DE69707901T2 - Verfahren zur herstellung von kontrastmitteln - Google Patents

Verfahren zur herstellung von kontrastmitteln

Info

Publication number: DE69707901T2
Authority: DE; Germany
Prior art keywords: carboxylic acid; contrasting agents; alkylation; phenyl; producing
Prior art date: 1996-08-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69707901T

Other languages

English (en)

Other versions

DE69707901D1 (de

Inventor

Trygve Gulbrandsen

Einar Ingvoldstad

Terje Holmaas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GE Healthcare AS

Original Assignee

Nycomed Imaging AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-29

Filing date

1997-08-29

Publication date

2002-07-18

1997-08-29 Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS

2001-12-06 Application granted granted Critical

2001-12-06 Publication of DE69707901D1 publication Critical patent/DE69707901D1/de

2002-07-18 Publication of DE69707901T2 publication Critical patent/DE69707901T2/de

2017-08-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Glass Compositions (AREA)
Hydrogenated Pyridines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)
Iron Core Of Rotating Electric Machines (AREA)

DE69707901T 1996-08-29 1997-08-29 Verfahren zur herstellung von kontrastmitteln Expired - Lifetime DE69707901T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9618055.9A GB9618055D0 (en)	1996-08-29	1996-08-29	Process
PCT/GB1997/002335 WO1998008805A1 (en)	1996-08-29	1997-08-29	Process for the preparation of contrast agents

Publications (2)

Publication Number	Publication Date
DE69707901D1 DE69707901D1 (de)	2001-12-06
DE69707901T2 true DE69707901T2 (de)	2002-07-18

Family

ID=10799119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69707901T Expired - Lifetime DE69707901T2 (de)	1996-08-29	1997-08-29	Verfahren zur herstellung von kontrastmitteln

Country Status (21)

Country	Link
EP (1)	EP0923537B1 (de)
JP (1)	JP4113587B2 (de)
KR (1)	KR100539647B1 (de)
CN (1)	CN1092182C (de)
AT (1)	ATE207880T1 (de)
AU (1)	AU717842B2 (de)
BG (1)	BG103288A (de)
BR (1)	BR9711358A (de)
CA (1)	CA2263426A1 (de)
CZ (1)	CZ296230B6 (de)
DE (1)	DE69707901T2 (de)
EE (1)	EE9900081A (de)
ES (1)	ES2167014T3 (de)
GB (1)	GB9618055D0 (de)
HU (1)	HUP9903852A3 (de)
IL (1)	IL128685A0 (de)
NO (1)	NO322141B1 (de)
NZ (1)	NZ334818A (de)
PL (1)	PL193698B1 (de)
SK (1)	SK26399A3 (de)
WO (1)	WO1998008805A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618056D0 (en) *	1996-08-29	1996-10-09	Nycomed Imaging As	Process
GB9903109D0 (en)	1999-02-11	1999-04-07	Nycomed Imaging As	Process
ITMI20010773A1 (it) *	2001-04-11	2002-10-11	Chemi Spa	Processo per la produzione di ioexolo ad elevata purezza
CN100344606C (zh) *	2005-12-28	2007-10-24	江苏省原子医学研究所	一种碘昔兰的制备方法
US20110021822A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
CN103058880B (zh) *	2011-10-21	2015-08-05	连云港润众制药有限公司	碘克沙醇及其合成中间体的制备方法
JP6506758B2 (ja)	2013-12-06	2019-04-24	ジーイー・ヘルスケア・アクスイェ・セルスカプ	非イオン性ｘ線造影剤の合成における中間体を精製するための代替プロセス
EP3077367B1 (de) *	2013-12-06	2018-07-11	GE Healthcare AS	Alternatives verfahren zur reinigung eines zwischenprodukts in der synthese von nichtionischen röntgenkontrastmitteln
CN104356023B (zh) *	2014-10-29	2016-04-13	武汉工程大学	一种碘曲仑的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2132530B1 (de) *	1971-04-07	1974-08-02	Guerbet Lab Andre
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
JP2568166B2 (ja) *	1982-10-01	1996-12-25	ニユコメド・イメージング・アクシェセルカペト	Ｘ線造影剤
US4584401A (en) *	1983-10-20	1986-04-22	Biophysica Foundation	Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
DE3689330T2 (de) *	1985-08-09	1994-05-19	Cook Imaging Corp	Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.

1996
- 1996-08-29 GB GBGB9618055.9A patent/GB9618055D0/en active Pending
1997
- 1997-08-29 AT AT97937743T patent/ATE207880T1/de not_active IP Right Cessation
- 1997-08-29 EE EEP199900081A patent/EE9900081A/xx unknown
- 1997-08-29 WO PCT/GB1997/002335 patent/WO1998008805A1/en active IP Right Grant
- 1997-08-29 SK SK263-99A patent/SK26399A3/sk unknown
- 1997-08-29 KR KR10-1999-7001685A patent/KR100539647B1/ko active IP Right Grant
- 1997-08-29 BR BR9711358A patent/BR9711358A/pt not_active Application Discontinuation
- 1997-08-29 PL PL97331821A patent/PL193698B1/pl unknown
- 1997-08-29 IL IL12868597A patent/IL128685A0/xx unknown
- 1997-08-29 NZ NZ334818A patent/NZ334818A/xx unknown
- 1997-08-29 JP JP51140198A patent/JP4113587B2/ja not_active Expired - Lifetime
- 1997-08-29 ES ES97937743T patent/ES2167014T3/es not_active Expired - Lifetime
- 1997-08-29 HU HU9903852A patent/HUP9903852A3/hu unknown
- 1997-08-29 CZ CZ0067099A patent/CZ296230B6/cs not_active IP Right Cessation
- 1997-08-29 CN CN97197523A patent/CN1092182C/zh not_active Expired - Lifetime
- 1997-08-29 EP EP97937743A patent/EP0923537B1/de not_active Expired - Lifetime
- 1997-08-29 CA CA002263426A patent/CA2263426A1/en not_active Abandoned
- 1997-08-29 DE DE69707901T patent/DE69707901T2/de not_active Expired - Lifetime
- 1997-08-29 AU AU40267/97A patent/AU717842B2/en not_active Ceased
1999
- 1999-02-25 NO NO19990890A patent/NO322141B1/no not_active IP Right Cessation
- 1999-03-26 BG BG103288A patent/BG103288A/xx unknown

Also Published As

Publication number	Publication date
NO990890L (no)	1999-02-25
NZ334818A (en)	2000-08-25
AU717842B2 (en)	2000-04-06
WO1998008805A1 (en)	1998-03-05
CZ67099A3 (cs)	1999-08-11
NO322141B1 (no)	2006-08-21
KR100539647B1 (ko)	2005-12-29
AU4026797A (en)	1998-03-19
ES2167014T3 (es)	2002-05-01
SK26399A3 (en)	2000-03-13
CN1092182C (zh)	2002-10-09
EP0923537B1 (de)	2001-10-31
PL331821A1 (en)	1999-08-02
IL128685A0 (en)	2000-01-31
CN1228762A (zh)	1999-09-15
JP4113587B2 (ja)	2008-07-09
BG103288A (en)	2000-01-31
ATE207880T1 (de)	2001-11-15
KR20000035944A (ko)	2000-06-26
HUP9903852A2 (hu)	2000-03-28
DE69707901D1 (de)	2001-12-06
GB9618055D0 (en)	1996-10-09
CZ296230B6 (cs)	2006-02-15
BR9711358A (pt)	1999-08-17
PL193698B1 (pl)	2007-03-30
EP0923537A1 (de)	1999-06-23
NO990890D0 (no)	1999-02-25
HUP9903852A3 (en)	2001-08-28
JP2000517313A (ja)	2000-12-26
EE9900081A (et)	1999-10-15
CA2263426A1 (en)	1998-03-05

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Legal Events

Date	Code	Title	Description
2002-11-28	8364	No opposition during term of opposition
2007-03-22	8327	Change in the person/name/address of the patent owner	Owner name: GE HEALTHCARE AS, OSLO, NO
2007-05-16	8328	Change in the person/name/address of the agent	Representative=s name: HAMMONDS RECHTSANWAELTE PATENTANWAELTE, 80539 MUENCHEN
2010-07-01	8328	Change in the person/name/address of the agent	Representative=s name: HAMMONDS LLP, LONDON, GB
2012-12-18	R082	Change of representative	Ref document number: 923537 Country of ref document: EP Representative=s name: J D REYNOLDS & CO., GB