DE69632152D1 - N-substituierte dioxothiazolidyl-benzamid-derivate und verfahren zu ihrer herstellung - Google Patents
N-substituierte dioxothiazolidyl-benzamid-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- DE69632152D1 DE69632152D1 DE69632152T DE69632152T DE69632152D1 DE 69632152 D1 DE69632152 D1 DE 69632152D1 DE 69632152 T DE69632152 T DE 69632152T DE 69632152 T DE69632152 T DE 69632152T DE 69632152 D1 DE69632152 D1 DE 69632152D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- denotes
- groups
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34834195 | 1995-12-18 | ||
JP34834195A JP3906935B2 (ja) | 1995-12-18 | 1995-12-18 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
PCT/JP1996/003664 WO1997022600A1 (fr) | 1995-12-18 | 1996-12-16 | Derives de la dioxothiazolidylbenzamide substitues en n et leur procede d'obtention |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69632152D1 true DE69632152D1 (de) | 2004-05-13 |
DE69632152T2 DE69632152T2 (de) | 2005-02-24 |
Family
ID=18396383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69632152T Expired - Fee Related DE69632152T2 (de) | 1995-12-18 | 1996-12-16 | N-substituierte dioxothiazolidyl-benzamid-derivate und verfahren zu ihrer herstellung |
Country Status (12)
Country | Link |
---|---|
US (1) | US5948803A (de) |
EP (1) | EP0881219B1 (de) |
JP (1) | JP3906935B2 (de) |
KR (1) | KR100492655B1 (de) |
CN (1) | CN1065863C (de) |
AT (1) | ATE263759T1 (de) |
AU (1) | AU705538B2 (de) |
CA (1) | CA2239245C (de) |
DE (1) | DE69632152T2 (de) |
HU (1) | HUP0000449A3 (de) |
TW (1) | TW339333B (de) |
WO (1) | WO1997022600A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147101A (en) * | 1995-06-02 | 2000-11-14 | Kyorin Pharmaceutical Co., Ltd. | N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same |
WO1998020871A1 (fr) * | 1996-11-08 | 1998-05-22 | Nippon Chemiphar Co., Ltd. | Agent diminuant la graisse viscerale |
WO1999032465A1 (en) * | 1997-12-19 | 1999-07-01 | Merck & Co., Inc. | Arylthiazolidinedione derivatives |
US6008237A (en) | 1997-12-19 | 1999-12-28 | Merck & Co., Inc. | Arylthiazolidinedione derivatives |
EP1194146B1 (de) * | 1999-06-18 | 2006-07-19 | Merck & Co., Inc. | Arylthiazolidinedione und aryloxa zolidinedion-derivate |
EP1194147B1 (de) | 1999-06-18 | 2007-01-10 | Merck & Co., Inc. | Arylthiazolidindion- und aryloxazolidinderivate |
WO2001014350A1 (fr) * | 1999-08-23 | 2001-03-01 | Kyorin Pharmaceutical Co., Ltd. | Derives de benzylthiazolidine-2,4-dione substitues |
DE60020375T2 (de) | 1999-08-23 | 2006-11-23 | Kyorin Pharmaceutical Co., Ltd. | Substituierte benzylthiazolidin-2,4-dion derivate |
WO2001014349A1 (fr) * | 1999-08-23 | 2001-03-01 | Kyorin Pharmaceutical Co., Ltd. | Derives de benzylthiazolidine-2,4-dione substitues |
ATE316071T1 (de) * | 1999-09-17 | 2006-02-15 | Kyorin Seiyaku Kk | O-anisamid-derivate |
AU2002222574A1 (en) | 2000-12-05 | 2002-06-18 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
US7329782B2 (en) * | 2001-06-12 | 2008-02-12 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
ATE355273T1 (de) | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
EP1837330B1 (de) * | 2003-05-12 | 2012-10-24 | Pfizer Products Inc. | Benzamidinhibitoren des P2X7-Rezeptors |
AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
JP2008504363A (ja) * | 2004-06-29 | 2008-02-14 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | P2x7受容体のベンズアミド阻害剤を利用する併用療法 |
EP1776352A1 (de) * | 2004-06-29 | 2007-04-25 | Pfizer Products Inc. | Verfahren zur herstellung von 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h[1,2,4]triazin-2-yl]benzamidderivativen durch entschützen der hydroxylgeschützten vorstufen |
AU2007220868B2 (en) * | 2006-02-28 | 2011-06-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
HUE028977T2 (en) | 2010-09-10 | 2017-02-28 | Epizyme Inc | A method for determining the suitability of human EZH2 inhibitors during treatment |
US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
WO2012118812A2 (en) | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
EP2836491B1 (de) | 2012-04-13 | 2016-12-07 | Epizyme, Inc. | Salzform eines menschlichen histonmethyltransferase-ezh2-inhibitors |
US9006242B2 (en) | 2012-10-15 | 2015-04-14 | Epizyme, Inc. | Substituted benzene compounds |
DK3057962T3 (da) | 2013-10-16 | 2023-11-06 | Epizyme Inc | Hydrochloridsaltform til ezh2-hæmning |
CN108929263B (zh) * | 2017-05-26 | 2022-07-22 | 中国医学科学院药物研究所 | 芳酰胺类Kv2.1抑制剂及其制备方法、药物组合物和用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6610081A (en) * | 1980-01-24 | 1981-07-30 | Senju Pharmaceutical Co., Ltd. | Thiazolidine derivatives |
JPS5728073A (en) * | 1980-07-29 | 1982-02-15 | Takeda Chem Ind Ltd | Inhibitor for aldose reducing enzyme |
US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
HU217432B (hu) * | 1988-03-08 | 2000-01-28 | Pfizer Inc. | Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények |
GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
JP3053490B2 (ja) * | 1991-02-25 | 2000-06-19 | 杏林製薬株式会社 | チアゾリジン−2,4−ジオン誘導体とその塩及び製造法 |
JPH04270273A (ja) * | 1991-02-25 | 1992-09-25 | Kyorin Pharmaceut Co Ltd | チアゾリジン−2,4−ジオン誘導体とその塩及びその製造法 |
FR2696743B1 (fr) * | 1992-10-12 | 1994-12-23 | Adir | Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
-
1995
- 1995-12-18 JP JP34834195A patent/JP3906935B2/ja not_active Expired - Fee Related
-
1996
- 1996-12-16 HU HU0000449A patent/HUP0000449A3/hu unknown
- 1996-12-16 US US09/077,899 patent/US5948803A/en not_active Expired - Fee Related
- 1996-12-16 CN CN96199100A patent/CN1065863C/zh not_active Expired - Fee Related
- 1996-12-16 DE DE69632152T patent/DE69632152T2/de not_active Expired - Fee Related
- 1996-12-16 AU AU20116/97A patent/AU705538B2/en not_active Ceased
- 1996-12-16 WO PCT/JP1996/003664 patent/WO1997022600A1/ja not_active Application Discontinuation
- 1996-12-16 KR KR10-1998-0704551A patent/KR100492655B1/ko not_active IP Right Cessation
- 1996-12-16 CA CA002239245A patent/CA2239245C/en not_active Expired - Fee Related
- 1996-12-16 AT AT96942555T patent/ATE263759T1/de not_active IP Right Cessation
- 1996-12-16 EP EP96942555A patent/EP0881219B1/de not_active Expired - Lifetime
- 1996-12-18 TW TW085115620A patent/TW339333B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100492655B1 (ko) | 2005-09-07 |
EP0881219A4 (de) | 2000-01-26 |
HUP0000449A3 (en) | 2001-04-28 |
AU705538B2 (en) | 1999-05-27 |
ATE263759T1 (de) | 2004-04-15 |
CN1065863C (zh) | 2001-05-16 |
HUP0000449A2 (hu) | 2001-02-28 |
JP3906935B2 (ja) | 2007-04-18 |
DE69632152T2 (de) | 2005-02-24 |
EP0881219B1 (de) | 2004-04-07 |
JPH09169746A (ja) | 1997-06-30 |
AU2011697A (en) | 1997-07-14 |
CN1205695A (zh) | 1999-01-20 |
EP0881219A1 (de) | 1998-12-02 |
US5948803A (en) | 1999-09-07 |
CA2239245C (en) | 2004-03-30 |
KR20000064428A (ko) | 2000-11-06 |
TW339333B (en) | 1998-09-01 |
CA2239245A1 (en) | 1997-06-26 |
WO1997022600A1 (fr) | 1997-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |