DE69404071T2 - 3-Deoxyoligosacchariden, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents

3-Deoxyoligosacchariden, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Info

Publication number
DE69404071T2
DE69404071T2 DE69404071T DE69404071T DE69404071T2 DE 69404071 T2 DE69404071 T2 DE 69404071T2 DE 69404071 T DE69404071 T DE 69404071T DE 69404071 T DE69404071 T DE 69404071T DE 69404071 T2 DE69404071 T2 DE 69404071T2
Authority
DE
Germany
Prior art keywords
radical
deoxyoligosaccharides
formula
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69404071T
Other languages
English (en)
Other versions
DE69404071D1 (de
Inventor
Maurice Petitou
Guy Francois Bernard Jaurand
Boeckel Constant Adriaan A Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA, Akzo Nobel NV filed Critical Sanofi SA
Publication of DE69404071D1 publication Critical patent/DE69404071D1/de
Application granted granted Critical
Publication of DE69404071T2 publication Critical patent/DE69404071T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69404071T 1993-04-22 1994-04-22 3-Deoxyoligosacchariden, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen Expired - Lifetime DE69404071T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9304769A FR2704226B1 (fr) 1993-04-22 1993-04-22 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69404071D1 DE69404071D1 (de) 1997-08-14
DE69404071T2 true DE69404071T2 (de) 1998-02-19

Family

ID=9446334

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69404071T Expired - Lifetime DE69404071T2 (de) 1993-04-22 1994-04-22 3-Deoxyoligosacchariden, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Country Status (18)

Country Link
US (1) US5514659A (de)
EP (1) EP0621282B1 (de)
JP (1) JP3594990B2 (de)
KR (1) KR100324583B1 (de)
CN (1) CN1040539C (de)
AT (1) ATE155140T1 (de)
AU (1) AU665901B2 (de)
CA (1) CA2121997C (de)
DE (1) DE69404071T2 (de)
ES (1) ES2106463T3 (de)
FI (1) FI111725B (de)
FR (1) FR2704226B1 (de)
HU (1) HU226807B1 (de)
NO (1) NO300137B1 (de)
NZ (1) NZ260357A (de)
RU (1) RU2133752C1 (de)
TW (1) TW318183B (de)
ZA (1) ZA942767B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
AUPO976897A0 (en) 1997-10-14 1997-11-06 Australian National University, The Use of sulfated oligosaccharides in lowering blood triglyceride levels
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
US8147126B2 (en) * 2009-01-26 2012-04-03 Spar Food Machinery Mfg. Co., Ltd. Covering structure of a mixer
US8288515B2 (en) 2009-07-31 2012-10-16 Reliable Biopharmaceutical Corporation Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
EP2614089A1 (de) 2010-09-10 2013-07-17 Sanofi-Aventis Biotinylierte polysaccharide mit antithrombotischer wirkung und erhöhter stoffwechselstabilität
US8889853B2 (en) * 2010-10-05 2014-11-18 Scinopharm Singapore Pte Ltd. Process for the preparation of disaccharides applied to heparin pentasaccharides
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
WO2014205115A2 (en) 2013-06-19 2014-12-24 The Regents Of The University Of California Regioselective silyl exchange of per-silylated oligosaccharides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
ES2060284T3 (es) * 1990-04-23 1994-11-16 Sanofi Elf Un procedimiento para la preparacion de un derivado de carbohidrato que comprende una unidad de trisacarido.
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
DE4140117C1 (de) * 1991-12-05 1993-01-28 Bayer Ag, 5090 Leverkusen, De

Also Published As

Publication number Publication date
FI941836A0 (fi) 1994-04-20
ES2106463T3 (es) 1997-11-01
NO941461L (no) 1994-10-24
HU9401150D0 (en) 1994-07-28
FR2704226B1 (fr) 1995-07-21
JPH0789977A (ja) 1995-04-04
DE69404071D1 (de) 1997-08-14
TW318183B (de) 1997-10-21
RU2133752C1 (ru) 1999-07-27
US5514659A (en) 1996-05-07
NO300137B1 (no) 1997-04-14
HUT67572A (en) 1995-04-28
KR100324583B1 (ko) 2002-11-13
HU226807B1 (en) 2009-10-28
CA2121997A1 (en) 1994-10-23
FR2704226A1 (fr) 1994-10-28
JP3594990B2 (ja) 2004-12-02
EP0621282B1 (de) 1997-07-09
FI111725B (fi) 2003-09-15
EP0621282A1 (de) 1994-10-26
ATE155140T1 (de) 1997-07-15
FI941836A (fi) 1994-10-23
NO941461D0 (no) 1994-04-21
NZ260357A (en) 1995-12-21
CA2121997C (en) 2005-09-27
CN1099038A (zh) 1995-02-22
AU6052494A (en) 1994-10-27
AU665901B2 (en) 1996-01-18
ZA942767B (en) 1995-10-23
CN1040539C (zh) 1998-11-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL SANOFI-SYNTHEL

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

R082 Change of representative

Ref document number: 621282

Country of ref document: EP

Representative=s name: TER MEER STEINMEISTER & PARTNER GBR PATENTANWA, DE