ATE211474T1 - Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente - Google Patents

Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente

Info

Publication number
ATE211474T1
ATE211474T1 AT94115961T AT94115961T ATE211474T1 AT E211474 T1 ATE211474 T1 AT E211474T1 AT 94115961 T AT94115961 T AT 94115961T AT 94115961 T AT94115961 T AT 94115961T AT E211474 T1 ATE211474 T1 AT E211474T1
Authority
AT
Austria
Prior art keywords
compounds
galanthamin
medications
derivatives
production
Prior art date
Application number
AT94115961T
Other languages
English (en)
Inventor
Raymond W Kosley Jr
Larry Davis
Veronica Taberna
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE211474T1 publication Critical patent/ATE211474T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
AT94115961T 1993-10-15 1994-10-10 Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente ATE211474T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/137,444 US6316439B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number Publication Date
ATE211474T1 true ATE211474T1 (de) 2002-01-15

Family

ID=22477461

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94115961T ATE211474T1 (de) 1993-10-15 1994-10-10 Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente

Country Status (23)

Country Link
US (1) US6316439B1 (de)
EP (1) EP0649846B1 (de)
JP (1) JP2664343B2 (de)
KR (1) KR100227957B1 (de)
CN (1) CN1039910C (de)
AT (1) ATE211474T1 (de)
AU (1) AU696170B2 (de)
CA (1) CA2118172C (de)
CZ (1) CZ283731B6 (de)
DE (1) DE69429570T2 (de)
DK (1) DK0649846T3 (de)
EG (1) EG20726A (de)
ES (1) ES2170759T3 (de)
FI (1) FI108722B (de)
IL (1) IL111275A (de)
NO (1) NO307464B1 (de)
NZ (1) NZ264682A (de)
PL (1) PL177549B1 (de)
PT (1) PT649846E (de)
RO (1) RO114134B1 (de)
RU (1) RU2109743C1 (de)
TW (1) TW289754B (de)
ZA (1) ZA948061B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
EP2311463A1 (de) * 1999-12-10 2011-04-20 Bonnie M. Davis Analoga des galanthamins und lycoramins als modulatoren von nikotinrezeptoren
US6849638B2 (en) * 2001-04-30 2005-02-01 Bayer Pharmaceuticals Corporation 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) * 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CA2552114A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
CA2590997A1 (en) * 2004-12-23 2006-07-06 Voyager Pharmaceutical Corporation Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer`s disease
PL1895994T3 (pl) * 2005-05-13 2011-02-28 Alza Corp Wielowarstwowy system podawania leków z barierą zabezpieczającą przed wypływaniem materiału ze zbiornika
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1937226A2 (de) * 2005-09-23 2008-07-02 Alza Corporation Transdermales galantaminzufuhrsystem
ES2463715T3 (es) 2008-04-14 2014-05-29 Neurodyn Life Sciences Inc. Derivados de galantamina como profármacos para el tratamiento de enfermedades del cerebro humano
US20110098278A1 (en) * 2009-07-23 2011-04-28 Shire Llc Galantamine amino acid and peptide prodrugs and uses thereof
AU2015258814B2 (en) * 2014-05-16 2018-04-05 Synaptec Development Llc Clearance of amyloid ss
EP4029867A1 (de) 2021-01-13 2022-07-20 Alpha Cognition Inc. Feste formen von galantaminbenzoat-gluconat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
WO1988008708A1 (en) * 1987-05-04 1988-11-17 Bonnie Davis Compounds for the treatment of alzheimer's disease
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
JP3291730B2 (ja) 1991-05-14 2002-06-10 エルニア スノラソン 疲労症候群の治療
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
IL111275A (en) 2003-01-12
JP2664343B2 (ja) 1997-10-15
KR950011445A (ko) 1995-05-15
NO307464B1 (no) 2000-04-10
NZ264682A (en) 1995-07-26
ZA948061B (en) 1995-06-06
CZ254594A3 (en) 1995-07-12
NO943895D0 (no) 1994-10-14
AU696170B2 (en) 1998-09-03
US6316439B1 (en) 2001-11-13
EP0649846A1 (de) 1995-04-26
CA2118172C (en) 2000-01-04
DE69429570T2 (de) 2002-08-29
DE69429570D1 (de) 2002-02-07
KR100227957B1 (ko) 1999-11-01
RU2109743C1 (ru) 1998-04-27
PT649846E (pt) 2002-06-28
FI108722B (fi) 2002-03-15
TW289754B (de) 1996-11-01
RU94036745A (ru) 1996-12-10
IL111275A0 (en) 1994-12-29
JPH07188239A (ja) 1995-07-25
PL177549B1 (pl) 1999-12-31
CN1108657A (zh) 1995-09-20
DK0649846T3 (da) 2002-04-15
AU7581394A (en) 1995-05-04
ES2170759T3 (es) 2002-08-16
EP0649846B1 (de) 2002-01-02
EG20726A (en) 1999-12-29
NO943895L (no) 1995-04-18
PL305457A1 (en) 1995-04-18
FI944823A0 (fi) 1994-10-13
RO114134B1 (ro) 1999-01-29
CN1039910C (zh) 1998-09-23
CZ283731B6 (cs) 1998-06-17
FI944823A (fi) 1995-04-16
CA2118172A1 (en) 1995-04-16

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UEP Publication of translation of european patent specification