DE69327720T2 - Endothelin rezeptor antagonisten - Google Patents
Endothelin rezeptor antagonistenInfo
- Publication number
- DE69327720T2 DE69327720T2 DE69327720T DE69327720T DE69327720T2 DE 69327720 T2 DE69327720 T2 DE 69327720T2 DE 69327720 T DE69327720 T DE 69327720T DE 69327720 T DE69327720 T DE 69327720T DE 69327720 T2 DE69327720 T2 DE 69327720T2
- Authority
- DE
- Germany
- Prior art keywords
- receptor antagonists
- endothelin receptor
- endothelin
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91605192A | 1992-07-17 | 1992-07-17 | |
US4960693A | 1993-04-19 | 1993-04-19 | |
PCT/US1993/006667 WO1994002474A1 (en) | 1992-07-17 | 1993-07-15 | Endothelin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69327720D1 DE69327720D1 (de) | 2000-03-02 |
DE69327720T2 true DE69327720T2 (de) | 2000-07-27 |
Family
ID=26727343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69327720T Expired - Lifetime DE69327720T2 (de) | 1992-07-17 | 1993-07-15 | Endothelin rezeptor antagonisten |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0650484B1 (de) |
JP (1) | JPH07509465A (de) |
CN (1) | CN1088581A (de) |
AU (1) | AU4679793A (de) |
DE (1) | DE69327720T2 (de) |
WO (1) | WO1994002474A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
RU2126418C1 (ru) * | 1993-11-01 | 1999-02-20 | Циба-Гейги Джапан Димитед | Антагонисты рецепторов эндотелина |
FR2723369B1 (fr) * | 1994-08-02 | 1996-09-13 | Roussel Uclaf | Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
FR2723370B1 (fr) * | 1994-08-02 | 1996-09-13 | Roussel Uclaf | Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
KR100483222B1 (ko) * | 1994-08-19 | 2005-04-15 | 아보트 러보러터리즈 | 엔도텔린 길항제 |
US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
US6162927A (en) * | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
US20030004202A1 (en) | 1997-04-28 | 2003-01-02 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
DE69526738T2 (de) * | 1994-09-02 | 2003-02-06 | Smithkline Beecham Corp | Endothelin-rezeptor-antagonisten |
US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
US6238042B1 (en) | 1994-09-16 | 2001-05-29 | Seiko Epson Corporation | Ink cartridge for ink jet printer and method of charging ink into said cartridge |
FR2725988B1 (fr) * | 1994-10-24 | 1997-01-24 | Roussel Uclaf | Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
JPH11502530A (ja) * | 1995-03-27 | 1999-03-02 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | エンドセリンレセプターアンタゴニストとして有用なフェニル誘導体 |
UA58494C2 (uk) * | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
EP0841916B9 (de) * | 1995-08-02 | 2004-03-03 | Smithkline Beecham Corporation | Endothelinrezeptorantagonisten |
EP0841926B1 (de) * | 1995-08-02 | 2003-03-26 | Smithkline Beecham Corporation | Endothelinrezeptorantagonist |
FR2740135B1 (fr) * | 1995-10-20 | 1997-12-19 | Roussel Uclaf | Nouveaux derives de pyrazoles acides, leur procede de preparation, leur application a titre de medicaments, leur nouvelle utilisation et les compositions pharmaceutiques les renfermant |
JP2000504016A (ja) * | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | エンドセリンレセプターアンタゴニスト |
US6136828A (en) * | 1996-02-01 | 2000-10-24 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
WO1997028159A1 (en) * | 1996-02-01 | 1997-08-07 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
AR006309A1 (es) * | 1996-02-13 | 1999-08-25 | Abbott Lab | Derivados de pirrolidina, antagonistas de endotelina, composiciones farmaceuticas, uso de dichos derivados para la preparacion de medicamentos y procedimientos para preparar dichos derivados |
DK0888340T3 (da) * | 1996-02-13 | 2002-11-04 | Abbott Lab | 4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carboxylsyre-derivater som antagonister for enodthelin |
US6043241A (en) * | 1996-04-10 | 2000-03-28 | Warner-Lambert Company | Ketoacid endothelin antagonists |
US5827898A (en) * | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
DE19711428A1 (de) * | 1997-03-19 | 1998-09-24 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
AU8759298A (en) * | 1997-10-06 | 1999-04-27 | Shaman Pharmaceuticals, Inc. | Use of nordihydroguaiaretic acid to lower serum triglycerides, blood pressure and to treat syndrome |
CA2405170A1 (en) * | 2000-04-24 | 2001-11-01 | Merck Frosst Canada & Co. | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore |
CN115093372B (zh) * | 2022-06-16 | 2023-05-30 | 安徽工程大学 | 一种咪唑衍生物的合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0403158A3 (de) * | 1989-06-14 | 1991-12-18 | Smithkline Beecham Corporation | Imidazolyl-Alkensäuren |
-
1993
- 1993-07-15 WO PCT/US1993/006667 patent/WO1994002474A1/en active IP Right Grant
- 1993-07-15 DE DE69327720T patent/DE69327720T2/de not_active Expired - Lifetime
- 1993-07-15 JP JP6504560A patent/JPH07509465A/ja active Pending
- 1993-07-15 AU AU46797/93A patent/AU4679793A/en not_active Abandoned
- 1993-07-15 EP EP93917208A patent/EP0650484B1/de not_active Expired - Lifetime
- 1993-07-17 CN CN93116592A patent/CN1088581A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
AU4679793A (en) | 1994-02-14 |
JPH07509465A (ja) | 1995-10-19 |
WO1994002474A1 (en) | 1994-02-03 |
CN1088581A (zh) | 1994-06-29 |
EP0650484A1 (de) | 1995-05-03 |
EP0650484B1 (de) | 2000-01-26 |
DE69327720D1 (de) | 2000-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |