DE69416245T2 - Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen - Google Patents

Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen

Info

Publication number
DE69416245T2
DE69416245T2 DE69416245T DE69416245T DE69416245T2 DE 69416245 T2 DE69416245 T2 DE 69416245T2 DE 69416245 T DE69416245 T DE 69416245T DE 69416245 T DE69416245 T DE 69416245T DE 69416245 T2 DE69416245 T2 DE 69416245T2
Authority
DE
Germany
Prior art keywords
chamber
powdered medicine
storage chamber
accomodation
dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69416245T
Other languages
English (en)
Other versions
DE69416245D1 (de
Inventor
Yuji Makino
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE69416245D1 publication Critical patent/DE69416245D1/de
Publication of DE69416245T2 publication Critical patent/DE69416245T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type
DE69416245T 1993-05-12 1994-05-12 Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen Expired - Fee Related DE69416245T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11041293 1993-05-12
PCT/JP1994/000771 WO1994026338A1 (en) 1993-05-12 1994-05-12 Device and method for dispensing powdered medicine in multiple doses

Publications (2)

Publication Number Publication Date
DE69416245D1 DE69416245D1 (de) 1999-03-11
DE69416245T2 true DE69416245T2 (de) 1999-07-08

Family

ID=14535130

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69416245T Expired - Fee Related DE69416245T2 (de) 1993-05-12 1994-05-12 Vorrichtung und verfahren zur dosierten abgabe von pulverförmigen arzneistoffen

Country Status (11)

Country Link
US (1) US5634900A (de)
EP (1) EP0652022B1 (de)
JP (1) JP3132830B2 (de)
KR (1) KR100244690B1 (de)
AT (1) ATE176164T1 (de)
AU (1) AU684779B2 (de)
CA (1) CA2140021C (de)
DE (1) DE69416245T2 (de)
DK (1) DK0652022T3 (de)
FI (1) FI112919B (de)
WO (1) WO1994026338A1 (de)

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JP3317823B2 (ja) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
RU2195965C2 (ru) * 1996-02-21 2003-01-10 Шеринг Корпорейшн Устройство для ингаляции порошка
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
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US6488648B1 (en) * 1999-01-14 2002-12-03 Teijin Limited Device for feeding a powder in a predetermined amount and method thereof
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
SE9903824D0 (sv) * 1999-10-22 1999-10-22 Medifront Ab Anordning för avgivning av multipla doser för pulverinhalatorer och motsvarande avgivningsförfarande
JP2003516200A (ja) * 1999-12-07 2003-05-13 オリオン コーポレーション 多数回投与パウダー吸入器
NZ517693A (en) * 2000-06-12 2003-09-26 Teijin Ltd Powder medicine multiple dose administration device
US6457471B1 (en) * 2000-06-30 2002-10-01 Medihale Ltd. Dual-purpose medical device for upper airway treatment and methods for using same
US20030041860A1 (en) * 2001-08-29 2003-03-06 Verona Steven N. Particulate dispenser
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
AU2003248075B2 (en) 2002-07-16 2008-06-05 Teijin Limited Method and device of producing multiple doser for powdered medicine
DE10233150B4 (de) * 2002-07-22 2013-03-07 Alfred Von Schuckmann Handbetätigbarer Inhalator für pulverförmige Substanzen
FI20031158A (fi) * 2003-08-15 2005-02-16 Perlos Oyj Inhalaattori
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
PL1791542T3 (pl) 2004-08-23 2015-11-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
JP2006087797A (ja) * 2004-09-27 2006-04-06 Hitachi Ltd 鼻腔用投薬器
AU2006290870B2 (en) 2005-09-14 2013-02-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
EP2497484A3 (de) 2006-02-22 2012-11-07 MannKind Corporation Verfahren zur Verbesserung der pharmazeutischen Eigenschaften von Mikropartikeln mit Diketopiperazin und einem Wirkstoff
DE102006044752A1 (de) * 2006-09-20 2008-04-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kolbendosierer
US8648085B2 (en) * 2007-11-30 2014-02-11 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
DK2570147T3 (da) 2008-06-13 2018-01-29 Mannkind Corp Tørpulverinhalator og system til lægemiddelindgivelse
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
PE20110383A1 (es) 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
EP2346554B1 (de) * 2008-09-26 2015-09-16 Oriel Therapeutics, Inc. Inhalationsmechanismus mit radial beanspruchten dornen und entsprechende verfahren
MX2011003244A (es) 2008-09-26 2011-04-28 Oriel Therapeutics Inc Inhaladores con discos de vias aereas con canales de vias aereas discretas y discos y metodos relacionados.
MX2011003233A (es) 2008-09-26 2011-04-28 Oriel Therapeutics Inc Inhaladores de polvo seco con miembros de perforacion doble y dispositivos y metodos relacionados.
CA2732827C (en) * 2008-10-01 2016-10-11 Oriel Therapeutics, Inc. Dry powder inhalers with rotating piercing mechanisms and related devices and methods
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
JP5542196B2 (ja) 2009-03-31 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−複素環−１，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｐｄｅ９ａモジュレーターとしてのそれらの使用
US8734845B2 (en) 2009-06-12 2014-05-27 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
TW201118099A (en) * 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
PL2603511T3 (pl) 2010-08-12 2017-08-31 Boehringer Ingelheim Int Pochodne 6-cykloalkilo-1,5-dihydropirazolo[3,4-d]pirymidyn-4-onu i ich zastosowanie jako inhibitorów PDE9A
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
MY180552A (en) 2011-04-01 2020-12-02 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
US9339638B2 (en) 2012-08-08 2016-05-17 Healthpartners Research & Education Antibiotic delivery system and method
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

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DE3708933A1 (de) * 1987-03-19 1988-09-29 Heinrich Prof Dr Ing Reents Verfahren mit den dazu gehoerigen vorrichtungen zur dosierung feiner und fester werkstoff- und wirkstoffteilchen mit hilfe schwingungserzeugender systeme
IT1237118B (it) * 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
DK544589D0 (da) * 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
GB9025705D0 (en) * 1990-11-27 1991-01-09 Britains Petite Ltd Powder inhaler
GB9027234D0 (en) * 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
FR2676929B1 (fr) * 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
IT1248059B (it) * 1991-06-14 1995-01-05 Miat Spa Insufflatore multidose per farmaci in polvere
DE69319107T2 (de) * 1992-03-25 1999-02-25 Galli Rosaria & C Pulverabgabevorrichtung für medizinische inhalationstherapien
DE59303719D1 (de) * 1992-06-05 1996-10-17 Hoechst Ag Inhalator
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
MY115140A (en) * 1992-12-18 2003-04-30 Schering Corp Inhaler for powdered medications

Also Published As

Publication number Publication date
AU684779B2 (en) 1998-01-08
FI950130A0 (fi) 1995-01-11
ATE176164T1 (de) 1999-02-15
EP0652022A1 (de) 1995-05-10
AU6690694A (en) 1994-12-12
CA2140021A1 (en) 1994-11-24
EP0652022B1 (de) 1999-01-27
US5634900A (en) 1997-06-03
CA2140021C (en) 2001-09-04
DE69416245D1 (de) 1999-03-11
DK0652022T3 (da) 1999-09-13
JP3132830B2 (ja) 2001-02-05
FI112919B (fi) 2004-02-13
KR100244690B1 (ko) 2000-02-15
EP0652022A4 (de) 1995-10-18
KR950702442A (ko) 1995-07-29
WO1994026338A1 (en) 1994-11-24
FI950130A (fi) 1995-03-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee