CA2243650C - Process for preparing purine derivatives - Google Patents

Process for preparing purine derivatives Download PDF

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Publication number
CA2243650C
CA2243650C CA002243650A CA2243650A CA2243650C CA 2243650 C CA2243650 C CA 2243650C CA 002243650 A CA002243650 A CA 002243650A CA 2243650 A CA2243650 A CA 2243650A CA 2243650 C CA2243650 C CA 2243650C
Authority
CA
Canada
Prior art keywords
formula
compound
amino
group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002243650A
Other languages
English (en)
French (fr)
Other versions
CA2243650A1 (en
Inventor
Humberto B. Arzeno
Steven D. Axt
Colin C. Beard
Charles A. Dvorak
Paul R. Fatheree
Lawrence E. Fisher
Yeun-Kwei Han
Eric R. Humphreys
Jan P. Lund
Sam Linh Nguyen
Douglas Leslie Wren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2243650A1 publication Critical patent/CA2243650A1/en
Application granted granted Critical
Publication of CA2243650C publication Critical patent/CA2243650C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002243650A 1996-01-26 1997-01-21 Process for preparing purine derivatives Expired - Lifetime CA2243650C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59207996A 1996-01-26 1996-01-26
US08/592,079 1996-01-26
PCT/EP1997/000262 WO1997027198A1 (en) 1996-01-26 1997-01-21 Process for preparing purine derivatives

Publications (2)

Publication Number Publication Date
CA2243650A1 CA2243650A1 (en) 1997-07-31
CA2243650C true CA2243650C (en) 2006-08-15

Family

ID=24369197

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002243650A Expired - Lifetime CA2243650C (en) 1996-01-26 1997-01-21 Process for preparing purine derivatives

Country Status (10)

Country Link
JP (1) JP4094667B2 (de)
KR (1) KR100491941B1 (de)
CN (1) CN1064683C (de)
AT (1) ATE222909T1 (de)
AU (1) AU1543797A (de)
CA (1) CA2243650C (de)
DE (1) DE69714971T3 (de)
ES (1) ES2180923T5 (de)
MX (1) MX9805935A (de)
WO (1) WO1997027198A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
CA2537849A1 (en) * 2003-09-11 2005-03-17 F. Hoffmann-La Roche Ag Process for preparing antiviral nucleoside derivatives
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
WO2012163373A1 (en) * 2011-05-31 2012-12-06 Pharmathen S.A. Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
AU618436B2 (en) * 1988-12-19 1991-12-19 Wellcome Foundation Limited, The Antiviral cytosine and guanine derivatives
JP3225545B2 (ja) * 1991-09-18 2001-11-05 味の素株式会社 非環状ヌクレオシド類の製造法
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Also Published As

Publication number Publication date
CN1064683C (zh) 2001-04-18
ES2180923T5 (es) 2005-10-16
KR19990081991A (ko) 1999-11-15
AU1543797A (en) 1997-08-20
DE69714971D1 (de) 2002-10-02
DE69714971T3 (de) 2005-12-15
JP4094667B2 (ja) 2008-06-04
JP2000503977A (ja) 2000-04-04
ES2180923T3 (es) 2003-02-16
KR100491941B1 (ko) 2005-08-05
ATE222909T1 (de) 2002-09-15
DE69714971T2 (de) 2003-05-28
MX9805935A (es) 1998-11-30
CA2243650A1 (en) 1997-07-31
WO1997027198A1 (en) 1997-07-31
CN1212693A (zh) 1999-03-31

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US5756736A (en) Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6103901A (en) Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
EP0694547B1 (de) 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivate
US20040102462A1 (en) 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US6340756B1 (en) Process for preparing a 2-(2-amino-1, 6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
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Effective date: 20170123