DE69714971T2 - Verfahren zur herstellung von purin-derivaten - Google Patents

Verfahren zur herstellung von purin-derivaten

Info

Publication number: DE69714971T2
Authority: DE; Germany
Prior art keywords: purine derivatives; intermediates; producing purine; purin; propanediol
Prior art date: 1996-01-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69714971T

Other languages

English (en)

Other versions

DE69714971D1 (de

DE69714971T3 (de

Inventor

B Arzeno

D Axt

C Beard

A Dvorak

R Fatheree

E Fisher

Yeun-Kwei Han

R Humphreys

P Lund

Linh Nguyen

Leslie Wren

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-26

Filing date

1997-01-21

Publication date

2003-05-28

1997-01-21 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2002-10-02 Publication of DE69714971D1 publication Critical patent/DE69714971D1/de

2003-05-28 Publication of DE69714971T2 publication Critical patent/DE69714971T2/de

2005-12-15 Application granted granted Critical

2005-12-15 Publication of DE69714971T3 publication Critical patent/DE69714971T3/de

2017-01-22 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69714971T 1996-01-26 1997-01-21 Verfahren zur herstellung von purin-derivaten Expired - Lifetime DE69714971T3 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US59207996A	1996-01-26	1996-01-26
US592079		1996-01-26
PCT/EP1997/000262 WO1997027198A1 (en)	1996-01-26	1997-01-21	Process for preparing purine derivatives

Publications (3)

Publication Number	Publication Date
DE69714971D1 DE69714971D1 (de)	2002-10-02
DE69714971T2 true DE69714971T2 (de)	2003-05-28
DE69714971T3 DE69714971T3 (de)	2005-12-15

Family

ID=24369197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69714971T Expired - Lifetime DE69714971T3 (de)	1996-01-26	1997-01-21	Verfahren zur herstellung von purin-derivaten

Country Status (10)

Country	Link
JP (1)	JP4094667B2 (de)
KR (1)	KR100491941B1 (de)
CN (1)	CN1064683C (de)
AT (1)	ATE222909T1 (de)
AU (1)	AU1543797A (de)
CA (1)	CA2243650C (de)
DE (1)	DE69714971T3 (de)
ES (1)	ES2180923T5 (de)
MX (1)	MX9805935A (de)
WO (1)	WO1997027198A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
JP2007505070A (ja) *	2003-09-11	2007-03-08	エフ．ホフマン−ラ　ロシュ　アーゲー	抗ウイルス性ヌクレオシド誘導体を製造する方法
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
WO2012163373A1 (en) *	2011-05-31	2012-12-06	Pharmathen S.A.	Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816447A (en) *	1981-08-26	1989-03-28	Merck & Co., Inc.	Anti-viral guanine compounds
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
AU618436B2 (en) *	1988-12-19	1991-12-19	Wellcome Foundation Limited, The	Antiviral cytosine and guanine derivatives
JP3225545B2 (ja) *	1991-09-18	2001-11-05	味の素株式会社	非環状ヌクレオシド類の製造法
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

1997
- 1997-01-21 KR KR10-1998-0705709A patent/KR100491941B1/ko not_active IP Right Cessation
- 1997-01-21 ES ES97901569T patent/ES2180923T5/es not_active Expired - Lifetime
- 1997-01-21 WO PCT/EP1997/000262 patent/WO1997027198A1/en active IP Right Grant
- 1997-01-21 DE DE69714971T patent/DE69714971T3/de not_active Expired - Lifetime
- 1997-01-21 JP JP52651797A patent/JP4094667B2/ja not_active Expired - Lifetime
- 1997-01-21 CA CA002243650A patent/CA2243650C/en not_active Expired - Lifetime
- 1997-01-21 AT AT97901569T patent/ATE222909T1/de active
- 1997-01-21 CN CN97192606A patent/CN1064683C/zh not_active Expired - Lifetime
- 1997-01-21 AU AU15437/97A patent/AU1543797A/en not_active Abandoned
1998
- 1998-07-23 MX MX9805935A patent/MX9805935A/es unknown

Also Published As

Publication number	Publication date
DE69714971D1 (de)	2002-10-02
CN1212693A (zh)	1999-03-31
JP4094667B2 (ja)	2008-06-04
CA2243650A1 (en)	1997-07-31
JP2000503977A (ja)	2000-04-04
WO1997027198A1 (en)	1997-07-31
CN1064683C (zh)	2001-04-18
AU1543797A (en)	1997-08-20
ES2180923T5 (es)	2005-10-16
DE69714971T3 (de)	2005-12-15
CA2243650C (en)	2006-08-15
KR19990081991A (ko)	1999-11-15
MX9805935A (es)	1998-11-30
ES2180923T3 (es)	2003-02-16
KR100491941B1 (ko)	2005-08-05
ATE222909T1 (de)	2002-09-15

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Legal Events

Date	Code	Title	Description
2003-08-28	8363	Opposition against the patent
2005-07-14	8366	Restricted maintained after opposition proceedings