DE69327720T2 - Endothelin rezeptor antagonisten - Google Patents

Endothelin rezeptor antagonisten

Info

Publication number
DE69327720T2
DE69327720T2 DE69327720T DE69327720T DE69327720T2 DE 69327720 T2 DE69327720 T2 DE 69327720T2 DE 69327720 T DE69327720 T DE 69327720T DE 69327720 T DE69327720 T DE 69327720T DE 69327720 T2 DE69327720 T2 DE 69327720T2
Authority
DE
Germany
Prior art keywords
receptor antagonists
endothelin receptor
endothelin
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69327720T
Other languages
English (en)
Other versions
DE69327720D1 (de
Inventor
Lynne Bryan
Duncan Elliot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE69327720D1 publication Critical patent/DE69327720D1/de
Publication of DE69327720T2 publication Critical patent/DE69327720T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69327720T 1992-07-17 1993-07-15 Endothelin rezeptor antagonisten Expired - Lifetime DE69327720T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91605192A 1992-07-17 1992-07-17
US4960693A 1993-04-19 1993-04-19
PCT/US1993/006667 WO1994002474A1 (en) 1992-07-17 1993-07-15 Endothelin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69327720D1 DE69327720D1 (de) 2000-03-02
DE69327720T2 true DE69327720T2 (de) 2000-07-27

Family

ID=26727343

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69327720T Expired - Lifetime DE69327720T2 (de) 1992-07-17 1993-07-15 Endothelin rezeptor antagonisten

Country Status (6)

Country Link
EP (1) EP0650484B1 (de)
JP (1) JPH07509465A (de)
CN (1) CN1088581A (de)
AU (1) AU4679793A (de)
DE (1) DE69327720T2 (de)
WO (1) WO1994002474A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
RU2126418C1 (ru) * 1993-11-01 1999-02-20 Циба-Гейги Джапан Димитед Антагонисты рецепторов эндотелина
FR2723369B1 (fr) * 1994-08-02 1996-09-13 Roussel Uclaf Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2723370B1 (fr) * 1994-08-02 1996-09-13 Roussel Uclaf Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
KR100483222B1 (ko) * 1994-08-19 2005-04-15 아보트 러보러터리즈 엔도텔린 길항제
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
US6162927A (en) * 1994-08-19 2000-12-19 Abbott Laboratories Endothelin antagonists
US7208517B1 (en) 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
US20030004202A1 (en) 1997-04-28 2003-01-02 Smithkline Beecham Corporation Endothelin receptor antagonists
DE69526738T2 (de) * 1994-09-02 2003-02-06 Smithkline Beecham Corp Endothelin-rezeptor-antagonisten
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US6238042B1 (en) 1994-09-16 2001-05-29 Seiko Epson Corporation Ink cartridge for ink jet printer and method of charging ink into said cartridge
FR2725988B1 (fr) * 1994-10-24 1997-01-24 Roussel Uclaf Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
JPH11502530A (ja) * 1995-03-27 1999-03-02 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー エンドセリンレセプターアンタゴニストとして有用なフェニル誘導体
UA58494C2 (uk) * 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
EP0841916B9 (de) * 1995-08-02 2004-03-03 Smithkline Beecham Corporation Endothelinrezeptorantagonisten
EP0841926B1 (de) * 1995-08-02 2003-03-26 Smithkline Beecham Corporation Endothelinrezeptorantagonist
FR2740135B1 (fr) * 1995-10-20 1997-12-19 Roussel Uclaf Nouveaux derives de pyrazoles acides, leur procede de preparation, leur application a titre de medicaments, leur nouvelle utilisation et les compositions pharmaceutiques les renfermant
JP2000504016A (ja) * 1996-02-01 2000-04-04 スミスクライン・ビーチャム・コーポレイション エンドセリンレセプターアンタゴニスト
US6136828A (en) * 1996-02-01 2000-10-24 Smithkline Beecham Corporation Endothelin receptor antagonists
WO1997028159A1 (en) * 1996-02-01 1997-08-07 Smithkline Beecham Corporation Endothelin receptor antagonists
AR006309A1 (es) * 1996-02-13 1999-08-25 Abbott Lab Derivados de pirrolidina, antagonistas de endotelina, composiciones farmaceuticas, uso de dichos derivados para la preparacion de medicamentos y procedimientos para preparar dichos derivados
DK0888340T3 (da) * 1996-02-13 2002-11-04 Abbott Lab 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin
US6043241A (en) * 1996-04-10 2000-03-28 Warner-Lambert Company Ketoacid endothelin antagonists
US5827898A (en) * 1996-10-07 1998-10-27 Shaman Pharmaceuticals, Inc. Use of bisphenolic compounds to treat type II diabetes
DE19711428A1 (de) * 1997-03-19 1998-09-24 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
AU8759298A (en) * 1997-10-06 1999-04-27 Shaman Pharmaceuticals, Inc. Use of nordihydroguaiaretic acid to lower serum triglycerides, blood pressure and to treat syndrome
CA2405170A1 (en) * 2000-04-24 2001-11-01 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
CN115093372B (zh) * 2022-06-16 2023-05-30 安徽工程大学 一种咪唑衍生物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403158A3 (de) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-Alkensäuren

Also Published As

Publication number Publication date
AU4679793A (en) 1994-02-14
JPH07509465A (ja) 1995-10-19
WO1994002474A1 (en) 1994-02-03
CN1088581A (zh) 1994-06-29
EP0650484A1 (de) 1995-05-03
EP0650484B1 (de) 2000-01-26
DE69327720D1 (de) 2000-03-02

Similar Documents

Publication Publication Date Title
DE69327720D1 (de) Endothelin rezeptor antagonisten
ATE205711T1 (de) Endothelin-rezeptor-antagonisten
FI961804A (fi) Endoteliinireseptoriantagonistit
ZA939516B (en) Endothelin receptor antagonists
FI960953A (fi) Endoteliinireseptoriantagonisteja
DE69207351T2 (de) Fibrinogen-Rezeptor-Antagoniste
ATE213156T1 (de) Endothelin-rezeptor-antagonisten
NO960473L (no) Substituerte bifenyl-sulfonamid-endotelin-antagonister
BR9507220A (pt) Antagonistas de receptores de endotelina
NO179550C (no) Tachykinin reseptorantagonister
DE69636597D1 (de) Endothelin rezeptor antagonisten
FI944905A0 (fi) Endoteliiniantagonistit II
BR9603432A (pt) Antagonistas de receptores de endotelina
EP0711157A4 (de) Endothelinrezeptorantagonisten
LV10425A (lv) Fibrinogena receptoru antagonisti
SG64880A1 (en) Endothelin receptor antagonists

Legal Events

Date Code Title Description
8364 No opposition during term of opposition