DE69615016T2 - Pentacyclische verbindungen - Google Patents

Pentacyclische verbindungen

Info

Publication number
DE69615016T2
DE69615016T2 DE69615016T DE69615016T DE69615016T2 DE 69615016 T2 DE69615016 T2 DE 69615016T2 DE 69615016 T DE69615016 T DE 69615016T DE 69615016 T DE69615016 T DE 69615016T DE 69615016 T2 DE69615016 T2 DE 69615016T2
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
alkynyl
alkyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69615016T
Other languages
English (en)
Other versions
DE69615016D1 (de
Inventor
Hirofumi-Daiichi Phar Terasawa
Ltd Soga
Takashi-Daiichi Pharm Ishiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14430058&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69615016(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69615016D1 publication Critical patent/DE69615016D1/de
Publication of DE69615016T2 publication Critical patent/DE69615016T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69615016T 1995-04-28 1996-04-25 Pentacyclische verbindungen Expired - Lifetime DE69615016T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10629595 1995-04-28
PCT/JP1996/001145 WO1996033998A1 (fr) 1995-04-28 1996-04-25 Composes pentacycliques

Publications (2)

Publication Number Publication Date
DE69615016D1 DE69615016D1 (de) 2001-10-11
DE69615016T2 true DE69615016T2 (de) 2002-05-02

Family

ID=14430058

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615016T Expired - Lifetime DE69615016T2 (de) 1995-04-28 1996-04-25 Pentacyclische verbindungen

Country Status (16)

Country Link
US (4) US6075140A (de)
EP (1) EP0826688B1 (de)
KR (1) KR100380875B1 (de)
CN (1) CN1094940C (de)
AT (1) ATE205213T1 (de)
BR (1) BR9608040B1 (de)
CA (1) CA2219675C (de)
DE (1) DE69615016T2 (de)
DK (1) DK0826688T3 (de)
EA (1) EA000701B1 (de)
ES (1) ES2164241T3 (de)
HK (1) HK1008529A1 (de)
NO (1) NO321942B1 (de)
PT (1) PT826688E (de)
TW (1) TW480262B (de)
WO (1) WO1996033998A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
CN1094940C (zh) * 1995-04-28 2002-11-27 第一制药株式会社 具有抗肿瘤活性的紫杉酚衍生物
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
EP1147226B1 (de) * 1999-01-27 2013-01-23 Folim G. Halaka Materialien und verfahren zur reinigung von polyelektrolyten
PT1221445E (pt) * 1999-10-15 2008-10-08 Daiichi Sankyo Co Ltd Compostos pentacíclicos derivados de taxamos
US6677456B2 (en) 1999-10-15 2004-01-13 Daiichi Pharmaceutical Co., Ltd. Pentacyclic taxan compound
BRPI0108024B8 (pt) * 2000-01-19 2021-05-25 Cadila Healthcare Ltd composto, processo para a preparação de um composto, composição farmacêutica, uso do composto, novo intermediário e processo para a preparação de um novo intermediário
US6362217B2 (en) * 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
US6987123B2 (en) 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
CA2468953C (en) * 2001-11-29 2010-05-11 Daiichi Pharmaceutical Co., Ltd. Taxane derivative crystal and method for preparing the same
US6787659B2 (en) 2001-12-11 2004-09-07 Barr Laboratories, Inc. Process for the production of oxandrolone
CN1617938A (zh) 2002-01-16 2005-05-18 戴诺生物技术有限公司 从单个样品中分离核酸和蛋白质的方法
ES2371947T3 (es) 2004-04-30 2012-01-11 Daiichi Sankyo Company, Limited Proceso para producir taxano pentacíclico.
JPWO2007049575A1 (ja) * 2005-10-25 2009-04-30 第一三共株式会社 アゼチジン環構造を有するタキサン化合物
CN100516067C (zh) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 具有抗肿瘤活性的紫杉酚衍生物
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
US8785669B2 (en) * 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
BR112013019352A2 (pt) 2011-01-31 2020-07-14 Cadila Healthcare Limited método para o tratamento de lipodistrofia, uso de um composto, dosagem diária, método de tratamento, composição farmacêutica, uso da composição farmacêutica e composto
WO2014174524A1 (en) 2013-04-22 2014-10-30 Cadila Healthcare Limited A novel composition for nonalcoholic fatty liver disease (nafld)
ES2889916T3 (es) 2013-05-30 2022-01-14 Cadila Healthcare Ltd Un procedimiento para la preparación de pirroles con actividades hipolipidémicas e hipocolesterémicas
TW201513857A (zh) 2013-07-05 2015-04-16 Cadila Healthcare Ltd 協同性組成物
IN2013MU02470A (de) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
IN2013MU02905A (de) 2013-09-06 2015-07-03 Cadila Healthcare Ltd
WO2017064635A2 (en) 2015-10-14 2017-04-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
WO2018104916A1 (en) 2016-12-09 2018-06-14 Cadila Healthcare Limited Treatment for primary biliary cholangitis
CN107188895B (zh) * 2017-04-17 2020-03-13 上海大学 C-13和c-14位结构改造的紫杉醇类化合物及其制备方法
CN108530400B (zh) * 2018-05-28 2022-07-12 上海大学 C-2位和c-4位修饰的1-去氧紫杉烷类化合物及其制备方法
CN110105368B (zh) * 2019-05-09 2022-01-07 上海大学 去氧紫杉烷类似物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5481010A (en) * 1991-07-16 1996-01-02 Centre National De La Recherche Scientifique 7-deacetoxy beccatine IV derivative and preparation and use thereof
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
DK0639186T3 (da) * 1992-04-17 1999-12-13 Abbott Lab Taxolderivater
ATE136460T1 (de) * 1992-07-01 1996-04-15 Bristol Myers Squibb Co Fluor-taxole mit antitumor-wirkung
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
JP3208517B2 (ja) * 1992-07-01 2001-09-17 ブリストル−マイヤーズ スクイブ カンパニー ７，８−シクロプロパタキサン類
DK1228759T3 (da) * 1993-03-22 2005-04-18 Univ Florida State Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CN1094940C (zh) * 1995-04-28 2002-11-27 第一制药株式会社 具有抗肿瘤活性的紫杉酚衍生物
US5780653A (en) * 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers

Also Published As

Publication number Publication date
CN1188477A (zh) 1998-07-22
AU5514596A (en) 1996-11-18
CA2219675A1 (en) 1996-10-31
AU704198B2 (en) 1999-04-15
WO1996033998A1 (fr) 1996-10-31
ATE205213T1 (de) 2001-09-15
EA000701B1 (ru) 2000-02-28
EP0826688A1 (de) 1998-03-04
PT826688E (pt) 2002-02-28
CN1094940C (zh) 2002-11-27
CA2219675C (en) 2009-08-18
BR9608040A (pt) 1999-01-12
DE69615016D1 (de) 2001-10-11
DK0826688T3 (da) 2001-10-22
EP0826688B1 (de) 2001-09-05
TW480262B (en) 2002-03-21
NO321942B1 (no) 2006-07-24
EA199700351A1 (ru) 1998-04-30
US6211363B1 (en) 2001-04-03
US20030162971A1 (en) 2003-08-28
EP0826688A4 (de) 1998-05-13
NO974912L (no) 1997-12-29
HK1008529A1 (en) 1999-07-16
BR9608040B1 (pt) 2010-02-23
US6646123B2 (en) 2003-11-11
US6545151B2 (en) 2003-04-08
KR19990008180A (ko) 1999-01-25
ES2164241T3 (es) 2002-02-16
KR100380875B1 (ko) 2003-10-10
US20010041796A1 (en) 2001-11-15
US6075140A (en) 2000-06-13
NO974912D0 (no) 1997-10-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition