DE69211892D1 - 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel - Google Patents

1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Info

Publication number: DE69211892D1
Authority: DE; Germany
Prior art keywords: loweralkyl; hydrogen; medicaments; chem; oxazinyl
Prior art date: 1991-04-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69211892T

Other languages

English (en)

Other versions

DE69211892T2 (de

Inventor

Richard Charles Effland

Larry Davis

Gordon Edward Olsen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharmaceuticals Inc

Original Assignee

Hoechst Roussel Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-15

Filing date

1992-04-09

Publication date

1996-08-08

1992-04-09 Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc

1996-08-08 Application granted granted Critical

1996-08-08 Publication of DE69211892D1 publication Critical patent/DE69211892D1/de

1996-12-19 Publication of DE69211892T2 publication Critical patent/DE69211892T2/de

2012-04-10 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE69211892T 1991-04-15 1992-04-09 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel Expired - Fee Related DE69211892T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/684,758 US5214038A (en)	1991-04-15	1991-04-15	1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof

Publications (2)

Publication Number	Publication Date
DE69211892D1 true DE69211892D1 (de)	1996-08-08
DE69211892T2 DE69211892T2 (de)	1996-12-19

Family

ID=24749434

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69211892T Expired - Fee Related DE69211892T2 (de)	1991-04-15	1992-04-09	1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Country Status (22)

Country	Link
US (3)	US5214038A (de)
EP (1)	EP0509400B1 (de)
JP (1)	JP2608359B2 (de)
KR (1)	KR100201509B1 (de)
AT (1)	ATE140006T1 (de)
AU (1)	AU643135B2 (de)
CA (1)	CA2065986C (de)
CZ (1)	CZ282054B6 (de)
DE (1)	DE69211892T2 (de)
DK (1)	DK0509400T3 (de)
ES (1)	ES2094840T3 (de)
FI (1)	FI97544C (de)
GR (1)	GR3020612T3 (de)
HU (1)	HUT62588A (de)
IE (1)	IE74907B1 (de)
IL (1)	IL101589A (de)
NO (1)	NO301765B1 (de)
NZ (2)	NZ242309A (de)
PL (1)	PL168671B1 (de)
RU (1)	RU2042680C1 (de)
TW (1)	TW211016B (de)
ZA (1)	ZA922721B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5360811A (en) *	1990-03-13	1994-11-01	Hoechst-Roussel Pharmaceuticals Incorporated	1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
US5264442A (en) *	1990-08-13	1993-11-23	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
GB9225859D0 (en) *	1992-12-11	1993-02-03	Smithkline Beecham Plc	Novel treatment
US5356910A (en) *	1993-07-19	1994-10-18	Hoechst-Roussel Pharmaceuticals Inc.	Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
GB0119435D0 (en) *	2001-02-15	2001-10-03	Aventis Pharm Prod Inc	Method of treating of demyelinating diseases or conditions
EP1424325A4 (de) *	2001-09-07	2005-12-21	Ono Pharmaceutical Co	Indolderivate, verfahren zu deren herstellung und arzneimittel, die diese als wirkstoff enthalten
GT200500063A (es) *	2004-04-01	2005-10-14		Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
CN105669540A (zh)	2009-01-28	2016-06-15	卡鲁斯治疗有限公司	Scriptaid电子等排体及其在治疗中的用途
NZ707366A (en) *	2012-11-07	2018-11-30	Karus Therapeutics Ltd	Novel histone deacetylase inhibitors and their use in therapy
DK2994465T3 (en)	2013-05-10	2018-10-08	Karus Therapeutics Ltd	HISTONDEACETYLASE INHIBITORS UNKNOWN
GB201419264D0 (en)	2014-10-29	2014-12-10	Karus Therapeutics Ltd	Compounds
GB201419228D0 (en)	2014-10-29	2014-12-10	Karus Therapeutics Ltd	Compounds
CA3104928A1 (en)	2018-08-13	2020-02-20	F. Hoffmann-La Roche Ag	New heterocyclic compounds as monoacylglycerol lipase inhibitors
CR20220104A (es)	2019-09-12	2022-04-20	Hoffmann La Roche	Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de magl

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029657A (en) *	1976-06-14	1977-06-14	The Dow Chemical Company	6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
DE2726437A1 (de) *	1977-06-11	1978-12-21	Bayer Ag	Hydrazonfarbstoffe
US4880822A (en) *	1987-04-24	1989-11-14	Hoechst-Roussel Pharmaceuticals, Inc.	N-(pyridinyl)-1H-indol-1-amines
US4970218A (en) *	1987-04-24	1990-11-13	Hoechst-Roussel Pharmaceuticals Inc.	N-(pyridinyl)-1H-indol-1-amines
EP0287982B1 (de) *	1987-04-24	1994-12-07	Hoechst-Roussel Pharmaceuticals Incorporated	N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
US5039811A (en) *	1987-04-24	1991-08-13	Hoechst-Roussel Pharmaceuticals Inc.	Preparation of N-(pyridinyl)-1H-indol-1-amines
US4916135A (en) *	1989-05-08	1990-04-10	Hoechst Roussel Pharmaceuticals Inc.	N-heteroaryl-4-quinolinamines
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
EP0415103B1 (de) *	1989-08-02	1995-02-01	Hoechst-Roussel Pharmaceuticals Incorporated	2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US4983608A (en) *	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines

1991
- 1991-04-15 US US07/684,758 patent/US5214038A/en not_active Expired - Lifetime
1992
- 1992-04-09 DK DK92106160.2T patent/DK0509400T3/da active
- 1992-04-09 DE DE69211892T patent/DE69211892T2/de not_active Expired - Fee Related
- 1992-04-09 AT AT92106160T patent/ATE140006T1/de not_active IP Right Cessation
- 1992-04-09 EP EP92106160A patent/EP0509400B1/de not_active Expired - Lifetime
- 1992-04-09 ES ES92106160T patent/ES2094840T3/es not_active Expired - Lifetime
- 1992-04-10 NZ NZ242309A patent/NZ242309A/en unknown
- 1992-04-10 NZ NZ248131A patent/NZ248131A/en unknown
- 1992-04-11 TW TW081102816A patent/TW211016B/zh active
- 1992-04-13 KR KR1019920006109A patent/KR100201509B1/ko not_active IP Right Cessation
- 1992-04-13 FI FI921641A patent/FI97544C/fi active
- 1992-04-14 IE IE921190A patent/IE74907B1/en not_active IP Right Cessation
- 1992-04-14 CA CA002065986A patent/CA2065986C/en not_active Expired - Fee Related
- 1992-04-14 ZA ZA922721A patent/ZA922721B/xx unknown
- 1992-04-14 IL IL10158992A patent/IL101589A/en not_active IP Right Cessation
- 1992-04-14 JP JP4094177A patent/JP2608359B2/ja not_active Expired - Fee Related
- 1992-04-14 PL PL92294221A patent/PL168671B1/pl unknown
- 1992-04-14 CZ CS921135A patent/CZ282054B6/cs not_active IP Right Cessation
- 1992-04-14 RU SU925011168A patent/RU2042680C1/ru active
- 1992-04-14 AU AU14852/92A patent/AU643135B2/en not_active Ceased
- 1992-04-14 NO NO921490A patent/NO301765B1/no unknown
- 1992-04-15 HU HU9201290A patent/HUT62588A/hu unknown
- 1992-11-16 US US07/976,778 patent/US5276156A/en not_active Expired - Lifetime
1993
- 1993-10-20 US US08/138,645 patent/US5519131A/en not_active Expired - Lifetime
1996
- 1996-07-24 GR GR960401978T patent/GR3020612T3/el unknown

Also Published As

Publication number	Publication date
JPH05112572A (ja)	1993-05-07
EP0509400B1 (de)	1996-07-03
NO921490L (no)	1992-10-16
PL294221A1 (en)	1993-08-09
IE74907B1 (en)	1997-08-13
HU9201290D0 (en)	1992-07-28
NO301765B1 (no)	1997-12-08
HUT62588A (en)	1993-05-28
ATE140006T1 (de)	1996-07-15
JP2608359B2 (ja)	1997-05-07
DE69211892T2 (de)	1996-12-19
NO921490D0 (no)	1992-04-14
DK0509400T3 (da)	1996-10-28
NZ242309A (en)	1995-07-26
ES2094840T3 (es)	1997-02-01
IL101589A0 (en)	1992-12-30
AU1485292A (en)	1992-10-22
KR920019796A (ko)	1992-11-20
FI921641A (fi)	1992-10-16
US5276156A (en)	1994-01-04
US5519131A (en)	1996-05-21
NZ248131A (en)	1995-07-26
AU643135B2 (en)	1993-11-04
IE921190A1 (en)	1992-10-21
GR3020612T3 (en)	1996-10-31
RU2042680C1 (ru)	1995-08-27
TW211016B (de)	1993-08-11
CA2065986C (en)	2006-02-21
EP0509400A1 (de)	1992-10-21
FI97544B (fi)	1996-09-30
CA2065986A1 (en)	1992-10-16
FI921641A0 (fi)	1992-04-13
PL168671B1 (pl)	1996-03-29
CS113592A3 (en)	1992-11-18
KR100201509B1 (ko)	1999-06-15
CZ282054B6 (cs)	1997-05-14
FI97544C (fi)	1997-01-10
ZA922721B (en)	1992-11-25
US5214038A (en)	1993-05-25
IL101589A (en)	1996-10-31

Legal Events

Date	Code	Title	Description
1997-07-31	8364	No opposition during term of opposition
2011-02-17	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE3772905D1 (de)	1991-10-17	Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69032020D1 (de)	1998-03-12	N-Substituierte 4-Pyrimidinamine und -Pyrimidindiamine, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE69025941D1 (de)	1996-04-18	Dem Physostigmin verwandte 4- und 6-Carbamate, ein Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69211892D1 (de)	1996-08-08	1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69130196D1 (de)	1998-10-22	1-(Substituierte Pyridinylamino)-1H-indol-5-yl substituierte Carbamate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3780015D1 (de)	1992-07-30	Kondensierte heterocyclische tetrahydroaminochinolinole und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE68918402D1 (de)	1994-10-27	1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
DE3671017D1 (de)	1990-06-13	Benzo(c)-1,5-naphthyridine, ein verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69131546D1 (de)	1999-09-30	Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepine und verwandte Analoge, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69019066T2 (de)	1995-10-19	4,5,5a,6-Tetrahydro-3H-isoxyzolo(5,4,3-k1)acridinderivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.