DE69609371D1 - Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen - Google Patents

Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Info

Publication number
DE69609371D1
DE69609371D1 DE69609371T DE69609371T DE69609371D1 DE 69609371 D1 DE69609371 D1 DE 69609371D1 DE 69609371 T DE69609371 T DE 69609371T DE 69609371 T DE69609371 T DE 69609371T DE 69609371 D1 DE69609371 D1 DE 69609371D1
Authority
DE
Germany
Prior art keywords
alkyl
aryl
substd
arylalkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69609371T
Other languages
English (en)
Other versions
DE69609371T2 (de
Inventor
Marie-Claude Viaud
Gerald Guillaumet
Daniel Mazeas
Herve Vandepoel
Pierre Renard
Bruno Pfeiffer
Philippe Delagrange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69609371D1 publication Critical patent/DE69609371D1/de
Application granted granted Critical
Publication of DE69609371T2 publication Critical patent/DE69609371T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
DE69609371T 1995-04-14 1996-04-11 Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen Expired - Fee Related DE69609371T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504504A FR2732969B1 (fr) 1995-04-14 1995-04-14 Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE69609371D1 true DE69609371D1 (de) 2000-08-24
DE69609371T2 DE69609371T2 (de) 2001-02-22

Family

ID=9478127

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609371T Expired - Fee Related DE69609371T2 (de) 1995-04-14 1996-04-11 Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Country Status (16)

Country Link
US (1) US5714495A (de)
EP (1) EP0737685B1 (de)
JP (1) JP3723274B2 (de)
CN (1) CN1058967C (de)
AT (1) ATE194839T1 (de)
AU (1) AU700071B2 (de)
CA (1) CA2174033C (de)
DE (1) DE69609371T2 (de)
DK (1) DK0737685T5 (de)
ES (1) ES2150642T3 (de)
FR (1) FR2732969B1 (de)
GR (1) GR3034620T3 (de)
NO (1) NO305988B1 (de)
NZ (1) NZ286360A (de)
PT (1) PT737685E (de)
ZA (1) ZA962934B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1178045T3 (da) * 1997-04-09 2003-06-23 Pfizer Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler
US5977131A (en) * 1997-04-09 1999-11-02 Pfizer Inc. Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TR200001079T2 (tr) 1997-10-20 2000-07-21 F.Hoffmann-La Roche Ag Bisiklik kinaz inhibitörleri.
EP1067931A1 (de) * 1998-04-02 2001-01-17 Merck & Co., Inc. (a New Jersey corp.) Gonadorelin antagonisten
US6025366A (en) * 1998-04-02 2000-02-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU3368299A (en) * 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6228867B1 (en) 1998-04-02 2001-05-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6110931A (en) * 1998-04-02 2000-08-29 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2326143A1 (en) * 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051231A1 (en) * 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US6696439B1 (en) 1999-02-26 2004-02-24 Eli Lilly And Company 5-HT1F agonists
BR0008479A (pt) * 1999-02-26 2002-01-29 Lilly Co Eli Agonistas de 5-ht 1f
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR0017038A (pt) * 1999-12-24 2003-01-07 Aventis Pharma Ltd Azaindóis
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US6921762B2 (en) 2001-11-16 2005-07-26 Amgen Inc. Substituted indolizine-like compounds and methods of use
EP1474420B1 (de) * 2002-02-01 2012-03-14 AstraZeneca AB Chinazoline verbindungen
AU2003214414B2 (en) 2002-03-28 2008-10-09 Eisai R & D Management Co., Ltd. Azaindoles as inhibitors of c-Jun N-terminal kinases
DE60316542T2 (de) 2002-03-28 2008-07-03 Eisai R&D Management Co., Ltd. 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen
AU2003257145B2 (en) 2002-08-02 2008-11-13 Merck Sharp & Dohme Corp. Substituted furo (2,3-b) pyridine derivatives
US7432375B2 (en) * 2003-03-06 2008-10-07 Eisai R & D Management Co., Ltd. JNK inhibitors
GB0305142D0 (en) * 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
EP1628975A2 (de) 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitoren
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
KR100958829B1 (ko) 2004-09-03 2010-05-25 주식회사유한양행 피롤로[2,3-ｃ]피리딘 유도체 및 그의 제조방법
US7642269B2 (en) * 2004-09-03 2010-01-05 Yuhan Corporation Pyrrolo[3,2-B]pyridine derivatives and processes for the preparation thereof
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
CN101305010A (zh) * 2005-09-01 2008-11-12 阿雷生物药品公司 Raf抑制剂化合物及其用法
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
CA2671354A1 (en) * 2006-12-08 2008-06-12 Takeda Pharmaceutical Company Limited Tricyclic compound and medical use thereof
WO2011109932A1 (en) * 2010-03-09 2011-09-15 F.Hoffmann-La Roche Ag Novel process for the manufacture of 5-halogenated-7-azaindoles
EP2940022B1 (de) * 2014-04-30 2020-09-02 Masarykova Univerzita Furopyridinen als Inhibitoren von Proteinkinasen
CN106045995B (zh) * 2016-06-13 2017-07-11 菏泽学院 一种5‑溴‑1H‑吡咯并[2,3‑b]吡啶的合成方法
TW202039481A (zh) 2018-12-21 2020-11-01 美商西建公司 Ripk2之噻吩并吡啶抑制劑

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5552428A (en) * 1992-06-24 1996-09-03 Instituto Farmacologico Lombardo-Iflo, S.A.S. Compounds effective in the treatment of circadian rhythms and related disorders, the novel pharmaceutical preparations and novel method of application
US6075037A (en) * 1994-06-09 2000-06-13 Smithkline Beecham Corporation Endothelin receptor antagonists
CA2195850A1 (en) * 1994-08-03 1996-02-15 Guillaume Lebaut Substituted indoles
US5541228A (en) * 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents

Also Published As

Publication number Publication date
ZA962934B (en) 1996-10-17
AU700071B2 (en) 1998-12-17
PT737685E (pt) 2000-10-31
CA2174033C (fr) 2001-07-24
DK0737685T3 (da) 2000-10-09
EP0737685B1 (de) 2000-07-19
CN1058967C (zh) 2000-11-29
CA2174033A1 (fr) 1996-10-15
CN1139111A (zh) 1997-01-01
ATE194839T1 (de) 2000-08-15
JP3723274B2 (ja) 2005-12-07
NO961457L (no) 1996-10-15
FR2732969B1 (fr) 1997-05-16
NZ286360A (en) 1997-09-22
ES2150642T3 (es) 2000-12-01
DK0737685T5 (da) 2001-01-02
AU5062996A (en) 1996-10-24
FR2732969A1 (fr) 1996-10-18
NO305988B1 (no) 1999-08-30
NO961457D0 (no) 1996-04-12
GR3034620T3 (en) 2001-01-31
EP0737685A1 (de) 1996-10-16
DE69609371T2 (de) 2001-02-22
US5714495A (en) 1998-02-03
JPH08291172A (ja) 1996-11-05

Similar Documents

Publication Publication Date Title
DE69609371T2 (de) Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DK131893D0 (da) 2-(substitueret methyl)-4-(substitueret ethoxy)-5-(lavere alkyl)-pyridinforbindelser, farmaceutisk praeparat, som indeholder saadanne samt anvendelse af en saadan forbindelse til fremstilling af et farmaceutisk praeparat
HUP0401293A2 (hu) Új dihidropteridinonok, eljárás előállításukra és alkalmazásuk gyógyszerként
DE69033915D1 (de) Xanthinderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Anwendung
NO933452L (no) Et terapeutisk middel for Parkinson's sykdom
DK393488D0 (da) N-((2-oxopyrrolidin-1-yl)acetyl)piperazinderivater og farmaceutisk praeparat mod senil demens
HUP0103020A2 (hu) Heterociklusos származékok mint FKBP inhibitorok, eljárás az előállításukra, köztitermékeik és ezeket tartalmazó gyógyszerkészítmények
DE69803894D1 (de) Heterozyclische Verbindungen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
DE69603309D1 (de) Tricyclische Amidverbindungen, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE69803648D1 (de) Metalloproteaseinhibitoren, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE68913167D1 (de) Indol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
HUP0004671A2 (hu) 5-Szubsztituált-3-oxadiazolil-1,6-naftiridin-2(1H)-on-származékok és ezeket tartalmazó gyógyszerkészítmények
DE69611594T2 (de) Tetrazyclische 1,4-Oxazinverbindungen, Verfahren zu ihrer Herstellung und dieseenthaltende pharmazeutische Zubereitungen
HUP0400304A2 (hu) Dihidroimidazo[5,1-a]-béta-karbolin-származékok, előállításuk és gyógyszerként való alkalmazásuk
ATE57913T1 (de) Catechinamide, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zubereitung.
NZ515355A (en) Cyclocarbamate derivatives as progesterone receptor modulators
ATE111467T1 (de) 4h-pyrrolo(1,2-a>thieno(3,2- f>(1,4>diazepinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
MY101878A (en) 1,3,4-thiadiazole
ATE1585T1 (de) Clavulansaeurederivate, ihre herstellung und sie enthaltende pharmazeutische praeparate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

8339 Ceased/non-payment of the annual fee