DE69718026D1 - Fluorierte 1,4-disubstituierte piperidin-derivate - Google Patents

Fluorierte 1,4-disubstituierte piperidin-derivate

Info

Publication number
DE69718026D1
DE69718026D1 DE69718026T DE69718026T DE69718026D1 DE 69718026 D1 DE69718026 D1 DE 69718026D1 DE 69718026 T DE69718026 T DE 69718026T DE 69718026 T DE69718026 T DE 69718026T DE 69718026 D1 DE69718026 D1 DE 69718026D1
Authority
DE
Germany
Prior art keywords
fluored
piperidine derivatives
disubstituted piperidine
disubstituted
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69718026T
Other languages
English (en)
Other versions
DE69718026T2 (de
Inventor
Ltd Tsuchiya
Ltd Nomoto
Ltd Ohsawa
Ltd Kawakami
Ltd Ohwaki
Ltd Nishikibe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of DE69718026D1 publication Critical patent/DE69718026D1/de
Publication of DE69718026T2 publication Critical patent/DE69718026T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69718026T 1996-08-01 1997-07-28 Fluorierte 1,4-disubstituierte piperidin-derivate Expired - Lifetime DE69718026T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21943696 1996-08-01
JP5397997 1997-02-21
PCT/JP1997/002600 WO1998005641A1 (fr) 1996-08-01 1997-07-28 Derives de piperidine fluores a disubstitution en position 1,4

Publications (2)

Publication Number Publication Date
DE69718026D1 true DE69718026D1 (de) 2003-01-30
DE69718026T2 DE69718026T2 (de) 2003-07-10

Family

ID=26394715

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69718026T Expired - Lifetime DE69718026T2 (de) 1996-08-01 1997-07-28 Fluorierte 1,4-disubstituierte piperidin-derivate

Country Status (29)

Country Link
US (2) US5948792A (de)
EP (1) EP0930298B1 (de)
JP (1) JP3063164B2 (de)
KR (1) KR20000022214A (de)
CN (1) CN1226888A (de)
AR (3) AR008272A1 (de)
AT (1) ATE229941T1 (de)
AU (1) AU716050B2 (de)
BG (1) BG103114A (de)
BR (1) BR9711108A (de)
CA (1) CA2261680C (de)
CO (1) CO4960641A1 (de)
CZ (1) CZ33199A3 (de)
DE (1) DE69718026T2 (de)
EE (1) EE9900038A (de)
ES (1) ES2188961T3 (de)
HR (1) HRP970426A2 (de)
HU (1) HUP9902381A3 (de)
ID (1) ID17259A (de)
IL (1) IL127685A0 (de)
IS (1) IS4960A (de)
NO (1) NO990472L (de)
NZ (1) NZ333842A (de)
PE (1) PE92198A1 (de)
PL (1) PL331431A1 (de)
SK (1) SK12299A3 (de)
TR (2) TR199900204T2 (de)
WO (1) WO1998005641A1 (de)
YU (1) YU1299A (de)

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ATE299494T1 (de) 1999-12-07 2005-07-15 Theravance Inc Carbamat-derivate als muscarin-rezeptor antonisten
ATE356624T1 (de) * 1999-12-17 2007-04-15 Sanofi Aventis Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
US6469172B2 (en) 2000-03-08 2002-10-22 Merck & Co., Inc. Process for the preparation of chemical compounds
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SI1345937T1 (sl) 2000-12-22 2006-02-28 Almirall Prodesfarma Ag Derivati kinulidinkarbamata in njihova uporaba kot M3 antagonisti
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JP2006518707A (ja) 2002-12-10 2006-08-17 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしての３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体
WO2004054560A1 (en) 2002-12-13 2004-07-01 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
AU2002347553A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
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BRPI0409302A (pt) * 2003-04-11 2006-04-11 Ranbaxy Lab Ltd derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
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Also Published As

Publication number Publication date
ATE229941T1 (de) 2003-01-15
HUP9902381A3 (en) 2000-06-28
TR199900204T2 (xx) 2000-01-21
CN1226888A (zh) 1999-08-25
EP0930298A1 (de) 1999-07-21
US6040449A (en) 2000-03-21
HRP970426A2 (en) 1998-08-31
US5948792A (en) 1999-09-07
NO990472D0 (no) 1999-02-01
AR016877A2 (es) 2001-08-01
SK12299A3 (en) 2000-05-16
AU716050B2 (en) 2000-02-17
CZ33199A3 (cs) 1999-07-14
TR200001482T2 (tr) 2000-11-21
DE69718026T2 (de) 2003-07-10
KR20000022214A (ko) 2000-04-25
IS4960A (is) 1999-01-29
IL127685A0 (en) 1999-10-28
CA2261680A1 (en) 1998-02-12
HUP9902381A2 (hu) 1999-11-29
EP0930298B1 (de) 2002-12-18
BG103114A (en) 1999-11-30
PL331431A1 (en) 1999-07-19
CA2261680C (en) 2005-03-08
ID17259A (id) 1997-12-11
PE92198A1 (es) 1999-01-09
BR9711108A (pt) 1999-08-17
WO1998005641A1 (fr) 1998-02-12
ES2188961T3 (es) 2003-07-01
EP0930298A4 (de) 2000-06-07
YU1299A (sh) 2002-03-18
AR017021A1 (es) 2001-08-22
AR008272A1 (es) 1999-12-29
AU3635197A (en) 1998-02-25
NZ333842A (en) 2001-05-25
NO990472L (no) 1999-02-01
CO4960641A1 (es) 2000-09-25
EE9900038A (et) 1999-08-16
JP3063164B2 (ja) 2000-07-12

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