B2 (ja) * | 1990-06-20 | 2000-05-08 | 財団法人相模中央化学研究所 | 2―アルコキシカルボニル―2―メチル―1―オキソ―1,2,3,6,7,8―ヘキサヒドロ―ベンゾ〔1,2―b;4,3―b´〕ジピロール誘導体 |
GB9213623D0 (en) * | 1992-06-26 | 1992-08-12 | Pfizer Ltd | Therapeutic agents |
JPH06116270A (ja) * | 1992-08-21 | 1994-04-26 | Kyorin Pharmaceut Co Ltd | テトラヒドロピロロインドール誘導体及びその製法並びにその中間体 |
-
1996
- 1996-09-18 JP JP8246097A patent/JPH1087666A/ja active Pending
-
1997
- 1997-06-26 DE DE69719781T patent/DE69719781D1/de not_active Expired - Lifetime
- 1997-06-26 KR KR1019997002272A patent/KR20000036211A/ko not_active Application Discontinuation
- 1997-06-26 US US09/254,515 patent/US6066742A/en not_active Expired - Fee Related
- 1997-06-26 WO PCT/JP1997/002207 patent/WO1998012197A1/ja not_active Application Discontinuation
- 1997-06-26 EP EP97928473A patent/EP0937726B1/de not_active Expired - Lifetime
- 1997-06-26 CA CA002266505A patent/CA2266505A1/en not_active Abandoned
- 1997-06-26 CN CN97198004A patent/CN1090632C/zh not_active Expired - Fee Related
- 1997-06-26 AU AU32749/97A patent/AU3274997A/en not_active Abandoned
- 1997-06-26 AT AT97928473T patent/ATE234304T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1090632C (zh) | 2002-09-11 |
CN1230960A (zh) | 1999-10-06 |
ATE234304T1 (de) | 2003-03-15 |
AU3274997A (en) | 1998-04-14 |
EP0937726A4 (de) | 2001-04-11 |
EP0937726A1 (de) | 1999-08-25 |
EP0937726B1 (de) | 2003-03-12 |
KR20000036211A (ko) | 2000-06-26 |
WO1998012197A1 (fr) | 1998-03-26 |
CA2266505A1 (en) | 1998-03-26 |
JPH1087666A (ja) | 1998-04-07 |
US6066742A (en) | 2000-05-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |