FR2799757B1 - Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2799757B1
FR2799757B1 FR9912900A FR9912900A FR2799757B1 FR 2799757 B1 FR2799757 B1 FR 2799757B1 FR 9912900 A FR9912900 A FR 9912900A FR 9912900 A FR9912900 A FR 9912900A FR 2799757 B1 FR2799757 B1 FR 2799757B1
Authority
FR
France
Prior art keywords
alkyl
group
alkoxy
polyhaloalkyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9912900A
Other languages
English (en)
Other versions
FR2799757A1 (fr
Inventor
Gerald Guillaumet
Marie Claude Viaud
De Poel Van
Philippe Delagrange
Caroline Bennejean
Pierre Renard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR9912900A priority Critical patent/FR2799757B1/fr
Priority to MXPA00009729A priority patent/MXPA00009729A/es
Priority to US09/689,578 priority patent/US6495543B1/en
Priority to CNB001304739A priority patent/CN1151152C/zh
Priority to EA200000948A priority patent/EA003666B1/ru
Priority to AU66502/00A priority patent/AU772126B2/en
Priority to ZA200005667A priority patent/ZA200005667B/xx
Priority to DE60001138T priority patent/DE60001138T2/de
Priority to CA002323720A priority patent/CA2323720C/fr
Priority to PT00402832T priority patent/PT1092717E/pt
Priority to AT00402832T priority patent/ATE230745T1/de
Priority to NZ507525A priority patent/NZ507525A/en
Priority to SI200030043T priority patent/SI1092717T1/xx
Priority to DK00402832T priority patent/DK1092717T3/da
Priority to PL00343187A priority patent/PL343187A1/xx
Priority to ES00402832T priority patent/ES2189730T3/es
Priority to JP2000314109A priority patent/JP3519357B2/ja
Priority to BR0004823-2A priority patent/BR0004823A/pt
Priority to EP00402832A priority patent/EP1092717B1/fr
Priority to HU0004007A priority patent/HUP0004007A3/hu
Priority to NO20005200A priority patent/NO317884B1/no
Priority to KR10-2000-0060725A priority patent/KR100460783B1/ko
Publication of FR2799757A1 publication Critical patent/FR2799757A1/fr
Priority to HK01106736A priority patent/HK1036061A1/xx
Application granted granted Critical
Publication of FR2799757B1 publication Critical patent/FR2799757B1/fr
Priority to US10/267,303 priority patent/US7235550B2/en
Priority to US10/267,238 priority patent/US6667304B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
FR9912900A 1999-10-15 1999-10-15 Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2799757B1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR9912900A FR2799757B1 (fr) 1999-10-15 1999-10-15 Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MXPA00009729A MXPA00009729A (es) 1999-10-15 2000-10-04 Compuestos de azaindol policiclicos nuevos, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
US09/689,578 US6495543B1 (en) 1999-10-15 2000-10-12 Polycyclic azaindole compounds
JP2000314109A JP3519357B2 (ja) 1999-10-15 2000-10-13 新規な多環式アザインドール化合物、それらの調製方法およびそれらを含有する薬学的組成物
AU66502/00A AU772126B2 (en) 1999-10-15 2000-10-13 New polycyclic azaindole compounds, a process for their preparation and pharmaceutical compositins containing them
ZA200005667A ZA200005667B (en) 1999-10-15 2000-10-13 Polycyclic azaindole compounds, a process for their preparation and pharmaceutical compositions containing them.
DE60001138T DE60001138T2 (de) 1999-10-15 2000-10-13 Polycyclische Azaindolderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CA002323720A CA2323720C (fr) 1999-10-15 2000-10-13 Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PT00402832T PT1092717E (pt) 1999-10-15 2000-10-13 Derivados policiclicos azaindolicos processo para a sua preparacao e as composicoes farmaceuticas que os contem
AT00402832T ATE230745T1 (de) 1999-10-15 2000-10-13 Polycyclische azaindolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
NZ507525A NZ507525A (en) 1999-10-15 2000-10-13 Polycyclic azaindole compounds
SI200030043T SI1092717T1 (en) 1999-10-15 2000-10-13 Polycyclic azaindole derivatives, process for their preparation and pharmaceutical compositions containing them
CNB001304739A CN1151152C (zh) 1999-10-15 2000-10-13 新的多环氮杂吲哚化合物,其制备方法及包含它们的药物组合物
PL00343187A PL343187A1 (en) 1999-10-15 2000-10-13 Novel polycyclic indole compounds, method of obtaining them and pharmacological compositions containing such compounds
ES00402832T ES2189730T3 (es) 1999-10-15 2000-10-13 Derivados policiclicos aza-indolinicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
EA200000948A EA003666B1 (ru) 1999-10-15 2000-10-13 Новые полициклические азаиндолы, способ их получения и фармацевтические композиции, содержащие их
BR0004823-2A BR0004823A (pt) 1999-10-15 2000-10-13 Compostos policìclicos de azaindol, processo para a preparação dos mesmos e composições farmacêuticas contendo os mesmos
EP00402832A EP1092717B1 (fr) 1999-10-15 2000-10-13 Dérivés polycycliques azaindolinques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
HU0004007A HUP0004007A3 (en) 1999-10-15 2000-10-13 New polycyclic azaindole derivatives, process for their preparation and pharmaceutical compositions containing them
DK00402832T DK1092717T3 (da) 1999-10-15 2000-10-13 Polycykliske azaindolforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske tilberedninger indeholdende disse
NO20005200A NO317884B1 (no) 1999-10-15 2000-10-16 Nye polycykliske azaindolforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
KR10-2000-0060725A KR100460783B1 (ko) 1999-10-15 2000-10-16 폴리시클릭 아자인돌 화합물, 이들을 제조하는 방법 및이들을 함유하는 약제 조성물
HK01106736A HK1036061A1 (en) 1999-10-15 2001-09-25 New polycyclic azaindole compounds, a process for their preparation and pharmaceutical compositions containing.
US10/267,303 US7235550B2 (en) 1999-10-15 2002-10-09 Polycyclic azaindole compounds
US10/267,238 US6667304B2 (en) 1999-10-15 2002-10-09 Polycyclic azaindole compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9912900A FR2799757B1 (fr) 1999-10-15 1999-10-15 Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2799757A1 FR2799757A1 (fr) 2001-04-20
FR2799757B1 true FR2799757B1 (fr) 2001-12-14

Family

ID=9550991

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9912900A Expired - Fee Related FR2799757B1 (fr) 1999-10-15 1999-10-15 Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (23)

Country Link
US (3) US6495543B1 (fr)
EP (1) EP1092717B1 (fr)
JP (1) JP3519357B2 (fr)
KR (1) KR100460783B1 (fr)
CN (1) CN1151152C (fr)
AT (1) ATE230745T1 (fr)
AU (1) AU772126B2 (fr)
BR (1) BR0004823A (fr)
CA (1) CA2323720C (fr)
DE (1) DE60001138T2 (fr)
DK (1) DK1092717T3 (fr)
EA (1) EA003666B1 (fr)
ES (1) ES2189730T3 (fr)
FR (1) FR2799757B1 (fr)
HK (1) HK1036061A1 (fr)
HU (1) HUP0004007A3 (fr)
MX (1) MXPA00009729A (fr)
NO (1) NO317884B1 (fr)
NZ (1) NZ507525A (fr)
PL (1) PL343187A1 (fr)
PT (1) PT1092717E (fr)
SI (1) SI1092717T1 (fr)
ZA (1) ZA200005667B (fr)

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US6269533B2 (en) * 1999-02-23 2001-08-07 Advanced Research Corporation Method of making a patterned magnetic recording head
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1132389A1 (fr) * 2000-03-06 2001-09-12 Vernalis Research Limited Nouveaux dérivés de l'azaindole pour le traitement de l'obésité
DE10143079A1 (de) * 2001-09-03 2003-05-15 Zentaris Ag Cyclische Indol- und Heteroindolderivate, deren Herstellung und Verwendung als Arzneimittel
US20050267303A1 (en) * 2001-09-04 2005-12-01 Zentaris Ag Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) * 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EA009193B1 (ru) 2002-11-28 2007-12-28 Сувен Лайф Сайенсиз Лимитед N-арилсульфонил-3-аминоалкоксииндолы
JP4571507B2 (ja) * 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
DE202007014474U1 (de) * 2007-10-16 2009-03-05 Schwan-Stabilo Cosmetics Gmbh & Co. Kg Aufgespritzte Applikatoren
CN102112480A (zh) * 2008-07-30 2011-06-29 菲尔若国际公司 1,6-二氢-2h-3-氧杂-6-氮杂-不对称引达省化合物
JP2012502928A (ja) * 2008-09-22 2012-02-02 メルク カナダ インコーポレイテッド Ｃｒｔｈ２受容体アンタゴニストとしてのアザインドール誘導体

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US3962236A (en) * 1972-02-14 1976-06-08 Ayerst Mckenna And Harrison Ltd. Oxazinoindole- and thiazinoindole derivatives
US3910901A (en) * 1972-02-14 1975-10-07 Ayerst Mckenna & Harrison Oxazinoindole- and thiazinoindole derivatives
US3912729A (en) * 1972-02-14 1975-10-14 Ayerst Mckenna & Harrison Oxazinoindole- and thiazinoindole derivatives
US3910903A (en) * 1974-02-14 1975-10-07 Ayerst Mckenna & Harrison Oxazinoindole- and thiazinoindole derivatives
US4012511A (en) * 1974-05-28 1977-03-15 Ayerst Mckenna & Harrison Ltd. Oxazinoindole derivatives useful as antidepressants
US4066763A (en) * 1975-07-07 1978-01-03 Ayerst Mckenna And Harrison Ltd. Thiazinoindoles useful as antidepressants
EP0183993A3 (fr) * 1984-11-16 1987-12-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2H-Imidazo[1',2':1,2]pyrrolo[3,4-b]pyridines et leur utilisation comme agents contre les mauvaises herbes
DE3674028D1 (de) * 1985-03-12 1990-10-18 Ciba Geigy Ag Heterocyclisch kondensierte pyridin-verbindungen als herbizide.
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
EP0572863A1 (fr) * 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag Pyrazinoindoles à activité sur le SNC
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
FR2732969B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2762598A1 (fr) * 1997-04-25 1998-10-30 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennnent
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2766824B1 (fr) * 1997-07-30 1999-09-10 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9902047D0 (en) * 1999-01-29 1999-03-17 Cerebrus Ltd Chemical compounds XI
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
CN101448012B (zh) * 2002-11-12 2013-04-24 雷特泽遥距管理有限责任公司 具有ip能力分区的数据存储设备

Also Published As

Publication number Publication date
DE60001138D1 (de) 2003-02-13
NO20005200D0 (no) 2000-10-16
EA200000948A1 (ru) 2001-04-23
EP1092717A2 (fr) 2001-04-18
EP1092717B1 (fr) 2003-01-08
HU0004007D0 (en) 2000-12-28
US7235550B2 (en) 2007-06-26
US20030134847A1 (en) 2003-07-17
CN1151152C (zh) 2004-05-26
DE60001138T2 (de) 2003-10-23
AU6650200A (en) 2001-04-26
JP2001114781A (ja) 2001-04-24
BR0004823A (pt) 2001-05-22
FR2799757A1 (fr) 2001-04-20
ZA200005667B (en) 2001-05-15
EA003666B1 (ru) 2003-08-28
CA2323720A1 (fr) 2001-04-15
KR100460783B1 (ko) 2004-12-09
ES2189730T3 (es) 2003-07-16
NO20005200L (no) 2001-04-17
US6667304B2 (en) 2003-12-23
SI1092717T1 (en) 2003-04-30
CA2323720C (fr) 2005-02-15
US6495543B1 (en) 2002-12-17
US20030105087A1 (en) 2003-06-05
CN1293195A (zh) 2001-05-02
ATE230745T1 (de) 2003-01-15
PL343187A1 (en) 2001-04-23
NZ507525A (en) 2001-09-28
NO317884B1 (no) 2004-12-27
KR20010067334A (ko) 2001-07-12
HUP0004007A2 (hu) 2001-05-28
PT1092717E (pt) 2003-04-30
JP3519357B2 (ja) 2004-04-12
AU772126B2 (en) 2004-04-08
HK1036061A1 (en) 2001-12-21
MXPA00009729A (es) 2002-06-04
DK1092717T3 (da) 2003-04-14
HUP0004007A3 (en) 2002-06-28
EP1092717A3 (fr) 2001-10-04

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