ATE279397T1 - Phtalazine derivate phosphodiesterase 4 inhibitoren - Google Patents

Phtalazine derivate phosphodiesterase 4 inhibitoren

Info

Publication number: ATE279397T1
Authority: AT; Austria
Prior art keywords: phtalazine; inhibitors; phosphodiesterase; derivatives; derivatives phosphodiesterase
Prior art date: 1998-07-21

Application number

AT99938229T

Other languages

English (en)

Inventor

Mauro Napoletano

Gabriele Norcini

Giancarlo Grancini

Franco Pellacini

Gian Marco Leali

Gabriele Morazzoni

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-21

Filing date

1999-07-13

Publication date

2004-10-15

1999-07-13 Application filed by Zambon Spa filed Critical Zambon Spa

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE279397T1 publication Critical patent/ATE279397T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

AT99938229T 1998-07-21 1999-07-13 Phtalazine derivate phosphodiesterase 4 inhibitoren ATE279397T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT98MI001670A ITMI981670A1 (it)	1998-07-21	1998-07-21	Derivati ftalazinici inibitori della fosfodiesterasi 4
PCT/EP1999/004904 WO2000005218A1 (en)	1998-07-21	1999-07-13	Phthalazine derivatives phosphodiesterase 4 inhibitors

Publications (1)

Publication Number	Publication Date
ATE279397T1 true ATE279397T1 (de)	2004-10-15

Family

ID=11380474

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99938229T ATE279397T1 (de)	1998-07-21	1999-07-13	Phtalazine derivate phosphodiesterase 4 inhibitoren

Country Status (35)

Country	Link
US (2)	US6329370B1 (de)
EP (2)	EP1097142B1 (de)
JP (1)	JP2002521370A (de)
KR (1)	KR20010087161A (de)
CN (1)	CN1127486C (de)
AP (1)	AP2000001993A0 (de)
AR (1)	AR019409A1 (de)
AT (1)	ATE279397T1 (de)
AU (1)	AU765457B2 (de)
BG (1)	BG105063A (de)
BR (1)	BR9911175A (de)
CA (1)	CA2338044A1 (de)
CO (1)	CO5090842A1 (de)
DE (1)	DE69921139T2 (de)
EA (1)	EA200100062A1 (de)
EE (1)	EE200100039A (de)
HK (1)	HK1039124B (de)
HR (1)	HRP20010057A2 (de)
HU (1)	HUP0102646A3 (de)
ID (1)	ID28874A (de)
IL (1)	IL139490A0 (de)
IS (1)	IS5772A (de)
IT (1)	ITMI981670A1 (de)
MX (1)	MXPA01000670A (de)
NO (1)	NO318988B1 (de)
NZ (1)	NZ507926A (de)
OA (1)	OA11582A (de)
PA (1)	PA8478301A1 (de)
PE (1)	PE20000755A1 (de)
PL (1)	PL345187A1 (de)
SK (1)	SK1002001A3 (de)
TW (1)	TW509682B (de)
UA (1)	UA68383C2 (de)
WO (1)	WO2000005218A1 (de)
YU (1)	YU77500A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CO4950519A1 (es) *	1997-02-13	2000-09-01	Novartis Ag	Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) *	1997-12-19	1999-08-03	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it)	1998-07-21	2000-01-21	Zambon Spa	Derivati ftalazinici inibitori della fosfodisterasi 4
DE19921567A1 (de)	1999-05-11	2000-11-16	Basf Ag	Verwendung von Phthalazine-Derivaten
DE19963607B4 (de) *	1999-12-23	2005-12-15	Schering Ag	Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
ITMI20000261A1 (it) *	2000-02-16	2001-08-16	Zambon Group	Processo per la preparazione di piridiniliden-ftalidi
WO2001079181A2 (en) *	2000-04-13	2001-10-25	Annovis, Inc.	Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors
US6525049B2 (en) *	2000-07-05	2003-02-25	Pharmacia & Upjohn Company	Pyrroloquinolones as antiviral agents
WO2002044157A2 (en) *	2000-12-01	2002-06-06	Iconix Pharmaceuticals, Inc.	Parb inhibitors
ITMI20022739A1 (it) *	2002-12-23	2004-06-24	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4.
ITMI20022738A1 (it) *	2002-12-23	2004-06-24	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4.
WO2004076386A2 (en)	2003-02-25	2004-09-10	Topotarget Uk Limited	Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
ITMI20031451A1 (it) *	2003-07-16	2005-01-17	Zambon Spa	Derivati diidro-ftalazinici inibitori della fosfodiesterasi 4
WO2006004589A2 (en) *	2004-05-08	2006-01-12	Neurogen Corporation	3-aryl-5,6-disubstituted pyridazines
CA2593005A1 (en) *	2005-01-03	2006-07-13	Myriad Genetics Inc.	Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
RU2008119323A (ru)	2005-10-19	2009-11-27	Рэнбакси Лабораториз Лимитед (In)	Фармацевтические композиции мускаринового рецептора
EP2131656A4 (de)	2006-11-15	2011-12-07	Forest Lab Holdings Ltd	Phthalazinderivate
US8969348B2 (en)	2008-08-13	2015-03-03	Boehringer Ingelheim International Gmbh	Chymase inhibitors
CN102108078B (zh) *	2009-12-24	2013-10-30	沈阳药科大学	1,4-取代酞嗪类化合物及其制备方法和用途
CN104203919A (zh) *	2011-11-09	2014-12-10	艾伯维德国有限责任两合公司	可用作10a型磷酸二酯酶的抑制剂的杂环甲酰胺类

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2063249A (en) *	1979-10-09	1981-06-03	Mitsubishi Yuka Pharma	4-Phenylphthalazine derivatives
JPH03106873A (ja) *	1989-09-20	1991-05-07	Morishita Pharmaceut Co Ltd	１―ピリジルフタラジン誘導体及びそれらを含有する血小板凝集抑制剤
DE69105572T2 (de) *	1990-03-30	1995-05-11	Mitsubishi Chem Ind	4-Phenylphthalazin-Derivate.
EP0634404A1 (de) *	1993-07-13	1995-01-18	Rhone Poulenc Agriculture Ltd.	Phtalazinderivate und deren Verwendung als pestizides Mittel
US5849741A (en) *	1994-08-09	1998-12-15	Eisai Co., Ltd.	Fused pyridazine compounds
IT1296984B1 (it) *	1997-12-19	1999-08-03	Zambon Spa	Derivati ftalazinici inibitori della fosfodiesterasi 4

1998
- 1998-07-21 IT IT98MI001670A patent/ITMI981670A1/it unknown
1999
- 1999-07-08 PE PE1999000670A patent/PE20000755A1/es not_active Application Discontinuation
- 1999-07-13 JP JP2000561174A patent/JP2002521370A/ja active Pending
- 1999-07-13 US US09/743,813 patent/US6329370B1/en not_active Expired - Fee Related
- 1999-07-13 KR KR1020017000971A patent/KR20010087161A/ko not_active Application Discontinuation
- 1999-07-13 ID IDW20010132A patent/ID28874A/id unknown
- 1999-07-13 EE EEP200100039A patent/EE200100039A/xx unknown
- 1999-07-13 AU AU52810/99A patent/AU765457B2/en not_active Ceased
- 1999-07-13 SK SK100-2001A patent/SK1002001A3/sk unknown
- 1999-07-13 IL IL13949099A patent/IL139490A0/xx not_active IP Right Cessation
- 1999-07-13 PL PL99345187A patent/PL345187A1/xx not_active Application Discontinuation
- 1999-07-13 HU HU0102646A patent/HUP0102646A3/hu unknown
- 1999-07-13 DE DE69921139T patent/DE69921139T2/de not_active Expired - Fee Related
- 1999-07-13 MX MXPA01000670A patent/MXPA01000670A/es not_active Application Discontinuation
- 1999-07-13 CN CN99807294A patent/CN1127486C/zh not_active Expired - Fee Related
- 1999-07-13 CA CA002338044A patent/CA2338044A1/en not_active Abandoned
- 1999-07-13 WO PCT/EP1999/004904 patent/WO2000005218A1/en not_active Application Discontinuation
- 1999-07-13 OA OA1200100019A patent/OA11582A/en unknown
- 1999-07-13 UA UA2001010439A patent/UA68383C2/uk unknown
- 1999-07-13 AT AT99938229T patent/ATE279397T1/de not_active IP Right Cessation
- 1999-07-13 EP EP99938229A patent/EP1097142B1/de not_active Expired - Lifetime
- 1999-07-13 EP EP03102377A patent/EP1371648A1/de not_active Withdrawn
- 1999-07-13 BR BR9911175-6A patent/BR9911175A/pt not_active IP Right Cessation
- 1999-07-13 NZ NZ507926A patent/NZ507926A/xx unknown
- 1999-07-13 EA EA200100062A patent/EA200100062A1/ru unknown
- 1999-07-13 YU YU77500A patent/YU77500A/sh unknown
- 1999-07-13 AP APAP/P/2000/001993A patent/AP2000001993A0/en unknown
- 1999-07-16 AR ARP990103501A patent/AR019409A1/es unknown
- 1999-07-19 TW TW088112218A patent/TW509682B/zh not_active IP Right Cessation
- 1999-07-19 PA PA19998478301A patent/PA8478301A1/es unknown
- 1999-07-19 CO CO99045518A patent/CO5090842A1/es unknown
2000
- 2000-12-15 IS IS5772A patent/IS5772A/is unknown
- 2000-12-18 BG BG105063A patent/BG105063A/xx unknown
2001
- 2001-01-19 NO NO20010331A patent/NO318988B1/no not_active IP Right Cessation
- 2001-01-22 HR HR20010057A patent/HRP20010057A2/hr not_active Application Discontinuation
- 2001-10-15 US US09/976,436 patent/US6492360B1/en not_active Expired - Fee Related
2002
- 2002-01-25 HK HK02100584.0A patent/HK1039124B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
MXPA01000670A (es)	2002-05-14
AU765457B2 (en)	2003-09-18
TW509682B (en)	2002-11-11
EE200100039A (et)	2002-06-17
SK1002001A3 (en)	2001-12-03
KR20010087161A (ko)	2001-09-15
UA68383C2 (en)	2004-08-16
CN1305467A (zh)	2001-07-25
EP1371648A1 (de)	2003-12-17
PE20000755A1 (es)	2000-09-01
BG105063A (en)	2001-07-31
US6492360B1 (en)	2002-12-10
IL139490A0 (en)	2001-11-25
CN1127486C (zh)	2003-11-12
CA2338044A1 (en)	2000-02-03
EP1097142A1 (de)	2001-05-09
HRP20010057A2 (en)	2002-04-30
AP2000001993A0 (en)	2000-12-31
ID28874A (id)	2001-07-12
EA200100062A1 (ru)	2001-08-27
EP1097142B1 (de)	2004-10-13
YU77500A (sh)	2002-11-15
DE69921139T2 (de)	2005-10-13
HUP0102646A2 (hu)	2001-12-28
AU5281099A (en)	2000-02-14
NZ507926A (en)	2002-10-25
AR019409A1 (es)	2002-02-20
HK1039124A1 (en)	2002-04-12
JP2002521370A (ja)	2002-07-16
PL345187A1 (en)	2001-12-03
US6329370B1 (en)	2001-12-11
HUP0102646A3 (en)	2003-01-28
NO20010331D0 (no)	2001-01-19
DE69921139D1 (de)	2004-11-18
HK1039124B (zh)	2005-04-01
ITMI981670A0 (it)	1998-07-21
NO20010331L (no)	2001-03-20
OA11582A (en)	2004-07-26
IS5772A (is)	2000-12-15
NO318988B1 (no)	2005-05-30
CO5090842A1 (es)	2001-10-30
BR9911175A (pt)	2001-03-20
ITMI981670A1 (it)	2000-01-21
PA8478301A1 (es)	2000-09-29
WO2000005218A1 (en)	2000-02-03

Legal Events

Date

Code

Title

Description

2005-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1097142

Country of ref document: EP

2006-10-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE279397T1 (de)	2004-10-15	Phtalazine derivate phosphodiesterase 4 inhibitoren
IL141445A0 (en)	2002-03-10	Benzazine derivatives as phosphodiesterase 4 inhibitors
HUP0103349A3 (en)	2003-01-28	Phthalazine derivatives as phosphodiesterase 4 inhibitors
NO20002121D0 (no)	2000-04-26	Benzotiazol-protein-tyrosin-kinaseinhibitorer
ATE245142T1 (de)	2003-08-15	No-synthase inhibitoren
NO20010193D0 (no)	2001-01-12	Tiobenzimidazol-derivater
DK0930302T3 (da)	2003-07-21	Benzosulfonderivater
NO20010514D0 (no)	2001-01-30	Aminometylkarboksylsyre-derivater
DE69832982D1 (de)	2006-02-02	Dolastatin 15 derivate
ATE259810T1 (de)	2004-03-15	Phenyl-xanthinderivate
DE69928262D1 (de)	2005-12-15	Substituierte chinazoline derivate
DE69811844T2 (de)	2003-12-04	Thiazole Derivate
DE69730962D1 (de)	2004-11-04	Alkylaminobenzothiazole und -benzoxazole derivate
IL141446A0 (en)	2002-03-10	Benzazine derivatives as phosphodiesterase 4 inhibitors
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
DE69904738D1 (de)	2003-02-06	2-phenylpyran-4-one derivate
ATE233253T1 (de)	2003-03-15	Chromanderivate
DK1134219T3 (da)	2005-10-17	Cucloalkylsubstituerede aminomethylpyrrolidinderivater
DK1060183T3 (da)	2003-08-11	5-deoxycytidinderivater
DE69805974T2 (de)	2003-02-20	5-aroylnaphthalin derivate
DE69917058D1 (de)	2004-06-09	Thiazole derivate
ATE238301T1 (de)	2003-05-15	Interleukin-5 hemmende 6-azauracil derivate
DE69838303D1 (de)	2007-10-04	Hydroxyprolin derivate
DK1077984T3 (da)	2003-09-15	2'-Deoxyhygromycin derivater
DE69709802D1 (de)	2002-02-28	Amythiamicin Amid-Derivate