DE69215983T2 - Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz - Google Patents

Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz

Info

Publication number
DE69215983T2
DE69215983T2 DE1992615983 DE69215983T DE69215983T2 DE 69215983 T2 DE69215983 T2 DE 69215983T2 DE 1992615983 DE1992615983 DE 1992615983 DE 69215983 T DE69215983 T DE 69215983T DE 69215983 T2 DE69215983 T2 DE 69215983T2
Authority
DE
Germany
Prior art keywords
immunoreactant
electrochemiluminescence
concentration
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1992615983
Other languages
English (en)
Other versions
DE69215983D1 (de
Inventor
Akira Shibue
Masaru Tanaka
Shinji Kamiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TDK Corp
Original Assignee
TDK Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP19580791A external-priority patent/JPH0518970A/ja
Priority claimed from JP19580891A external-priority patent/JPH0518971A/ja
Application filed by TDK Corp filed Critical TDK Corp
Application granted granted Critical
Publication of DE69215983D1 publication Critical patent/DE69215983D1/de
Publication of DE69215983T2 publication Critical patent/DE69215983T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
DE1992615983 1991-07-10 1992-03-11 Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz Expired - Fee Related DE69215983T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19580791A JPH0518970A (ja) 1991-07-10 1991-07-10 化学発光を利用した抗原・抗体の測定方法
JP19580891A JPH0518971A (ja) 1991-07-10 1991-07-10 化学発光を利用した抗原・抗体の測定方法

Publications (2)

Publication Number Publication Date
DE69215983D1 DE69215983D1 (de) 1997-01-30
DE69215983T2 true DE69215983T2 (de) 1997-05-22

Family

ID=26509364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1992615983 Expired - Fee Related DE69215983T2 (de) 1991-07-10 1992-03-11 Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz

Country Status (2)

Country Link
EP (1) EP0522677B1 (de)
DE (1) DE69215983T2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
CN1192097C (zh) * 1995-03-10 2005-03-09 梅索磅秤技术有限公司 多阵列、多特异性的电化学发光检验
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
FI970593A (fi) * 1997-02-12 1998-08-13 Sakari Mikael Kulmala Pinnoitettujen johteiden käyttö analyyttisiin tarkoituksiin
GB9809160D0 (en) * 1998-04-29 1998-07-01 Queen Mary & Westfield College Assay
AU1561002A (en) * 2000-06-26 2002-01-08 Lumigen Inc Electrochemiluminescence from acridan compounds
US7186568B1 (en) * 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
US6703210B2 (en) * 2000-11-02 2004-03-09 Satake Corporation Method and device for determining concentration of dioxins
EP2135943A1 (de) * 2001-07-30 2009-12-23 Meso Scale Technologies, LLC. Prüfelektrode mit festen Lipid- bzw. Proteinschichten, Herstellungsverfahren dafür und Verfahren zu deren Verwendung bei Lumineszenzprüfmessungen
CN101038255B (zh) * 2007-04-06 2010-05-19 福州大学 吖啶酯、吖啶磺酰胺及其标记物的毛细管电泳化学发光仪器及检测方法
WO2012028167A2 (en) * 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
JP6010110B2 (ja) * 2011-04-20 2016-10-19 アクセス メディカル システムズ，リミティド 発光重合体の反復増幅
CN105717098B (zh) * 2016-02-25 2018-03-27 济南大学 一种基于氮掺杂二氧化钛纳米片的电致化学发光双酚a生物传感器的制备方法及应用
CN106248658B (zh) * 2016-09-08 2018-11-13 济南大学 纸基电化学发光转化器的制备及在癌胚抗原检测中的应用
CN109696461B (zh) * 2017-10-24 2023-05-26 上海药明生物技术有限公司 一种治疗性抗体的放行检测方法
WO2019079970A1 (zh) * 2017-10-24 2019-05-02 上海药明生物技术有限公司 一种治疗性抗体的放行检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352791A (en) * 1965-01-22 1967-11-14 American Cyanamid Co Generation of light by the reaction of peroxide with heterocyclic derivatives
FR2043486B1 (de) * 1969-05-28 1973-07-13 Roussel Uclaf
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
ES2063735T3 (es) * 1986-10-22 1995-01-16 Abbott Lab Sales de acridinio quimioluminiscentes.
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
CA1325527C (en) * 1988-04-28 1993-12-28 Nicholas Leventis Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5068088A (en) * 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
GB2233450B (en) * 1989-06-24 1993-06-30 Univ Wales Medicine Detecting or quantifing multiple analytes with luminescent reagents

Also Published As

Publication number Publication date
EP0522677B1 (de) 1996-12-18
EP0522677A1 (de) 1993-01-13
DE69215983D1 (de) 1997-01-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8320 Willingness to grant licences declared (paragraph 23)
8339 Ceased/non-payment of the annual fee