DE69319391T2 - 1,2,4-Oxadiazolyl oder 1,2,4-Thiadiazolyl-Derivate als Angiotensin II Antagonisten - Google Patents

1,2,4-Oxadiazolyl oder 1,2,4-Thiadiazolyl-Derivate als Angiotensin II Antagonisten

Info

Publication number
DE69319391T2
DE69319391T2 DE69319391T DE69319391T DE69319391T2 DE 69319391 T2 DE69319391 T2 DE 69319391T2 DE 69319391 T DE69319391 T DE 69319391T DE 69319391 T DE69319391 T DE 69319391T DE 69319391 T2 DE69319391 T2 DE 69319391T2
Authority
DE
Germany
Prior art keywords
angiotensin
action
oxadiazolyl
antagonists
thiadiazolyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69319391T
Other languages
English (en)
Other versions
DE69319391D1 (de
Inventor
Keiji Kubo
Yoshiyuki Inada
Takehiko Naka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69319391D1 publication Critical patent/DE69319391D1/de
Publication of DE69319391T2 publication Critical patent/DE69319391T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69319391T 1992-09-14 1993-09-14 1,2,4-Oxadiazolyl oder 1,2,4-Thiadiazolyl-Derivate als Angiotensin II Antagonisten Expired - Fee Related DE69319391T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24530892 1992-09-14
JP34385592 1992-12-24

Publications (2)

Publication Number Publication Date
DE69319391D1 DE69319391D1 (de) 1998-08-06
DE69319391T2 true DE69319391T2 (de) 1998-10-29

Family

ID=26537163

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69319391T Expired - Fee Related DE69319391T2 (de) 1992-09-14 1993-09-14 1,2,4-Oxadiazolyl oder 1,2,4-Thiadiazolyl-Derivate als Angiotensin II Antagonisten
DE69333489T Expired - Fee Related DE69333489T2 (de) 1992-09-14 1993-09-14 Heterocyclische Verbindungen und ihre Verwendung als Angiotensin II Antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69333489T Expired - Fee Related DE69333489T2 (de) 1992-09-14 1993-09-14 Heterocyclische Verbindungen und ihre Verwendung als Angiotensin II Antagonisten

Country Status (5)

Country Link
US (1) US5500427A (de)
EP (2) EP0829479B1 (de)
AT (2) ATE264323T1 (de)
CA (1) CA2106135A1 (de)
DE (2) DE69319391T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
GB9514160D0 (en) * 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
JPH10203981A (ja) * 1997-01-21 1998-08-04 Kureha Chem Ind Co Ltd 心疾患改善剤
WO2003041739A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticaner agents
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
ME01142B (me) * 2005-01-07 2013-03-20 Pfizer Prod Inc Heteroaromatična jedinjenja hinolina i njihova upotreba kao pde10 inhibitora
WO2006094034A1 (en) 2005-03-01 2006-09-08 Wyeth Cinnoline compounds and their use as liver x receptor modilators
EP2054383A2 (de) * 2006-08-09 2009-05-06 SmithKline Beecham Corporation Neue verbindungen als antagonisten oder inverse agonisten an opioidrezeptoren
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
MX2009005449A (es) * 2006-11-24 2009-06-02 Takeda Pharmaceutical Compuesto heteromonociclico y uso del mismo.
US7803940B2 (en) * 2006-11-24 2010-09-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
DE102017115778A1 (de) 2017-07-13 2019-01-17 Karl Storz Se & Co. Kg Medizinisches Instrument zum Abtragen von Gewebe
CN110143955B (zh) * 2018-02-11 2023-01-20 中国科学院上海药物研究所 含杂环侧链的噁二唑衍生物、合成方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104891A (en) * 1989-12-11 1992-04-14 G. D. Searle & Co. Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
EP0434038A1 (de) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Kondensierte Imidazolderivate, ihre Herstellung und Verwendung
IL99246A0 (en) * 1990-09-10 1992-07-15 Abbott Lab Angiotensin ii receptor antagonists and pharmaceutical compositions containing them
FR2673427B1 (fr) * 1991-03-01 1993-06-18 Sanofi Elf Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69333489T2 (de) 2005-04-14
ATE167861T1 (de) 1998-07-15
EP0588299B1 (de) 1998-07-01
ATE264323T1 (de) 2004-04-15
EP0588299A3 (en) 1994-06-01
CA2106135A1 (en) 1994-03-15
DE69333489D1 (de) 2004-05-19
EP0829479B1 (de) 2004-04-14
DE69319391D1 (de) 1998-08-06
EP0829479A1 (de) 1998-03-18
EP0588299A2 (de) 1994-03-23
US5500427A (en) 1996-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

8339 Ceased/non-payment of the annual fee