DE69511240D1 - Derivate des hydroxamsäure als metalloproteinaseinhibitoren - Google Patents

Derivate des hydroxamsäure als metalloproteinaseinhibitoren

Info

Publication number
DE69511240D1
DE69511240D1 DE69511240T DE69511240T DE69511240D1 DE 69511240 D1 DE69511240 D1 DE 69511240D1 DE 69511240 T DE69511240 T DE 69511240T DE 69511240 T DE69511240 T DE 69511240T DE 69511240 D1 DE69511240 D1 DE 69511240D1
Authority
DE
Germany
Prior art keywords
metalloproteinas
inhibitors
derivatives
hydroxamic acid
hydroxamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69511240T
Other languages
English (en)
Other versions
DE69511240T2 (de
Inventor
Raymond Beckett
Mark Whittaker
Andrew Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of DE69511240D1 publication Critical patent/DE69511240D1/de
Application granted granted Critical
Publication of DE69511240T2 publication Critical patent/DE69511240T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE69511240T 1994-01-21 1995-01-23 Derivate des hydroxamsäure als metalloproteinaseinhibitoren Expired - Fee Related DE69511240T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401129A GB9401129D0 (en) 1994-01-21 1994-01-21 Hydroxamic acid derivatives as metalloproteinase inhibitors
PCT/GB1995/000120 WO1995019957A1 (en) 1994-01-21 1995-01-23 Hydroxamic acid derivatives as metalloproteinase inhibitors

Publications (2)

Publication Number Publication Date
DE69511240D1 true DE69511240D1 (de) 1999-09-09
DE69511240T2 DE69511240T2 (de) 1999-12-09

Family

ID=10749121

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69511240T Expired - Fee Related DE69511240T2 (de) 1994-01-21 1995-01-23 Derivate des hydroxamsäure als metalloproteinaseinhibitoren

Country Status (7)

Country Link
US (1) US5861436A (de)
EP (1) EP0740653B1 (de)
JP (1) JPH09508115A (de)
DE (1) DE69511240T2 (de)
ES (1) ES2133727T3 (de)
GB (1) GB9401129D0 (de)
WO (1) WO1995019957A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3827324B2 (ja) * 1994-01-22 2006-09-27 ブリテッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
GB9601042D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Medical use
GB9414157D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Medical use
AU711804B2 (en) 1995-11-23 1999-10-21 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US7608262B2 (en) * 1996-02-16 2009-10-27 The Kennedy Institute Of Rheumatology Methods of preventing or treating thrombosis with tumor necrosis factor antagonists
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
BR9712019A (pt) 1996-09-10 1999-08-24 British Biotech Pharm Derivados de cidos hirox-mico citoest ticos
EP0897908A1 (de) * 1997-08-19 1999-02-24 Roche Diagnostics GmbH 3-Aryl-Succinamido-Hydroxamsäuren, Prozesse zu ihrer Herstellung und diese Substanzen enthaltende Medikamente
CA2325741C (en) 1998-03-26 2007-05-08 Santen Pharmaceutical Co., Ltd. Urea derivatives having tnf- .alpha. production inhibitory effects
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
CA2339525A1 (en) 1998-08-05 2000-02-17 Santen Pharmaceutical Co., Ltd. Novel urea derivatives having nitrogen aromatic heterocycle
CN1342078A (zh) * 1999-01-13 2002-03-27 朱马制药有限公司 3－异噁唑烷酮及羟氨酸用于治疗感染的用途
GB9901863D0 (en) * 1999-01-29 1999-03-17 British Biotech Pharm Antibacterial agents
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
IL151250A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
WO2001070682A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
BR0109328A (pt) * 2000-03-21 2003-06-10 Procter & Gamble Inibidores de metaloprotease n-substituìdos, contendo cadeia lateral heterocìclica
US7098226B2 (en) * 2000-05-31 2006-08-29 Santen Pharmaceutical Co., Ltd. TNF-α production inhibitors
US20040192658A1 (en) * 2002-12-27 2004-09-30 Angiotech International Ag Compositions and methods of using collajolie
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
JP2006517960A (ja) * 2003-02-18 2006-08-03 ファイザー インコーポレイテッド Ｃ型肝炎ウイルスの阻害剤、それを使用する組成物および治療法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122359C (de) * 1964-03-06
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
US5310121A (en) * 1992-07-24 1994-05-10 Consilium Bulk Babcock Atlanta, Inc. Cold weather bulk stacker/reclaimer apparatus and method
JP3827324B2 (ja) * 1994-01-22 2006-09-27 ブリテッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤

Also Published As

Publication number Publication date
EP0740653A1 (de) 1996-11-06
DE69511240T2 (de) 1999-12-09
GB9401129D0 (en) 1994-03-16
EP0740653B1 (de) 1999-08-04
US5861436A (en) 1999-01-19
WO1995019957A1 (en) 1995-07-27
ES2133727T3 (es) 1999-09-16
JPH09508115A (ja) 1997-08-19

Similar Documents

Publication Publication Date Title
DE69511240T2 (de) Derivate des hydroxamsäure als metalloproteinaseinhibitoren
DE69519751T2 (de) Arylsulfonamido-substituierte hydroxamsäure derivate als inhibitoren von mmp und tnf
ATE325791T1 (de) Hydroxypipecolate-hydroxamsäure-derivative als mmp inhibitoren
DE69820906D1 (de) Hydroxamsäure-derivate als matrix metalloproteinaseinhibitoren
PT1070069E (pt) Derivados biciclicos do acido hidroxamico
ATE263147T1 (de) Derivate von aryloxyarylsulfonylamino hydroxyaminsäuren
DE69621830T2 (de) Alpha-substituierte arylsulphonamidohydroxamsaüre als tnf-alpha und matrix-metalloproteinase-inhibitoren
NO993836D0 (no) Arylsulfonyl-hydroksamsyre-derivater
DE69813616D1 (de) Cyclohexencarboxylate als inhibitoren der neuraminidase
NO993730L (no) Arylsulfonylamino-hydroksamsyrederivater
DE69725465D1 (de) 6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
PT927183E (pt) Inibidores espirociclicos de metaloproteases
DE69315662D1 (de) Aminderivate als Korrosionsinhibitoren
FI971784A (fi) Apolipoproteiini B-synteesin estäjiä
ATE279397T1 (de) Phtalazine derivate phosphodiesterase 4 inhibitoren
EE04241B1 (et) Apolipoproteiin-B sünteesi inhibiitorid
ATE240943T1 (de) Isochinolin derivate als urokinase inhibitoren
EA200000204A1 (ru) Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
EE03745B1 (et) Asendatud 4-bifenüül-4-hüdroksübutaanhappe derivaadid metalloproteaasimaatriksi inhibiitoritena
DE69526475T2 (de) 5-Alphareduktase-Inhibitoren
DE60012303D1 (de) Alkinylische hydroxamsäureverbindungen als tace inhibitoren
DE69802692D1 (de) Derivate der chinoloncarbonsäure
ID29966A (id) Sulfoniloksazolamina-sulfoniloksazolamina sebagai senyawa-senyawa aktif terapi
EE9600160A (et) Kinoliin-3-karboksamiidi ühendite kasutamine uuel otstarbel
EE9600127A (et) Kinoliin-3-karboksamiidi ühendite kasutamine uuel otstarbel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee