DE69511181D1 - Mittel für Behandlung der Leber-Gallenerkrankungen - Google Patents

Mittel für Behandlung der Leber-Gallenerkrankungen

Info

Publication number
DE69511181D1
DE69511181D1 DE69511181T DE69511181T DE69511181D1 DE 69511181 D1 DE69511181 D1 DE 69511181D1 DE 69511181 T DE69511181 T DE 69511181T DE 69511181 T DE69511181 T DE 69511181T DE 69511181 D1 DE69511181 D1 DE 69511181D1
Authority
DE
Germany
Prior art keywords
treatment
bilious
agent
liver diseases
methyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69511181T
Other languages
English (en)
Other versions
DE69511181T2 (de
Inventor
Ryuji Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Application granted granted Critical
Publication of DE69511181D1 publication Critical patent/DE69511181D1/de
Publication of DE69511181T2 publication Critical patent/DE69511181T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69511181T 1994-06-03 1995-05-31 Mittel für Behandlung der Leber-Gallenerkrankungen Expired - Lifetime DE69511181T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12248794 1994-06-03

Publications (2)

Publication Number Publication Date
DE69511181D1 true DE69511181D1 (de) 1999-09-09
DE69511181T2 DE69511181T2 (de) 1999-12-02

Family

ID=14837070

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69511181T Expired - Lifetime DE69511181T2 (de) 1994-06-03 1995-05-31 Mittel für Behandlung der Leber-Gallenerkrankungen

Country Status (14)

Country Link
US (1) US5739161A (de)
EP (1) EP0690049B1 (de)
KR (1) KR100260573B1 (de)
CN (1) CN1076605C (de)
AT (1) ATE182884T1 (de)
AU (1) AU690241B2 (de)
CA (1) CA2150287C (de)
DE (1) DE69511181T2 (de)
DK (1) DK0690049T3 (de)
ES (1) ES2137456T3 (de)
FI (1) FI952721A (de)
GR (1) GR3031066T3 (de)
NO (1) NO308993B1 (de)
NZ (1) NZ272234A (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE29717252U1 (de) * 1997-09-26 1998-02-19 Dr. Falk Pharma GmbH, 79108 Freiburg Arzneimittelkit aus einem Budesonid-haltigen und einem Ursodesoxycholsäure-haltigen Arzneimittel zur Behandlung von cholestatischen Lebererkrankungen
TWI225398B (en) 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
DE60010913T2 (de) 1999-10-15 2005-06-09 Sucampo Ag Bizyklische Verbindungen, Zusammenstellung und Verfahren zu ihrer Stabilisierung
AU2001239551B8 (en) 2000-03-24 2005-11-24 Sucampo Ag Apoptosis inhibiting composition comprising a 15-keto-prostaglandin or derivative thereof
ATE433754T1 (de) * 2000-04-06 2009-07-15 Sucampo Ag Gallensäurefördernde zusammensetzung für lebertransplantation welche ein 15-keto prostaglandin enthält
US6414016B1 (en) 2000-09-05 2002-07-02 Sucampo, A.G. Anti-constipation composition
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
NZ531503A (en) 2001-08-31 2006-01-27 Sucampo Ag Prostaglandin analogs as chloride channel opener
TWI331920B (en) * 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
US7732487B2 (en) * 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
WO2005018646A1 (ja) 2003-08-21 2005-03-03 Sucampo Ag 眼科用組成物
ATE539756T1 (de) * 2002-10-23 2012-01-15 Sucampo Ag Prostaglandinsubstanzen für die behandlung von fettsucht
AU2003292556B2 (en) 2002-12-27 2009-09-10 Sucampo Ag Derivatives of prostaglandins for treating abdominal discomfort
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
TWI384988B (zh) * 2005-01-27 2013-02-11 Sucampo Ag 處理中樞神經系統失常用之組成物
EP2329825B1 (de) * 2005-03-04 2015-10-07 Sucampo AG Verfahren und Zusammensetzung zur Behandlung von peripheren Gefässkrankheiten
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
PL1871380T3 (pl) * 2005-04-12 2012-03-30 Sucampo Ag Zastosowanie kombinacji związku prostaglandyny i inhibitora pompy protonowej w leczeniu zaburzeń żołądkowo-jelitowych
AU2007208637B2 (en) 2006-01-24 2012-04-26 R-Tech Ueno, Ltd. Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
DK1978944T3 (da) 2006-01-24 2012-11-05 Sucampo Ag Blød-gelatine-kapselformulering
JP4648340B2 (ja) * 2006-02-07 2011-03-09 株式会社アールテック・ウエノ １５−ケトプロスタグランジンｅ誘導体の製造法
WO2007091697A2 (en) * 2006-02-07 2007-08-16 R-Tech Ueno, Ltd. Method for preparing prostaglandin derivative
EP1988905B1 (de) * 2006-02-28 2014-06-04 Sucampo AG Verfahren und zusammensetzung zur behandlung von chronisch obstruktiver lungenerkrankung
CN103768070A (zh) * 2006-03-13 2014-05-07 株式会社·R-技术上野 水性组合物
US8871752B2 (en) * 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
WO2012137987A1 (en) 2011-04-07 2012-10-11 Sucampo Ag Method for treating asthenopia
US20120270945A1 (en) * 2011-04-19 2012-10-25 Sucampo Ag Method for modulating cytokine activity
CN103764639B (zh) * 2011-07-01 2016-04-13 株式会社·R-技术上野 用于制备脂肪酸衍生物的方法
CN102875586A (zh) * 2011-07-11 2013-01-16 上海天伟生物制药有限公司 一种利马前列素关键中间体的制备方法
WO2013022079A1 (en) 2011-08-05 2013-02-14 Sucampo Ag Method for treating schizophrenia
CN103058907B (zh) * 2011-10-21 2016-05-11 武汉启瑞药业有限公司 鲁比前列酮或其中间体的制备方法
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
WO2016203317A1 (en) 2015-06-19 2016-12-22 Sucampo Ag Pharmaceutical compositions comprising fatty acid derivative
US10428566B2 (en) * 2017-04-17 2019-10-01 James G. Arendts Flexible unitary sandwich-like panel overhead door

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306078A (en) * 1979-12-03 1981-12-15 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4374856A (en) 1980-09-10 1983-02-22 The Upjohn Company Liver cytoprotection using PGE's
JPS58164512A (ja) 1982-03-25 1983-09-29 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤
JPS58203911A (ja) 1982-05-25 1983-11-28 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤
JPS62129218A (ja) 1985-12-02 1987-06-11 Teijin Ltd チアプロスタグランジン類を活性成分として含有する肝疾患治療剤
JPH0688966B2 (ja) 1987-01-28 1994-11-09 株式会社アールテック・ウエノ プロスタグランジンｅ類およびそれを含む抗潰瘍剤
US5166174A (en) * 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
CA1323364C (en) * 1987-01-28 1993-10-19 Ryuzo Ueno Prostaglandins e and anti ulcer agents containing same
GB2210556B (en) * 1987-10-02 1991-07-17 Ueno Seiyaku Oyo Kenkyujo Kk The use of 15-keto-16-halo-prostaglandins in cathartic compositions
JPH0681728B2 (ja) 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
JP2579193B2 (ja) * 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
DD295522A5 (de) * 1989-07-26 1991-11-07 �����@������������������k�� 5-Alkyl-1,3,4-Thiadiazole, Verfahren zu ihrer Herstellung und Verwendung als Schädlingsbekämpfungsmittel
CA2027814C (en) * 1989-10-20 1996-07-30 Ryuji Ueno Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds

Also Published As

Publication number Publication date
KR960000230A (ko) 1996-01-25
US5739161A (en) 1998-04-14
CN1076605C (zh) 2001-12-26
NO952214L (no) 1995-12-04
ATE182884T1 (de) 1999-08-15
DK0690049T3 (da) 2000-03-06
DE69511181T2 (de) 1999-12-02
NZ272234A (en) 1996-02-27
KR100260573B1 (ko) 2000-07-01
CA2150287C (en) 2004-08-10
FI952721A0 (fi) 1995-06-02
EP0690049A3 (de) 1997-03-26
EP0690049B1 (de) 1999-08-04
CA2150287A1 (en) 1995-12-04
CN1126591A (zh) 1996-07-17
NO308993B1 (no) 2000-11-27
AU2041295A (en) 1995-12-14
GR3031066T3 (en) 1999-12-31
EP0690049A2 (de) 1996-01-03
ES2137456T3 (es) 1999-12-16
AU690241B2 (en) 1998-04-23
FI952721A (fi) 1995-12-04
NO952214D0 (no) 1995-06-02

Similar Documents

Publication Publication Date Title
DE69511181T2 (de) Mittel für Behandlung der Leber-Gallenerkrankungen
ATE233730T1 (de) Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende mittel und verfahren zu ihrer herstellung
EA200200262A1 (ru) Пиперазиновые производные и их применение в качестве противовоспалительных агентов
TR199901905T2 (xx) 2-(P�rin-9-il)-tetrahidrofuran-3,4-diol t�revleri.
DE69113155D1 (de) 17-beta-substituierte-4-aza-5-alpha-androstan-3-one-derivate und verfahren zu ihrer herstellung.
DE69317044T2 (de) Mittel zur regulierung vom hautfettigkeitsgrad
PT896533E (pt) Pentafluorobenzenosulfonamidas e analogos
DE69838789D1 (de) Verfahren zur behandlung oder prävention der alzheimerischen krankheit
DE69716810D1 (de) 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
DE69519577T2 (de) Prednisolonmetasulfobenzoat-zusammensetzung zur behandlung von entzündungserkrankung des darmes
DE69707033D1 (de) Verfahren zur Behandlung von Gasen die Organohalogenzusammensetzungen enthalten
EA200000741A1 (ru) Новые производные дигидроксигексановой кислоты
BR9711225A (pt) Composi-{es de propentofilina transd-rmica para o tratamento do mal de alzheimer
ATE164578T1 (de) Verzweigte aminothiazole-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammenstellungen die sie enthalten
DE69405919D1 (de) Zusammensetzungen zur Behandlung von Keratinfasern
NL930052I2 (nl) 2,6-Dialkoxybenzamiden, werkwijze ter bereiding ervan, samenstellingen en deze verbindingen voor toepassing bij de behandeling van psychotische afwijkingen.
DE69735417D1 (de) 2,5-dihydroxybenzylsulfonderivate zur behandlung von sexuellen störungen
ATE157660T1 (de) Hydroxymethylfurazancarbonsäurederivate und ihre verwendung in der behandlung von kardiovaskulären erkrankungen
ATE274905T1 (de) 4,5-dihydroxy-2-cyclopentene-1-on für die behandlung von rheumatismus, entzündungen und autoimmunerkrankungen
ATE330604T1 (de) Behandlung von manischen erkrankungen
DE68913995D1 (de) Zusammensetzung zur behandlung progressiver myopie.
ITRG940010A0 (it) Cura di varie forme di alopecie

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SUCAMPO AG, ZUG, CH