DK1228759T3 - Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde - Google Patents

Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde

Info

Publication number
DK1228759T3
DK1228759T3 DK02009839T DK02009839T DK1228759T3 DK 1228759 T3 DK1228759 T3 DK 1228759T3 DK 02009839 T DK02009839 T DK 02009839T DK 02009839 T DK02009839 T DK 02009839T DK 1228759 T3 DK1228759 T3 DK 1228759T3
Authority
DK
Denmark
Prior art keywords
furyl
side chain
taxane
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK02009839T
Other languages
English (en)
Inventor
Ki-Byung Chai
Robert A Holton
Hossain Nadizadeh
Ronald J Biediger
Kasthuri Rengan
Yukio Suzuki
Hamid Idmoumaz
Chunlin Tao
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of DK1228759T3 publication Critical patent/DK1228759T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK02009839T 1993-03-22 1994-03-21 Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde DK1228759T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3485293A 1993-03-22 1993-03-22
US9471793A 1993-07-20 1993-07-20
EP94911675A EP0690867B1 (en) 1993-03-22 1994-03-21 Taxanes having furyl or thienyl substituted side-chain

Publications (1)

Publication Number Publication Date
DK1228759T3 true DK1228759T3 (da) 2005-04-18

Family

ID=26711460

Family Applications (5)

Application Number Title Priority Date Filing Date
DK94911675T DK0690867T3 (da) 1993-03-22 1994-03-21 Taxaner med furyl- eller thienylsubstitueret sidekæde
DK02019282T DK1260223T3 (da) 1993-03-22 1994-03-21 Taxaner med furyl- eller thienylsubstituerede sidekæde
DK94910982T DK0689436T3 (da) 1993-03-22 1994-03-21 Texaner, der ikke har en oxogruppe ved C-9, og farmaceutiske præparater, der indeholder disse
DK02009840T DK1227093T3 (da) 1993-03-22 1994-03-21 Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde
DK02009839T DK1228759T3 (da) 1993-03-22 1994-03-21 Farmaceutiske præparater indeholdende en taxan med en furyl- eller thienylsubstitueret sidekæde

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DK94911675T DK0690867T3 (da) 1993-03-22 1994-03-21 Taxaner med furyl- eller thienylsubstitueret sidekæde
DK02019282T DK1260223T3 (da) 1993-03-22 1994-03-21 Taxaner med furyl- eller thienylsubstituerede sidekæde
DK94910982T DK0689436T3 (da) 1993-03-22 1994-03-21 Texaner, der ikke har en oxogruppe ved C-9, og farmaceutiske præparater, der indeholder disse
DK02009840T DK1227093T3 (da) 1993-03-22 1994-03-21 Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde

Country Status (12)

Country Link
EP (6) EP1260223B1 (da)
JP (2) JPH08508469A (da)
AT (5) ATE284689T1 (da)
AU (3) AU6367994A (da)
CA (2) CA2158862C (da)
DE (5) DE69434373T2 (da)
DK (5) DK0690867T3 (da)
ES (5) ES2193155T3 (da)
IL (4) IL180090A0 (da)
PT (5) PT690867E (da)
SG (3) SG89298A1 (da)
WO (2) WO1994021651A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
ATE205213T1 (de) * 1995-04-28 2001-09-15 Daiichi Seiyaku Co Pentacyclische verbindungen
EP0855909A4 (en) * 1995-09-13 2000-06-07 Univ Florida State TAXANES WITH RADIOSENSITIZING EFFECT AND THEIR PHARMACEUTICAL PREPARATIONS
FR2745814B1 (fr) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2746797B1 (fr) * 1996-03-27 1998-06-19 Centre Nat Rech Scient Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation
CN1221412A (zh) * 1996-05-06 1999-06-30 佛罗里达州立大学 1－脱氧浆果赤霉素ⅲ,1－脱氧紫杉醇和1－脱氧紫杉醇类似物及其制备方法
AU4768797A (en) 1996-10-24 1998-05-15 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
AU776765B2 (en) * 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
WO2001057032A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 ester substituted taxanes as antitumor agents
CA2539975C (en) 2003-09-25 2012-11-20 Tapestry Pharmaceuticals, Inc. 9,10-.alpha.,.alpha.-oh-taxane analogs and methods for production thereof
SI1664033T1 (sl) * 2003-09-25 2008-04-30 Tapestry Pharmaceuticals Inc Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
GT200500041A (es) * 2004-03-05 2005-10-24 Taxanos con sustituyente lactiloxilo en el c7
BRPI0611959A2 (pt) * 2005-06-10 2011-12-20 Univ Florida State Res Found resolução de misturas enantioméricas de beta-lactamas
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6075458A (ja) * 1983-06-17 1985-04-27 Osaka Soda Co Ltd ３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
US4751299A (en) * 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
JPS61243079A (ja) * 1985-04-01 1986-10-29 Mect Corp １−（アルコキシカルボニルアルキル）−４−（２−フリル）−３−置換−２−アゼチジノン及びその製造方法
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
AU637109B2 (en) * 1989-06-22 1993-05-20 Rijksuniversiteit Utrecht Improved synthesis of beta-lactams using a metal compound
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
ES2141727T3 (es) * 1991-09-23 2000-04-01 Univ Florida State Derivados de 10-desacetoxitaxol.
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
CZ290590B6 (en) * 1991-09-23 2002-08-14 Beta-Lactams useful for preparation of substituted isoserine esters using metal alkoxides
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
FR2688518B1 (fr) * 1992-03-13 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
ES2134847T3 (es) * 1992-04-17 1999-10-16 Abbott Lab Derivados de taxol.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.

Also Published As

Publication number Publication date
EP0690867A1 (en) 1996-01-10
DK0689436T3 (da) 2004-03-29
EP1228759B1 (en) 2004-12-15
PT690867E (pt) 2003-06-30
EP1260223A1 (en) 2002-11-27
EP0690867B1 (en) 2003-02-19
DE69434190T2 (de) 2005-05-25
WO1994021250A1 (en) 1994-09-29
EP0689436A4 (da) 1996-02-07
DK1260223T3 (da) 2005-09-05
ATE254914T1 (de) 2003-12-15
EP1398028A2 (en) 2004-03-17
ATE284689T1 (de) 2005-01-15
CA2158454A1 (en) 1994-09-29
EP1227093A3 (en) 2002-08-07
PT1227093E (pt) 2005-09-30
DE69433355D1 (de) 2004-01-08
AU7863698A (en) 1998-10-01
ATE295363T1 (de) 2005-05-15
PT689436E (pt) 2004-04-30
CA2158862A1 (en) 1994-09-29
SG73401A1 (en) 2000-06-20
IL109052A0 (en) 1994-06-24
AU714180B2 (en) 1999-12-23
DE69432141T2 (de) 2003-07-31
DE69434374T2 (de) 2005-11-24
WO1994021651A1 (en) 1994-09-29
EP1227093B1 (en) 2005-05-11
AU6367994A (en) 1994-10-11
ES2241923T3 (es) 2005-11-01
IL190945A0 (en) 2009-02-11
CA2158862C (en) 2006-10-10
EP0690867A4 (en) 1996-03-20
AU6413894A (en) 1994-10-11
ES2211879T3 (es) 2004-07-16
IL180090A0 (en) 2007-05-15
PT1228759E (pt) 2005-04-29
PT1260223E (pt) 2005-09-30
ES2193155T3 (es) 2003-11-01
EP1398028A3 (en) 2004-03-24
JPH08508469A (ja) 1996-09-10
EP1227093A2 (en) 2002-07-31
DE69434373D1 (de) 2005-06-16
SG89298A1 (en) 2002-06-18
DE69434374D1 (de) 2005-06-16
AU691804B2 (en) 1998-05-28
ES2242807T3 (es) 2005-11-16
DK0690867T3 (da) 2003-06-10
DE69434190D1 (de) 2005-01-20
DE69433355T2 (de) 2004-05-27
EP1228759A2 (en) 2002-08-07
SG68049A1 (en) 2001-08-21
DK1227093T3 (da) 2005-08-29
DE69432141D1 (de) 2003-03-27
IL109052A (en) 2009-07-20
EP1260223B1 (en) 2005-05-11
EP1228759A3 (en) 2002-09-25
IL109050A0 (en) 1994-06-24
DE69434373T2 (de) 2006-03-09
ES2232694T3 (es) 2005-06-01
ATE232871T1 (de) 2003-03-15
ATE295164T1 (de) 2005-05-15
CA2158454C (en) 2006-05-23
JPH08508255A (ja) 1996-09-03
EP0689436A1 (en) 1996-01-03
EP0689436B1 (en) 2003-11-26

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