DE69528058D1 - Bmp-9 zusammensetzungen - Google Patents
Bmp-9 zusammensetzungenInfo
- Publication number
- DE69528058D1 DE69528058D1 DE69528058T DE69528058T DE69528058D1 DE 69528058 D1 DE69528058 D1 DE 69528058D1 DE 69528058 T DE69528058 T DE 69528058T DE 69528058 T DE69528058 T DE 69528058T DE 69528058 D1 DE69528058 D1 DE 69528058D1
- Authority
- DE
- Germany
- Prior art keywords
- bmp
- compositions
- proteins
- bone
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000037280 Growth Differentiation Factor 2 Human genes 0.000 title abstract 2
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dental Preparations (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/254,353 US6287816B1 (en) | 1991-06-25 | 1994-06-06 | BMP-9 compositions |
PCT/US1995/007084 WO1995033830A1 (en) | 1994-06-06 | 1995-06-05 | Bmp-9 compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69528058D1 true DE69528058D1 (de) | 2002-10-10 |
DE69528058T2 DE69528058T2 (de) | 2003-05-28 |
Family
ID=22963968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69528058T Expired - Fee Related DE69528058T2 (de) | 1994-06-06 | 1995-06-05 | Bmp-9 zusammensetzungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US6287816B1 (de) |
EP (2) | EP1230930A3 (de) |
JP (1) | JP3706133B2 (de) |
KR (1) | KR100255417B1 (de) |
AT (1) | ATE223486T1 (de) |
AU (1) | AU709869B2 (de) |
DE (1) | DE69528058T2 (de) |
WO (1) | WO1995033830A1 (de) |
Families Citing this family (78)
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---|---|---|---|---|
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5656593A (en) * | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
US20080070842A1 (en) * | 1991-11-04 | 2008-03-20 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
ATE238417T1 (de) * | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
DE69814352T3 (de) | 1997-02-07 | 2009-08-13 | Stryker Corp., Kalamazoo | Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
EP0980252B1 (de) | 1997-05-05 | 2004-10-06 | Curis, Inc. | Therapien zur behandlung von akutem nierenversagen |
EP0985149A1 (de) | 1997-05-30 | 2000-03-15 | Creative Biomolecules, Inc. | Verfahren zur bestimmung der gewebemorphogenese und morphogenesische tätigkeit |
US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
CA2349038C (en) * | 1998-11-13 | 2011-08-02 | Curis, Inc. | Methods of alleviating cancer symptoms |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
WO2001017547A2 (en) * | 1999-09-08 | 2001-03-15 | Genetics Institute, Inc. | Bmp-9 compositions and methods for inducing differentiation of cholinergic neurons |
US6723334B1 (en) * | 2000-03-01 | 2004-04-20 | Iowa State University Research Foundation, Inc. | Biologically compatible bone cements and orthopedic methods |
WO2002077006A1 (en) * | 2001-03-23 | 2002-10-03 | Human Genome Sciences, Inc. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
CA2438934A1 (en) * | 2001-02-23 | 2002-09-06 | Wyeth | Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp |
WO2002099037A2 (en) * | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
KR20050010778A (ko) | 2002-05-03 | 2005-01-28 | 밀레늄 바이올로직스 인코포레이티드 | 결합조직 자극 펩티드 |
JP4879482B2 (ja) * | 2002-05-17 | 2012-02-22 | ワイス・エルエルシー | 骨原性タンパク質を送達するための注入可能な固体ヒアルロン酸キャリア |
JP2007524376A (ja) * | 2003-03-27 | 2007-08-30 | チルドレンズ ホスピタル メディカル センター | 軟骨形成を誘導するfgf−18タンパク質、標的タンパク質、およびそれぞれをコードするヌクレオチド配列の使用 |
EP1675608B1 (de) | 2003-09-12 | 2007-03-21 | Wyeth | Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen |
ES2350939T3 (es) | 2004-03-10 | 2011-01-28 | Scil Technology Gmbh | Implantes recubiertos, su fabricación y uso de los mismos. |
CA2567405A1 (en) | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
EP2332977B1 (de) | 2004-07-23 | 2015-11-25 | Acceleron Pharma Inc. | AvtRII-Rezeptor-Polypeptide |
WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
US20060239951A1 (en) * | 2005-03-30 | 2006-10-26 | Alexandre Valentin | Methods for stimulating hair growth by administering BMPs |
DK1973559T3 (da) | 2005-11-23 | 2013-03-25 | Acceleron Pharma Inc | Activin-ActRIIa antagonister samt anvendelser til fremme af knoglevækst |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
US20090298761A1 (en) | 2006-05-17 | 2009-12-03 | Donald Engelman | Methods of treating cartilage defects using a soluble morphogenic protein complex |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
JP5452230B2 (ja) | 2006-12-21 | 2014-03-26 | ストライカー コーポレイション | 生物学的因子の結晶、高分子ゲルおよび粒子懸濁液を含む持続放出処方物 |
CN103920139B (zh) | 2007-02-01 | 2018-02-02 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂及在治疗或预防乳腺癌中的用途 |
TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
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DE102007006843A1 (de) | 2007-02-12 | 2008-08-14 | Bioregeneration Gmbh | Verfahren und Stützstruktur zum Kultivieren lebender Zellen |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
EP2187932B1 (de) | 2007-08-07 | 2015-01-28 | DePuy Synthes Products, LLC | Proteinformulierungen mit gdf-5 in wässriger saurer lösung |
CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
AU2009214629A1 (en) | 2008-02-13 | 2009-08-20 | Eric T. Choi | BMP-7 for use in treating vascular sclerosis |
CA2720845A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
TWI626945B (zh) | 2008-08-14 | 2018-06-21 | 艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
AU2010204985A1 (en) | 2009-01-13 | 2011-08-04 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
US20100204124A1 (en) | 2009-02-12 | 2010-08-12 | Mary Elizabeth Pecquet Goad | Compositions and Methods for Minimally-Invasive Systemic Delivery of Proteins Including TGF-Beta Superfamily Members |
AU2010213575B2 (en) | 2009-02-12 | 2013-11-14 | Stryker Corporation | Peripheral administration of proteins including TGF-beta superfamily members for systemic treatment of disorders and disease |
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EP2440576A4 (de) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | Verfahren zur erhöhung der zahl thermogener adipozyten |
KR20210034684A (ko) | 2009-06-12 | 2021-03-30 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
KR20120062874A (ko) * | 2009-09-09 | 2012-06-14 | 악셀레론 파마 인코포레이티드 | ActRIIb 길항제들와 이의 투약 및 용도 |
US20110224138A1 (en) | 2009-09-09 | 2011-09-15 | Julie Krop | Methods for treating pain induced by injuries and diseases of an articular joint |
EP2352750B1 (de) | 2009-09-17 | 2012-06-13 | Stryker Corporation | Puffer zur steuerung des ph-wertes knochenmorphogenetischer proteine |
US20110129469A1 (en) * | 2009-11-03 | 2011-06-02 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
EP2501400B1 (de) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib-proteine und varianten davon sowie ihre anwendung zur utrophin-induktion für therapien gegen muskuläre dystrophie |
EP2516456A1 (de) | 2009-12-22 | 2012-10-31 | Stryker Corporation | Bmp-7-varianten mit reduzierter immunogenität |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
KR101800596B1 (ko) | 2010-08-20 | 2017-11-22 | 와이어쓰 엘엘씨 | 디자이너 골형성 단백질 |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
JP2014502260A (ja) | 2010-11-08 | 2014-01-30 | アクセルロン ファーマ, インコーポレイテッド | Actriia結合剤およびその使用 |
US8613938B2 (en) | 2010-11-15 | 2013-12-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
CA2918486C (en) * | 2012-07-20 | 2020-12-08 | The Regents Of The University Of California | Methods for producing cartilage and bone |
US9833481B2 (en) * | 2012-09-01 | 2017-12-05 | Ken Muneoka | Method for articular cartilage and joint formation |
KR102279522B1 (ko) | 2012-11-02 | 2021-07-19 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
KR20160078375A (ko) * | 2013-10-17 | 2016-07-04 | 재단법인 제이씨비 공동생물과학연구소 | 박테리아로부터 발현 및 분리된 생체활성 재조합 bmp-9 단백질인 mb109 |
EP3154566B1 (de) | 2014-06-13 | 2022-08-03 | Acceleron Pharma Inc. | Actrii antagonist zur behandlung oder prävention eines hautulzers in einem patienten mit anämie |
GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
HUE062189T2 (hu) | 2014-12-03 | 2023-09-28 | Celgene Corp | Aktivin-ACTRII-antagonisták és alkalmazások mielodiszpláziás szindróma kezelésére |
SG11201707815RA (en) | 2015-06-05 | 2017-12-28 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
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US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
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US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US4968590A (en) | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
ATE231523T1 (de) | 1988-04-08 | 2003-02-15 | Stryker Corp | Osteogene vorrichtungen |
FR2636063B1 (fr) * | 1988-09-05 | 1993-04-30 | Centre Nat Rech Scient | Composes phenylpyrroliques utiles en tant que medicaments, leur preparation et leur application |
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DE69027961T2 (de) | 1989-09-06 | 1997-01-09 | Chichibu Onoda Cement Corp | Protein, DNA und ihre Verwendung |
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DE69129865T2 (de) | 1990-10-18 | 1999-03-04 | Stryker Corp., Kalamazoo, Mich. | Osteogene peptide |
WO1992007004A1 (en) | 1990-10-18 | 1992-04-30 | Creative Biomolecules, Inc. | Osteogenic protein |
KR100255415B1 (ko) * | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
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EP0601106B2 (de) | 1991-08-30 | 2003-11-05 | Curis, Inc. | Morphogen-induzierte Modulation von entzündlichen Antworten |
ATE162078T1 (de) * | 1992-09-16 | 1998-01-15 | Creative Biomolecules Inc | Morphogeninduzierte regenerierung der leber |
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-
1994
- 1994-06-06 US US08/254,353 patent/US6287816B1/en not_active Expired - Fee Related
-
1995
- 1995-06-05 KR KR1019960707067A patent/KR100255417B1/ko not_active IP Right Cessation
- 1995-06-05 EP EP01129313A patent/EP1230930A3/de not_active Withdrawn
- 1995-06-05 EP EP95923706A patent/EP0764208B1/de not_active Expired - Lifetime
- 1995-06-05 JP JP50125096A patent/JP3706133B2/ja not_active Expired - Fee Related
- 1995-06-05 WO PCT/US1995/007084 patent/WO1995033830A1/en active IP Right Grant
- 1995-06-05 AT AT95923706T patent/ATE223486T1/de not_active IP Right Cessation
- 1995-06-05 DE DE69528058T patent/DE69528058T2/de not_active Expired - Fee Related
- 1995-06-05 AU AU28170/95A patent/AU709869B2/en not_active Ceased
-
1996
- 1996-12-04 US US08/750,222 patent/US6034061A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH10503927A (ja) | 1998-04-14 |
US6287816B1 (en) | 2001-09-11 |
AU2817095A (en) | 1996-01-04 |
ATE223486T1 (de) | 2002-09-15 |
JP3706133B2 (ja) | 2005-10-12 |
AU709869B2 (en) | 1999-09-09 |
EP0764208B1 (de) | 2002-09-04 |
KR100255417B1 (ko) | 2000-05-01 |
EP0764208A1 (de) | 1997-03-26 |
US6034061A (en) | 2000-03-07 |
DE69528058T2 (de) | 2003-05-28 |
WO1995033830A1 (en) | 1995-12-14 |
EP1230930A3 (de) | 2002-11-27 |
EP1230930A2 (de) | 2002-08-14 |
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