DE69329344T2 - Spezifische modulationen des immunsystems - Google Patents
Spezifische modulationen des immunsystemsInfo
- Publication number
- DE69329344T2 DE69329344T2 DE69329344T DE69329344T DE69329344T2 DE 69329344 T2 DE69329344 T2 DE 69329344T2 DE 69329344 T DE69329344 T DE 69329344T DE 69329344 T DE69329344 T DE 69329344T DE 69329344 T2 DE69329344 T2 DE 69329344T2
- Authority
- DE
- Germany
- Prior art keywords
- antigen
- cells
- cell
- peptide antigen
- major histocompatibility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Claims (14)
1. Verfahren zur Bildung eines mit einem autologen
Peptidantigen assoziierten Leukozyten, umfassend
die Schritte:
(a) Bestrahlen eines Präparats, welches mehrere
normale Leukozyten enthält, in Gegenwart einer
photoaktivierbaren Substanz bei einer Temperatur
unterhalb physiologischer Temperatur zur
Verstärkung der Expression eines
Haupthistokompatibilitätskomplex-Moleküls durch
den normalen Leukozyten; und
(b) In-Reaktion-bringen des bestrahlten Leukozyten,
der die verstärkte Expression eines
Haupthistokompatibilitätskomplex-Moleküls
aufweist, mit einem autologen Peptidantigen, um
außerhalb des Körpers peptidantigenassoziierte
Leukozyten zu bilden.
2. Verfahren nach Anspruch 1, wobei der normale
Leukozyt aus Menschen stammt.
3. Verfahren nach Anspruch 1, wobei das
Haupthistokompatibilitätskomplex-Molekül ein Klasse-I- oder
Klasse-II-Molekül ist.
4. Verfahren nach Anspruch 1, wobei das Präparat
einer Temperatur zwischen etwa 20ºC und etwa
28ºC, bevorzugt einer Temperatur zwischen etwa
21ºC und etwa 22ºC, ausgesetzt wird.
5. Verfahren nach Anspruch 1, wobei die
photoaktivierbare Substanz ein Psoralen ist.
6. Verfahren nach Anspruch 5, wobei das Psoralen
ausgewählt ist aus 8-Methoxypsoralen, Aminomethyl-
Trimethylpsoralen, 2-Methoxypsoralen und
Trimethylpsoralen.
7. Verfahren nach Anspruch 6, wobei das Psoralen 8-
Methoxypsoralen ist.
8. Verfahren nach Anspruch 1, zusätzlich umfassend
das In-Kontakt-bringen des Präparats mit einem
Cytokin.
9. Verfahren nach Anspruch 1, wobei das autologe
Peptidantigen ein zirkulierendes Gewebeantigen
ist.
10. Verfahren nach Anspruch 1, wobei das Peptidantigen
assoziiert ist mit einer Malignität solider
Tumoren, einer Überempfindlichkeitskrankheit oder
einer Autoimmunkrankheit.
11. Verfahren nach Anspruch 1, zusätzlich umfassend
den Schritt der Zugabe einer Menge von Beta-2-
Mikroglobulin zu dem bestrahlten Leukozyten,
während der bestrahle Leukozyt mit dem autologen
Peptidantigen zur Reaktion gebracht wird.
12. Eine pharmazeutische Zusammensetzung zur
Modifikation einer Immunantwort auf ein autologes
Peptidantigen, umfassend:
ein Präparat, enthaltend mehrere mit dem autologen
Peptidantigen assoziierte normale Leukozyten und
Beta-2-Mikroglobulin, wobei das Präparat eine
ausreichende Menge normaler Leukozyten zur
Modifikation der Immunantwort und eine Menge Beta-
2-Mikroglobulin, die größer ist als die
Konzentration von Beta-2-Mikroglobulin, die
invivo gefunden würde, enthält; und
einen pharmazeutisch akzeptablen Träger.
13. Eine pharmazeutische Zusammensetzung zur
Modifikation einer Immunantwort auf ein autologes
Peptidantigen, umfassend:
ein Präparat, das mehrere normale Leukozyten
enthält, die eine verstärkte Expression von
Haupthistokompatibilitätskomplex-Molekülen und ein
mit dem Haupthistokompatibilitätskomplex-Molekül
assoziiertes autologes Peptidantigen aufweisen,
wobei das Präparat eine ausreichende Menge
normaler Leukozyten zur Modifikation der
Immunantwort enthält; und
einen pharmazeutisch akzeptablen Träger.
14. Eine pharmazeutische Zusammensetzung, enthaltend
mehrere mit dem autologen Peptidantigen
assoziierte Leukozyten, hergestellt durch ein in
einem der Ansprüche 1-11 beanspruchten Verfahren.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/977,672 US5651993A (en) | 1992-11-18 | 1992-11-18 | Specific immune system modulation |
| PCT/US1993/011220 WO1994011016A1 (en) | 1992-11-18 | 1993-11-18 | Specific immune system modulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69329344D1 DE69329344D1 (de) | 2000-10-05 |
| DE69329344T2 true DE69329344T2 (de) | 2001-01-04 |
Family
ID=25525390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69329344T Expired - Lifetime DE69329344T2 (de) | 1992-11-18 | 1993-11-18 | Spezifische modulationen des immunsystems |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5651993A (de) |
| EP (1) | EP0668772B1 (de) |
| JP (1) | JPH08503470A (de) |
| AT (1) | ATE195875T1 (de) |
| DE (1) | DE69329344T2 (de) |
| DK (1) | DK0668772T3 (de) |
| ES (1) | ES2149254T3 (de) |
| GR (1) | GR3034908T3 (de) |
| PT (1) | PT668772E (de) |
| WO (1) | WO1994011016A1 (de) |
Cited By (1)
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|---|---|---|---|---|
| EP1644451B2 (de) † | 2003-07-15 | 2018-11-28 | NOF Metal Coatings Europe | Verwendung von yttrium, zirkonium, lanthan, cer, praseodym und/oder neodym als verstärkungsmittel für eine antikorrosion-beschichtung |
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| US7585512B1 (en) * | 1990-05-08 | 2009-09-08 | Thomas Jefferson University | Composition and method of using tumor cells |
| US5651993A (en) | 1992-11-18 | 1997-07-29 | Yale University | Specific immune system modulation |
| US5820872A (en) * | 1992-11-18 | 1998-10-13 | Yale University | Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor |
| AU697847B2 (en) * | 1993-09-24 | 1998-10-15 | Advanced Immunit, Inc. | Method for the treatment or prevention of eczema/dermatitis |
| US6168787B1 (en) * | 1995-04-24 | 2001-01-02 | John Wayne Cancer Institute | Pluripotent vaccine against enveloped viruses |
| US20020098469A1 (en) * | 1996-03-22 | 2002-07-25 | Morgan ,Lewis, Bockius Llp | Extracorporeal methods for enhancing antigen presentation and immune responsiveness |
| EP0896506A4 (de) * | 1996-03-22 | 2003-06-18 | Univ Yale | Verfahren zum induzieren der möglichkeit einer immunantwort |
| IL126366A (en) * | 1996-03-29 | 2011-10-31 | Therakos Inc | Use of a photoactivatable compound in the manufacture of a medicament for the treatment of an infection |
| WO1997037536A1 (en) | 1996-04-09 | 1997-10-16 | Therakos, Inc. | Method for removal of psoralens from biological fluids |
| EP0994743B1 (de) * | 1997-07-10 | 2006-05-31 | Therakos, Inc. | Behandlung von Darm- oder Blasenentzündungen |
| JP2003520563A (ja) * | 1997-07-21 | 2003-07-08 | シーラス コーポレイション | 白血球を処置する方法、白血球組成物およびそれを使用する方法 |
| US6331388B1 (en) * | 1997-10-17 | 2001-12-18 | Wisconsin Alumni Research Foundation | Immune response enhancer |
| US6068844A (en) * | 1997-12-19 | 2000-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Increased resistance to stroke by developing immunologic tolerance to myelin or components thereof |
| FR2777188A1 (fr) * | 1998-04-08 | 1999-10-15 | Sephra | Utilisation d'une porphyrine pour la realisation d'un medicament abaissant le nombre d'eosinophiles |
| US6749785B2 (en) * | 1998-09-01 | 2004-06-15 | E. I. Du Pont De Nemours And Company | Multilayer structures of poly(1,3-propylene 2,6 napthalate) and poly (ethylene terephthalate) |
| GB9905911D0 (en) * | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| US7109031B2 (en) | 1999-04-20 | 2006-09-19 | Yale University | Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells |
| US8313945B2 (en) | 1999-04-20 | 2012-11-20 | Yale University | Methods for inducing the differentiation of blood monocytes into functional dendritic cells |
| EP1176986B1 (de) | 1999-04-20 | 2018-07-04 | Yale University | Differenzierung von monozyten in funktionale dentritische zellen |
| US6219584B1 (en) | 1999-07-09 | 2001-04-17 | Therakos, Inc. | Method and system for determining an effective amount of light energy to delivery to fluids having targets for the light energy |
| US6495366B1 (en) * | 1999-09-03 | 2002-12-17 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US8722422B2 (en) | 1999-09-03 | 2014-05-13 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US6303154B1 (en) * | 1999-09-24 | 2001-10-16 | Boris Breivogel | Chemical alteration of mammal urine and mammal blood |
| US6793643B1 (en) | 2000-04-21 | 2004-09-21 | Therakos, Inc. | Low extracorporeal volume treatment system |
| US20070129307A1 (en) * | 2001-06-22 | 2007-06-07 | The University Of British Columbia | Insulin epitopes for the treatment of type 1 diabetes |
| US20050129617A1 (en) * | 2001-06-22 | 2005-06-16 | Rusung Tan | Type1 diabetes diagnostics and therapeutics |
| US20040076646A1 (en) * | 2001-07-18 | 2004-04-22 | Caplan Michael J. | Haptenizing cancer cell components |
| US8524495B2 (en) | 2007-05-16 | 2013-09-03 | Yale University | Methods for inducing the differentiation of blood monocytes into functional dendritic cells |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4428744A (en) | 1979-12-11 | 1984-01-31 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
| US4398906A (en) | 1979-12-11 | 1983-08-16 | Frederic A. Bourke, Jr. | Method for externally treating the blood |
| US4321919A (en) | 1979-12-11 | 1982-03-30 | Leukocyte Research, Inc. | Method and system for externally treating human blood |
| US4464166A (en) | 1981-06-12 | 1984-08-07 | Frederic A. Bourke, Jr. | Method for externally treating the blood |
| US4612007A (en) | 1981-06-16 | 1986-09-16 | Edelson Richard Leslie | Method and system for externally treating the blood |
| US4613322A (en) | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
| US4684521A (en) * | 1982-12-08 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
| US4683889A (en) | 1983-03-29 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
| US4838852A (en) * | 1987-03-27 | 1989-06-13 | Therakos, Inc. | Active specific immune suppression |
| IL85746A (en) * | 1988-03-15 | 1994-05-30 | Yeda Res & Dev | Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases |
| US5167657A (en) | 1988-11-14 | 1992-12-01 | Baxter International Inc. | Plastic composition with anti-hemolytic effect |
| US4999375A (en) * | 1989-04-11 | 1991-03-12 | Hoffmann-La Roche Inc. | Psoralen reagent compositions for extracorporeal treatment of blood |
| US5231012A (en) * | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
| US20030072751A1 (en) | 1990-03-14 | 2003-04-17 | Heribert Bohlen | Idiotypic vaccination against b cell lymphoma |
| US5147289A (en) * | 1990-03-29 | 1992-09-15 | Therakos, Inc | Non-specific immune system enhancement |
| WO1993003766A1 (en) | 1991-08-13 | 1993-03-04 | Repligen Corporation | Multiple antigen peptides for use as hiv vaccines |
| AU687733B2 (en) | 1992-04-01 | 1998-03-05 | Rockefeller University, The | Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens |
| CA2069541C (en) | 1992-05-26 | 2005-02-01 | Cornelis J. M. Melief | Induction of an antigen-specific t-lymphocyte response |
| WO1994002156A1 (en) | 1992-07-16 | 1994-02-03 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate t cells |
| US5820872A (en) * | 1992-11-18 | 1998-10-13 | Yale University | Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor |
| US5651993A (en) | 1992-11-18 | 1997-07-29 | Yale University | Specific immune system modulation |
| US5462733A (en) | 1993-02-04 | 1995-10-31 | Yale University | Immune system modulation using psoralens activated with visible light |
| KR960700739A (ko) | 1993-03-05 | 1996-02-24 | 카린 이스텀 | Hla-a2. 1 결합 펩티드 및 그의 용도(hla-a2. 1 binding peptides and their uses) |
| CA2158281A1 (en) | 1993-03-15 | 1994-09-29 | Jay A. Berzofsky | Peptide coated dendritic cells as immunogens |
| DE4412794A1 (de) | 1994-04-14 | 1995-12-14 | Univ Ludwigs Albert | Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens |
| IL109540A0 (en) | 1994-05-03 | 1994-08-26 | Yeda Res & Dev | Synthetic peptides and their use in tumor diagnosis and therapy |
| US5683768A (en) | 1994-12-21 | 1997-11-04 | Baxter International Inc. | Plastic formulations for platelet storage containers and the like |
| EP0896506A4 (de) | 1996-03-22 | 2003-06-18 | Univ Yale | Verfahren zum induzieren der möglichkeit einer immunantwort |
-
1992
- 1992-11-18 US US07/977,672 patent/US5651993A/en not_active Expired - Lifetime
-
1993
- 1993-11-18 AT AT94901598T patent/ATE195875T1/de active
- 1993-11-18 JP JP6512497A patent/JPH08503470A/ja active Pending
- 1993-11-18 DK DK94901598T patent/DK0668772T3/da active
- 1993-11-18 WO PCT/US1993/011220 patent/WO1994011016A1/en active IP Right Grant
- 1993-11-18 PT PT94901598T patent/PT668772E/pt unknown
- 1993-11-18 DE DE69329344T patent/DE69329344T2/de not_active Expired - Lifetime
- 1993-11-18 EP EP94901598A patent/EP0668772B1/de not_active Expired - Lifetime
- 1993-11-18 ES ES94901598T patent/ES2149254T3/es not_active Expired - Lifetime
-
1997
- 1997-03-21 US US08/822,940 patent/US6355238B1/en not_active Expired - Fee Related
-
2000
- 2000-11-24 GR GR20000402614T patent/GR3034908T3/el not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1644451B2 (de) † | 2003-07-15 | 2018-11-28 | NOF Metal Coatings Europe | Verwendung von yttrium, zirkonium, lanthan, cer, praseodym und/oder neodym als verstärkungsmittel für eine antikorrosion-beschichtung |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2149254T3 (es) | 2000-11-01 |
| WO1994011016A1 (en) | 1994-05-26 |
| EP0668772A4 (de) | 1996-07-31 |
| US6355238B1 (en) | 2002-03-12 |
| US5651993A (en) | 1997-07-29 |
| ATE195875T1 (de) | 2000-09-15 |
| EP0668772A1 (de) | 1995-08-30 |
| DE69329344D1 (de) | 2000-10-05 |
| JPH08503470A (ja) | 1996-04-16 |
| EP0668772B1 (de) | 2000-08-30 |
| PT668772E (pt) | 2000-12-29 |
| DK0668772T3 (da) | 2000-10-16 |
| GR3034908T3 (en) | 2001-02-28 |
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